Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q60Y65 (HPPD_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxyphenylpyruvate dioxygenase

EC=1.13.11.27
Alternative name(s):
4-hydroxyphenylpyruvic acid oxidase
Short name=4HPPD
Short name=HPD
Short name=HPPDase
Gene names
Name:hpd-1
ORF Names:CBG18361
OrganismCaenorhabditis briggsae
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the degradation of tyrosine By similarity.

Catalytic activity

4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.

Cofactor

Binds 1 iron ion per subunit By similarity.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.

Sequence similarities

Belongs to the 4HPPD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3933934-hydroxyphenylpyruvate dioxygenase
PRO_0000088394

Sites

Metal binding1821Iron By similarity
Metal binding2671Iron By similarity
Metal binding3501Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60Y65 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 8A5C3CAF60DF0B42

FASTA39344,600
        10         20         30         40         50         60 
MTTFDRGEKP DIGTLVAFDH VRFVVGNAKQ AAYWYCANFG FEPFAYKGLE TGSRITAQHA 

        70         80         90        100        110        120 
IKQDKIVFVF ESALLPDNTE LGEHLVQHGD GVKDVCFEVE DLDSIVAHAK AAGATIVRDI 

       130        140        150        160        170        180 
TEESDENGSV RFATLRTYGE TDHTLLERKK YKGAFLPGFK PHPMPPTFFH SLPRVGLNFL 

       190        200        210        220        230        240 
DHCVGNQPDL QMAPAVEWYE NILKFHRFWS VDDSMIHTEY SALRSIVVTN FEETIKMPIN 

       250        260        270        280        290        300 
EPASSNKKAV SQIQEFVDYY GGSGVQHIAL NTTDIITAIE ALRARGCEFL SIPSSYYDNL 

       310        320        330        340        350        360 
RQRLSVSSMK IKEDMDRLQK LHILVDFDEN GYLLQIFSKP CQDRPTLFLE IIQRQNHQGF 

       370        380        390 
GAGNFKALFE SIELEQTKRG NLFYENVKDG QHK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CAAC02000548 Genomic DNA. Translation: CAP35833.1.
RefSeqXP_002642363.1. XM_002642317.1.

3D structure databases

ProteinModelPortalQ60Y65.
SMRQ60Y65. Positions 7-367.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ60Y65.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8584357.
KEGGcbr:CBG18361.

Organism-specific databases

CTD8584357.
WormBaseCBG18361; CBP04281; WBGene00037803; Cbr-hpd-1.

Phylogenomic databases

HOGENOMHBG680392.
OMAHCVGNVE.
PhylomeDBQ60Y65.

Family and domain databases

InterProIPR005956. 4OHPhenylPyrv_dOase.
IPR004360. Glyas_Fos-R_dOase.
[Graphical view]
KOK00457.
PANTHERPTHR11959. HPP_dOase. 1 hit.
PfamPF00903. Glyoxalase. 1 hit.
[Graphical view]
PIRSFPIRSF009283. HPP_dOase. 1 hit.
TIGRFAMsTIGR01263. 4HPPD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHPPD_CAEBR
AccessionPrimary (citable) accession number: Q60Y65
Secondary accession number(s): A8XSJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 23, 2004
Last modified: November 16, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families