Q60W34 (3HAO_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-hydroxyanthranilate 3,4-dioxygenase
EC=1.13.11.6

Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD

Gene names

Name:	haao-1
ORF Names:	CBG19288

Organism

Caenorhabditis briggsae

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.
Catalytic activity	3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.
Cofactor	Fe2+ ion By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the 3-HAO family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-hydroxyanthranilate 3,4-dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 281	281	3-hydroxyanthranilate 3,4-dioxygenase		PRO_0000245469
Sites
	Metal binding	49	1	Iron; catalytic By similarity
	Metal binding	55	1	Iron; catalytic By similarity
	Metal binding	93	1	Iron; catalytic By similarity
	Binding site	45	1	Dioxygen By similarity
	Binding site	55	1	Substrate By similarity
	Binding site	97	1	Substrate By similarity
	Binding site	107	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q60W34 [UniParc]. Last modified October 5, 2010. Version 2. Checksum: DC701B8DC727C9FD	FASTA	281	32,044
	10 20 30 40 50 60 MAGVTAIEIP QWIQDNQGDF VPPVCNKCMF SDQLKVFYVG GPNQRKDFHL EEGEEFFFQR 70 80 90 100 110 120 KGDMVLKVIE KGQVRDLVIK QGEMFMLPAR VEHSPQRFAN SIGLVVERER KNTEFDCVRF 130 140 150 160 170 180 LVGSSNVTLF ERWFFLTDVV KDLPPLIKEF YNSNEFKTGK PGKGTFACNA PYEARWTDLP 190 200 210 220 230 240 VPINRKEFIY DHISEVKNGP VKIYGAPEYK TEVMLLGEGS YDLEAGAVEL IIWLQENTFA 250 260 270 280 VVEESGFTYA LKSETMVRIK PNTKCLLNVK GGFAITIRMP G

References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed: 14624247] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CAAC02000558 Genomic DNA. Translation: CAP36564.3.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q60W34.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
WormBase	CBG19288; CBP37579; WBGene00038535.
Phylogenomic databases
HOGENOM	HBG717838.
Family and domain databases
InterPro	IPR010329. 3hydroanth_dOase. IPR016700. 3hydroanth_dOase_met. IPR011051. Cupin_RmlC_type. IPR014710. RmlC-like_jellyroll. [Graphical view]
Gene3D	G3DSA:2.60.120.10. RmlC-like_jellyroll. 1 hit.
PANTHER	PTHR15497. PTHR15497. 1 hit.
Pfam	PF06052. 3-HAO. 1 hit. [Graphical view]
PIRSF	PIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMs	TIGR03037. Anthran_nbaC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

3HAO_CAEBR

Accession

Primary (citable) accession number: Q60W34
Secondary accession number(s): A8XV97

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	October 5, 2010
Last modified:	December 14, 2011
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project