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Q61017

- GBGT2_MOUSE

UniProt

Q61017 - GBGT2_MOUSE

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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

Gene

Gngt2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. GTPase activity Source: Ensembl
  2. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
REACT_213947. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_231304. Glucagon-type ligand receptors.
REACT_248547. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_250590. Adrenaline,noradrenaline inhibits insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Alternative name(s):
G gamma-C
G-gamma-8
Gene namesi
Name:Gngt2
Synonyms:Gng8, Gngt8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:893584. Gngt2.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6666Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2PRO_0000012647Add
BLAST
Propeptidei67 – 693Removed in mature formBy similarityPRO_0000012648

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 661Cysteine methyl esterBy similarity
Lipidationi66 – 661S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ61017.
PRIDEiQ61017.

Expressioni

Gene expression databases

BgeeiQ61017.
ExpressionAtlasiQ61017. differential.
GenevestigatoriQ61017.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliQ61017.
SMRiQ61017. Positions 5-62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG304504.
GeneTreeiENSGT00530000063397.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiQ61017.
KOiK04549.
OMAiMISKTGK.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ61017.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61017-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQDLSEKEL LRMEVEQLKK EVKNPRDLIS KTGKEIKDYV EAQAGTDPLL
60
KGIPEDKNPF KEKGTCVLS
Length:69
Mass (Da):7,802
Last modified:September 27, 2004 - v2
Checksum:i80A9586CD56BB304
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010554 mRNA. Translation: BAB27023.1.
U38500 mRNA. Translation: AAB01731.1.
CCDSiCCDS25284.1.
RefSeqiNP_001033753.2. NM_001038664.2.
NP_001271322.1. NM_001284393.1.
NP_001271326.1. NM_001284397.1.
NP_075610.1. NM_023121.2.
XP_006532293.1. XM_006532230.1.
XP_006532294.1. XM_006532231.1.
UniGeneiMm.46299.

Genome annotation databases

EnsembliENSMUST00000036088; ENSMUSP00000047586; ENSMUSG00000038811.
ENSMUST00000100532; ENSMUSP00000098101; ENSMUSG00000038811.
ENSMUST00000107708; ENSMUSP00000103336; ENSMUSG00000038811.
ENSMUST00000107709; ENSMUSP00000103337; ENSMUSG00000038811.
ENSMUST00000107711; ENSMUSP00000103339; ENSMUSG00000038811.
ENSMUST00000107712; ENSMUSP00000103340; ENSMUSG00000038811.
ENSMUST00000107714; ENSMUSP00000103342; ENSMUSG00000038811.
GeneIDi14710.
KEGGimmu:14710.
UCSCiuc007lau.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010554 mRNA. Translation: BAB27023.1 .
U38500 mRNA. Translation: AAB01731.1 .
CCDSi CCDS25284.1.
RefSeqi NP_001033753.2. NM_001038664.2.
NP_001271322.1. NM_001284393.1.
NP_001271326.1. NM_001284397.1.
NP_075610.1. NM_023121.2.
XP_006532293.1. XM_006532230.1.
XP_006532294.1. XM_006532231.1.
UniGenei Mm.46299.

3D structure databases

ProteinModelPortali Q61017.
SMRi Q61017. Positions 5-62.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi Q61017.
PRIDEi Q61017.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036088 ; ENSMUSP00000047586 ; ENSMUSG00000038811 .
ENSMUST00000100532 ; ENSMUSP00000098101 ; ENSMUSG00000038811 .
ENSMUST00000107708 ; ENSMUSP00000103336 ; ENSMUSG00000038811 .
ENSMUST00000107709 ; ENSMUSP00000103337 ; ENSMUSG00000038811 .
ENSMUST00000107711 ; ENSMUSP00000103339 ; ENSMUSG00000038811 .
ENSMUST00000107712 ; ENSMUSP00000103340 ; ENSMUSG00000038811 .
ENSMUST00000107714 ; ENSMUSP00000103342 ; ENSMUSG00000038811 .
GeneIDi 14710.
KEGGi mmu:14710.
UCSCi uc007lau.1. mouse.

Organism-specific databases

CTDi 2793.
MGIi MGI:893584. Gngt2.

Phylogenomic databases

eggNOGi NOG304504.
GeneTreei ENSGT00530000063397.
HOGENOMi HOG000231034.
HOVERGENi HBG014983.
InParanoidi Q61017.
KOi K04549.
OMAi MISKTGK.
OrthoDBi EOG7H1JP7.
PhylomeDBi Q61017.
TreeFami TF319909.

Enzyme and pathway databases

Reactomei REACT_208837. Activation of G protein gated Potassium channels.
REACT_213947. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_231304. Glucagon-type ligand receptors.
REACT_248547. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_250590. Adrenaline,noradrenaline inhibits insulin secretion.

Miscellaneous databases

NextBioi 286705.
PROi Q61017.
SOURCEi Search...

Gene expression databases

Bgeei Q61017.
ExpressionAtlasi Q61017. differential.
Genevestigatori Q61017.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view ]
PANTHERi PTHR13809. PTHR13809. 1 hit.
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
PRINTSi PR00321. GPROTEING.
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. "G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development."
    Williams C.J., Schultz R.M., Kopf G.S.
    Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-54.
    Strain: CF-1 / Harlan.
    Tissue: Retina.

Entry informationi

Entry nameiGBGT2_MOUSE
AccessioniPrimary (citable) accession number: Q61017
Secondary accession number(s): Q9CWL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2004
Last modified: November 26, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3