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Q60LW7

- ELP3_CAEBR

UniProt

Q60LW7 - ELP3_CAEBR

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Protein
Probable elongator complex protein 3
Gene
elpc-3, CBG23399
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity By similarity.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Cofactori

Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi95 – 951Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal bindingi105 – 1051Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal bindingi108 – 1081Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
  2. iron-sulfur cluster binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. phosphorylase kinase regulator activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. regulation of protein kinase activity Source: GOC
  2. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable elongator complex protein 3 (EC:2.3.1.48)
Gene namesi
Name:elpc-3
ORF Names:CBG23399
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome V, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG23399; CBP12416; WBGene00041763; Cbr-elpc-3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. transcription elongation factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Probable elongator complex protein 3
PRO_0000283993Add
BLAST

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.

Protein-protein interaction databases

STRINGi6238.CBG23399.

Structurei

3D structure databases

ProteinModelPortaliQ60LW7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini392 – 548157N-acetyltransferase
Add
BLAST

Sequence similaritiesi

Belongs to the ELP3 family.

Phylogenomic databases

eggNOGiCOG1243.
HOGENOMiHOG000227514.
KOiK07739.
OMAiGYKVVSH.
OrthoDBiEOG7V765W.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01211. ELP3. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60LW7-1 [UniParc]FASTAAdd to Basket

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MDDKGSQRAL LAQTVNEIVK LLIEAHNQKK DVNLNRLKCI VAQKNGLSFQ    50
PKLVDIIAGV PADYKDTLLP KLKAKPVRTA SGIAVVAVMS KPHRCPHINF 100
TGNICVYCPG GPDSDFEYST QSYTGYEPTS MRAIRARYNP YLQTRGRLNQ 150
LMQLGHSVDK VEFIVMGGTF MSLPEDYRDF FIRNLHDALS GHTSASVEEA 200
VAYSERSKMK CIGITIETRP DYCLPRHLND MLLYGCTRLE IGVQSTYEDV 250
ARDTNRGHTV KSVCETFHMA KDTGYKVVIH MMPDLPNVGL ERDKEQFLEL 300
FESPAFRPDG LKLYPTLVIR GTGLYELWKT GRYQSYPPSV LVDLIATILS 350
LVPPWTRVYR VQRDIPMPLV SSGVEHGNLR EHAMAKMKEL GLKCRDVRTR 400
EVGIQEIHNK VRPEDVELIR RDYTANGGWE TFISYEDPKQ DILIGLLRLR 450
KISDKAHRAE LKGNVSVVRE LHVYGSVVSV ADRDPKKFQH QGYGSLLMEE 500
AERIAREEHE SDKIAVISGV GTRDYYRKLG YELDGPYMSK TLDASSAA 548
Length:548
Mass (Da):61,970
Last modified:November 23, 2004 - v1
Checksum:iD4E1EAD89305B037
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601533 Genomic DNA. Translation: CAP39624.3.
RefSeqiXP_002636685.1. XM_002636639.1.

Genome annotation databases

EnsemblMetazoaiCBG23399; CBG23399; CBG23399.
GeneIDi8578680.
KEGGicbr:CBG23399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601533 Genomic DNA. Translation: CAP39624.3 .
RefSeqi XP_002636685.1. XM_002636639.1.

3D structure databases

ProteinModelPortali Q60LW7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 6238.CBG23399.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG23399 ; CBG23399 ; CBG23399 .
GeneIDi 8578680.
KEGGi cbr:CBG23399.

Organism-specific databases

CTDi 8578680.
WormBasei CBG23399 ; CBP12416 ; WBGene00041763 ; Cbr-elpc-3.

Phylogenomic databases

eggNOGi COG1243.
HOGENOMi HOG000227514.
KOi K07739.
OMAi GYKVVSH.
OrthoDBi EOG7V765W.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
TIGRFAMsi TIGR01211. ELP3. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiELP3_CAEBR
AccessioniPrimary (citable) accession number: Q60LW7
Secondary accession number(s): A8Y404
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi