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Q60XN1

- ATX3_CAEBR

UniProt

Q60XN1 - ATX3_CAEBR

Protein

Ataxin-3 homolog

Gene

atx-3

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei21 – 211NucleophilePROSITE-ProRule annotation
    Active sitei118 – 1181Proton acceptorPROSITE-ProRule annotation
    Active sitei133 – 1331By similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. omega peptidase activity Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Transcription, Transcription regulation, Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC86.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ataxin-3 homolog (EC:3.4.19.12)
    Alternative name(s):
    Machado-Joseph disease-like protein
    Gene namesi
    Name:atx-3By similarity
    ORF Names:CBG18600
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome V, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG18600; CBP10927; WBGene00037987; Cbr-atx-3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319Ataxin-3 homologPRO_0000232395Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6238.CBG18600.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60XN1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 179172JosephinPROSITE-ProRule annotationAdd
    BLAST
    Repeati218 – 23720UIM 1Sequence AnalysisAdd
    BLAST
    Repeati242 – 26120UIM 2Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Josephin domain.PROSITE-ProRule annotation
    Contains 2 UIM (ubiquitin-interacting motif) repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG327234.
    HOGENOMiHOG000006034.
    KOiK11863.
    OMAiKEGSANY.
    OrthoDBiEOG779NZ3.

    Family and domain databases

    InterProiIPR006155. Josephin.
    IPR003903. Ubiquitin-int_motif.
    [Graphical view]
    PfamiPF02099. Josephin. 1 hit.
    PF02809. UIM. 2 hits.
    [Graphical view]
    PRINTSiPR01233. JOSEPHIN.
    SMARTiSM00726. UIM. 2 hits.
    [Graphical view]
    PROSITEiPS50957. JOSEPHIN. 1 hit.
    PS50330. UIM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60XN1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPSDDPISS IFFERQQAAL CAQHALNMLL QDSLFTYENL RDLARQMDQM    50
    EHDILGNNAN AVGRSENMND SGFFSIQVIE KALETFDLKL INMENPAMAE 100
    FKANPLTARA YVLNLREHWF VLRKFGNQWF ELNSVKNGPK LLTDTYVKEY 150
    LHQFAAENYS IFVVQGILPN SEADDFITLC PVVPKPTDFD KKEPNLVQKF 200
    FNSVGRRLGG SQEIPDSQED RDLAIAMALS MESKESSESS GSDEDQLAKA 250
    IEMSLSQDPN IPSTSAAPSE LTETPILGPS TSSETPSGRI PSAEQQRRDR 300
    AKFLEKLEEE KKSQNVPEE 319
    Length:319
    Mass (Da):35,834
    Last modified:November 23, 2004 - v1
    Checksum:iAD08AAAF3065CA0C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601466 Genomic DNA. Translation: CAP36017.3.
    RefSeqiXP_002638391.1. XM_002638345.1.

    Genome annotation databases

    EnsemblMetazoaiCBG18600; CBG18600; CBG18600.
    GeneIDi8580388.
    KEGGicbr:CBG18600.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601466 Genomic DNA. Translation: CAP36017.3 .
    RefSeqi XP_002638391.1. XM_002638345.1.

    3D structure databases

    ProteinModelPortali Q60XN1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG18600.

    Protein family/group databases

    MEROPSi C86.003.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG18600 ; CBG18600 ; CBG18600 .
    GeneIDi 8580388.
    KEGGi cbr:CBG18600.

    Organism-specific databases

    CTDi 8580388.
    WormBasei CBG18600 ; CBP10927 ; WBGene00037987 ; Cbr-atx-3.

    Phylogenomic databases

    eggNOGi NOG327234.
    HOGENOMi HOG000006034.
    KOi K11863.
    OMAi KEGSANY.
    OrthoDBi EOG779NZ3.

    Family and domain databases

    InterProi IPR006155. Josephin.
    IPR003903. Ubiquitin-int_motif.
    [Graphical view ]
    Pfami PF02099. Josephin. 1 hit.
    PF02809. UIM. 2 hits.
    [Graphical view ]
    PRINTSi PR01233. JOSEPHIN.
    SMARTi SM00726. UIM. 2 hits.
    [Graphical view ]
    PROSITEi PS50957. JOSEPHIN. 1 hit.
    PS50330. UIM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiATX3_CAEBR
    AccessioniPrimary (citable) accession number: Q60XN1
    Secondary accession number(s): A8XTP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3