JmjC domain-containing histone demethylation protein 1

Names and origin

Protein names

Recommended name:
    JmjC domain-containing histone demethylation protein 1
    EC=1.14.11.27
Alternative name(s):
    [Histone-H3]-lysine-36 demethylase 1

Gene names

Name:	jhd-1
ORF Names:	CBG19679

Organism

Caenorhabditis briggsae [Complete proteome]

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length	1063 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code By similarity.
Catalytic activity	Protein N₆,N(6)-dimethyl-L-lysine + 2-oxoglutarate + O₂ = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO₂. Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O₂ = protein L-lysine + succinate + formaldehyde + CO₂.
Cofactor	Binds 1 Fe²⁺ ion per subunit By similarity.
Subcellular location	Nucleus By similarity.
Domain	The JmjC domain mediates the demethylation activity By similarity.
Sequence similarities	Belongs to the JHDM1 histone demethylase family. Contains 1 JmjC domain.
Sequence caution	The sequence CAE72500.1 differs from that shown. Reason: Erroneous gene model prediction.

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Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	Iron Metal-binding
Molecular function	Chromatin regulator Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone demethylase activity (H3-K36 specific) Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1063

1063

JmjC domain-containing histone demethylation protein 1

PRO_0000226788

Regions

Domain

86 – 266

181

JmjC

Compositional bias

584 – 709

126

Glu-rich

Compositional bias

655 – 727

73

Lys-rich

Sites

Metal binding

163

1

Iron; catalytic By similarity

Metal binding

165

1

Iron; catalytic By similarity

Metal binding

234

1

Iron; catalytic By similarity

Binding site

160

1

Substrate By similarity

Binding site

180

1

Substrate By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

Q60V67-1 [UniParc].

Last modified March 7, 2006. Version 2.
Checksum: 1A904471269FDA24
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FASTA

1,063

121,968

        10         20         30         40         50         60 
MEPEELTIEW YEENGLEKPI HFRCDPTRIG MKLPSPSTFT VDSVLELVGG NRMIEVVQVE 

        70         80         90        100        110        120 
DQGSVKMTLE EFVEFYKTPR DQRKNLYNVL SLEYSLTPLE DLVNSPALVR QIDWVGNIWP 

       130        140        150        160        170        180 
DALRQRWISF NGREKKSYFP HHTFPKVQNY CLMSVANCYT DFHIDFSGTS VWYHVLKGRK 

       190        200        210        220        230        240 
VFWLIPPTAT NFFIYQEFIK TVSDNAFFGR SVEACHVAVL EPGDTMLIPS GWIHAVYTPD 

       250        260        270        280        290        300 
DSLVFGGNFL HSLSCQTQLR VYQVENKLNI TRKFRLPYNE ELLFYVMADY VKKWTGREYV 

       310        320        330        340        350        360 
RPLLVEDAKL DYVGEKWKAA GGHLKKIRFE DYNVEVTSEM VKNEEESEKD EVKVIAMHAG 

       370        380        390        400        410        420 
SSNYDNAMIS KMSYTEATGL EEEAEDEDVK PETKKEAEER RDAEIDLLAA TNSLIFYRNS 

       430        440        450        460        470        480 
KHDFIRNKSV PDHKLPIGHE PPVYFNDEEV SRISPRLLEE LEALGAYIRR KNRVEVAEGI 

       490        500        510        520        530        540 
CHPASLINLF NTVLKKRRAE LTGKPFQFNQ IMPRRYTRAA IETGDYDFEP VRTIEDSRRA 

       550        560        570        580        590        600 
SQFKVEDFPD ELLESDEPDE TSRIHLPHQP SSGPLEYIPT PRGEIRENSL GFEPEYDEDM 

       610        620        630        640        650        660 
EEYDPAEQVV KEELEEEEEE EEGEEEEEEE YVAPVTRRSS TRGSASTKEE PQEEKEEKEA 

       670        680        690        700        710        720 
APKKEKKEKK VKKEKSSKPE KDTTEAKLKK EKKKKEMERR LRDSELEAEL RAAHGGKNAK 

       730        740        750        760        770        780 
SKKKPEKPAY VGGLPTAPIQ NDPVVSNPYN YDPRMEMMKL GTGQLKSAYR KTKANVELHI 

       790        800        810        820        830        840 
EKNLYKLEPK RDESESREPS MEHEDSPTTP HAPYDRYSHY HTENSHFQED QDSHRTPAKR 

       850        860        870        880        890        900 
SKYDNISVDT SESPHIPKKR SLEGRPSPYS VISPPHNRPK LSSPAMFSPS SEPRRSNDRR 

       910        920        930        940        950        960 
TSDPAVNAMK KGVYMPPMSR QDKMIAEAAS ASSSRHSSFS ERRPSFIPDL NSSRHSSTDT 

       970        980        990       1000       1010       1020 
PMYTPTAPAR SSWLPNTSNV TRHSLDDDSP IDVVSESPID VLNSPPFPRS ITPPPVSLSE 

      1030       1040       1050       1060 
LKSQSNGRKS NYSEDGKRAK IPAREAVAEL KTLIGKLKTL NEA

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References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics."
Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W.

Waterston R.H.
PLoS Biol. 1:166-192(2003) [PubMed: 14624247] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AF16.

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Cross-references

Sequence databases
	CAAC01000101 Genomic DNA. Translation: CAE72500.1. Sequence problems.
3D structure databases
ModBase	Search...
Organism-specific databases
WormBase	WBGene00038854. CBG19679.
Enzyme and pathway databases
BRENDA	1.14.11.27. 261794.
Family and domain databases
InterPro	IPR013129. TF_JmjC. IPR003347. TF_JmjC_AAH. [Graphical view]
Pfam	PF02373. JmjC. 1 hit. [Graphical view]
SMART	SM00558. JmjC. 1 hit. [Graphical view]
PROSITE	PS51184. JMJC. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

JHD1_CAEBR

Accession

Primary (citable) accession number: Q60V67

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 25 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Organism-specific databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents