Q60XN1 (ATX3_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ataxin-3 homolog
EC=3.4.19.12

Alternative name(s):
Machado-Joseph disease-like protein

Gene names

Name:	atx-3
ORF Names:	CBG18600

Organism

Caenorhabditis briggsae [Reference proteome]

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme By similarity. UniProtKB P54252
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Subcellular location	Nucleus By similarity UniProtKB P54252.
Sequence similarities	Contains 1 Josephin domain. Contains 2 UIM (ubiquitin-interacting motif) repeats.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Ubl conjugation pathway
Cellular component	Nucleus
Domain	Repeat
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW omega peptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Ataxin-3 homolog		PRO_0000232395
Regions
	Domain	8 – 179	172	Josephin
	Repeat	218 – 237	20	UIM 1
	Repeat	242 – 261	20	UIM 2
Sites
	Active site	21	1	Nucleophile By similarity UniProtKB P54252
	Active site	118	1	Proton acceptor By similarity UniProtKB P54252
	Active site	133	1	By similarity UniProtKB P54252

Sequences

	Sequence		Length	Mass (Da)
	Q60XN1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: AD08AAAF3065CA0C	FASTA	319	35,834
	10 20 30 40 50 60 MSPSDDPISS IFFERQQAAL CAQHALNMLL QDSLFTYENL RDLARQMDQM EHDILGNNAN 70 80 90 100 110 120 AVGRSENMND SGFFSIQVIE KALETFDLKL INMENPAMAE FKANPLTARA YVLNLREHWF 130 140 150 160 170 180 VLRKFGNQWF ELNSVKNGPK LLTDTYVKEY LHQFAAENYS IFVVQGILPN SEADDFITLC 190 200 210 220 230 240 PVVPKPTDFD KKEPNLVQKF FNSVGRRLGG SQEIPDSQED RDLAIAMALS MESKESSESS 250 260 270 280 290 300 GSDEDQLAKA IEMSLSQDPN IPSTSAAPSE LTETPILGPS TSSETPSGRI PSAEQQRRDR 310 AKFLEKLEEE KKSQNVPEE

References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HE601466 Genomic DNA. Translation: CAP36017.1.
RefSeq	XP_002638391.1. XM_002638345.1.
3D structure databases
ProteinModelPortal	Q60XN1.
ModBase	Search...
Protein family/group databases
MEROPS	C86.003.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	CBG18600; CBG18600; CBG18600.
GeneID	8580388.
KEGG	cbr:CBG18600.
Organism-specific databases
CTD	8580388.
WormBase	CBG18600; CBP10927; WBGene00037987; Cbr-atx-3.
Phylogenomic databases
eggNOG	NOG327234.
HOGENOM	HOG000006034.
KO	K11863.
OMA	FITLCPV.
Family and domain databases
InterPro	IPR006155. Josephin. IPR003903. Ubiquitin-int_motif. [Graphical view]
Pfam	PF02099. Josephin. 1 hit. PF02809. UIM. 2 hits. [Graphical view]
PRINTS	PR01233. JOSEPHIN.
SMART	SM00726. UIM. 2 hits. [Graphical view]
PROSITE	PS50957. JOSEPHIN. 1 hit. PS50330. UIM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATX3_CAEBR

Accession

Primary (citable) accession number: Q60XN1
Secondary accession number(s): A8XTP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	November 23, 2004
Last modified:	March 6, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project