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Q60TI7

- CDO_CAEBR

UniProt

Q60TI7 - CDO_CAEBR

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Protein

Cysteine dioxygenase

Gene

cdo-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

L-cysteine + O2 = 3-sulfinoalanine.

Cofactori

Binds 1 iron ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Iron; catalyticBy similarity
Metal bindingi80 – 801Iron; catalyticBy similarity
Metal bindingi132 – 1321Iron; catalyticBy similarity

GO - Molecular functioni

  1. cysteine dioxygenase activity Source: UniProtKB-EC
  2. iron ion binding Source: InterPro

GO - Biological processi

  1. L-cysteine metabolic process Source: InterPro
  2. taurine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00012; UER00537.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine dioxygenase (EC:1.13.11.20)
Short name:
CDO
Gene namesi
Name:cdo-1
ORF Names:CBG20456
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome II, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG20456; CBP11524; WBGene00039434; Cbr-cdo-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Cysteine dioxygenasePRO_0000206611Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki85 ↔ 1493'-(S-cysteinyl)-tyrosine (Cys-Tyr)By similarity

Post-translational modificationi

The thioether cross-link between Cys-85 and Tyr-149 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.By similarity

Keywords - PTMi

Thioether bond

Structurei

3D structure databases

ProteinModelPortaliQ60TI7.
SMRiQ60TI7. Positions 3-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cysteine dioxygenase family.Curated

Phylogenomic databases

HOGENOMiHOG000177818.
InParanoidiQ60TI7.
KOiK00456.
OMAiKMTFWSK.
OrthoDBiEOG77M8PK.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60TI7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSFVQLVVQ IREIFEHKMV DVDEVMKLMG SYKSDINEWR RFAIFDMNKY
60 70 80 90 100
TRNLVDIGNG KYNLMILCWG PGMASSVHDH TDAHCFVKIL DGELTETKYD
110 120 130 140 150
WPKKKHTPLE TIENKTYGLN GVSYMNDELG LHRMENQSHS NGAVSLHLYI
160 170 180 190
PPYSTCNAFD ERTGKKTKCT VTFYSKYGEK IDYHGSKEGK
Length:190
Mass (Da):21,962
Last modified:November 23, 2004 - v1
Checksum:i85AC945875B513F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601085 Genomic DNA. Translation: CAP37450.3.
RefSeqiXP_002632069.1. XM_002632023.1.

Genome annotation databases

EnsemblMetazoaiCBG20456; CBG20456; CBG20456.
GeneIDi8574068.
KEGGicbr:CBG20456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601085 Genomic DNA. Translation: CAP37450.3 .
RefSeqi XP_002632069.1. XM_002632023.1.

3D structure databases

ProteinModelPortali Q60TI7.
SMRi Q60TI7. Positions 3-181.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG20456 ; CBG20456 ; CBG20456 .
GeneIDi 8574068.
KEGGi cbr:CBG20456.

Organism-specific databases

CTDi 8574068.
WormBasei CBG20456 ; CBP11524 ; WBGene00039434 ; Cbr-cdo-1.

Phylogenomic databases

HOGENOMi HOG000177818.
InParanoidi Q60TI7.
KOi K00456.
OMAi KMTFWSK.
OrthoDBi EOG77M8PK.

Enzyme and pathway databases

UniPathwayi UPA00012 ; UER00537 .

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF05995. CDO_I. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiCDO_CAEBR
AccessioniPrimary (citable) accession number: Q60TI7
Secondary accession number(s): A8XXT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3