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Q60XN1 (ATX3_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ataxin-3 homolog

EC=3.4.19.12
Alternative name(s):
Machado-Joseph disease-like protein
Gene names
Name:atx-3
ORF Names:CBG18600
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme By similarity. UniProtKB P54252

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Nucleus By similarity UniProtKB P54252.

Sequence similarities

Contains 1 Josephin domain.

Contains 2 UIM (ubiquitin-interacting motif) repeats.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Ataxin-3 homolog
PRO_0000232395

Regions

Domain8 – 179172Josephin
Repeat218 – 23720UIM 1
Repeat242 – 26120UIM 2

Sites

Active site211Nucleophile By similarity UniProtKB P54252
Active site1181Proton acceptor By similarity UniProtKB P54252
Active site1331 By similarity UniProtKB P54252

Sequences

Sequence LengthMass (Da)Tools
Q60XN1 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: AD08AAAF3065CA0C

FASTA31935,834
        10         20         30         40         50         60 
MSPSDDPISS IFFERQQAAL CAQHALNMLL QDSLFTYENL RDLARQMDQM EHDILGNNAN 

        70         80         90        100        110        120 
AVGRSENMND SGFFSIQVIE KALETFDLKL INMENPAMAE FKANPLTARA YVLNLREHWF 

       130        140        150        160        170        180 
VLRKFGNQWF ELNSVKNGPK LLTDTYVKEY LHQFAAENYS IFVVQGILPN SEADDFITLC 

       190        200        210        220        230        240 
PVVPKPTDFD KKEPNLVQKF FNSVGRRLGG SQEIPDSQED RDLAIAMALS MESKESSESS 

       250        260        270        280        290        300 
GSDEDQLAKA IEMSLSQDPN IPSTSAAPSE LTETPILGPS TSSETPSGRI PSAEQQRRDR 

       310 
AKFLEKLEEE KKSQNVPEE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE601466 Genomic DNA. Translation: CAP36017.3.
RefSeqXP_002638391.1. XM_002638345.1.

3D structure databases

ProteinModelPortalQ60XN1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG18600.

Protein family/group databases

MEROPSC86.003.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG18600; CBG18600; CBG18600.
GeneID8580388.
KEGGcbr:CBG18600.

Organism-specific databases

CTD8580388.
WormBaseCBG18600; CBP10927; WBGene00037987; Cbr-atx-3.

Phylogenomic databases

eggNOGNOG327234.
HOGENOMHOG000006034.
KOK11863.
OMAKEGSANY.
OrthoDBEOG779NZ3.

Family and domain databases

InterProIPR006155. Josephin.
IPR003903. Ubiquitin-int_motif.
[Graphical view]
PfamPF02099. Josephin. 1 hit.
PF02809. UIM. 2 hits.
[Graphical view]
PRINTSPR01233. JOSEPHIN.
SMARTSM00726. UIM. 2 hits.
[Graphical view]
PROSITEPS50957. JOSEPHIN. 1 hit.
PS50330. UIM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATX3_CAEBR
AccessionPrimary (citable) accession number: Q60XN1
Secondary accession number(s): A8XTP1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families