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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

Gene

Gngt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. GTPase activity Source: Ensembl
  2. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: InterPro
  2. metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_272374. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_286837. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_297430. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_308732. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_339334. Activation of G protein gated Potassium channels.
REACT_339920. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Alternative name(s):
G gamma-C
G-gamma-8
Gene namesi
Name:Gngt2
Synonyms:Gng8, Gngt8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:893584. Gngt2.

Subcellular locationi

  1. Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6666Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2PRO_0000012647Add
BLAST
Propeptidei67 – 693Removed in mature formBy similarityPRO_0000012648

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 661Cysteine methyl esterBy similarity
Lipidationi66 – 661S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ61017.
PRIDEiQ61017.

Expressioni

Gene expression databases

BgeeiQ61017.
ExpressionAtlasiQ61017. baseline and differential.
GenevestigatoriQ61017.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliQ61017.
SMRiQ61017. Positions 5-62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG304504.
GeneTreeiENSGT00530000063397.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiQ61017.
KOiK04549.
OMAiKEVKNPR.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ61017.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQDLSEKEL LRMEVEQLKK EVKNPRDLIS KTGKEIKDYV EAQAGTDPLL
60
KGIPEDKNPF KEKGTCVLS
Length:69
Mass (Da):7,802
Last modified:September 27, 2004 - v2
Checksum:i80A9586CD56BB304
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010554 mRNA. Translation: BAB27023.1.
U38500 mRNA. Translation: AAB01731.1.
CCDSiCCDS25284.1.
RefSeqiNP_001033753.2. NM_001038664.2.
NP_001271322.1. NM_001284393.1.
NP_001271326.1. NM_001284397.1.
NP_075610.1. NM_023121.2.
XP_006532294.1. XM_006532231.2.
UniGeneiMm.46299.

Genome annotation databases

EnsembliENSMUST00000036088; ENSMUSP00000047586; ENSMUSG00000038811.
ENSMUST00000100532; ENSMUSP00000098101; ENSMUSG00000038811.
ENSMUST00000107708; ENSMUSP00000103336; ENSMUSG00000038811.
ENSMUST00000107709; ENSMUSP00000103337; ENSMUSG00000038811.
ENSMUST00000107711; ENSMUSP00000103339; ENSMUSG00000038811.
ENSMUST00000107712; ENSMUSP00000103340; ENSMUSG00000038811.
ENSMUST00000107714; ENSMUSP00000103342; ENSMUSG00000038811.
GeneIDi14710.
KEGGimmu:14710.
UCSCiuc007lau.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010554 mRNA. Translation: BAB27023.1.
U38500 mRNA. Translation: AAB01731.1.
CCDSiCCDS25284.1.
RefSeqiNP_001033753.2. NM_001038664.2.
NP_001271322.1. NM_001284393.1.
NP_001271326.1. NM_001284397.1.
NP_075610.1. NM_023121.2.
XP_006532294.1. XM_006532231.2.
UniGeneiMm.46299.

3D structure databases

ProteinModelPortaliQ61017.
SMRiQ61017. Positions 5-62.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ61017.
PRIDEiQ61017.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036088; ENSMUSP00000047586; ENSMUSG00000038811.
ENSMUST00000100532; ENSMUSP00000098101; ENSMUSG00000038811.
ENSMUST00000107708; ENSMUSP00000103336; ENSMUSG00000038811.
ENSMUST00000107709; ENSMUSP00000103337; ENSMUSG00000038811.
ENSMUST00000107711; ENSMUSP00000103339; ENSMUSG00000038811.
ENSMUST00000107712; ENSMUSP00000103340; ENSMUSG00000038811.
ENSMUST00000107714; ENSMUSP00000103342; ENSMUSG00000038811.
GeneIDi14710.
KEGGimmu:14710.
UCSCiuc007lau.1. mouse.

Organism-specific databases

CTDi2793.
MGIiMGI:893584. Gngt2.

Phylogenomic databases

eggNOGiNOG304504.
GeneTreeiENSGT00530000063397.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiQ61017.
KOiK04549.
OMAiKEVKNPR.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ61017.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiREACT_272374. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_286837. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_297430. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_308732. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_339334. Activation of G protein gated Potassium channels.
REACT_339920. Glucagon-type ligand receptors.

Miscellaneous databases

NextBioi286705.
PROiQ61017.
SOURCEiSearch...

Gene expression databases

BgeeiQ61017.
ExpressionAtlasiQ61017. baseline and differential.
GenevestigatoriQ61017.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. "G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development."
    Williams C.J., Schultz R.M., Kopf G.S.
    Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-54.
    Strain: CF-1 / Harlan.
    Tissue: Retina.

Entry informationi

Entry nameiGBGT2_MOUSE
AccessioniPrimary (citable) accession number: Q61017
Secondary accession number(s): Q9CWL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2004
Last modified: April 1, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.