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Protein

Serine hydroxymethyltransferase

Gene

mel-32

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Interconversion of serine and glycine.By similarityCurated

Catalytic activityi

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.Curated

Cofactori

pyridoxal 5'-phosphateBy similarity

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

GO - Molecular functioni

  • glycine hydroxymethyltransferase activity Source: UniProtKB
  • pyridoxal phosphate binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine hydroxymethyltransferase (EC:2.1.2.1)
Short name:
SHMT
Alternative name(s):
Glycine hydroxymethyltransferase
Maternal effect lethal protein 32
Serine methylase
Gene namesi
Name:mel-32By similarity
ORF Names:CBG19673
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome III, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG19673; CBP36659; WBGene00038848; Cbr-mel-32.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002829551 – 511Serine hydroxymethyltransferaseAdd BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei287N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiQ60V73.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi6238.CBG19673.

Structurei

3D structure databases

ProteinModelPortaliQ60V73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SHMT family.Sequence analysis

Phylogenomic databases

eggNOGiKOG2467. Eukaryota.
COG0112. LUCA.
HOGENOMiHOG000239405.
InParanoidiQ60V73.
OMAiVGDFIHE.
OrthoDBiEOG091G05AU.

Family and domain databases

CDDicd00378. SHMT. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00051. SHMT. 1 hit.
InterProiIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
PANTHERiPTHR11680. PTHR11680. 1 hit.
PfamiPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000412. SHMT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00096. SHMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60V73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFARAVSRKT MTGLLAGSRV LLASQFTMAD RQVHTPLEPV QRQKYANNEN
60 70 80 90 100
LLKDHVEKID PEVFNIMKNE KSRQRRGLEL IASENFTSKA VMDALGSAMC
110 120 130 140 150
NKYSEGYPGA RYYGGNEFID QMEILCQKRA LEVFGLDPAK WGVNVQSLSG
160 170 180 190 200
SPANFAVYTA LVGANGRIMG LDLPDGGHLT HGFFTPARKV SATSEFFQSM
210 220 230 240 250
PYKVDAQSGL IDYDKLEENA MLFRPKVLIA GVSCYARHLD YERFRKIATK
260 270 280 290 300
AGAYLMSDMA HISGLVAAGL IPSPFEYSDV VTTTTHKSLR GPRGAMIFYR
310 320 330 340 350
KGVRSVNAKG VETLYDLEEK INSAVFPGLQ GGPHNHTIAG IAVALKQCLS
360 370 380 390 400
EDFVQYGEQI LKNAKTLAER LKKHGYSLAT GGTDNHLLLV DLRPIGVEGA
410 420 430 440 450
RAEHILDLAH IACNKNTCPG DVSALRPGGI RLGTPALTSR GFKEQDFEKV
460 470 480 490 500
GDFIHEGVQI AKKYNAEAGK TLKDFKAFTA TNEQFKQEVA ELAKRVEEFS
510
GKFEIPGNDL F
Length:511
Mass (Da):56,213
Last modified:September 22, 2009 - v3
Checksum:i715AA585E4D2AECF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600934 Genomic DNA. Translation: CAP36877.2.

Genome annotation databases

EnsemblMetazoaiCBG19673; CBG19673; WBGene00038848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600934 Genomic DNA. Translation: CAP36877.2.

3D structure databases

ProteinModelPortaliQ60V73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG19673.

Proteomic databases

PRIDEiQ60V73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG19673; CBG19673; WBGene00038848.

Organism-specific databases

WormBaseiCBG19673; CBP36659; WBGene00038848; Cbr-mel-32.

Phylogenomic databases

eggNOGiKOG2467. Eukaryota.
COG0112. LUCA.
HOGENOMiHOG000239405.
InParanoidiQ60V73.
OMAiVGDFIHE.
OrthoDBiEOG091G05AU.

Enzyme and pathway databases

UniPathwayiUPA00193.

Family and domain databases

CDDicd00378. SHMT. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00051. SHMT. 1 hit.
InterProiIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
PANTHERiPTHR11680. PTHR11680. 1 hit.
PfamiPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000412. SHMT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLYC_CAEBR
AccessioniPrimary (citable) accession number: Q60V73
Secondary accession number(s): A8XW58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 22, 2009
Last modified: September 7, 2016
This is version 63 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.