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Protein

Tropomyosin

Gene

lev-11

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Muscle protein

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin
Alternative name(s):
Levamisole resistant protein 11
Gene namesi
Name:lev-11By similarity
ORF Names:CBG19793
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome I, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG19793a ; CBP39999 ; WBGene00038957 ; Cbr-lev-11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002745361 – 256TropomyosinAdd BLAST256

Proteomic databases

PRIDEiQ60UW4

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ60UW4
SMRiQ60UW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 256Sequence analysisAdd BLAST256

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.Curated

Sequence similaritiesi

Belongs to the tropomyosin family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000231522
InParanoidiQ60UW4
KOiK10373
OMAiEKYKAVC

Family and domain databases

InterProiView protein in InterPro
IPR000533 Tropomyosin
PfamiView protein in Pfam
PF00261 Tropomyosin, 1 hit
PRINTSiPR00194 TROPOMYOSIN
PROSITEiView protein in PROSITE
PS00326 TROPOMYOSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q60UW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVNKEGAQ QTSLLDVLKK KMRQAREEAE AAKDEADEVK RQLEEERKKR
60 70 80 90 100
EDAEAEVAAL NRRIVLVEED LERTEDRLKV ATSKLEQATK AADEADRARK
110 120 130 140 150
SMETRSQQDE ERANFLETQV DEAKVIAEDA DRKYEEVARK LAMVEADLER
160 170 180 190 200
AEERAEAGEN KIVELEEELR VVGNNLKSLE VSEEKALQRE DSYEEQIRTV
210 220 230 240 250
SSRLKEAETR AEFAERSVQK LQKEVDRLED ELLLEKERVR NLTEEIEQTV

QEIQGS
Length:256
Mass (Da):29,630
Last modified:November 23, 2004 - v1
Checksum:i7599F445015ADB48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601474 Genomic DNA Translation: CCG58661.1
RefSeqiXP_002640726.1, XM_002640680.1

Genome annotation databases

EnsemblMetazoaiCBG19793h; CBG19793h; WBGene00038957
GeneIDi8582720
KEGGicbr:CBG19793

Similar proteinsi

Entry informationi

Entry nameiTPM_CAEBR
AccessioniPrimary (citable) accession number: Q60UW4
Secondary accession number(s): A8XWA7, H8WHA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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