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Protein

Probable elongator complex protein 3

Gene

elpc-3

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi95 – 951Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
Metal bindingi105 – 1051Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
Metal bindingi108 – 1081Iron-sulfur (4Fe-4S-S-AdoMet)By similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
  2. iron-sulfur cluster binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. phosphorylase kinase regulator activity Source: UniProtKB

GO - Biological processi

  1. regulation of protein kinase activity Source: GOC
  2. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable elongator complex protein 3 (EC:2.3.1.48)
Gene namesi
Name:elpc-3
ORF Names:CBG23399
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549 Componentsi: Chromosome V, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG23399; CBP12416; WBGene00041763; Cbr-elpc-3.

Subcellular locationi

  1. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. transcription elongation factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Probable elongator complex protein 3PRO_0000283993Add
BLAST

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit (By similarity).By similarity

Protein-protein interaction databases

STRINGi6238.CBG23399.

Structurei

3D structure databases

ProteinModelPortaliQ60LW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini392 – 548157N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ELP3 family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1243.
HOGENOMiHOG000227514.
InParanoidiQ60LW7.
KOiK07739.
OMAiGYKVVSH.
OrthoDBiEOG7V765W.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01211. ELP3. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60LW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDKGSQRAL LAQTVNEIVK LLIEAHNQKK DVNLNRLKCI VAQKNGLSFQ
60 70 80 90 100
PKLVDIIAGV PADYKDTLLP KLKAKPVRTA SGIAVVAVMS KPHRCPHINF
110 120 130 140 150
TGNICVYCPG GPDSDFEYST QSYTGYEPTS MRAIRARYNP YLQTRGRLNQ
160 170 180 190 200
LMQLGHSVDK VEFIVMGGTF MSLPEDYRDF FIRNLHDALS GHTSASVEEA
210 220 230 240 250
VAYSERSKMK CIGITIETRP DYCLPRHLND MLLYGCTRLE IGVQSTYEDV
260 270 280 290 300
ARDTNRGHTV KSVCETFHMA KDTGYKVVIH MMPDLPNVGL ERDKEQFLEL
310 320 330 340 350
FESPAFRPDG LKLYPTLVIR GTGLYELWKT GRYQSYPPSV LVDLIATILS
360 370 380 390 400
LVPPWTRVYR VQRDIPMPLV SSGVEHGNLR EHAMAKMKEL GLKCRDVRTR
410 420 430 440 450
EVGIQEIHNK VRPEDVELIR RDYTANGGWE TFISYEDPKQ DILIGLLRLR
460 470 480 490 500
KISDKAHRAE LKGNVSVVRE LHVYGSVVSV ADRDPKKFQH QGYGSLLMEE
510 520 530 540
AERIAREEHE SDKIAVISGV GTRDYYRKLG YELDGPYMSK TLDASSAA
Length:548
Mass (Da):61,970
Last modified:November 23, 2004 - v1
Checksum:iD4E1EAD89305B037
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601533 Genomic DNA. Translation: CAP39624.3.
RefSeqiXP_002636685.1. XM_002636639.1.

Genome annotation databases

EnsemblMetazoaiCBG23399; CBG23399; CBG23399.
GeneIDi8578680.
KEGGicbr:CBG23399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601533 Genomic DNA. Translation: CAP39624.3.
RefSeqiXP_002636685.1. XM_002636639.1.

3D structure databases

ProteinModelPortaliQ60LW7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG23399.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG23399; CBG23399; CBG23399.
GeneIDi8578680.
KEGGicbr:CBG23399.

Organism-specific databases

CTDi8578680.
WormBaseiCBG23399; CBP12416; WBGene00041763; Cbr-elpc-3.

Phylogenomic databases

eggNOGiCOG1243.
HOGENOMiHOG000227514.
InParanoidiQ60LW7.
KOiK07739.
OMAiGYKVVSH.
OrthoDBiEOG7V765W.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01211. ELP3. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiELP3_CAEBR
AccessioniPrimary (citable) accession number: Q60LW7
Secondary accession number(s): A8Y404
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 23, 2004
Last modified: January 7, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.