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Q60TI7

- CDO_CAEBR

UniProt

Q60TI7 - CDO_CAEBR

Protein

Cysteine dioxygenase

Gene

cdo-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-cysteine + O2 = 3-sulfinoalanine.

    Cofactori

    Binds 1 iron ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi78 – 781Iron; catalyticBy similarity
    Metal bindingi80 – 801Iron; catalyticBy similarity
    Metal bindingi132 – 1321Iron; catalyticBy similarity

    GO - Molecular functioni

    1. cysteine dioxygenase activity Source: UniProtKB-EC
    2. iron ion binding Source: InterPro

    GO - Biological processi

    1. L-cysteine metabolic process Source: InterPro
    2. taurine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00012; UER00537.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine dioxygenase (EC:1.13.11.20)
    Short name:
    CDO
    Gene namesi
    Name:cdo-1
    ORF Names:CBG20456
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome II, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG20456; CBP11524; WBGene00039434; Cbr-cdo-1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 190190Cysteine dioxygenasePRO_0000206611Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki85 ↔ 1493'-(S-cysteinyl)-tyrosine (Cys-Tyr)By similarity

    Post-translational modificationi

    The thioether cross-link between Cys-85 and Tyr-149 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.By similarity

    Keywords - PTMi

    Thioether bond

    Structurei

    3D structure databases

    ProteinModelPortaliQ60TI7.
    SMRiQ60TI7. Positions 3-181.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cysteine dioxygenase family.Curated

    Phylogenomic databases

    HOGENOMiHOG000177818.
    KOiK00456.
    OMAiKMTFWSK.
    OrthoDBiEOG77M8PK.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR010300. Cys_dOase_I.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PfamiPF05995. CDO_I. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q60TI7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSFVQLVVQ IREIFEHKMV DVDEVMKLMG SYKSDINEWR RFAIFDMNKY    50
    TRNLVDIGNG KYNLMILCWG PGMASSVHDH TDAHCFVKIL DGELTETKYD 100
    WPKKKHTPLE TIENKTYGLN GVSYMNDELG LHRMENQSHS NGAVSLHLYI 150
    PPYSTCNAFD ERTGKKTKCT VTFYSKYGEK IDYHGSKEGK 190
    Length:190
    Mass (Da):21,962
    Last modified:November 23, 2004 - v1
    Checksum:i85AC945875B513F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601085 Genomic DNA. Translation: CAP37450.3.
    RefSeqiXP_002632069.1. XM_002632023.1.

    Genome annotation databases

    EnsemblMetazoaiCBG20456; CBG20456; CBG20456.
    GeneIDi8574068.
    KEGGicbr:CBG20456.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601085 Genomic DNA. Translation: CAP37450.3 .
    RefSeqi XP_002632069.1. XM_002632023.1.

    3D structure databases

    ProteinModelPortali Q60TI7.
    SMRi Q60TI7. Positions 3-181.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG20456 ; CBG20456 ; CBG20456 .
    GeneIDi 8574068.
    KEGGi cbr:CBG20456.

    Organism-specific databases

    CTDi 8574068.
    WormBasei CBG20456 ; CBP11524 ; WBGene00039434 ; Cbr-cdo-1.

    Phylogenomic databases

    HOGENOMi HOG000177818.
    KOi K00456.
    OMAi KMTFWSK.
    OrthoDBi EOG77M8PK.

    Enzyme and pathway databases

    UniPathwayi UPA00012 ; UER00537 .

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR010300. Cys_dOase_I.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    Pfami PF05995. CDO_I. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiCDO_CAEBR
    AccessioniPrimary (citable) accession number: Q60TI7
    Secondary accession number(s): A8XXT1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3