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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Gene

Gng7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum.1 Publication

GO - Molecular functioni

  1. signal transducer activity Source: MGI

GO - Biological processi

  1. behavioral fear response Source: MGI
  2. G-protein coupled receptor signaling pathway Source: InterPro
  3. locomotory behavior Source: MGI
  4. receptor guanylyl cyclase signaling pathway Source: MGI
  5. regulation of adenylate cyclase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_231304. Glucagon-type ligand receptors.
REACT_248547. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_250590. Adrenaline,noradrenaline inhibits insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Gene namesi
Name:Gng7
Synonyms:Gngt7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:95787. Gng7.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
  2. heterotrimeric G-protein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display increased startle response but normal prepulse inhibition of the startle response. No effect on survival to weaning, fertility and mortality.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7PRO_0000012637Add
BLAST
Propeptidei66 – 683Removed in mature formBy similarityPRO_0000012638

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei65 – 651Cysteine methyl esterBy similarity
Lipidationi65 – 651S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ61016.
PaxDbiQ61016.
PRIDEiQ61016.

PTM databases

PhosphoSiteiQ61016.

Expressioni

Tissue specificityi

Brain. Found in the hippocampus, striatum, midbrain and cortex.1 Publication

Gene expression databases

BgeeiQ61016.
ExpressionAtlasiQ61016. baseline and differential.
GenevestigatoriQ61016.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

IntActiQ61016. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ61016.
SMRiQ61016. Positions 9-58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG265454.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiQ61016.
KOiK04543.
OMAiSELMNYC.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ61016.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61016-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGTNNVAQA RKLVEQLRIE AGIERIKVSK ASSDLMGYCE QHARNDPLLV
60
GVPASENPFK DKKPCIIL
Length:68
Mass (Da):7,480
Last modified:September 27, 2004 - v2
Checksum:i0F07C667A29ADC07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY035844 mRNA. Translation: AAK61365.1.
BC034108 mRNA. Translation: AAH34108.1.
U38499 mRNA. Translation: AAB01730.1.
RefSeqiNP_001033744.1. NM_001038655.1.
NP_034449.2. NM_010319.3.
XP_006513301.1. XM_006513238.1.
UniGeneiMm.222496.

Genome annotation databases

EnsembliENSMUST00000117805; ENSMUSP00000112409; ENSMUSG00000048240.
ENSMUST00000118233; ENSMUSP00000114003; ENSMUSG00000048240.
ENSMUST00000118465; ENSMUSP00000113798; ENSMUSG00000048240.
GeneIDi14708.
KEGGimmu:14708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY035844 mRNA. Translation: AAK61365.1.
BC034108 mRNA. Translation: AAH34108.1.
U38499 mRNA. Translation: AAB01730.1.
RefSeqiNP_001033744.1. NM_001038655.1.
NP_034449.2. NM_010319.3.
XP_006513301.1. XM_006513238.1.
UniGeneiMm.222496.

3D structure databases

ProteinModelPortaliQ61016.
SMRiQ61016. Positions 9-58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61016. 1 interaction.

PTM databases

PhosphoSiteiQ61016.

Proteomic databases

MaxQBiQ61016.
PaxDbiQ61016.
PRIDEiQ61016.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117805; ENSMUSP00000112409; ENSMUSG00000048240.
ENSMUST00000118233; ENSMUSP00000114003; ENSMUSG00000048240.
ENSMUST00000118465; ENSMUSP00000113798; ENSMUSG00000048240.
GeneIDi14708.
KEGGimmu:14708.

Organism-specific databases

CTDi2788.
MGIiMGI:95787. Gng7.

Phylogenomic databases

eggNOGiNOG265454.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiQ61016.
KOiK04543.
OMAiSELMNYC.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ61016.

Enzyme and pathway databases

ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_231304. Glucagon-type ligand receptors.
REACT_248547. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_250590. Adrenaline,noradrenaline inhibits insulin secretion.

Miscellaneous databases

NextBioi286695.
PROiQ61016.
SOURCEiSearch...

Gene expression databases

BgeeiQ61016.
ExpressionAtlasiQ61016. baseline and differential.
GenevestigatoriQ61016.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse G-protein gamma 7 cDNA."
    Xiong X., Han J.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. "G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development."
    Williams C.J., Schultz R.M., Kopf G.S.
    Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-51.
    Strain: CF-1 / Harlan.
  4. "Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP production."
    Schwindinger W.F., Betz K.S., Giger K.E., Sabol A., Bronson S.K., Robishaw J.D.
    J. Biol. Chem. 278:6575-6579(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGBG7_MOUSE
AccessioniPrimary (citable) accession number: Q61016
Secondary accession number(s): Q8JZP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2004
Last modified: February 4, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.