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Protein

Ataxin-3 homolog

Gene

atx-3

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei21 – 211NucleophilePROSITE-ProRule annotation
Active sitei118 – 1181Proton acceptorPROSITE-ProRule annotation
Active sitei133 – 1331By similarityPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. omega peptidase activity Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Protein family/group databases

MEROPSiC86.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Ataxin-3 homolog (EC:3.4.19.12)
Alternative name(s):
Machado-Joseph disease-like protein
Gene namesi
Name:atx-3By similarity
ORF Names:CBG18600
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome V, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG18600; CBP10927; WBGene00037987; Cbr-atx-3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Ataxin-3 homologPRO_0000232395Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG18600.

Structurei

3D structure databases

ProteinModelPortaliQ60XN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 179172JosephinPROSITE-ProRule annotationAdd
BLAST
Domaini218 – 23720UIM 1PROSITE-ProRule annotationAdd
BLAST
Domaini242 – 26120UIM 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Josephin domain.PROSITE-ProRule annotation
Contains 2 UIM (ubiquitin-interacting motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG327234.
HOGENOMiHOG000006034.
InParanoidiQ60XN1.
KOiK11863.
OMAiKEGSANY.
OrthoDBiEOG779NZ3.

Family and domain databases

InterProiIPR006155. Josephin.
IPR003903. Ubiquitin-int_motif.
[Graphical view]
PfamiPF02099. Josephin. 1 hit.
PF02809. UIM. 2 hits.
[Graphical view]
PRINTSiPR01233. JOSEPHIN.
SMARTiSM00726. UIM. 2 hits.
[Graphical view]
PROSITEiPS50957. JOSEPHIN. 1 hit.
PS50330. UIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60XN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPSDDPISS IFFERQQAAL CAQHALNMLL QDSLFTYENL RDLARQMDQM
60 70 80 90 100
EHDILGNNAN AVGRSENMND SGFFSIQVIE KALETFDLKL INMENPAMAE
110 120 130 140 150
FKANPLTARA YVLNLREHWF VLRKFGNQWF ELNSVKNGPK LLTDTYVKEY
160 170 180 190 200
LHQFAAENYS IFVVQGILPN SEADDFITLC PVVPKPTDFD KKEPNLVQKF
210 220 230 240 250
FNSVGRRLGG SQEIPDSQED RDLAIAMALS MESKESSESS GSDEDQLAKA
260 270 280 290 300
IEMSLSQDPN IPSTSAAPSE LTETPILGPS TSSETPSGRI PSAEQQRRDR
310
AKFLEKLEEE KKSQNVPEE
Length:319
Mass (Da):35,834
Last modified:November 23, 2004 - v1
Checksum:iAD08AAAF3065CA0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601466 Genomic DNA. Translation: CAP36017.3.
RefSeqiXP_002638391.1. XM_002638345.1.

Genome annotation databases

EnsemblMetazoaiCBG18600; CBG18600; CBG18600.
GeneIDi8580388.
KEGGicbr:CBG18600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601466 Genomic DNA. Translation: CAP36017.3.
RefSeqiXP_002638391.1. XM_002638345.1.

3D structure databases

ProteinModelPortaliQ60XN1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG18600.

Protein family/group databases

MEROPSiC86.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG18600; CBG18600; CBG18600.
GeneIDi8580388.
KEGGicbr:CBG18600.

Organism-specific databases

CTDi8580388.
WormBaseiCBG18600; CBP10927; WBGene00037987; Cbr-atx-3.

Phylogenomic databases

eggNOGiNOG327234.
HOGENOMiHOG000006034.
InParanoidiQ60XN1.
KOiK11863.
OMAiKEGSANY.
OrthoDBiEOG779NZ3.

Family and domain databases

InterProiIPR006155. Josephin.
IPR003903. Ubiquitin-int_motif.
[Graphical view]
PfamiPF02099. Josephin. 1 hit.
PF02809. UIM. 2 hits.
[Graphical view]
PRINTSiPR01233. JOSEPHIN.
SMARTiSM00726. UIM. 2 hits.
[Graphical view]
PROSITEiPS50957. JOSEPHIN. 1 hit.
PS50330. UIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiATX3_CAEBR
AccessioniPrimary (citable) accession number: Q60XN1
Secondary accession number(s): A8XTP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 23, 2004
Last modified: January 7, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.