Q60TI7 (CDO_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cysteine dioxygenase
Short name=CDO
EC=1.13.11.20

Gene names

Name:	cdo-1
ORF Names:	CBG20456

Organism

Caenorhabditis briggsae [Reference proteome]

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-cysteine + O2 = 3-sulfinoalanine.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.
Post-translational modification	The thioether cross-link between Cys-85 and Tyr-149 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.
Sequence similarities	Belongs to the cysteine dioxygenase family.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
PTM	Thioether bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	L-cysteine metabolic process Inferred from electronic annotation. Source: InterPro taurine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	cysteine dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Cysteine dioxygenase		PRO_0000206611
Sites
	Metal binding	78	1	Iron; catalytic By similarity
	Metal binding	80	1	Iron; catalytic By similarity
	Metal binding	132	1	Iron; catalytic By similarity
Amino acid modifications
	Cross-link	85 ↔ 149		3'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q60TI7 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 85AC945875B513F7	FASTA	190	21,962
	10 20 30 40 50 60 MVSFVQLVVQ IREIFEHKMV DVDEVMKLMG SYKSDINEWR RFAIFDMNKY TRNLVDIGNG 70 80 90 100 110 120 KYNLMILCWG PGMASSVHDH TDAHCFVKIL DGELTETKYD WPKKKHTPLE TIENKTYGLN 130 140 150 160 170 180 GVSYMNDELG LHRMENQSHS NGAVSLHLYI PPYSTCNAFD ERTGKKTKCT VTFYSKYGEK 190 IDYHGSKEGK

References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HE601085 Genomic DNA. Translation: CAP37450.1.
RefSeq	XP_002632069.1. XM_002632023.1.
3D structure databases
ProteinModelPortal	Q60TI7.
SMR	Q60TI7. Positions 3-181.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	CBG20456; CBG20456; CBG20456.
GeneID	8574068.
KEGG	cbr:CBG20456.
Organism-specific databases
CTD	8574068.
WormBase	CBG20456; CBP11524; WBGene00039434; Cbr-cdo-1.
Phylogenomic databases
HOGENOM	HOG000177818.
KO	K00456.
OMA	KVAYIND.
Enzyme and pathway databases
UniPathway	UPA00012; UER00537.
Family and domain databases
Gene3D	2.60.120.10. 1 hit.
InterPro	IPR010300. Cys_dOase_I. IPR014710. RmlC-like_jellyroll. IPR011051. RmlC_Cupin. [Graphical view]
Pfam	PF05995. CDO_I. 1 hit. [Graphical view]
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CDO_CAEBR

Accession

Primary (citable) accession number: Q60TI7
Secondary accession number(s): A8XXT1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	November 23, 2004
Last modified:	March 6, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project