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Q60LW7 (ELP3_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable elongator complex protein 3

EC=2.3.1.48
Gene names
Name:elpc-3
ORF Names:CBG23399
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length548 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Cofactor

Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Subunit structure

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the ELP3 family.

Contains 1 N-acetyltransferase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 548548Probable elongator complex protein 3
PRO_0000283993

Regions

Domain392 – 548157N-acetyltransferase

Sites

Metal binding951Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal binding1051Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal binding1081Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60LW7 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: D4E1EAD89305B037

FASTA54861,970
        10         20         30         40         50         60 
MDDKGSQRAL LAQTVNEIVK LLIEAHNQKK DVNLNRLKCI VAQKNGLSFQ PKLVDIIAGV 

        70         80         90        100        110        120 
PADYKDTLLP KLKAKPVRTA SGIAVVAVMS KPHRCPHINF TGNICVYCPG GPDSDFEYST 

       130        140        150        160        170        180 
QSYTGYEPTS MRAIRARYNP YLQTRGRLNQ LMQLGHSVDK VEFIVMGGTF MSLPEDYRDF 

       190        200        210        220        230        240 
FIRNLHDALS GHTSASVEEA VAYSERSKMK CIGITIETRP DYCLPRHLND MLLYGCTRLE 

       250        260        270        280        290        300 
IGVQSTYEDV ARDTNRGHTV KSVCETFHMA KDTGYKVVIH MMPDLPNVGL ERDKEQFLEL 

       310        320        330        340        350        360 
FESPAFRPDG LKLYPTLVIR GTGLYELWKT GRYQSYPPSV LVDLIATILS LVPPWTRVYR 

       370        380        390        400        410        420 
VQRDIPMPLV SSGVEHGNLR EHAMAKMKEL GLKCRDVRTR EVGIQEIHNK VRPEDVELIR 

       430        440        450        460        470        480 
RDYTANGGWE TFISYEDPKQ DILIGLLRLR KISDKAHRAE LKGNVSVVRE LHVYGSVVSV 

       490        500        510        520        530        540 
ADRDPKKFQH QGYGSLLMEE AERIAREEHE SDKIAVISGV GTRDYYRKLG YELDGPYMSK 


TLDASSAA 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE601533 Genomic DNA. Translation: CAP39624.3.
RefSeqXP_002636685.1. XM_002636639.1.

3D structure databases

ProteinModelPortalQ60LW7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG23399.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG23399; CBG23399; CBG23399.
GeneID8578680.
KEGGcbr:CBG23399.

Organism-specific databases

CTD8578680.
WormBaseCBG23399; CBP12416; WBGene00041763; Cbr-elpc-3.

Phylogenomic databases

eggNOGCOG1243.
HOGENOMHOG000227514.
KOK07739.
OMAGYKVVSH.
OrthoDBEOG7V765W.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTSM00729. Elp3. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
TIGRFAMsTIGR01211. ELP3. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameELP3_CAEBR
AccessionPrimary (citable) accession number: Q60LW7
Secondary accession number(s): A8Y404
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families