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Q61016

- GBG7_MOUSE

UniProt

Q61016 - GBG7_MOUSE

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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Gene

Gng7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum.1 Publication

GO - Molecular functioni

  1. signal transducer activity Source: MGI

GO - Biological processi

  1. behavioral fear response Source: MGI
  2. G-protein coupled receptor signaling pathway Source: InterPro
  3. locomotory behavior Source: MGI
  4. receptor guanylyl cyclase signaling pathway Source: MGI
  5. regulation of adenylate cyclase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Gene namesi
Name:Gng7
Synonyms:Gngt7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:95787. Gng7.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display increased startle response but normal prepulse inhibition of the startle response. No effect on survival to weaning, fertility and mortality.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7PRO_0000012637Add
BLAST
Propeptidei66 – 683Removed in mature formBy similarityPRO_0000012638

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei65 – 651Cysteine methyl esterBy similarity
Lipidationi65 – 651S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ61016.
PaxDbiQ61016.
PRIDEiQ61016.

PTM databases

PhosphoSiteiQ61016.

Expressioni

Tissue specificityi

Brain. Found in the hippocampus, striatum, midbrain and cortex.1 Publication

Gene expression databases

BgeeiQ61016.
ExpressionAtlasiQ61016. baseline and differential.
GenevestigatoriQ61016.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

IntActiQ61016. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ61016.
SMRiQ61016. Positions 9-58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG265454.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiQ61016.
KOiK04543.
OMAiPECHEGV.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ61016.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61016-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGTNNVAQA RKLVEQLRIE AGIERIKVSK ASSDLMGYCE QHARNDPLLV
60
GVPASENPFK DKKPCIIL
Length:68
Mass (Da):7,480
Last modified:September 27, 2004 - v2
Checksum:i0F07C667A29ADC07
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY035844 mRNA. Translation: AAK61365.1.
BC034108 mRNA. Translation: AAH34108.1.
U38499 mRNA. Translation: AAB01730.1.
RefSeqiNP_001033744.1. NM_001038655.1.
NP_034449.2. NM_010319.3.
XP_006513301.1. XM_006513238.1.
UniGeneiMm.222496.

Genome annotation databases

EnsembliENSMUST00000117805; ENSMUSP00000112409; ENSMUSG00000048240.
ENSMUST00000118233; ENSMUSP00000114003; ENSMUSG00000048240.
ENSMUST00000118465; ENSMUSP00000113798; ENSMUSG00000048240.
GeneIDi14708.
KEGGimmu:14708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY035844 mRNA. Translation: AAK61365.1 .
BC034108 mRNA. Translation: AAH34108.1 .
U38499 mRNA. Translation: AAB01730.1 .
RefSeqi NP_001033744.1. NM_001038655.1.
NP_034449.2. NM_010319.3.
XP_006513301.1. XM_006513238.1.
UniGenei Mm.222496.

3D structure databases

ProteinModelPortali Q61016.
SMRi Q61016. Positions 9-58.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61016. 1 interaction.

PTM databases

PhosphoSitei Q61016.

Proteomic databases

MaxQBi Q61016.
PaxDbi Q61016.
PRIDEi Q61016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000117805 ; ENSMUSP00000112409 ; ENSMUSG00000048240 .
ENSMUST00000118233 ; ENSMUSP00000114003 ; ENSMUSG00000048240 .
ENSMUST00000118465 ; ENSMUSP00000113798 ; ENSMUSG00000048240 .
GeneIDi 14708.
KEGGi mmu:14708.

Organism-specific databases

CTDi 2788.
MGIi MGI:95787. Gng7.

Phylogenomic databases

eggNOGi NOG265454.
GeneTreei ENSGT00760000119218.
HOGENOMi HOG000231034.
HOVERGENi HBG014983.
InParanoidi Q61016.
KOi K04543.
OMAi PECHEGV.
OrthoDBi EOG7H1JP7.
PhylomeDBi Q61016.

Enzyme and pathway databases

Reactomei REACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

NextBioi 286695.
PROi Q61016.
SOURCEi Search...

Gene expression databases

Bgeei Q61016.
ExpressionAtlasi Q61016. baseline and differential.
Genevestigatori Q61016.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view ]
PANTHERi PTHR13809. PTHR13809. 1 hit.
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
PRINTSi PR00321. GPROTEING.
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse G-protein gamma 7 cDNA."
    Xiong X., Han J.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. "G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development."
    Williams C.J., Schultz R.M., Kopf G.S.
    Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-51.
    Strain: CF-1 / Harlan.
  4. "Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP production."
    Schwindinger W.F., Betz K.S., Giger K.E., Sabol A., Bronson S.K., Robishaw J.D.
    J. Biol. Chem. 278:6575-6579(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGBG7_MOUSE
AccessioniPrimary (citable) accession number: Q61016
Secondary accession number(s): Q8JZP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2004
Last modified: October 29, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3