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Q60MK8 (UBP7_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 7
EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7
Gene names
Name:usp-7
ORF Names:CBG23105
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length1129 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves ubiquitin fusion protein substrates By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Nucleus By similarity.

Post-translational modification

Polyneddylated By similarity.

Polyubiquitinated By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 MATH domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11291129Ubiquitin carboxyl-terminal hydrolase 7
PRO_0000268009

Regions

Domain29 – 169141MATH

Sites

Active site1991Nucleophile By similarity
Active site4391Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60MK8 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 0230AA8BC1806610

FASTA1,129130,838
        10         20         30         40         50         60 
MCSPDPEDMH ILTNDIPSFD KSLDPYGPEG HLALDIERFS SFMNKPDSRI MSKPVIVRGI 

        70         80         90        100        110        120 
PWRILAICRH QQNNRQVATS RSRNNYNFGF FLQCNNDDLL QKRGMWRCYG QATLEVLNAN 

       130        140        150        160        170        180 
GPPIQKKIHH SFHNTEVDWG FSNYDQYDTL TSPKDGYVID DVIRLRCRFT ADVPTGANYM 

       190        200        210        220        230        240 
WDSKKHTGCI GLRNQGATCY MNSILQSFYF TTGFRRAVYN MEVGTEPNES NIVLAMQRVF 

       250        260        270        280        290        300 
YELQMSSEAV ETNSLTRAFG WDKLDAFNQH DVQEFCRVLL DNLETKMKGT SEEKSIPNLF 

       310        320        330        340        350        360 
RGNMKSYIKC LDVDYESSRT ESFYDVQLNV LGMDSLERAF DAYTTPETLD DDNKYDAGDH 

       370        380        390        400        410        420 
GLQRAEKGVK FVELPPVLHV QLMRFQYCGV EQKINERFSF PEKMNLSNCC ELGPMLNEED 

       430        440        450        460        470        480 
CVYSLHAVLV HSGEFHGGHY VTYINVNLHE SAVDPTATAK WCKFDDDVVS RTTTDDAIVS 

       490        500        510        520        530        540 
NFGGEKAMNS SAYMLVYVRD NAIDQVLAPI PDTQIPQSVS RTFEMERMHR NREKKKQEEE 

       550        560        570        580        590        600 
QMCMSITLVT PDILATNHSF DLIEPVTITD VLPHETVYKH MVTAELYQFV QEKLFEKSTL 

       610        620        630        640        650        660 
PKVDMFDSDD ETRMKRKEIL RRLKTKKFGF RLWRMTDSYT VDKPQKMASR LRPSDFIEYS 

       670        680        690        700        710        720 
IDTRLDHTLS HDTETIYVEH SQFLQPLNEY LPTRDILFFL KYYDAITDKF TIIGHVTLDS 

       730        740        750        760        770        780 
HKRLNLYRMT FCDLLGLPKD TELKYYIEHA PNHVEQIDDP NRSTISRLVD DQDGAIVIVE 

       790        800        810        820        830        840 
KADPTAKKDA KTKMIELYND VEFEFSQQFY SKMPNEEPFE LFTKRFCLEQ KLTDVTEFIG 

       850        860        870        880        890        900 
SELNVDPRNV MLWTRVSGSR FEPNFDDYAV TGIQCKYLTL RTLHDPRQHK KYSVSYAIFP 

       910        920        930        940        950        960 
FPVNEVHTTR MFVRLYRQMP NGNVEELNLF PPKDGTVTDL IAEAKRYYPS VEGGSGKFRL 

       970        980        990       1000       1010       1020 
LQIGTSPLNN QRVFQIYNEN TAIVDLDQRP VYKQQAQHTL NCRIEEIPHD ELDVAQGEFF 

      1030       1040       1050       1060       1070       1080 
CPVVHYDREP TKLFGVSFVI KIRNGELMTD VRDRLRRKLP DVSDAEFAKY KFALLSRDKL 

      1090       1100       1110       1120 
CRNIEFNAGE KVNLMDMANQ TTGVPQVYIG LDHKSPSQHS NEAAIRILN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		HE601533 Genomic DNA. Translation: CAP39865.1.
RefSeqXP_002636444.1. XM_002636398.1.

3D structure databases

HSSPHSSP built from PDB template 1NBF based on UniProtKB Q93009.
ProteinModelPortalQ60MK8.
SMRQ60MK8. Positions 184-524.
ModBaseSearch...

Protein-protein interaction databases

STRING6238.CBG23105.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG23105; CBG23105; CBG23105.
GeneID8578439.
KEGGcbr:CBG23105.

Organism-specific databases

CTD8578439.
WormBaseCBG23105; CBP12468; WBGene00041522.

Phylogenomic databases

eggNOGCOG5077.
HOGENOMHOG000160240.
KOK11838.

Family and domain databases

InterProIPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19.
IPR008974. TRAF-like.
[Graphical view]
PfamPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMSSF49599. Traf_like. 1 hit.
PROSITEPS50144. MATH. 1 hit.
PS00972. UCH_2_1. 1 hit.
PS00973. UCH_2_2. 1 hit.
PS50235. UCH_2_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP7_CAEBR
AccessionPrimary (citable) accession number: Q60MK8
Secondary accession number(s): A8Y4P5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 23, 2004
Last modified: April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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