SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q60MK8

- UBP7_CAEBR

UniProt

Q60MK8 - UBP7_CAEBR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ubiquitin carboxyl-terminal hydrolase 7

Gene
usp-7, CBG23105
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves ubiquitin fusion protein substrates By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei199 – 1991Nucleophile By similarity
Active sitei439 – 4391Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. protein deubiquitination Source: UniProtKB
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 7 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7
Gene namesi
Name:usp-7
ORF Names:CBG23105
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome V, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG23105; CBP12468; WBGene00041522.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11291129Ubiquitin carboxyl-terminal hydrolase 7PRO_0000268009Add
BLAST

Post-translational modificationi

Polyneddylated By similarity.
Polyubiquitinated By similarity.

Keywords - PTMi

Ubl conjugation

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG23105.

Structurei

3D structure databases

ProteinModelPortaliQ60MK8.
SMRiQ60MK8. Positions 184-524.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 169141MATHAdd
BLAST
Domaini190 – 500311USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 MATH domain.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5077.
HOGENOMiHOG000160240.
KOiK11838.
OMAiLQCNNDD.
OrthoDBiEOG75B84G.

Family and domain databases

InterProiIPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view]
PfamiPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view]
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
PROSITEiPS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60MK8-1 [UniParc]FASTAAdd to Basket

« Hide

MCSPDPEDMH ILTNDIPSFD KSLDPYGPEG HLALDIERFS SFMNKPDSRI     50
MSKPVIVRGI PWRILAICRH QQNNRQVATS RSRNNYNFGF FLQCNNDDLL 100
QKRGMWRCYG QATLEVLNAN GPPIQKKIHH SFHNTEVDWG FSNYDQYDTL 150
TSPKDGYVID DVIRLRCRFT ADVPTGANYM WDSKKHTGCI GLRNQGATCY 200
MNSILQSFYF TTGFRRAVYN MEVGTEPNES NIVLAMQRVF YELQMSSEAV 250
ETNSLTRAFG WDKLDAFNQH DVQEFCRVLL DNLETKMKGT SEEKSIPNLF 300
RGNMKSYIKC LDVDYESSRT ESFYDVQLNV LGMDSLERAF DAYTTPETLD 350
DDNKYDAGDH GLQRAEKGVK FVELPPVLHV QLMRFQYCGV EQKINERFSF 400
PEKMNLSNCC ELGPMLNEED CVYSLHAVLV HSGEFHGGHY VTYINVNLHE 450
SAVDPTATAK WCKFDDDVVS RTTTDDAIVS NFGGEKAMNS SAYMLVYVRD 500
NAIDQVLAPI PDTQIPQSVS RTFEMERMHR NREKKKQEEE QMCMSITLVT 550
PDILATNHSF DLIEPVTITD VLPHETVYKH MVTAELYQFV QEKLFEKSTL 600
PKVDMFDSDD ETRMKRKEIL RRLKTKKFGF RLWRMTDSYT VDKPQKMASR 650
LRPSDFIEYS IDTRLDHTLS HDTETIYVEH SQFLQPLNEY LPTRDILFFL 700
KYYDAITDKF TIIGHVTLDS HKRLNLYRMT FCDLLGLPKD TELKYYIEHA 750
PNHVEQIDDP NRSTISRLVD DQDGAIVIVE KADPTAKKDA KTKMIELYND 800
VEFEFSQQFY SKMPNEEPFE LFTKRFCLEQ KLTDVTEFIG SELNVDPRNV 850
MLWTRVSGSR FEPNFDDYAV TGIQCKYLTL RTLHDPRQHK KYSVSYAIFP 900
FPVNEVHTTR MFVRLYRQMP NGNVEELNLF PPKDGTVTDL IAEAKRYYPS 950
VEGGSGKFRL LQIGTSPLNN QRVFQIYNEN TAIVDLDQRP VYKQQAQHTL 1000
NCRIEEIPHD ELDVAQGEFF CPVVHYDREP TKLFGVSFVI KIRNGELMTD 1050
VRDRLRRKLP DVSDAEFAKY KFALLSRDKL CRNIEFNAGE KVNLMDMANQ 1100
TTGVPQVYIG LDHKSPSQHS NEAAIRILN 1129
Length:1,129
Mass (Da):130,838
Last modified:November 23, 2004 - v1
Checksum:i0230AA8BC1806610
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601533 Genomic DNA. Translation: CAP39865.3.
RefSeqiXP_002636444.1. XM_002636398.1.

Genome annotation databases

EnsemblMetazoaiCBG23105; CBG23105; CBG23105.
GeneIDi8578439.
KEGGicbr:CBG23105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601533 Genomic DNA. Translation: CAP39865.3 .
RefSeqi XP_002636444.1. XM_002636398.1.

3D structure databases

ProteinModelPortali Q60MK8.
SMRi Q60MK8. Positions 184-524.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG23105.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG23105 ; CBG23105 ; CBG23105 .
GeneIDi 8578439.
KEGGi cbr:CBG23105.

Organism-specific databases

CTDi 8578439.
WormBasei CBG23105 ; CBP12468 ; WBGene00041522 .

Phylogenomic databases

eggNOGi COG5077.
HOGENOMi HOG000160240.
KOi K11838.
OMAi LQCNNDD.
OrthoDBi EOG75B84G.

Family and domain databases

InterProi IPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view ]
Pfami PF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view ]
SMARTi SM00061. MATH. 1 hit.
[Graphical view ]
SUPFAMi SSF49599. SSF49599. 1 hit.
PROSITEi PS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiUBP7_CAEBR
AccessioniPrimary (citable) accession number: Q60MK8
Secondary accession number(s): A8Y4P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi