Q61016 (GBG7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Gene names

Name:	Gng7
Synonyms:	Gngt7

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	68 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum. Ref.4
Subunit structure	G proteins are composed of 3 units, alpha, beta and gamma.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Tissue specificity	Brain. Found in the hippocampus, striatum, midbrain and cortex. Ref.4
Disruption phenotype	Mice display increased startle response but normal prepulse inhibition of the startle response. No effect on survival to weaning, fertility and mortality. Ref.4
Sequence similarities	Belongs to the G protein gamma family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Molecular function	Transducer
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro behavioral fear response Inferred from mutant phenotype Ref.4. Source: MGI locomotory behavior Inferred from mutant phenotype Ref.4. Source: MGI receptor guanylyl cyclase signaling pathway Inferred from mutant phenotype Ref.4. Source: MGI regulation of adenylate cyclase activity Inferred from mutant phenotype Ref.4. Source: UniProtKB
Cellular_component	heterotrimeric G-protein complex Inferred from electronic annotation. Source: InterPro
Molecular_function	signal transducer activity Inferred from mutant phenotype Ref.4. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 65	64	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7		PRO_0000012637
	Propeptide	66 – 68	3	Removed in mature form By similarity		PRO_0000012638
Amino acid modifications
	Modified residue	65	1	Cysteine methyl ester By similarity
	Lipidation	65	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q61016 [UniParc]. Last modified September 27, 2004. Version 2. Checksum: 0F07C667A29ADC07	FASTA	68	7,480
	10 20 30 40 50 60 MSGTNNVAQA RKLVEQLRIE AGIERIKVSK ASSDLMGYCE QHARNDPLLV GVPASENPFK DKKPCIIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mouse G-protein gamma 7 cDNA." Xiong X., Han J. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[3]	"G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development." Williams C.J., Schultz R.M., Kopf G.S. Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-51. Strain: CF-1 / Harlan.
[4]	"Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP production." Schwindinger W.F., Betz K.S., Giger K.E., Sabol A., Bronson S.K., Robishaw J.D. J. Biol. Chem. 278:6575-6579(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY035844 mRNA. Translation: AAK61365.1. BC034108 mRNA. Translation: AAH34108.1. U38499 mRNA. Translation: AAB01730.1.
IPI	IPI00230566.
RefSeq	NP_001033744.1. NM_001038655.1. NP_034449.2. NM_010319.3.
UniGene	Mm.222496.
3D structure databases
ProteinModelPortal	Q61016.
SMR	Q61016. Positions 9-58.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q61016. 1 interaction.
PTM databases
PhosphoSite	Q61016.
Proteomic databases
PaxDb	Q61016.
PRIDE	Q61016.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000117805; ENSMUSP00000112409; ENSMUSG00000048240. ENSMUST00000118233; ENSMUSP00000114003; ENSMUSG00000048240. ENSMUST00000118465; ENSMUSP00000113798; ENSMUSG00000048240.
GeneID	14708.
KEGG	mmu:14708.
Organism-specific databases
CTD	2788.
MGI	MGI:95787. Gng7.
Phylogenomic databases
eggNOG	NOG265454.
GeneTree	ENSGT00550000074352.
HOGENOM	HOG000231034.
HOVERGEN	HBG014983.
InParanoid	Q61016.
KO	K04543.
OMA	NNVAQAR.
OrthoDB	EOG4ZGPF1.
Gene expression databases
ArrayExpress	Q61016.
Bgee	Q61016.
Genevestigator	Q61016.
GermOnline	ENSMUSG00000048240. Mus musculus.
Family and domain databases
Gene3D	4.10.260.10. 1 hit.
InterPro	IPR015898. G-protein_gamma-like_dom. IPR001770. Gprotein-gamma. [Graphical view]
PANTHER	PTHR13809. PTHR13809. 1 hit.
Pfam	PF00631. G-gamma. 1 hit. [Graphical view]
PRINTS	PR00321. GPROTEING.
SMART	SM00224. GGL. 1 hit. [Graphical view]
SUPFAM	SSF48670. G-protein_gamma-like. 1 hit.
PROSITE	PS50058. G_PROTEIN_GAMMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	286695.
SOURCE	Search...

Entry information

Entry name

GBG7_MOUSE

Accession

Primary (citable) accession number: Q61016
Secondary accession number(s): Q8JZP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	September 27, 2004
Last modified:	May 1, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program