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Protein

Scavenger receptor class B member 1

Gene

Scarb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (By similarity). Plays an important role in the uptake of HDL cholesteryl ester (By similarity).By similarity

GO - Molecular functioni

  • apolipoprotein A-I binding Source: MGI
  • apolipoprotein binding Source: BHF-UCL
  • high-density lipoprotein particle binding Source: BHF-UCL
  • high-density lipoprotein particle receptor activity Source: BHF-UCL
  • lipopolysaccharide binding Source: MGI
  • lipopolysaccharide receptor activity Source: MGI
  • low-density lipoprotein particle binding Source: BHF-UCL
  • phosphatidylserine binding Source: Ensembl

GO - Biological processi

  • adhesion of symbiont to host Source: MGI
  • androgen biosynthetic process Source: Ensembl
  • blood vessel endothelial cell migration Source: MGI
  • cholesterol catabolic process Source: MGI
  • cholesterol efflux Source: BHF-UCL
  • cholesterol homeostasis Source: BHF-UCL
  • cholesterol import Source: BHF-UCL
  • cholesterol transport Source: MGI
  • detection of lipopolysaccharide Source: MGI
  • endothelial cell proliferation Source: MGI
  • high-density lipoprotein particle clearance Source: BHF-UCL
  • high-density lipoprotein particle remodeling Source: BHF-UCL
  • intestinal absorption Source: MGI
  • lipopolysaccharide transport Source: MGI
  • low-density lipoprotein particle clearance Source: BHF-UCL
  • phospholipid transport Source: BHF-UCL
  • positive regulation of cholesterol storage Source: BHF-UCL
  • positive regulation of nitric-oxide synthase activity Source: MGI
  • positive regulation of triglyceride biosynthetic process Source: BHF-UCL
  • recognition of apoptotic cell Source: BHF-UCL
  • regulation of phagocytosis Source: Ensembl
  • regulation of phosphatidylcholine catabolic process Source: BHF-UCL
  • reverse cholesterol transport Source: BHF-UCL
  • triglyceride homeostasis Source: BHF-UCL
  • vitamin transmembrane transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-194223. HDL-mediated lipid transport.
R-MMU-3000471. Scavenging by Class B Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Scavenger receptor class B member 1
Short name:
SRB1
Alternative name(s):
SR-BI
Gene namesi
Name:Scarb1
Synonyms:Srb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:893578. Scarb1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 440ExtracellularSequence analysisAdd BLAST408
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 509CytoplasmicSequence analysisAdd BLAST48

GO - Cellular componenti

  • caveola Source: MGI
  • cell surface Source: BHF-UCL
  • cytoplasm Source: BHF-UCL
  • extracellular exosome Source: MGI
  • integral component of membrane Source: MGI
  • integral component of plasma membrane Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • lysosomal membrane Source: MGI
  • microvillus membrane Source: Ensembl
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1741203.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001441611 – 509Scavenger receptor class B member 1Add BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Glycosylationi108N-linked (GlcNAc...)Sequence analysis1
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1
Glycosylationi212N-linked (GlcNAc...)Sequence analysis1
Glycosylationi227N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi251 ↔ 3841 Publication
Glycosylationi255N-linked (GlcNAc...)Sequence analysis1
Glycosylationi288N-linked (GlcNAc...)Sequence analysis1
Glycosylationi310N-linked (GlcNAc...)Sequence analysis1
Glycosylationi330N-linked (GlcNAc...)Sequence analysis1
Glycosylationi383N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity
The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ61009.
MaxQBiQ61009.
PaxDbiQ61009.
PRIDEiQ61009.

PTM databases

iPTMnetiQ61009.
PhosphoSitePlusiQ61009.
SwissPalmiQ61009.

Expressioni

Tissue specificityi

Expressed primarily in liver and non-placental steroidogenic tissues.

Gene expression databases

BgeeiENSMUSG00000037936.
CleanExiMM_SCARB1.
ExpressionAtlasiQ61009. baseline and differential.
GenevisibleiQ61009. MM.

Interactioni

Subunit structurei

The C-terminal region binds to PDZK1.By similarity

GO - Molecular functioni

  • apolipoprotein A-I binding Source: MGI
  • apolipoprotein binding Source: BHF-UCL

Protein-protein interaction databases

MINTiMINT-242627.
STRINGi10090.ENSMUSP00000083242.

Chemistry databases

BindingDBiQ61009.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R69X-ray1.50A/B505-509[»]
ProteinModelPortaliQ61009.
SMRiQ61009.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD36 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3776. Eukaryota.
ENOG410XS17. LUCA.
GeneTreeiENSGT00530000062927.
HOGENOMiHOG000252951.
HOVERGENiHBG106577.
InParanoidiQ61009.
KOiK13885.
OMAiMWKEIPI.
OrthoDBiEOG091G0CH9.
PhylomeDBiQ61009.
TreeFamiTF317925.

Family and domain databases

InterProiIPR005428. CD36/SCARB1/SNMP1.
IPR002159. CD36_fam.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.

Sequencei

Sequence statusi: Complete.

Q61009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGSSRARWV ALGLGALGLL FAALGVVMIL MVPSLIKQQV LKNVRIDPSS
60 70 80 90 100
LSFGMWKEIP VPFYLSVYFF EVVNPNEVLN GQKPVVRERG PYVYREFRQK
110 120 130 140 150
VNITFNDNDT VSFVENRSLH FQPDKSHGSE SDYIVLPNIL VLGGSILMES
160 170 180 190 200
KPVSLKLMMT LALVTMGQRA FMNRTVGEIL WGYDDPFVHF LNTYLPDMLP
210 220 230 240 250
IKGKFGLFVG MNNSNSGVFT VFTGVQNFSR IHLVDKWNGL SKIDYWHSEQ
260 270 280 290 300
CNMINGTSGQ MWAPFMTPES SLEFFSPEAC RSMKLTYNES RVFEGIPTYR
310 320 330 340 350
FTAPDTLFAN GSVYPPNEGF CPCRESGIQN VSTCRFGAPL FLSHPHFYNA
360 370 380 390 400
DPVLSEAVLG LNPNPKEHSL FLDIHPVTGI PMNCSVKMQL SLYIKSVKGI
410 420 430 440 450
GQTGKIEPVV LPLLWFEQSG AMGGKPLSTF YTQLVLMPQV LHYAQYVLLG
460 470 480 490 500
LGGLLLLVPI ICQLRSQEKC FLFWSGSKKG SQDKEAIQAY SESLMSPAAK

GTVLQEAKL
Length:509
Mass (Da):56,754
Last modified:November 1, 1996 - v1
Checksum:i5CFCDD62DD6ECB1C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti396S → F in BAB27068 (PubMed:16141072).Curated1
Sequence conflicti468 – 509EKCFL…QEAKL → GPEDTISPPNLIAWSDQPPS PYTPLLEDSLSGQPTSAMA in BAB27068 (PubMed:16141072).CuratedAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37799 mRNA. Translation: AAC52378.1.
AK010622 mRNA. Translation: BAB27068.1.
AK028191 mRNA. Translation: BAC25802.1.
AK033114 mRNA. Translation: BAC28157.1.
BC004656 mRNA. Translation: AAH04656.1.
CCDSiCCDS19683.1.
RefSeqiNP_001192011.1. NM_001205082.1.
NP_058021.1. NM_016741.2.
UniGeneiMm.282242.
Mm.474018.

Genome annotation databases

EnsembliENSMUST00000086075; ENSMUSP00000083242; ENSMUSG00000037936.
GeneIDi20778.
KEGGimmu:20778.
UCSCiuc008zrd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37799 mRNA. Translation: AAC52378.1.
AK010622 mRNA. Translation: BAB27068.1.
AK028191 mRNA. Translation: BAC25802.1.
AK033114 mRNA. Translation: BAC28157.1.
BC004656 mRNA. Translation: AAH04656.1.
CCDSiCCDS19683.1.
RefSeqiNP_001192011.1. NM_001205082.1.
NP_058021.1. NM_016741.2.
UniGeneiMm.282242.
Mm.474018.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R69X-ray1.50A/B505-509[»]
ProteinModelPortaliQ61009.
SMRiQ61009.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-242627.
STRINGi10090.ENSMUSP00000083242.

Chemistry databases

BindingDBiQ61009.
ChEMBLiCHEMBL1741203.

PTM databases

iPTMnetiQ61009.
PhosphoSitePlusiQ61009.
SwissPalmiQ61009.

Proteomic databases

EPDiQ61009.
MaxQBiQ61009.
PaxDbiQ61009.
PRIDEiQ61009.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086075; ENSMUSP00000083242; ENSMUSG00000037936.
GeneIDi20778.
KEGGimmu:20778.
UCSCiuc008zrd.2. mouse.

Organism-specific databases

CTDi949.
MGIiMGI:893578. Scarb1.

Phylogenomic databases

eggNOGiKOG3776. Eukaryota.
ENOG410XS17. LUCA.
GeneTreeiENSGT00530000062927.
HOGENOMiHOG000252951.
HOVERGENiHBG106577.
InParanoidiQ61009.
KOiK13885.
OMAiMWKEIPI.
OrthoDBiEOG091G0CH9.
PhylomeDBiQ61009.
TreeFamiTF317925.

Enzyme and pathway databases

ReactomeiR-MMU-194223. HDL-mediated lipid transport.
R-MMU-3000471. Scavenging by Class B Receptors.

Miscellaneous databases

ChiTaRSiScarb1. mouse.
PROiQ61009.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037936.
CleanExiMM_SCARB1.
ExpressionAtlasiQ61009. baseline and differential.
GenevisibleiQ61009. MM.

Family and domain databases

InterProiIPR005428. CD36/SCARB1/SNMP1.
IPR002159. CD36_fam.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.
ProtoNetiSearch...

Entry informationi

Entry nameiSCRB1_MOUSE
AccessioniPrimary (citable) accession number: Q61009
Secondary accession number(s): Q9CWJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.