Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein G(T) subunit gamma-T1

Gene

Gngt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

  • cardiac muscle cell apoptotic process Source: MGI
  • cellular response to hypoxia Source: MGI
  • eye photoreceptor cell development Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
  • phototransduction Source: MGI
  • protein localization Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiR-MMU-1296041. Activation of G protein gated Potassium channels.
R-MMU-2485179. Activation of the phototransduction cascade.
R-MMU-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-381753. Olfactory Signaling Pathway.
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(T) subunit gamma-T1
Alternative name(s):
Transducin gamma chain
Gene namesi
Name:Gngt1
Synonyms:Gng1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:109165. Gngt1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 7170Guanine nucleotide-binding protein G(T) subunit gamma-T1PRO_0000012607Add
BLAST
Propeptidei72 – 743Removed in mature formBy similarityPRO_0000012608

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei71 – 711Cysteine methyl ester1 Publication
Lipidationi71 – 711S-farnesyl cysteine1 Publication

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ61012.
PaxDbiQ61012.
PRIDEiQ61012.

PTM databases

PhosphoSiteiQ61012.

Expressioni

Tissue specificityi

Retinal rod outer segment.

Gene expression databases

BgeeiENSMUSG00000029663.
GenevisibleiQ61012. MM.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

IntActiQ61012. 1 interaction.
STRINGi10090.ENSMUSP00000031673.

Structurei

3D structure databases

ProteinModelPortaliQ61012.
SMRiQ61012. Positions 1-68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00530000063397.
HOVERGENiHBG014983.
InParanoidiQ61012.
KOiK04548.
OMAiKGGCVIC.
OrthoDBiEOG091G17J0.
PhylomeDBiQ61012.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVINIEDLT EKDKLKMEVD QLKKEVTLER MMVSKCCEEV RDYIEERSGE
60 70
DPLVKGIPED KNPFKELKGG CVIS
Length:74
Mass (Da):8,528
Last modified:January 23, 2007 - v3
Checksum:i3ABB43EF45CE02F4
GO

Mass spectrometryi

Molecular mass is 8314.5±0.1 Da from positions 2 - 71. Determined by ESI. Includes farnesylation and methylation.1 Publication
Molecular mass is 695.5±0.1 Da from positions 67 - 71. Determined by MALDI. Includes farnesylation and methylation.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020863 mRNA. Translation: BAB32232.1.
AK020903 mRNA. Translation: BAB32247.1.
BC025929 mRNA. Translation: AAH25929.1.
U38495 mRNA. Translation: AAB01726.1.
CCDSiCCDS39418.1.
RefSeqiNP_034444.1. NM_010314.2.
XP_006505047.1. XM_006504984.1.
XP_006505048.1. XM_006504985.2.
XP_006505049.1. XM_006504986.1.
UniGeneiMm.95398.

Genome annotation databases

EnsembliENSMUST00000031673; ENSMUSP00000031673; ENSMUSG00000029663.
GeneIDi14699.
KEGGimmu:14699.
UCSCiuc009avi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020863 mRNA. Translation: BAB32232.1.
AK020903 mRNA. Translation: BAB32247.1.
BC025929 mRNA. Translation: AAH25929.1.
U38495 mRNA. Translation: AAB01726.1.
CCDSiCCDS39418.1.
RefSeqiNP_034444.1. NM_010314.2.
XP_006505047.1. XM_006504984.1.
XP_006505048.1. XM_006504985.2.
XP_006505049.1. XM_006504986.1.
UniGeneiMm.95398.

3D structure databases

ProteinModelPortaliQ61012.
SMRiQ61012. Positions 1-68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61012. 1 interaction.
STRINGi10090.ENSMUSP00000031673.

PTM databases

PhosphoSiteiQ61012.

Proteomic databases

MaxQBiQ61012.
PaxDbiQ61012.
PRIDEiQ61012.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031673; ENSMUSP00000031673; ENSMUSG00000029663.
GeneIDi14699.
KEGGimmu:14699.
UCSCiuc009avi.1. mouse.

Organism-specific databases

CTDi2792.
MGIiMGI:109165. Gngt1.

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00530000063397.
HOVERGENiHBG014983.
InParanoidiQ61012.
KOiK04548.
OMAiKGGCVIC.
OrthoDBiEOG091G17J0.
PhylomeDBiQ61012.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiR-MMU-1296041. Activation of G protein gated Potassium channels.
R-MMU-2485179. Activation of the phototransduction cascade.
R-MMU-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-381753. Olfactory Signaling Pathway.
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

ChiTaRSiGngt1. mouse.
PROiQ61012.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029663.
GenevisibleiQ61012. MM.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBG1_MOUSE
AccessioniPrimary (citable) accession number: Q61012
Secondary accession number(s): Q9CR01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.