Reviewed, UniProtKB/Swiss-Prot Q60TI7 (CDO_CAEBR)

Names and origin

Protein names

Recommended name:
    Cysteine dioxygenase
      Short name=CDO
    EC=1.13.11.20

Gene names

Name:	cdo-1
ORF Names:	CBG20456

Organism

Caenorhabditis briggsae [Complete proteome]

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-cysteine + O2 = 3-sulfinoalanine.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.
Post-translational modification	The thioether cross-link between Cys-85 and Tyr-149 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.
Sequence similarities	Belongs to the cysteine dioxygenase family.
Sequence caution	The sequence CAP37450.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
PTM	Thioether bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-cysteine metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cysteine dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Cysteine dioxygenase		PRO_0000206611
Sites
	Metal binding	78	1	Iron; catalytic By similarity
	Metal binding	80	1	Iron; catalytic By similarity
	Metal binding	132	1	Iron; catalytic By similarity
Amino acid modifications
	Cross-link	85 ↔ 149		3'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q60TI7-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 85AC945875B513F7	FASTA	190	21,962
	10 20 30 40 50 60 MVSFVQLVVQ IREIFEHKMV DVDEVMKLMG SYKSDINEWR RFAIFDMNKY TRNLVDIGNG 70 80 90 100 110 120 KYNLMILCWG PGMASSVHDH TDAHCFVKIL DGELTETKYD WPKKKHTPLE TIENKTYGLN 130 140 150 160 170 180 GVSYMNDELG LHRMENQSHS NGAVSLHLYI PPYSTCNAFD ERTGKKTKCT VTFYSKYGEK 190 IDYHGSKEGK

References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed: 14624247] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CAAC02000571 Genomic DNA. Translation: CAP37450.2. Sequence problems.
RefSeq	XP_002632069.1.
3D structure databases
SMR	Q60TI7. Positions 3-181.
ModBase	Search...
Genome annotation databases
GeneID	8574068.
Organism-specific databases
WormBase	WBGene00039434. Cbr-cdo-1.
Phylogenomic databases
HOGENOM	HBG380588.
OMA	MNDELGL.
PhylomeDB	Q60TI7.
Enzyme and pathway databases
BRENDA	1.13.11.20. 261794.
Family and domain databases
InterPro	IPR010300. Cys_dOase_I. [Graphical view]
Pfam	PF05995. CDO_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDO_CAEBR

Accession

Primary (citable) accession number: Q60TI7
Secondary accession number(s): A8XXT1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	November 23, 2004
Last modified:	February 9, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project