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Q60MK8

- UBP7_CAEBR

UniProt

Q60MK8 - UBP7_CAEBR

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Protein

Ubiquitin carboxyl-terminal hydrolase 7

Gene

usp-7

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves ubiquitin fusion protein substrates.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei199 – 1991NucleophilePROSITE-ProRule annotation
Active sitei439 – 4391Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. protein deubiquitination Source: UniProtKB
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 7 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7
Gene namesi
Name:usp-7
ORF Names:CBG23105
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome V, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG23105; CBP12468; WBGene00041522.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11291129Ubiquitin carboxyl-terminal hydrolase 7PRO_0000268009Add
BLAST

Post-translational modificationi

Polyneddylated.By similarity
Polyubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG23105.

Structurei

3D structure databases

ProteinModelPortaliQ60MK8.
SMRiQ60MK8. Positions 184-524.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 169141MATHPROSITE-ProRule annotationAdd
BLAST
Domaini190 – 500311USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 MATH domain.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5077.
HOGENOMiHOG000160240.
InParanoidiQ60MK8.
KOiK11838.
OMAiLQCNNDD.
OrthoDBiEOG75B84G.

Family and domain databases

InterProiIPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view]
PfamiPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view]
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
PROSITEiPS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60MK8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCSPDPEDMH ILTNDIPSFD KSLDPYGPEG HLALDIERFS SFMNKPDSRI
60 70 80 90 100
MSKPVIVRGI PWRILAICRH QQNNRQVATS RSRNNYNFGF FLQCNNDDLL
110 120 130 140 150
QKRGMWRCYG QATLEVLNAN GPPIQKKIHH SFHNTEVDWG FSNYDQYDTL
160 170 180 190 200
TSPKDGYVID DVIRLRCRFT ADVPTGANYM WDSKKHTGCI GLRNQGATCY
210 220 230 240 250
MNSILQSFYF TTGFRRAVYN MEVGTEPNES NIVLAMQRVF YELQMSSEAV
260 270 280 290 300
ETNSLTRAFG WDKLDAFNQH DVQEFCRVLL DNLETKMKGT SEEKSIPNLF
310 320 330 340 350
RGNMKSYIKC LDVDYESSRT ESFYDVQLNV LGMDSLERAF DAYTTPETLD
360 370 380 390 400
DDNKYDAGDH GLQRAEKGVK FVELPPVLHV QLMRFQYCGV EQKINERFSF
410 420 430 440 450
PEKMNLSNCC ELGPMLNEED CVYSLHAVLV HSGEFHGGHY VTYINVNLHE
460 470 480 490 500
SAVDPTATAK WCKFDDDVVS RTTTDDAIVS NFGGEKAMNS SAYMLVYVRD
510 520 530 540 550
NAIDQVLAPI PDTQIPQSVS RTFEMERMHR NREKKKQEEE QMCMSITLVT
560 570 580 590 600
PDILATNHSF DLIEPVTITD VLPHETVYKH MVTAELYQFV QEKLFEKSTL
610 620 630 640 650
PKVDMFDSDD ETRMKRKEIL RRLKTKKFGF RLWRMTDSYT VDKPQKMASR
660 670 680 690 700
LRPSDFIEYS IDTRLDHTLS HDTETIYVEH SQFLQPLNEY LPTRDILFFL
710 720 730 740 750
KYYDAITDKF TIIGHVTLDS HKRLNLYRMT FCDLLGLPKD TELKYYIEHA
760 770 780 790 800
PNHVEQIDDP NRSTISRLVD DQDGAIVIVE KADPTAKKDA KTKMIELYND
810 820 830 840 850
VEFEFSQQFY SKMPNEEPFE LFTKRFCLEQ KLTDVTEFIG SELNVDPRNV
860 870 880 890 900
MLWTRVSGSR FEPNFDDYAV TGIQCKYLTL RTLHDPRQHK KYSVSYAIFP
910 920 930 940 950
FPVNEVHTTR MFVRLYRQMP NGNVEELNLF PPKDGTVTDL IAEAKRYYPS
960 970 980 990 1000
VEGGSGKFRL LQIGTSPLNN QRVFQIYNEN TAIVDLDQRP VYKQQAQHTL
1010 1020 1030 1040 1050
NCRIEEIPHD ELDVAQGEFF CPVVHYDREP TKLFGVSFVI KIRNGELMTD
1060 1070 1080 1090 1100
VRDRLRRKLP DVSDAEFAKY KFALLSRDKL CRNIEFNAGE KVNLMDMANQ
1110 1120
TTGVPQVYIG LDHKSPSQHS NEAAIRILN
Length:1,129
Mass (Da):130,838
Last modified:November 23, 2004 - v1
Checksum:i0230AA8BC1806610
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601533 Genomic DNA. Translation: CAP39865.3.
RefSeqiXP_002636444.1. XM_002636398.1.

Genome annotation databases

EnsemblMetazoaiCBG23105; CBG23105; CBG23105.
GeneIDi8578439.
KEGGicbr:CBG23105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601533 Genomic DNA. Translation: CAP39865.3 .
RefSeqi XP_002636444.1. XM_002636398.1.

3D structure databases

ProteinModelPortali Q60MK8.
SMRi Q60MK8. Positions 184-524.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG23105.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG23105 ; CBG23105 ; CBG23105 .
GeneIDi 8578439.
KEGGi cbr:CBG23105.

Organism-specific databases

CTDi 8578439.
WormBasei CBG23105 ; CBP12468 ; WBGene00041522 .

Phylogenomic databases

eggNOGi COG5077.
HOGENOMi HOG000160240.
InParanoidi Q60MK8.
KOi K11838.
OMAi LQCNNDD.
OrthoDBi EOG75B84G.

Family and domain databases

InterProi IPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view ]
Pfami PF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view ]
SMARTi SM00061. MATH. 1 hit.
[Graphical view ]
SUPFAMi SSF49599. SSF49599. 1 hit.
PROSITEi PS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiUBP7_CAEBR
AccessioniPrimary (citable) accession number: Q60MK8
Secondary accession number(s): A8Y4P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3