##gff-version 3
Q61036	UniProtKB	Chain	1	559	.	.	.	ID=PRO_0000086470;Note=Serine/threonine-protein kinase PAK 3	
Q61036	UniProtKB	Domain	70	83	.	.	.	Note=CRIB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00057	
Q61036	UniProtKB	Domain	283	534	.	.	.	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
Q61036	UniProtKB	Region	1	70	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q61036	UniProtKB	Region	65	150	.	.	.	Note=Autoregulatory region;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q61036	UniProtKB	Region	65	123	.	.	.	Note=GTPase-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q61036	UniProtKB	Region	84	282	.	.	.	Note=Linker	
Q61036	UniProtKB	Region	171	215	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q61036	UniProtKB	Compositional bias	18	32	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q61036	UniProtKB	Compositional bias	56	70	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q61036	UniProtKB	Compositional bias	184	201	.	.	.	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q61036	UniProtKB	Active site	402	402	.	.	.	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027	
Q61036	UniProtKB	Binding site	289	297	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
Q61036	UniProtKB	Binding site	312	312	.	.	.	Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q61036	UniProtKB	Modified residue	2	2	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62829	
Q61036	UniProtKB	Modified residue	4	4	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62829	
Q61036	UniProtKB	Modified residue	50	50	.	.	.	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62829	
Q61036	UniProtKB	Modified residue	154	154	.	.	.	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62829	
Q61036	UniProtKB	Modified residue	186	186	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079	
Q61036	UniProtKB	Modified residue	436	436	.	.	.	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62829	
Q61036	UniProtKB	Alternative sequence	93	107	.	.	.	ID=VSP_010243;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10352232,ECO:0000303|PubMed:12464619,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7559398;Dbxref=PMID:10352232,PMID:12464619,PMID:15489334,PMID:7559398	
Q61036	UniProtKB	Mutagenesis	67	67	.	.	.	Note=Decreases interaction of PAK3 with CDC42 but increases interaction with RAC1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17537723;Dbxref=PMID:17537723	
Q61036	UniProtKB	Mutagenesis	78	78	.	.	.	Note=When expressed in hippocampal neurons%2C strongly decreases the number of dendritic spines%3B when associated with L-81 and R-312. H->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15800193;Dbxref=PMID:15800193	
Q61036	UniProtKB	Mutagenesis	81	81	.	.	.	Note=When expressed in hippocampal neurons%2C strongly decreases the number of dendritic spines%3B when associated with L-78 and R-312. H->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15800193;Dbxref=PMID:15800193	
Q61036	UniProtKB	Mutagenesis	312	312	.	.	.	Note=Loss of kinase activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15574732;Dbxref=PMID:15574732	
Q61036	UniProtKB	Mutagenesis	312	312	.	.	.	Note=When expressed in hippocampal neurons%2C decreases the number of dendritic spines. Strong decrease in the number of dendritic spines%3B when associated with L-78 and L-81. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15800193;Dbxref=PMID:15800193	
Q61036	UniProtKB	Mutagenesis	436	436	.	.	.	Note=When expressed in hippocampal neurons%2C increases the density of both spines and dendritic protrusions. T->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15800193;Dbxref=PMID:15800193	
Q61036	UniProtKB	Sequence conflict	176	176	.	.	.	Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q61036	UniProtKB	Sequence conflict	286	286	.	.	.	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q61036	UniProtKB	Sequence conflict	376	376	.	.	.	Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q61036	UniProtKB	Sequence conflict	508	508	.	.	.	Note=R->H;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q61036	UniProtKB	Sequence conflict	540	540	.	.	.	Note=L->M;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q61036	UniProtKB	Helix	115	118	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1EES