Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase PAK 3

Gene

Pak3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.4 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-436 and allows the kinase domain to adopt an active structure (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei312 – 3121ATPCurated
Active sitei402 – 4021Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi289 – 2979ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase kinase activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. receptor signaling protein serine/threonine kinase activity Source: GO_Central
  5. Rho GTPase binding Source: BHF-UCL

GO - Biological processi

  1. actin cytoskeleton organization Source: GO_Central
  2. activation of MAPK activity Source: MGI
  3. axonogenesis Source: UniProtKB
  4. dendrite development Source: UniProtKB
  5. intracellular signal transduction Source: GO_Central
  6. MAPK cascade Source: MGI
  7. positive regulation of dendritic spine morphogenesis Source: Ensembl
  8. positive regulation of DNA biosynthetic process Source: Ensembl
  9. positive regulation of neuron apoptotic process Source: Ensembl
  10. regulation of actin filament polymerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.12. 3474.
ReactomeiREACT_225768. Generation of second messenger molecules.
REACT_241951. Ephrin signaling.
REACT_254306. Sema3A PAK dependent Axon repulsion.
REACT_260744. Activation of Rac.
REACT_261451. CD28 dependent Vav1 pathway.
REACT_261840. VEGFR2 mediated vascular permeability.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PAK 3 (EC:2.7.11.1)
Alternative name(s):
Beta-PAK
CDC42/RAC effector kinase PAK-B
p21-activated kinase 3
Short name:
PAK-3
Gene namesi
Name:Pak3
Synonyms:Pak-3, Pakb, Stk4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1339656. Pak3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. endosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Mice show significant abnormalities in synaptic plasticity as well as deficiencies in learning and memory. Pak1 and Pak3 double knockout mice display reduced brains characterized by simplified neuronal dendrites/axons and reduced synapse density.2 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi67 – 671R → C: Decreases interaction of PAK3 with CDC42 but increases interaction with RAC1. 1 Publication
Mutagenesisi312 – 3121K → A: Loss of kinase activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Serine/threonine-protein kinase PAK 3PRO_0000086470Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei50 – 501Phosphoserine; by autocatalysisBy similarity
Modified residuei154 – 1541Phosphoserine; by autocatalysisBy similarity
Modified residuei436 – 4361Phosphothreonine; by autocatalysisBy similarity

Post-translational modificationi

Autophosphorylated when activated by CDC42/p21.
Neddylated.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ61036.
PaxDbiQ61036.
PRIDEiQ61036.

PTM databases

PhosphoSiteiQ61036.

Expressioni

Gene expression databases

BgeeiQ61036.
CleanExiMM_PAK3.
MM_STK4.
ExpressionAtlasiQ61036. baseline and differential.
GenevestigatoriQ61036.

Interactioni

Subunit structurei

Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK. Interacts with the C-terminal of APP. Interacts with ARHGEF6 and ARHGEF7 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC42P609533EBI-457317,EBI-81752From a different organism.

Protein-protein interaction databases

BioGridi202021. 3 interactions.
DIPiDIP-447N.
IntActiQ61036. 5 interactions.
MINTiMINT-151864.

Structurei

Secondary structure

1
559
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi115 – 1184Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EESNMR-B63-123[»]
ProteinModelPortaliQ61036.
SMRiQ61036. Positions 65-156, 229-553.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ61036.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 8314CRIBPROSITE-ProRule annotationAdd
BLAST
Domaini283 – 534252Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni65 – 15086Autoregulatory regionBy similarityAdd
BLAST
Regioni65 – 12359GTPase-bindingBy similarityAdd
BLAST
Regioni84 – 282199LinkerAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi187 – 19711Poly-GluAdd
BLAST

Sequence similaritiesi

Contains 1 CRIB domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121858.
HOGENOMiHOG000234202.
HOVERGENiHBG108518.
InParanoidiQ61036.
KOiK05733.
OMAiLYRNADR.
OrthoDBiEOG7CK36J.
TreeFamiTF105351.

Family and domain databases

Gene3Di3.90.810.10. 1 hit.
InterProiIPR000095. CRIB_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00786. PBD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50108. CRIB. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q61036-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDSLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS
60 70 80 90 100
IFPGGGDKTN KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTPDLYGSQM
110 120 130 140 150
CPGKLPEGIP EQWARLLQTS NITKLEQKKN PQAVLDVLKF YDSKETVNNQ
160 170 180 190 200
KYMSFTSGDK SAHGYIAAHQ SNTKTASEPP LAPPVSEEED EEEEEEEDDN
210 220 230 240 250
EPPPVIAPRP EHTKSIYTRS VVESIASPAA PNKEDIPPSA ENANSTTLYR
260 270 280 290 300
NTDRQRKKSK MTDEEILEKL RSIVSVGDPK KKYTRFEKIG QGASGTVYTA
310 320 330 340 350
LDIATGQEVA IKQMNLQQQP KKELIINEIL VMRENKNPNI VNYLDSYLVG
360 370 380 390 400
DELWVVMEYL AGGSLTDVVT ETCMDEGQIA AVCRECLQAL DFLHSNQVIH
410 420 430 440 450
RDIKSDNILL GMDGSVKLTD FGFCAQITPE QSKRSTMVGT PYWMAPEVVT
460 470 480 490 500
RKAYGPKVDI WSLGIMAIEM VEGEPPYLNE NPLRALYLIA TNGTPELQNP
510 520 530 540 550
ERLSAVFRDF LNRCLEMDVD RRGSAKELLQ HPFLKLAKPL SSLTPLIIAA

KEAIKNSSR
Length:559
Mass (Da):62,398
Last modified:May 10, 2004 - v2
Checksum:i9AD07B0328F0B08C
GO
Isoform 2 (identifier: Q61036-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-107: Missing.

Show »
Length:544
Mass (Da):60,781
Checksum:i72E323575DC18E0F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti176 – 1761A → G in AAC52354. (PubMed:7559398)Curated
Sequence conflicti286 – 2861F → L(PubMed:7559398)Curated
Sequence conflicti286 – 2861F → L(PubMed:10352232)Curated
Sequence conflicti376 – 3761E → V in AAC52354. (PubMed:7559398)Curated
Sequence conflicti508 – 5081R → H in AAC52354. (PubMed:7559398)Curated
Sequence conflicti540 – 5401L → M in AAC31969. (PubMed:10352232)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei93 – 10715Missing in isoform 2. 4 PublicationsVSP_010243Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39738 mRNA. Translation: AAC52354.1.
AF082297 mRNA. Translation: AAC31969.1.
AJ496262 mRNA. Translation: CAD42790.1.
AJ496263 mRNA. Translation: CAD42791.1.
AK031853 mRNA. Translation: BAC27580.1.
BC053403 mRNA. Translation: AAH53403.1.
CCDSiCCDS30454.1. [Q61036-2]
CCDS57779.1. [Q61036-1]
PIRiI49376.
RefSeqiNP_001181977.1. NM_001195048.1. [Q61036-1]
NP_001181978.1. NM_001195049.1. [Q61036-2]
NP_032804.2. NM_008778.3. [Q61036-2]
XP_006528814.1. XM_006528751.1. [Q61036-1]
XP_006528815.1. XM_006528752.1. [Q61036-1]
XP_006528816.1. XM_006528753.1. [Q61036-2]
XP_006528817.1. XM_006528754.1. [Q61036-2]
UniGeneiMm.40035.

Genome annotation databases

EnsembliENSMUST00000033640; ENSMUSP00000033640; ENSMUSG00000031284. [Q61036-1]
ENSMUST00000112863; ENSMUSP00000108484; ENSMUSG00000031284. [Q61036-1]
ENSMUST00000112864; ENSMUSP00000108485; ENSMUSG00000031284. [Q61036-2]
ENSMUST00000112865; ENSMUSP00000108486; ENSMUSG00000031284. [Q61036-2]
ENSMUST00000112868; ENSMUSP00000108489; ENSMUSG00000031284. [Q61036-2]
ENSMUST00000172330; ENSMUSP00000126562; ENSMUSG00000031284. [Q61036-2]
GeneIDi18481.
KEGGimmu:18481.
UCSCiuc009umg.2. mouse. [Q61036-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39738 mRNA. Translation: AAC52354.1.
AF082297 mRNA. Translation: AAC31969.1.
AJ496262 mRNA. Translation: CAD42790.1.
AJ496263 mRNA. Translation: CAD42791.1.
AK031853 mRNA. Translation: BAC27580.1.
BC053403 mRNA. Translation: AAH53403.1.
CCDSiCCDS30454.1. [Q61036-2]
CCDS57779.1. [Q61036-1]
PIRiI49376.
RefSeqiNP_001181977.1. NM_001195048.1. [Q61036-1]
NP_001181978.1. NM_001195049.1. [Q61036-2]
NP_032804.2. NM_008778.3. [Q61036-2]
XP_006528814.1. XM_006528751.1. [Q61036-1]
XP_006528815.1. XM_006528752.1. [Q61036-1]
XP_006528816.1. XM_006528753.1. [Q61036-2]
XP_006528817.1. XM_006528754.1. [Q61036-2]
UniGeneiMm.40035.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EESNMR-B63-123[»]
ProteinModelPortaliQ61036.
SMRiQ61036. Positions 65-156, 229-553.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202021. 3 interactions.
DIPiDIP-447N.
IntActiQ61036. 5 interactions.
MINTiMINT-151864.

PTM databases

PhosphoSiteiQ61036.

Proteomic databases

MaxQBiQ61036.
PaxDbiQ61036.
PRIDEiQ61036.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033640; ENSMUSP00000033640; ENSMUSG00000031284. [Q61036-1]
ENSMUST00000112863; ENSMUSP00000108484; ENSMUSG00000031284. [Q61036-1]
ENSMUST00000112864; ENSMUSP00000108485; ENSMUSG00000031284. [Q61036-2]
ENSMUST00000112865; ENSMUSP00000108486; ENSMUSG00000031284. [Q61036-2]
ENSMUST00000112868; ENSMUSP00000108489; ENSMUSG00000031284. [Q61036-2]
ENSMUST00000172330; ENSMUSP00000126562; ENSMUSG00000031284. [Q61036-2]
GeneIDi18481.
KEGGimmu:18481.
UCSCiuc009umg.2. mouse. [Q61036-1]

Organism-specific databases

CTDi5063.
MGIiMGI:1339656. Pak3.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121858.
HOGENOMiHOG000234202.
HOVERGENiHBG108518.
InParanoidiQ61036.
KOiK05733.
OMAiLYRNADR.
OrthoDBiEOG7CK36J.
TreeFamiTF105351.

Enzyme and pathway databases

BRENDAi2.7.1.12. 3474.
ReactomeiREACT_225768. Generation of second messenger molecules.
REACT_241951. Ephrin signaling.
REACT_254306. Sema3A PAK dependent Axon repulsion.
REACT_260744. Activation of Rac.
REACT_261451. CD28 dependent Vav1 pathway.
REACT_261840. VEGFR2 mediated vascular permeability.

Miscellaneous databases

EvolutionaryTraceiQ61036.
NextBioi294190.
PROiQ61036.
SOURCEiSearch...

Gene expression databases

BgeeiQ61036.
CleanExiMM_PAK3.
MM_STK4.
ExpressionAtlasiQ61036. baseline and differential.
GenevestigatoriQ61036.

Family and domain databases

Gene3Di3.90.810.10. 1 hit.
InterProiIPR000095. CRIB_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00786. PBD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50108. CRIB. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Fibroblast.
  2. Erratum
    Bagrodia S., Taylor S.J., Creasy C.L., Chernoff J., Cerione R.A.
    J. Biol. Chem. 271:1250-1250(1996)
  3. "Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes."
    Burbelo P.D., Kozak C.A., Finegold A.A., Hall A., Pirone D.M.
    Gene 232:209-215(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. "A new constitutively active brain Pak3 isoform displays modified specificities towards Rac and Cdc42 GTPases."
    Rousseau V., Goupille O., Morin N., Barnier J.V.
    J. Biol. Chem. 278:3912-3920(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Medulla oblongata.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C3H/He.
    Tissue: Mesenchymal stem cell.
  7. "p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I."
    Buscemi N., Foster D.B., Neverova I., Van Eyk J.E.
    Circ. Res. 91:509-516(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF TNNI3.
  8. "The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus."
    Boda B., Alberi S., Nikonenko I., Node-Langlois R., Jourdain P., Moosmayer M., Parisi-Jourdain L., Muller D.
    J. Neurosci. 24:10816-10825(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF LYS-312.
  9. "Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3."
    Meng J., Meng Y., Hanna A., Janus C., Jia Z.
    J. Neurosci. 25:6641-6650(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  10. "The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway."
    Kreis P., Thevenot E., Rousseau V., Boda B., Muller D., Barnier J.V.
    J. Biol. Chem. 282:21497-21506(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF ARG-67.
  11. "Structural and kinetic effects of PAK3 phosphorylation mimic of cTnI(S151E) on the cTnC-cTnI interaction in the cardiac thin filament."
    Ouyang Y., Mamidi R., Jayasundar J.J., Chandra M., Dong W.J.
    J. Mol. Biol. 400:1036-1045(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF TNNI3.
  12. "p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties."
    Huang W., Zhou Z., Asrar S., Henkelman M., Xie W., Jia Z.
    Mol. Cell. Biol. 31:388-403(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  13. "Structure of the complex of Cdc42Hs with a peptide derived from P-21 activated kinase."
    Gizachew D., Guo W., Chohan K.K., Sutcliffe M.J., Oswald R.E.
    Biochemistry 39:3963-3971(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 65-92 AND 108-123 IN COMPLEX WITH CDC42.

Entry informationi

Entry nameiPAK3_MOUSE
AccessioniPrimary (citable) accession number: Q61036
Secondary accession number(s): O88645, Q8K1R5, Q8K1R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 10, 2004
Last modified: February 4, 2015
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.