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Protein

Tropomyosin

Gene

lev-11

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin (By similarity).By similarity

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin
Alternative name(s):
Levamisole resistant protein 11
Gene namesi
Name:lev-11By similarity
ORF Names:CBG19793
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome I, Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256TropomyosinPRO_0000274536Add
BLAST

Proteomic databases

PRIDEiQ60UW4.

Structurei

3D structure databases

ProteinModelPortaliQ60UW4.
SMRiQ60UW4. Positions 15-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 256256Sequence analysisAdd
BLAST

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.Curated

Sequence similaritiesi

Belongs to the tropomyosin family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000231522.
InParanoidiQ60UW4.
KOiK10373.
OMAiANDRANN.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60UW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVNKEGAQ QTSLLDVLKK KMRQAREEAE AAKDEADEVK RQLEEERKKR
60 70 80 90 100
EDAEAEVAAL NRRIVLVEED LERTEDRLKV ATSKLEQATK AADEADRARK
110 120 130 140 150
SMETRSQQDE ERANFLETQV DEAKVIAEDA DRKYEEVARK LAMVEADLER
160 170 180 190 200
AEERAEAGEN KIVELEEELR VVGNNLKSLE VSEEKALQRE DSYEEQIRTV
210 220 230 240 250
SSRLKEAETR AEFAERSVQK LQKEVDRLED ELLLEKERVR NLTEEIEQTV

QEIQGS
Length:256
Mass (Da):29,630
Last modified:November 23, 2004 - v1
Checksum:i7599F445015ADB48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601474 Genomic DNA. Translation: CCG58661.1.
RefSeqiXP_002640726.1. XM_002640680.1.

Genome annotation databases

EnsemblMetazoaiCBG19793a; CBG19793a; WBGene00038957.
GeneIDi8582720.
KEGGicbr:CBG19793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601474 Genomic DNA. Translation: CCG58661.1.
RefSeqiXP_002640726.1. XM_002640680.1.

3D structure databases

ProteinModelPortaliQ60UW4.
SMRiQ60UW4. Positions 15-254.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ60UW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG19793a; CBG19793a; WBGene00038957.
GeneIDi8582720.
KEGGicbr:CBG19793.

Organism-specific databases

CTDi8582720.

Phylogenomic databases

HOGENOMiHOG000231522.
InParanoidiQ60UW4.
KOiK10373.
OMAiANDRANN.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPM_CAEBR
AccessioniPrimary (citable) accession number: Q60UW4
Secondary accession number(s): A8XWA7, H8WHA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.