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Protein

Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma

Gene

Tmpo

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma
Alternative name(s):
Thymopoietin isoforms beta/delta/epsilon/gamma
Short name:
TP beta/delta/epsilon/gamma
Gene namesi
Name:Tmpo
Synonyms:Lap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:106920. Tmpo.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei410 – 43021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini431 – 45222LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gammaPRO_0000206146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei59 – 591PhosphoserineBy similarity
Modified residuei66 – 661Phosphoserine2 Publications
Modified residuei67 – 671Phosphoserine2 Publications
Modified residuei74 – 741Phosphothreonine3 Publications
Modified residuei79 – 791PhosphoserineBy similarity
Modified residuei153 – 1531PhosphothreonineBy similarity
Modified residuei155 – 1551PhosphoserineBy similarity
Modified residuei159 – 1591Phosphothreonine2 Publications
Modified residuei163 – 1631PhosphothreonineBy similarity
Modified residuei176 – 1761Phosphoserine1 Publication
Modified residuei179 – 1791Phosphoserine; by PKC1 Publication
Modified residuei206 – 2061N6-acetyllysine1 Publication
Modified residuei210 – 2101PhosphothreonineBy similarity
Modified residuei264 – 2641PhosphoserineBy similarity
Modified residuei291 – 2911PhosphoserineBy similarity
Modified residuei305 – 3051PhosphoserineBy similarity
Modified residuei311 – 3111PhosphothreonineBy similarity
Modified residuei314 – 3141PhosphoserineBy similarity
Modified residuei319 – 3191Citrulline1 Publication
Modified residuei361 – 3611PhosphoserineBy similarity
Modified residuei384 – 3841PhosphoserineBy similarity
Modified residuei388 – 3881N6-acetyllysine1 Publication
Isoform Zeta (identifier: Q61033-2)
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