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Protein

Scavenger receptor class B member 1

Gene

Scarb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (By similarity). Plays an important role in the uptake of HDL cholesteryl ester (By similarity).By similarity

GO - Molecular functioni

  1. apolipoprotein A-I binding Source: MGI
  2. apolipoprotein binding Source: BHF-UCL
  3. high-density lipoprotein particle binding Source: BHF-UCL
  4. high-density lipoprotein particle receptor activity Source: BHF-UCL
  5. lipopolysaccharide binding Source: MGI
  6. lipopolysaccharide receptor activity Source: MGI
  7. low-density lipoprotein particle binding Source: BHF-UCL

GO - Biological processi

  1. adhesion of symbiont to host Source: MGI
  2. androgen biosynthetic process Source: Ensembl
  3. blood vessel endothelial cell migration Source: MGI
  4. cell adhesion Source: InterPro
  5. cholesterol catabolic process Source: MGI
  6. cholesterol efflux Source: BHF-UCL
  7. cholesterol homeostasis Source: BHF-UCL
  8. cholesterol import Source: BHF-UCL
  9. cholesterol transport Source: MGI
  10. detection of lipopolysaccharide Source: MGI
  11. endothelial cell proliferation Source: MGI
  12. high-density lipoprotein particle clearance Source: BHF-UCL
  13. high-density lipoprotein particle remodeling Source: BHF-UCL
  14. lipopolysaccharide-mediated signaling pathway Source: MGI
  15. lipopolysaccharide transport Source: MGI
  16. low-density lipoprotein particle clearance Source: BHF-UCL
  17. phospholipid transport Source: BHF-UCL
  18. positive regulation of cholesterol storage Source: BHF-UCL
  19. positive regulation of nitric-oxide synthase activity Source: MGI
  20. positive regulation of triglyceride biosynthetic process Source: BHF-UCL
  21. recognition of apoptotic cell Source: BHF-UCL
  22. regulation of phosphatidylcholine catabolic process Source: BHF-UCL
  23. reverse cholesterol transport Source: BHF-UCL
  24. triglyceride homeostasis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_282527. Scavenging by Class B Receptors.
REACT_326379. HDL-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Scavenger receptor class B member 1
Short name:
SRB1
Alternative name(s):
SR-BI
Gene namesi
Name:Scarb1
Synonyms:Srb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:893578. Scarb1.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity. Membranecaveola By similarity; Multi-pass membrane protein By similarity
Note: Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Topological domaini33 – 440408ExtracellularSequence AnalysisAdd
BLAST
Transmembranei441 – 46121HelicalSequence AnalysisAdd
BLAST
Topological domaini462 – 50948CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. caveola Source: MGI
  2. cell surface Source: Ensembl
  3. extracellular vesicular exosome Source: MGI
  4. integral component of membrane Source: MGI
  5. integral component of plasma membrane Source: MGI
  6. lysosomal membrane Source: MGI
  7. microvillus membrane Source: Ensembl
  8. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Scavenger receptor class B member 1PRO_0000144161Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi251 ↔ 3841 Publication
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity
The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61009.
PaxDbiQ61009.
PRIDEiQ61009.

PTM databases

PhosphoSiteiQ61009.

Expressioni

Tissue specificityi

Expressed primarily in liver and non-placental steroidogenic tissues.

Gene expression databases

BgeeiQ61009.
CleanExiMM_SCARB1.
ExpressionAtlasiQ61009. baseline and differential.
GenevestigatoriQ61009.

Interactioni

Subunit structurei

The C-terminal region binds to PDZK1.By similarity

Protein-protein interaction databases

MINTiMINT-242627.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R69X-ray1.50A/B505-509[»]
ProteinModelPortaliQ61009.
SMRiQ61009. Positions 52-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD36 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257244.
GeneTreeiENSGT00530000062927.
HOGENOMiHOG000252951.
HOVERGENiHBG106577.
InParanoidiQ61009.
KOiK13885.
OMAiPDACRSM.
OrthoDBiEOG79SDWX.
PhylomeDBiQ61009.
TreeFamiTF317925.

Family and domain databases

InterProiIPR002159. CD36.
IPR005428. CD36_antigen.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.

Sequencei

Sequence statusi: Complete.

Q61009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGSSRARWV ALGLGALGLL FAALGVVMIL MVPSLIKQQV LKNVRIDPSS
60 70 80 90 100
LSFGMWKEIP VPFYLSVYFF EVVNPNEVLN GQKPVVRERG PYVYREFRQK
110 120 130 140 150
VNITFNDNDT VSFVENRSLH FQPDKSHGSE SDYIVLPNIL VLGGSILMES
160 170 180 190 200
KPVSLKLMMT LALVTMGQRA FMNRTVGEIL WGYDDPFVHF LNTYLPDMLP
210 220 230 240 250
IKGKFGLFVG MNNSNSGVFT VFTGVQNFSR IHLVDKWNGL SKIDYWHSEQ
260 270 280 290 300
CNMINGTSGQ MWAPFMTPES SLEFFSPEAC RSMKLTYNES RVFEGIPTYR
310 320 330 340 350
FTAPDTLFAN GSVYPPNEGF CPCRESGIQN VSTCRFGAPL FLSHPHFYNA
360 370 380 390 400
DPVLSEAVLG LNPNPKEHSL FLDIHPVTGI PMNCSVKMQL SLYIKSVKGI
410 420 430 440 450
GQTGKIEPVV LPLLWFEQSG AMGGKPLSTF YTQLVLMPQV LHYAQYVLLG
460 470 480 490 500
LGGLLLLVPI ICQLRSQEKC FLFWSGSKKG SQDKEAIQAY SESLMSPAAK

GTVLQEAKL
Length:509
Mass (Da):56,754
Last modified:October 31, 1996 - v1
Checksum:i5CFCDD62DD6ECB1C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti396 – 3961S → F in BAB27068 (PubMed:16141072).Curated
Sequence conflicti468 – 50942EKCFL…QEAKL → GPEDTISPPNLIAWSDQPPS PYTPLLEDSLSGQPTSAMA in BAB27068 (PubMed:16141072).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37799 mRNA. Translation: AAC52378.1.
AK010622 mRNA. Translation: BAB27068.1.
AK028191 mRNA. Translation: BAC25802.1.
AK033114 mRNA. Translation: BAC28157.1.
BC004656 mRNA. Translation: AAH04656.1.
CCDSiCCDS19683.1.
RefSeqiNP_001192011.1. NM_001205082.1.
NP_058021.1. NM_016741.2.
UniGeneiMm.282242.
Mm.474018.

Genome annotation databases

EnsembliENSMUST00000086075; ENSMUSP00000083242; ENSMUSG00000037936.
GeneIDi20778.
KEGGimmu:20778.
UCSCiuc008zrd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37799 mRNA. Translation: AAC52378.1.
AK010622 mRNA. Translation: BAB27068.1.
AK028191 mRNA. Translation: BAC25802.1.
AK033114 mRNA. Translation: BAC28157.1.
BC004656 mRNA. Translation: AAH04656.1.
CCDSiCCDS19683.1.
RefSeqiNP_001192011.1. NM_001205082.1.
NP_058021.1. NM_016741.2.
UniGeneiMm.282242.
Mm.474018.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R69X-ray1.50A/B505-509[»]
ProteinModelPortaliQ61009.
SMRiQ61009. Positions 52-419.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-242627.

Chemistry

ChEMBLiCHEMBL1741203.

PTM databases

PhosphoSiteiQ61009.

Proteomic databases

MaxQBiQ61009.
PaxDbiQ61009.
PRIDEiQ61009.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086075; ENSMUSP00000083242; ENSMUSG00000037936.
GeneIDi20778.
KEGGimmu:20778.
UCSCiuc008zrd.2. mouse.

Organism-specific databases

CTDi949.
MGIiMGI:893578. Scarb1.

Phylogenomic databases

eggNOGiNOG257244.
GeneTreeiENSGT00530000062927.
HOGENOMiHOG000252951.
HOVERGENiHBG106577.
InParanoidiQ61009.
KOiK13885.
OMAiPDACRSM.
OrthoDBiEOG79SDWX.
PhylomeDBiQ61009.
TreeFamiTF317925.

Enzyme and pathway databases

ReactomeiREACT_282527. Scavenging by Class B Receptors.
REACT_326379. HDL-mediated lipid transport.

Miscellaneous databases

ChiTaRSiScarb1. mouse.
NextBioi299499.
PROiQ61009.
SOURCEiSearch...

Gene expression databases

BgeeiQ61009.
CleanExiMM_SCARB1.
ExpressionAtlasiQ61009. baseline and differential.
GenevestigatoriQ61009.

Family and domain databases

InterProiIPR002159. CD36.
IPR005428. CD36_antigen.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of scavenger receptor SR-BI as a high density lipoprotein receptor."
    Acton S., Rigotti A., Landschulz K.T., Xu S., Hobbs H.H., Krieger M.
    Science 271:518-520(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Extracellular disulfide bonds support scavenger receptor class B type I-mediated cholesterol transport."
    Papale G.A., Hanson P.J., Sahoo D.
    Biochemistry 50:6245-6254(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.

Entry informationi

Entry nameiSCRB1_MOUSE
AccessioniPrimary (citable) accession number: Q61009
Secondary accession number(s): Q9CWJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 9, 2003
Last sequence update: October 31, 1996
Last modified: March 31, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.