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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Gene

Gng7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum.1 Publication

GO - Molecular functioni

  • signal transducer activity Source: MGI

GO - Biological processi

  • behavioral fear response Source: MGI
  • G-protein coupled receptor signaling pathway Source: InterPro
  • locomotory behavior Source: MGI
  • receptor guanylyl cyclase signaling pathway Source: MGI
  • regulation of adenylate cyclase activity Source: UniProtKB

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-MMU-1296041. Activation of G protein gated Potassium channels.
R-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Gene namesi
Name:Gng7
Synonyms:Gngt7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:95787. Gng7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display increased startle response but normal prepulse inhibition of the startle response. No effect on survival to weaning, fertility and mortality.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000126372 – 65Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7Add BLAST64
PropeptideiPRO_000001263866 – 68Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei65Cysteine methyl esterBy similarity1
Lipidationi65S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ61016.
PaxDbiQ61016.
PRIDEiQ61016.

PTM databases

iPTMnetiQ61016.
PhosphoSitePlusiQ61016.

Expressioni

Tissue specificityi

Brain. Found in the hippocampus, striatum, midbrain and cortex.1 Publication

Gene expression databases

BgeeiENSMUSG00000048240.
ExpressionAtlasiQ61016. baseline and differential.
GenevisibleiQ61016. MM.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

BioGridi199992. 1 interactor.
IntActiQ61016. 1 interactor.
STRINGi10090.ENSMUSP00000089936.

Structurei

3D structure databases

ProteinModelPortaliQ61016.
SMRiQ61016.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiQ61016.
OMAiSELMNYC.
PhylomeDBiQ61016.

Family and domain databases

CDDicd00068. GGL. 1 hit.
InterProiView protein in InterPro
IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiView protein in Pfam
PF00631. G-gamma. 1 hit.
PRINTSiPR00321. GPROTEING.
SMARTiView protein in SMART
SM00224. GGL. 1 hit.
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiView protein in PROSITE
PS50058. G_PROTEIN_GAMMA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61016-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTNNVAQA RKLVEQLRIE AGIERIKVSK ASSDLMGYCE QHARNDPLLV
60
GVPASENPFK DKKPCIIL
Length:68
Mass (Da):7,480
Last modified:September 27, 2004 - v2
Checksum:i0F07C667A29ADC07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY035844 mRNA. Translation: AAK61365.1.
BC034108 mRNA. Translation: AAH34108.1.
U38499 mRNA. Translation: AAB01730.1.
UniGeneiMm.222496.

Genome annotation databases

EnsembliENSMUST00000117805; ENSMUSP00000112409; ENSMUSG00000048240.
ENSMUST00000118233; ENSMUSP00000114003; ENSMUSG00000048240.
ENSMUST00000118465; ENSMUSP00000113798; ENSMUSG00000048240.

Similar proteinsi

Entry informationi

Entry nameiGBG7_MOUSE
AccessioniPrimary (citable) accession number: Q61016
Secondary accession number(s): Q8JZP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2004
Last modified: September 27, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families