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Q61009

- SCRB1_MOUSE

UniProt

Q61009 - SCRB1_MOUSE

Protein

Scavenger receptor class B member 1

Gene

Scarb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity By similarity. Plays an important role in the uptake of HDL cholesteryl ester By similarity.By similarity

    GO - Molecular functioni

    1. apolipoprotein binding Source: BHF-UCL
    2. high-density lipoprotein particle binding Source: BHF-UCL
    3. high-density lipoprotein particle receptor activity Source: BHF-UCL
    4. lipopolysaccharide binding Source: Ensembl
    5. lipopolysaccharide receptor activity Source: Ensembl
    6. low-density lipoprotein particle binding Source: BHF-UCL

    GO - Biological processi

    1. androgen biosynthetic process Source: Ensembl
    2. blood vessel endothelial cell migration Source: MGI
    3. cell adhesion Source: InterPro
    4. cholesterol catabolic process Source: MGI
    5. cholesterol efflux Source: BHF-UCL
    6. cholesterol homeostasis Source: BHF-UCL
    7. cholesterol import Source: BHF-UCL
    8. cholesterol transport Source: MGI
    9. detection of lipopolysaccharide Source: Ensembl
    10. endothelial cell proliferation Source: MGI
    11. high-density lipoprotein particle clearance Source: BHF-UCL
    12. high-density lipoprotein particle remodeling Source: BHF-UCL
    13. lipopolysaccharide transport Source: Ensembl
    14. low-density lipoprotein particle clearance Source: BHF-UCL
    15. phospholipid transport Source: BHF-UCL
    16. positive regulation of cholesterol storage Source: BHF-UCL
    17. positive regulation of nitric-oxide synthase activity Source: Ensembl
    18. positive regulation of triglyceride biosynthetic process Source: BHF-UCL
    19. receptor-mediated endocytosis Source: GOC
    20. recognition of apoptotic cell Source: BHF-UCL
    21. regulation of phosphatidylcholine catabolic process Source: BHF-UCL
    22. reverse cholesterol transport Source: BHF-UCL
    23. triglyceride homeostasis Source: BHF-UCL

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_196592. Scavenging by Class B Receptors.
    REACT_213857. HDL-mediated lipid transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Scavenger receptor class B member 1
    Short name:
    SRB1
    Alternative name(s):
    SR-BI
    Gene namesi
    Name:Scarb1
    Synonyms:Srb1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:893578. Scarb1.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Membranecaveola By similarity; Multi-pass membrane protein By similarity
    Note: Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.By similarity

    GO - Cellular componenti

    1. caveola Source: MGI
    2. cell surface Source: Ensembl
    3. integral component of membrane Source: MGI
    4. integral component of plasma membrane Source: MGI
    5. lysosomal membrane Source: Ensembl
    6. microvillus membrane Source: Ensembl
    7. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Scavenger receptor class B member 1PRO_0000144161Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi251 ↔ 3841 Publication
    Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity
    The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ61009.
    PaxDbiQ61009.
    PRIDEiQ61009.

    PTM databases

    PhosphoSiteiQ61009.

    Expressioni

    Tissue specificityi

    Expressed primarily in liver and non-placental steroidogenic tissues.

    Gene expression databases

    ArrayExpressiQ61009.
    BgeeiQ61009.
    CleanExiMM_SCARB1.
    GenevestigatoriQ61009.

    Interactioni

    Subunit structurei

    The C-terminal region binds to PDZK1.By similarity

    Protein-protein interaction databases

    MINTiMINT-242627.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3R69X-ray1.50A/B505-509[»]
    ProteinModelPortaliQ61009.
    SMRiQ61009. Positions 52-419.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini33 – 440408ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini462 – 50948CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei441 – 46121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CD36 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257244.
    GeneTreeiENSGT00530000062927.
    HOGENOMiHOG000252951.
    HOVERGENiHBG106577.
    InParanoidiQ61009.
    KOiK13885.
    OMAiDNDTVSF.
    OrthoDBiEOG79SDWX.
    PhylomeDBiQ61009.
    TreeFamiTF317925.

    Family and domain databases

    InterProiIPR002159. CD36.
    IPR005428. CD36_antigen.
    [Graphical view]
    PANTHERiPTHR11923. PTHR11923. 1 hit.
    PfamiPF01130. CD36. 1 hit.
    [Graphical view]
    PRINTSiPR01610. CD36ANTIGEN.
    PR01609. CD36FAMILY.

    Sequencei

    Sequence statusi: Complete.

    Q61009-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGGSSRARWV ALGLGALGLL FAALGVVMIL MVPSLIKQQV LKNVRIDPSS    50
    LSFGMWKEIP VPFYLSVYFF EVVNPNEVLN GQKPVVRERG PYVYREFRQK 100
    VNITFNDNDT VSFVENRSLH FQPDKSHGSE SDYIVLPNIL VLGGSILMES 150
    KPVSLKLMMT LALVTMGQRA FMNRTVGEIL WGYDDPFVHF LNTYLPDMLP 200
    IKGKFGLFVG MNNSNSGVFT VFTGVQNFSR IHLVDKWNGL SKIDYWHSEQ 250
    CNMINGTSGQ MWAPFMTPES SLEFFSPEAC RSMKLTYNES RVFEGIPTYR 300
    FTAPDTLFAN GSVYPPNEGF CPCRESGIQN VSTCRFGAPL FLSHPHFYNA 350
    DPVLSEAVLG LNPNPKEHSL FLDIHPVTGI PMNCSVKMQL SLYIKSVKGI 400
    GQTGKIEPVV LPLLWFEQSG AMGGKPLSTF YTQLVLMPQV LHYAQYVLLG 450
    LGGLLLLVPI ICQLRSQEKC FLFWSGSKKG SQDKEAIQAY SESLMSPAAK 500
    GTVLQEAKL 509
    Length:509
    Mass (Da):56,754
    Last modified:November 1, 1996 - v1
    Checksum:i5CFCDD62DD6ECB1C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti396 – 3961S → F in BAB27068. (PubMed:16141072)Curated
    Sequence conflicti468 – 50942EKCFL…QEAKL → GPEDTISPPNLIAWSDQPPS PYTPLLEDSLSGQPTSAMA in BAB27068. (PubMed:16141072)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37799 mRNA. Translation: AAC52378.1.
    AK010622 mRNA. Translation: BAB27068.1.
    AK028191 mRNA. Translation: BAC25802.1.
    AK033114 mRNA. Translation: BAC28157.1.
    BC004656 mRNA. Translation: AAH04656.1.
    CCDSiCCDS19683.1.
    RefSeqiNP_001192011.1. NM_001205082.1.
    NP_058021.1. NM_016741.2.
    UniGeneiMm.282242.
    Mm.474018.

    Genome annotation databases

    EnsembliENSMUST00000086075; ENSMUSP00000083242; ENSMUSG00000037936.
    GeneIDi20778.
    KEGGimmu:20778.
    UCSCiuc008zrd.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37799 mRNA. Translation: AAC52378.1 .
    AK010622 mRNA. Translation: BAB27068.1 .
    AK028191 mRNA. Translation: BAC25802.1 .
    AK033114 mRNA. Translation: BAC28157.1 .
    BC004656 mRNA. Translation: AAH04656.1 .
    CCDSi CCDS19683.1.
    RefSeqi NP_001192011.1. NM_001205082.1.
    NP_058021.1. NM_016741.2.
    UniGenei Mm.282242.
    Mm.474018.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3R69 X-ray 1.50 A/B 505-509 [» ]
    ProteinModelPortali Q61009.
    SMRi Q61009. Positions 52-419.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-242627.

    Chemistry

    ChEMBLi CHEMBL1741203.

    PTM databases

    PhosphoSitei Q61009.

    Proteomic databases

    MaxQBi Q61009.
    PaxDbi Q61009.
    PRIDEi Q61009.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000086075 ; ENSMUSP00000083242 ; ENSMUSG00000037936 .
    GeneIDi 20778.
    KEGGi mmu:20778.
    UCSCi uc008zrd.2. mouse.

    Organism-specific databases

    CTDi 949.
    MGIi MGI:893578. Scarb1.

    Phylogenomic databases

    eggNOGi NOG257244.
    GeneTreei ENSGT00530000062927.
    HOGENOMi HOG000252951.
    HOVERGENi HBG106577.
    InParanoidi Q61009.
    KOi K13885.
    OMAi DNDTVSF.
    OrthoDBi EOG79SDWX.
    PhylomeDBi Q61009.
    TreeFami TF317925.

    Enzyme and pathway databases

    Reactomei REACT_196592. Scavenging by Class B Receptors.
    REACT_213857. HDL-mediated lipid transport.

    Miscellaneous databases

    ChiTaRSi SCARB1. mouse.
    NextBioi 299499.
    PROi Q61009.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61009.
    Bgeei Q61009.
    CleanExi MM_SCARB1.
    Genevestigatori Q61009.

    Family and domain databases

    InterProi IPR002159. CD36.
    IPR005428. CD36_antigen.
    [Graphical view ]
    PANTHERi PTHR11923. PTHR11923. 1 hit.
    Pfami PF01130. CD36. 1 hit.
    [Graphical view ]
    PRINTSi PR01610. CD36ANTIGEN.
    PR01609. CD36FAMILY.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of scavenger receptor SR-BI as a high density lipoprotein receptor."
      Acton S., Rigotti A., Landschulz K.T., Xu S., Hobbs H.H., Krieger M.
      Science 271:518-520(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Extracellular disulfide bonds support scavenger receptor class B type I-mediated cholesterol transport."
      Papale G.A., Hanson P.J., Sahoo D.
      Biochemistry 50:6245-6254(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS.

    Entry informationi

    Entry nameiSCRB1_MOUSE
    AccessioniPrimary (citable) accession number: Q61009
    Secondary accession number(s): Q9CWJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3