Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q61016

- GBG7_MOUSE

UniProt

Q61016 - GBG7_MOUSE

Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Gene

Gng7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum.1 Publication

    GO - Molecular functioni

    1. signal transducer activity Source: MGI

    GO - Biological processi

    1. behavioral fear response Source: MGI
    2. G-protein coupled receptor signaling pathway Source: InterPro
    3. locomotory behavior Source: MGI
    4. receptor guanylyl cyclase signaling pathway Source: MGI
    5. regulation of adenylate cyclase activity Source: UniProtKB

    Keywords - Molecular functioni

    Transducer

    Enzyme and pathway databases

    ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
    REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_221970. Ca2+ pathway.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
    Gene namesi
    Name:Gng7
    Synonyms:Gngt7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:95787. Gng7.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice display increased startle response but normal prepulse inhibition of the startle response. No effect on survival to weaning, fertility and mortality.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7PRO_0000012637Add
    BLAST
    Propeptidei66 – 683Removed in mature formBy similarityPRO_0000012638

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei65 – 651Cysteine methyl esterBy similarity
    Lipidationi65 – 651S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    MaxQBiQ61016.
    PaxDbiQ61016.
    PRIDEiQ61016.

    PTM databases

    PhosphoSiteiQ61016.

    Expressioni

    Tissue specificityi

    Brain. Found in the hippocampus, striatum, midbrain and cortex.1 Publication

    Gene expression databases

    BgeeiQ61016.
    GenevestigatoriQ61016.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma.

    Protein-protein interaction databases

    IntActiQ61016. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61016.
    SMRiQ61016. Positions 9-58.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G protein gamma family.Curated

    Phylogenomic databases

    eggNOGiNOG265454.
    GeneTreeiENSGT00740000115214.
    HOGENOMiHOG000231034.
    HOVERGENiHBG014983.
    InParanoidiQ61016.
    KOiK04543.
    OMAiPECHEGV.
    OrthoDBiEOG7H1JP7.
    PhylomeDBiQ61016.

    Family and domain databases

    Gene3Di4.10.260.10. 1 hit.
    InterProiIPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view]
    PANTHERiPTHR13809. PTHR13809. 1 hit.
    PfamiPF00631. G-gamma. 1 hit.
    [Graphical view]
    PRINTSiPR00321. GPROTEING.
    SMARTiSM00224. GGL. 1 hit.
    [Graphical view]
    SUPFAMiSSF48670. SSF48670. 1 hit.
    PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61016-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGTNNVAQA RKLVEQLRIE AGIERIKVSK ASSDLMGYCE QHARNDPLLV   50
    GVPASENPFK DKKPCIIL 68
    Length:68
    Mass (Da):7,480
    Last modified:September 27, 2004 - v2
    Checksum:i0F07C667A29ADC07
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY035844 mRNA. Translation: AAK61365.1.
    BC034108 mRNA. Translation: AAH34108.1.
    U38499 mRNA. Translation: AAB01730.1.
    RefSeqiNP_001033744.1. NM_001038655.1.
    NP_034449.2. NM_010319.3.
    XP_006513301.1. XM_006513238.1.
    UniGeneiMm.222496.

    Genome annotation databases

    EnsembliENSMUST00000117805; ENSMUSP00000112409; ENSMUSG00000048240.
    ENSMUST00000118233; ENSMUSP00000114003; ENSMUSG00000048240.
    ENSMUST00000118465; ENSMUSP00000113798; ENSMUSG00000048240.
    GeneIDi14708.
    KEGGimmu:14708.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY035844 mRNA. Translation: AAK61365.1 .
    BC034108 mRNA. Translation: AAH34108.1 .
    U38499 mRNA. Translation: AAB01730.1 .
    RefSeqi NP_001033744.1. NM_001038655.1.
    NP_034449.2. NM_010319.3.
    XP_006513301.1. XM_006513238.1.
    UniGenei Mm.222496.

    3D structure databases

    ProteinModelPortali Q61016.
    SMRi Q61016. Positions 9-58.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61016. 1 interaction.

    PTM databases

    PhosphoSitei Q61016.

    Proteomic databases

    MaxQBi Q61016.
    PaxDbi Q61016.
    PRIDEi Q61016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000117805 ; ENSMUSP00000112409 ; ENSMUSG00000048240 .
    ENSMUST00000118233 ; ENSMUSP00000114003 ; ENSMUSG00000048240 .
    ENSMUST00000118465 ; ENSMUSP00000113798 ; ENSMUSG00000048240 .
    GeneIDi 14708.
    KEGGi mmu:14708.

    Organism-specific databases

    CTDi 2788.
    MGIi MGI:95787. Gng7.

    Phylogenomic databases

    eggNOGi NOG265454.
    GeneTreei ENSGT00740000115214.
    HOGENOMi HOG000231034.
    HOVERGENi HBG014983.
    InParanoidi Q61016.
    KOi K04543.
    OMAi PECHEGV.
    OrthoDBi EOG7H1JP7.
    PhylomeDBi Q61016.

    Enzyme and pathway databases

    Reactomei REACT_208837. Activation of G protein gated Potassium channels.
    REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_221970. Ca2+ pathway.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Miscellaneous databases

    NextBioi 286695.
    PROi Q61016.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61016.
    Genevestigatori Q61016.

    Family and domain databases

    Gene3Di 4.10.260.10. 1 hit.
    InterProi IPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view ]
    PANTHERi PTHR13809. PTHR13809. 1 hit.
    Pfami PF00631. G-gamma. 1 hit.
    [Graphical view ]
    PRINTSi PR00321. GPROTEING.
    SMARTi SM00224. GGL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48670. SSF48670. 1 hit.
    PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse G-protein gamma 7 cDNA."
      Xiong X., Han J.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    3. "G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development."
      Williams C.J., Schultz R.M., Kopf G.S.
      Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-51.
      Strain: CF-1 / Harlan.
    4. "Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP production."
      Schwindinger W.F., Betz K.S., Giger K.E., Sabol A., Bronson S.K., Robishaw J.D.
      J. Biol. Chem. 278:6575-6579(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiGBG7_MOUSE
    AccessioniPrimary (citable) accession number: Q61016
    Secondary accession number(s): Q8JZP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: September 27, 2004
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3