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Q60W34

- 3HAO_CAEBR

UniProt

Q60W34 - 3HAO_CAEBR

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Protein
3-hydroxyanthranilate 3,4-dioxygenase
Gene
haao-1, CBG19288
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+ ion By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451Dioxygen By similarity
Metal bindingi49 – 491Iron; catalytic By similarity
Metal bindingi55 – 551Iron; catalytic By similarity
Binding sitei55 – 551Substrate By similarity
Metal bindingi93 – 931Iron; catalytic By similarity
Binding sitei97 – 971Substrate By similarity
Binding sitei107 – 1071Substrate By similarity

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenase (EC:1.13.11.6)
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name:
3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name:
HAD
Gene namesi
Name:haao-1
ORF Names:CBG19288
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome V, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG19288; CBP37579; WBGene00038535; Cbr-haao-1.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2812813-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation
PRO_0000245469Add
BLAST

Proteomic databases

PRIDEiQ60W34.

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG19288.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 162162Domain A (catalytic) By similarity
Add
BLAST
Regioni163 – 17917Linker By similarity
Add
BLAST
Regioni180 – 281102Domain B By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the 3-HAO family.

Phylogenomic databases

eggNOGiNOG77058.
HOGENOMiHOG000218448.
OrthoDBiEOG7FFMS4.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
PIRSFiPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60W34-1 [UniParc]FASTAAdd to Basket

« Hide

MAGVTAIEIP QWIQDNQGDF VPPVCNKCMF SDQLKVFYVG GPNQRKDFHL    50
EEGEEFFFQR KGDMVLKVIE KGQVRDLVIK QGEMFMLPAR VEHSPQRFAN 100
SIGLVVERER KNTEFDCVRF LVGSSNVTLF ERWFFLTDVV KDLPPLIKEF 150
YNSNEFKTGK PGKGTFACNA PYEARWTDLP VPINRKEFIY DHISEVKNGP 200
VKIYGAPEYK TEVMLLGEGS YDLEAGAVEL IIWLQENTFA VVEESGFTYA 250
LKSETMVRIK PNTKCLLNVK GGFAITIRMP G 281
Length:281
Mass (Da):32,044
Last modified:October 5, 2010 - v2
Checksum:iDC701B8DC727C9FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601047 Genomic DNA. Translation: CAP36564.3.

Genome annotation databases

EnsemblMetazoaiCBG19288; CBG19288; CBG19288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601047 Genomic DNA. Translation: CAP36564.3 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG19288.

Proteomic databases

PRIDEi Q60W34.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG19288 ; CBG19288 ; CBG19288 .

Organism-specific databases

WormBasei CBG19288 ; CBP37579 ; WBGene00038535 ; Cbr-haao-1.

Phylogenomic databases

eggNOGi NOG77058.
HOGENOMi HOG000218448.
OrthoDBi EOG7FFMS4.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
PIRSFi PIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry namei3HAO_CAEBR
AccessioniPrimary (citable) accession number: Q60W34
Secondary accession number(s): A8XV97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 5, 2010
Last modified: June 11, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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