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Reviewed, UniProtKB/Swiss-Prot Q60W34 (3HAO_CAEBR)

Last modified November 3, 2009. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    3-hydroxyanthranilate 3,4-dioxygenase
    EC=1.13.11.6
Alternative name(s):
    3-hydroxyanthranilic acid dioxygenase
      Short name=HAD
    3-hydroxyanthranilate oxygenase
      Short name=3-HAO
Gene names
Name: haao-1
ORF Names: CBG19288
OrganismCaenorhabditis briggsae [Complete proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.

Cofactor

Fe2+ ion By similarity.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the 3-HAO family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

pyridine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-hydroxyanthranilate 3,4-dioxygenase activity

Inferred from electronic annotation. Source: EC

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2802803-hydroxyanthranilate 3,4-dioxygenase
PRO_0000245469

Sites

Metal binding491Iron; catalytic By similarity
Metal binding551Iron; catalytic By similarity
Metal binding931Iron; catalytic By similarity
Binding site451Dioxygen By similarity
Binding site551Substrate By similarity
Binding site971Substrate By similarity
Binding site1071Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60W34-1 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 601B8DC727C9FDC0

FASTA28031,987
        10         20         30         40         50         60 
MAGVTAIEIP QWIQDNQGDF VPPVCNKCMF SDQLKVFYVG GPNQRKDFHL EEGEEFFFQR 

        70         80         90        100        110        120 
KGDMVLKVIE KGQVRDLVIK QGEMFMLPAR VEHSPQRFAN SIGLVVERER KNTEFDCVRF 

       130        140        150        160        170        180 
LVGSSNVTLF ERWFFLTDVV KDLPPLIKEF YNSNEFKTGK PGKGTFACNA PYEARWTDLP 

       190        200        210        220        230        240 
VPINRKEFIY DHISEVKNGP VKIYGAPEYK TEVMLLGEGS YDLEAGAVEL IIWLQENTFA 

       250        260        270        280 
VVEESGFTYA LKSETMVRIK PNTKCLLNVK GGFAITIRMP 

« Hide

Cross-references

Sequence databases

CAAC02000558 Genomic DNA. Translation: CAP36564.2. Different initiation.

3D structure databases

ModBaseSearch...

Organism-specific databases

WormBaseWBGene00038535. Cbr-haao-1.

Phylogenomic databases

OMAIEIPQWI.

Enzyme and pathway databases

BRENDA1.13.11.6. 261794.

Family and domain databases

InterProIPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
[Graphical view]
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
PIRSFPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Entry information

Entry name3HAO_CAEBR
AccessionPrimary (citable) accession number: Q60W34
Secondary accession number(s): A8XV97
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 23, 2004
Last modified: November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents