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Q61029

- LAP2B_MOUSE

UniProt

Q61029 - LAP2B_MOUSE

Protein

Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma

Gene

Tmpo

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 4 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95 By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: MGI

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma
    Alternative name(s):
    Thymopoietin isoforms beta/delta/epsilon/gamma
    Short name:
    TP beta/delta/epsilon/gamma
    Gene namesi
    Name:Tmpo
    Synonyms:Lap2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:106920. Tmpo.

    Subcellular locationi

    Nucleus inner membrane By similarity; Single-pass type II membrane protein By similarity. Chromosome By similarity
    Note: Tightly associated with the nuclear lamina.By similarity

    GO - Cellular componenti

    1. chromatin Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. nuclear envelope Source: MGI
    4. nuclear inner membrane Source: UniProtKB-SubCell
    5. nucleus Source: MGI

    Keywords - Cellular componenti

    Chromosome, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gammaPRO_0000206146Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei59 – 591PhosphoserineBy similarity
    Modified residuei66 – 661Phosphoserine2 Publications
    Modified residuei67 – 671Phosphoserine2 Publications
    Modified residuei74 – 741Phosphothreonine3 Publications
    Modified residuei79 – 791PhosphoserineBy similarity
    Modified residuei153 – 1531PhosphothreonineBy similarity
    Modified residuei155 – 1551PhosphoserineBy similarity
    Modified residuei159 – 1591Phosphothreonine2 Publications
    Modified residuei163 – 1631PhosphothreonineBy similarity
    Modified residuei176 – 1761Phosphoserine1 Publication
    Modified residuei179 – 1791Phosphoserine; by PKC1 Publication
    Modified residuei183 – 1831PhosphoserineBy similarity
    Modified residuei206 – 2061N6-acetyllysine1 Publication
    Modified residuei210 – 2101PhosphothreonineBy similarity
    Modified residuei264 – 2641PhosphoserineBy similarity
    Modified residuei291 – 2911PhosphoserineBy similarity
    Modified residuei305 – 3051PhosphoserineBy similarity
    Modified residuei311 – 3111PhosphothreonineBy similarity
    Modified residuei314 – 3141PhosphoserineBy similarity
    Modified residuei319 – 3191Citrulline1 Publication
    Modified residuei361 – 3611PhosphoserineBy similarity
    Modified residuei384 – 3841PhosphoserineBy similarity
    Modified residuei388 – 3881N6-acetyllysine1 Publication

    Post-translational modificationi

    Mitosis-specific phosphorylation specifically abolishes its binding to lamin B and chromosomes.By similarity
    Citrullinated by PADI4.1 Publication

    Keywords - PTMi

    Acetylation, Citrullination, Phosphoprotein

    Proteomic databases

    PRIDEiQ61029.

    Expressioni

    Gene expression databases

    ArrayExpressiQ61029.
    BgeeiQ61029.
    CleanExiMM_TMPO.
    GenevestigatoriQ61029.

    Interactioni

    Subunit structurei

    Interacts with LMNB1, LMNB2, BANF1, AKAP8L, GMCL and chromosomes.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Zbtb7bQ643212EBI-6172136,EBI-642868

    Protein-protein interaction databases

    BioGridi204234. 3 interactions.
    IntActiQ61029. 3 interactions.
    MINTiMINT-4109431.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61029.
    SMRiQ61029. Positions 2-56, 102-158.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini431 – 45222LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei410 – 43021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 4844LEM-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini109 – 15345LEMPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 409409NucleoplasmicSequence AnalysisAdd
    BLAST
    Regioni49 – 10860LinkerAdd
    BLAST
    Regioni137 – 242106NAKAP95-binding NAdd
    BLAST
    Regioni298 – 37073Binds lamins BAdd
    BLAST
    Regioni299 – 37375NAKAP95-binding CAdd
    BLAST

    Domaini

    Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1 By similarity.By similarity

    Sequence similaritiesi

    Belongs to the LEM family.Curated
    Contains 1 LEM domain.PROSITE-ProRule annotation
    Contains 1 LEM-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00510000048934.
    HOGENOMiHOG000113280.
    HOVERGENiHBG000166.
    OMAiTGNFKHA.

    Family and domain databases

    Gene3Di1.10.720.40. 2 hits.
    InterProiIPR013146. LEM-like_dom.
    IPR011015. LEM/LEM-like_dom.
    IPR003887. LEM_dom.
    [Graphical view]
    PfamiPF03020. LEM. 1 hit.
    PF08198. Thymopoietin. 1 hit.
    [Graphical view]
    SMARTiSM00540. LEM. 1 hit.
    [Graphical view]
    SUPFAMiSSF63451. SSF63451. 2 hits.
    PROSITEiPS50954. LEM. 1 hit.
    PS50955. LEM_LIKE. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform Beta (identifier: Q61029-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR    50
    PPLAAGANSK GPPDFSSDEE REPTPVLGSG ASVGRGRGAV GRKATKKTDK 100
    PRLEDKDDLD VTELSNEELL DQLVRYGVNP GPIVGTTRKL YEKKLLKLRE 150
    QGTESRSSTP LPTVSSSAEN TRQNGSNDSD RYSDNDEDSK IELKLEKREP 200
    LKGRAKTPVT LKQRRTEHNQ SYSQAGVTET EWTSGSSTGG PLQALTREST 250
    RGSRRTPRKR VETSQHFRID GAVISESTPI AETIKASSNE SLVANRLTGN 300
    FKHASSILPI TEFSDITRRT PKKPLTRAEV GEKTEERRVD RDILKEMFPY 350
    EASTPTGISA SCRRPIKGAA GRPLELSDFR MEESFSSKYV PKYAPLADVK 400
    SEKTKKRRSV PMWIKMLLFA LVAVFLFLVY QAMETNQGNP FTNFLQDTKI 450
    SN 452
    Length:452
    Mass (Da):50,373
    Last modified:July 27, 2011 - v4
    Checksum:i132AF11B458DCFBA
    GO
    Isoform Alpha (identifier: Q61033-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q61033.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:693
    Mass (Da):75,168
    GO
    Isoform Zeta (identifier: Q61033-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q61033.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Contains a N6-acetyllysine at position 206.

    Length:225
    Mass (Da):24,990
    GO
    Isoform Delta (identifier: Q61029-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         221-292: Missing.

    Show »
    Length:380
    Mass (Da):42,650
    Checksum:iF2BE6B5556030A49
    GO
    Isoform Epsilon (identifier: Q61029-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         221-260: Missing.

    Show »
    Length:412
    Mass (Da):46,050
    Checksum:iC54639DAB8788CEE
    GO
    Isoform Gamma (identifier: Q61029-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         221-329: Missing.

    Show »
    Length:343
    Mass (Da):38,502
    Checksum:iBA62B6D869B0FDAD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti72 – 732EP → DA in AAC52574. (PubMed:8743987)Curated
    Sequence conflicti72 – 732EP → DA in AAC52575. (PubMed:8743987)Curated
    Sequence conflicti72 – 732EP → DA in AAC52576. (PubMed:8743987)Curated
    Sequence conflicti72 – 732EP → DA in AAC52577. (PubMed:8743987)Curated
    Sequence conflicti422 – 4243VAV → GAC in AAC52574. (PubMed:8743987)Curated
    Sequence conflicti422 – 4243VAV → GAC in AAC52575. (PubMed:8743987)Curated
    Sequence conflicti422 – 4243VAV → GAC in AAC52576. (PubMed:8743987)Curated
    Sequence conflicti422 – 4243VAV → GAC in AAC52577. (PubMed:8743987)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei221 – 329109Missing in isoform Gamma. 1 PublicationVSP_010132Add
    BLAST
    Alternative sequencei221 – 29272Missing in isoform Delta. 1 PublicationVSP_010131Add
    BLAST
    Alternative sequencei221 – 26040Missing in isoform Epsilon. 1 PublicationVSP_010130Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39074 mRNA. Translation: AAC52574.1.
    U39075 mRNA. Translation: AAC52575.1.
    U39076 mRNA. Translation: AAC52576.1.
    U39077 mRNA. Translation: AAC52577.1.
    AK150305 mRNA. Translation: BAE29455.1.
    AK150515 mRNA. Translation: BAE29627.1.
    AK153281 mRNA. Translation: BAE31865.1.
    AK165851 mRNA. Translation: BAE38413.1.
    CH466539 Genomic DNA. Translation: EDL21533.1.
    CCDSiCCDS36032.1. [Q61029-4]
    CCDS36033.1. [Q61029-2]
    CCDS36034.1. [Q61029-3]
    CCDS36035.1. [Q61029-1]
    RefSeqiNP_001073598.1. NM_001080129.2. [Q61029-1]
    NP_001073600.1. NM_001080131.2. [Q61029-2]
    NP_001073601.1. NM_001080132.2. [Q61029-4]
    UniGeneiMm.159684.
    Mm.439157.

    Genome annotation databases

    EnsembliENSMUST00000072239; ENSMUSP00000072092; ENSMUSG00000019961. [Q61029-1]
    ENSMUST00000092219; ENSMUSP00000089864; ENSMUSG00000019961. [Q61029-3]
    ENSMUST00000099355; ENSMUSP00000096956; ENSMUSG00000019961. [Q61029-2]
    ENSMUST00000105293; ENSMUSP00000100930; ENSMUSG00000019961. [Q61029-4]
    GeneIDi21917.
    KEGGimmu:21917.
    UCSCiuc007gtq.1. mouse. [Q61029-1]
    uc007gts.1. mouse. [Q61029-2]
    uc007gtt.1. mouse. [Q61029-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39074 mRNA. Translation: AAC52574.1 .
    U39075 mRNA. Translation: AAC52575.1 .
    U39076 mRNA. Translation: AAC52576.1 .
    U39077 mRNA. Translation: AAC52577.1 .
    AK150305 mRNA. Translation: BAE29455.1 .
    AK150515 mRNA. Translation: BAE29627.1 .
    AK153281 mRNA. Translation: BAE31865.1 .
    AK165851 mRNA. Translation: BAE38413.1 .
    CH466539 Genomic DNA. Translation: EDL21533.1 .
    CCDSi CCDS36032.1. [Q61029-4 ]
    CCDS36033.1. [Q61029-2 ]
    CCDS36034.1. [Q61029-3 ]
    CCDS36035.1. [Q61029-1 ]
    RefSeqi NP_001073598.1. NM_001080129.2. [Q61029-1 ]
    NP_001073600.1. NM_001080131.2. [Q61029-2 ]
    NP_001073601.1. NM_001080132.2. [Q61029-4 ]
    UniGenei Mm.159684.
    Mm.439157.

    3D structure databases

    ProteinModelPortali Q61029.
    SMRi Q61029. Positions 2-56, 102-158.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204234. 3 interactions.
    IntActi Q61029. 3 interactions.
    MINTi MINT-4109431.

    Proteomic databases

    PRIDEi Q61029.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072239 ; ENSMUSP00000072092 ; ENSMUSG00000019961 . [Q61029-1 ]
    ENSMUST00000092219 ; ENSMUSP00000089864 ; ENSMUSG00000019961 . [Q61029-3 ]
    ENSMUST00000099355 ; ENSMUSP00000096956 ; ENSMUSG00000019961 . [Q61029-2 ]
    ENSMUST00000105293 ; ENSMUSP00000100930 ; ENSMUSG00000019961 . [Q61029-4 ]
    GeneIDi 21917.
    KEGGi mmu:21917.
    UCSCi uc007gtq.1. mouse. [Q61029-1 ]
    uc007gts.1. mouse. [Q61029-2 ]
    uc007gtt.1. mouse. [Q61029-4 ]

    Organism-specific databases

    CTDi 7112.
    MGIi MGI:106920. Tmpo.

    Phylogenomic databases

    GeneTreei ENSGT00510000048934.
    HOGENOMi HOG000113280.
    HOVERGENi HBG000166.
    OMAi TGNFKHA.

    Miscellaneous databases

    ChiTaRSi TMPO. mouse.
    NextBioi 301476.
    PROi Q61029.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61029.
    Bgeei Q61029.
    CleanExi MM_TMPO.
    Genevestigatori Q61029.

    Family and domain databases

    Gene3Di 1.10.720.40. 2 hits.
    InterProi IPR013146. LEM-like_dom.
    IPR011015. LEM/LEM-like_dom.
    IPR003887. LEM_dom.
    [Graphical view ]
    Pfami PF03020. LEM. 1 hit.
    PF08198. Thymopoietin. 1 hit.
    [Graphical view ]
    SMARTi SM00540. LEM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63451. SSF63451. 2 hits.
    PROSITEi PS50954. LEM. 1 hit.
    PS50955. LEM_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The characterization and localization of the mouse thymopoietin/lamina-associated polypeptide 2 gene and its alternatively spliced products."
      Berger R., Theodor L., Shoham J., Gokkel E., Brok-Simoni F., Avraham K.B., Copeland N.G., Jenkins N.A., Rechavi G., Simon A.J.
      Genome Res. 6:361-370(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA; BETA; GAMMA; DELTA; EPSILON AND ZETA).
      Strain: C57BL/6 X DBA/2.
      Tissue: Thymus.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow and Lung.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Identification of phosphorylation sites in native lamina-associated polypeptide 2 beta."
      Dreger M., Otto H., Neubauer G., Mann M., Hucho F.
      Biochemistry 38:9426-9434(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 61-85 AND 173-194 (ISOFORM BETA), PHOSPHORYLATION AT THR-74; THR-159; SER-176 AND SER-179, IDENTIFICATION BY MASS SPECTROMETRY.
    5. "LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction."
      Furukawa K.
      J. Cell Sci. 112:2485-2492(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BANF1.
    6. "Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less)."
      Nili E., Cojocaru G.S., Kalma Y., Ginsberg D., Copeland N.G., Gilbert D.J., Jenkins N.A., Berger R., Shaklai S., Amariglio N., Brok-Simoni F., Simon A.J., Rechavi G.
      J. Cell Sci. 114:3297-3307(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GMCL.
    7. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66; SER-67; THR-74 AND THR-159, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    9. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66; SER-67 AND THR-74, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    11. Cited for: CITRULLINATION AT ARG-319.
    12. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-206 AND LYS-388, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiLAP2B_MOUSE
    AccessioniPrimary (citable) accession number: Q61029
    Secondary accession number(s): Q3UCI5
    , Q61030, Q61031, Q61032
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 125 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3