Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q61012

- GBG1_MOUSE

UniProt

Q61012 - GBG1_MOUSE

Protein

Guanine nucleotide-binding protein G(T) subunit gamma-T1

Gene

Gngt1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

    GO - Molecular functioni

    1. GTPase activity Source: MGI
    2. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. cardiac muscle cell apoptotic process Source: MGI
    2. cellular response to hypoxia Source: MGI
    3. eye photoreceptor cell development Source: MGI
    4. G-protein coupled receptor signaling pathway Source: MGI
    5. GTP catabolic process Source: GOC
    6. phototransduction Source: MGI
    7. protein localization Source: MGI

    Keywords - Molecular functioni

    Transducer

    Enzyme and pathway databases

    ReactomeiREACT_188252. Activation of the phototransduction cascade.
    REACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.
    REACT_208837. Activation of G protein gated Potassium channels.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_221970. Ca2+ pathway.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(T) subunit gamma-T1
    Alternative name(s):
    Transducin gamma chain
    Gene namesi
    Name:Gngt1
    Synonyms:Gng1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:109165. Gngt1.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: MGI
    2. photoreceptor inner segment Source: Ensembl
    3. photoreceptor outer segment Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 7170Guanine nucleotide-binding protein G(T) subunit gamma-T1PRO_0000012607Add
    BLAST
    Propeptidei72 – 743Removed in mature formBy similarityPRO_0000012608

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei71 – 711Cysteine methyl ester1 Publication
    Lipidationi71 – 711S-farnesyl cysteine1 Publication

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    MaxQBiQ61012.
    PRIDEiQ61012.

    PTM databases

    PhosphoSiteiQ61012.

    Expressioni

    Tissue specificityi

    Retinal rod outer segment.

    Gene expression databases

    BgeeiQ61012.
    GenevestigatoriQ61012.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma.

    Protein-protein interaction databases

    IntActiQ61012. 1 interaction.
    STRINGi10090.ENSMUSP00000031673.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61012.
    SMRiQ61012. Positions 1-68.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G protein gamma family.Curated

    Phylogenomic databases

    eggNOGiNOG291971.
    GeneTreeiENSGT00530000063397.
    HOVERGENiHBG014983.
    InParanoidiQ61012.
    KOiK04548.
    OMAiTSKCCEE.
    OrthoDBiEOG7H1JP7.
    PhylomeDBiQ61012.
    TreeFamiTF319909.

    Family and domain databases

    Gene3Di4.10.260.10. 1 hit.
    InterProiIPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view]
    PANTHERiPTHR13809. PTHR13809. 1 hit.
    PfamiPF00631. G-gamma. 1 hit.
    [Graphical view]
    PRINTSiPR00321. GPROTEING.
    SMARTiSM00224. GGL. 1 hit.
    [Graphical view]
    SUPFAMiSSF48670. SSF48670. 1 hit.
    PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61012-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVINIEDLT EKDKLKMEVD QLKKEVTLER MMVSKCCEEV RDYIEERSGE   50
    DPLVKGIPED KNPFKELKGG CVIS 74
    Length:74
    Mass (Da):8,528
    Last modified:January 23, 2007 - v3
    Checksum:i3ABB43EF45CE02F4
    GO

    Mass spectrometryi

    Molecular mass is 8314.5±0.1 Da from positions 2 - 71. Determined by ESI. Includes farnesylation and methylation.1 Publication
    Molecular mass is 695.5±0.1 Da from positions 67 - 71. Determined by MALDI. Includes farnesylation and methylation.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK020863 mRNA. Translation: BAB32232.1.
    AK020903 mRNA. Translation: BAB32247.1.
    BC025929 mRNA. Translation: AAH25929.1.
    U38495 mRNA. Translation: AAB01726.1.
    CCDSiCCDS39418.1.
    RefSeqiNP_034444.1. NM_010314.2.
    XP_006505047.1. XM_006504984.1.
    XP_006505048.1. XM_006504985.1.
    XP_006505049.1. XM_006504986.1.
    UniGeneiMm.95398.

    Genome annotation databases

    EnsembliENSMUST00000031673; ENSMUSP00000031673; ENSMUSG00000029663.
    GeneIDi14699.
    KEGGimmu:14699.
    UCSCiuc009avi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK020863 mRNA. Translation: BAB32232.1 .
    AK020903 mRNA. Translation: BAB32247.1 .
    BC025929 mRNA. Translation: AAH25929.1 .
    U38495 mRNA. Translation: AAB01726.1 .
    CCDSi CCDS39418.1.
    RefSeqi NP_034444.1. NM_010314.2.
    XP_006505047.1. XM_006504984.1.
    XP_006505048.1. XM_006504985.1.
    XP_006505049.1. XM_006504986.1.
    UniGenei Mm.95398.

    3D structure databases

    ProteinModelPortali Q61012.
    SMRi Q61012. Positions 1-68.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61012. 1 interaction.
    STRINGi 10090.ENSMUSP00000031673.

    PTM databases

    PhosphoSitei Q61012.

    Proteomic databases

    MaxQBi Q61012.
    PRIDEi Q61012.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031673 ; ENSMUSP00000031673 ; ENSMUSG00000029663 .
    GeneIDi 14699.
    KEGGi mmu:14699.
    UCSCi uc009avi.1. mouse.

    Organism-specific databases

    CTDi 2792.
    MGIi MGI:109165. Gngt1.

    Phylogenomic databases

    eggNOGi NOG291971.
    GeneTreei ENSGT00530000063397.
    HOVERGENi HBG014983.
    InParanoidi Q61012.
    KOi K04548.
    OMAi TSKCCEE.
    OrthoDBi EOG7H1JP7.
    PhylomeDBi Q61012.
    TreeFami TF319909.

    Enzyme and pathway databases

    Reactomei REACT_188252. Activation of the phototransduction cascade.
    REACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.
    REACT_208837. Activation of G protein gated Potassium channels.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_221970. Ca2+ pathway.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Miscellaneous databases

    ChiTaRSi GNGT1. mouse.
    NextBioi 286659.
    PROi Q61012.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61012.
    Genevestigatori Q61012.

    Family and domain databases

    Gene3Di 4.10.260.10. 1 hit.
    InterProi IPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view ]
    PANTHERi PTHR13809. PTHR13809. 1 hit.
    Pfami PF00631. G-gamma. 1 hit.
    [Graphical view ]
    PRINTSi PR00321. GPROTEING.
    SMARTi SM00224. GGL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48670. SSF48670. 1 hit.
    PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Retina.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    3. "Top-down analysis of protein isoprenylation by electrospray ionization hybrid quadrupole time-of-flight tandem mass spectrometry; the mouse Tgamma protein."
      Kassai H., Satomi Y., Fukada Y., Takao T.
      Rapid Commun. Mass Spectrom. 19:269-274(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-71, ISOPRENYLATION AT CYS-71, METHYLATION AT CYS-71, MASS SPECTROMETRY.
    4. "G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development."
      Williams C.J., Schultz R.M., Kopf G.S.
      Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-66.
      Strain: CF-1 / Harlan.
      Tissue: Retina.

    Entry informationi

    Entry nameiGBG1_MOUSE
    AccessioniPrimary (citable) accession number: Q61012
    Secondary accession number(s): Q9CR01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 119 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3