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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

Gene

Gngt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiR-MMU-1296041. Activation of G protein gated Potassium channels.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Alternative name(s):
G gamma-C
G-gamma-8
Gene namesi
Name:Gngt2
Synonyms:Gng8, Gngt8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:893584. Gngt2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6666Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2PRO_0000012647Add
BLAST
Propeptidei67 – 693Removed in mature formBy similarityPRO_0000012648

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 661Cysteine methyl esterBy similarity
Lipidationi66 – 661S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ61017.
MaxQBiQ61017.
PaxDbiQ61017.
PRIDEiQ61017.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038811.
ExpressionAtlasiQ61017. baseline and differential.
GenevisibleiQ61017. MM.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047586.

Structurei

3D structure databases

ProteinModelPortaliQ61017.
SMRiQ61017. Positions 5-62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00530000063397.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiQ61017.
KOiK04549.
OMAiKNERQMV.
OrthoDBiEOG091G17J0.
PhylomeDBiQ61017.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQDLSEKEL LRMEVEQLKK EVKNPRDLIS KTGKEIKDYV EAQAGTDPLL
60
KGIPEDKNPF KEKGTCVLS
Length:69
Mass (Da):7,802
Last modified:September 27, 2004 - v2
Checksum:i80A9586CD56BB304
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010554 mRNA. Translation: BAB27023.1.
U38500 mRNA. Translation: AAB01731.1.
CCDSiCCDS25284.1.
RefSeqiNP_001033753.2. NM_001038664.2.
NP_001271322.1. NM_001284393.1.
NP_001271326.1. NM_001284397.1.
NP_075610.1. NM_023121.2.
XP_006532294.1. XM_006532231.2.
XP_011247039.1. XM_011248737.1.
UniGeneiMm.46299.

Genome annotation databases

EnsembliENSMUST00000036088; ENSMUSP00000047586; ENSMUSG00000038811.
ENSMUST00000100532; ENSMUSP00000098101; ENSMUSG00000038811.
ENSMUST00000107708; ENSMUSP00000103336; ENSMUSG00000038811.
ENSMUST00000107709; ENSMUSP00000103337; ENSMUSG00000038811.
ENSMUST00000107711; ENSMUSP00000103339; ENSMUSG00000038811.
ENSMUST00000107712; ENSMUSP00000103340; ENSMUSG00000038811.
ENSMUST00000107714; ENSMUSP00000103342; ENSMUSG00000038811.
GeneIDi14710.
KEGGimmu:14710.
UCSCiuc007lau.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010554 mRNA. Translation: BAB27023.1.
U38500 mRNA. Translation: AAB01731.1.
CCDSiCCDS25284.1.
RefSeqiNP_001033753.2. NM_001038664.2.
NP_001271322.1. NM_001284393.1.
NP_001271326.1. NM_001284397.1.
NP_075610.1. NM_023121.2.
XP_006532294.1. XM_006532231.2.
XP_011247039.1. XM_011248737.1.
UniGeneiMm.46299.

3D structure databases

ProteinModelPortaliQ61017.
SMRiQ61017. Positions 5-62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047586.

Proteomic databases

EPDiQ61017.
MaxQBiQ61017.
PaxDbiQ61017.
PRIDEiQ61017.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036088; ENSMUSP00000047586; ENSMUSG00000038811.
ENSMUST00000100532; ENSMUSP00000098101; ENSMUSG00000038811.
ENSMUST00000107708; ENSMUSP00000103336; ENSMUSG00000038811.
ENSMUST00000107709; ENSMUSP00000103337; ENSMUSG00000038811.
ENSMUST00000107711; ENSMUSP00000103339; ENSMUSG00000038811.
ENSMUST00000107712; ENSMUSP00000103340; ENSMUSG00000038811.
ENSMUST00000107714; ENSMUSP00000103342; ENSMUSG00000038811.
GeneIDi14710.
KEGGimmu:14710.
UCSCiuc007lau.1. mouse.

Organism-specific databases

CTDi2793.
MGIiMGI:893584. Gngt2.

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00530000063397.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiQ61017.
KOiK04549.
OMAiKNERQMV.
OrthoDBiEOG091G17J0.
PhylomeDBiQ61017.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiR-MMU-1296041. Activation of G protein gated Potassium channels.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

PROiQ61017.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038811.
ExpressionAtlasiQ61017. baseline and differential.
GenevisibleiQ61017. MM.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBGT2_MOUSE
AccessioniPrimary (citable) accession number: Q61017
Secondary accession number(s): Q9CWL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2004
Last modified: September 7, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.