Q60Y65 (HPPD_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
4-hydroxyphenylpyruvate dioxygenase
EC=1.13.11.27

Alternative name(s):
4-hydroxyphenylpyruvic acid oxidase
Short name=4HPPD
Short name=HPD
Short name=HPPDase

Gene names

Name:	hpd-1
ORF Names:	CBG18361

Organism

Caenorhabditis briggsae

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key enzyme in the degradation of tyrosine By similarity.
Catalytic activity	4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.
Sequence similarities	Belongs to the 4HPPD family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from sequence or structural similarity. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	4-hydroxyphenylpyruvate dioxygenase		PRO_0000088394
Sites
	Metal binding	182	1	Iron By similarity
	Metal binding	267	1	Iron By similarity
	Metal binding	350	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q60Y65 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 8A5C3CAF60DF0B42	FASTA	393	44,600
	10 20 30 40 50 60 MTTFDRGEKP DIGTLVAFDH VRFVVGNAKQ AAYWYCANFG FEPFAYKGLE TGSRITAQHA 70 80 90 100 110 120 IKQDKIVFVF ESALLPDNTE LGEHLVQHGD GVKDVCFEVE DLDSIVAHAK AAGATIVRDI 130 140 150 160 170 180 TEESDENGSV RFATLRTYGE TDHTLLERKK YKGAFLPGFK PHPMPPTFFH SLPRVGLNFL 190 200 210 220 230 240 DHCVGNQPDL QMAPAVEWYE NILKFHRFWS VDDSMIHTEY SALRSIVVTN FEETIKMPIN 250 260 270 280 290 300 EPASSNKKAV SQIQEFVDYY GGSGVQHIAL NTTDIITAIE ALRARGCEFL SIPSSYYDNL 310 320 330 340 350 360 RQRLSVSSMK IKEDMDRLQK LHILVDFDEN GYLLQIFSKP CQDRPTLFLE IIQRQNHQGF 370 380 390 GAGNFKALFE SIELEQTKRG NLFYENVKDG QHK

References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed: 14624247] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CAAC02000548 Genomic DNA. Translation: CAP35833.1.
RefSeq	XP_002642363.1. XM_002642317.1.
3D structure databases
ProteinModelPortal	Q60Y65.
SMR	Q60Y65. Positions 7-367.
ModBase	Search...
Protein-protein interaction databases
STRING	Q60Y65.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8584357.
KEGG	cbr:CBG18361.
Organism-specific databases
CTD	8584357.
WormBase	CBG18361; CBP04281; WBGene00037803; Cbr-hpd-1.
Phylogenomic databases
HOGENOM	HBG680392.
OMA	HCVGNVE.
PhylomeDB	Q60Y65.
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_Fos-R_dOase. [Graphical view]
KO	K00457.
PANTHER	PTHR11959. HPP_dOase. 1 hit.
Pfam	PF00903. Glyoxalase. 1 hit. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HPPD_CAEBR

Accession

Primary (citable) accession number: Q60Y65
Secondary accession number(s): A8XSJ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	November 23, 2004
Last modified:	November 16, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project