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Q60TI7 (CDO_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine dioxygenase

Short name=CDO
EC=1.13.11.20
Gene names
Name:cdo-1
ORF Names:CBG20456
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length190 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-cysteine + O2 = 3-sulfinoalanine.

Cofactor

Binds 1 iron ion per subunit By similarity.

Pathway

Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.

Post-translational modification

The thioether cross-link between Cys-85 and Tyr-149 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.

Sequence similarities

Belongs to the cysteine dioxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 190190Cysteine dioxygenase
PRO_0000206611

Sites

Metal binding781Iron; catalytic By similarity
Metal binding801Iron; catalytic By similarity
Metal binding1321Iron; catalytic By similarity

Amino acid modifications

Cross-link85 ↔ 1493'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60TI7 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 85AC945875B513F7

FASTA19021,962
        10         20         30         40         50         60 
MVSFVQLVVQ IREIFEHKMV DVDEVMKLMG SYKSDINEWR RFAIFDMNKY TRNLVDIGNG 

        70         80         90        100        110        120 
KYNLMILCWG PGMASSVHDH TDAHCFVKIL DGELTETKYD WPKKKHTPLE TIENKTYGLN 

       130        140        150        160        170        180 
GVSYMNDELG LHRMENQSHS NGAVSLHLYI PPYSTCNAFD ERTGKKTKCT VTFYSKYGEK 

       190 
IDYHGSKEGK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE601085 Genomic DNA. Translation: CAP37450.3.
RefSeqXP_002632069.1. XM_002632023.1.

3D structure databases

ProteinModelPortalQ60TI7.
SMRQ60TI7. Positions 3-181.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG20456; CBG20456; CBG20456.
GeneID8574068.
KEGGcbr:CBG20456.

Organism-specific databases

CTD8574068.
WormBaseCBG20456; CBP11524; WBGene00039434; Cbr-cdo-1.

Phylogenomic databases

HOGENOMHOG000177818.
KOK00456.
OMAKMTFWSK.
OrthoDBEOG77M8PK.

Enzyme and pathway databases

UniPathwayUPA00012; UER00537.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCDO_CAEBR
AccessionPrimary (citable) accession number: Q60TI7
Secondary accession number(s): A8XXT1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: November 23, 2004
Last modified: November 13, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways