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Protein
Submitted name:

SRY-box containing gene 2

Gene

Sox2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi43 – 111HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-3769402. Deactivation of the beta-catenin transactivating complex.

Names & Taxonomyi

Protein namesi
Submitted name:
SRY-box containing gene 2Imported
Submitted name:
Sox2 proteinImported
Submitted name:
Transcription factor SOX-2Imported
Submitted name:
Transcriptional factor SOX2Imported
Gene namesi
Name:Sox2Imported
ORF Names:mCG_15247Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:98364. Sox2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000074637.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 111HMG boxInterPro annotationAdd BLAST69

Phylogenomic databases

eggNOGiENOG410IPZI. Eukaryota.
ENOG411009V. LUCA.
GeneTreeiENSGT00760000118988.
HOVERGENiHBG105663.
KOiK16796.
OMAiQSYMNGS.
OrthoDBiEOG091G0F15.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
IPR036910. HMG_box_dom_sf.
IPR032643. SOX-2.
IPR022097. SOX_fam.
PANTHERiPTHR10270:SF231. PTHR10270:SF231. 1 hit.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60I23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNMMETELK PPGPQQASGG GGGGGNATAA ATGGNQKNSP DRVKRPMNAF
60 70 80 90 100
MVWSRGQRRK MAQENPKMHN SEISKRLGAE WKLLSETEKR PFIDEAKRLR
110 120 130 140 150
ALHMKEHPDY KYRPRRKTKT LMKKDKYTLP GGLLAPGGNS MASGVGVGAG
160 170 180 190 200
LGAGVNQRMD SYAHMNGWSN GSYSMMQEQL GYPQHPGLNA HGAAQMQPMH
210 220 230 240 250
RYDVSALQYN SMTSSQTYMN GSPTYSMSYS QQGTPGMALG SMGSVVKSEA
260 270 280 290 300
SSSPPVVTSS SHSRAPCQAG DLRDMISMYL PGAEVPEPAA PSRLHMAQHY
310
QSGPVPGTAI NGTLPLSHM
Length:319
Mass (Da):34,406
Last modified:May 10, 2005 - v1
Checksum:i07A6DFDCA205991F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606746 Genomic DNA. No translation available.
BC057574 mRNA. Translation: AAH57574.1.
AB108673 mRNA. Translation: BAC75668.1.
CH466530 Genomic DNA. Translation: EDL35051.1.
RefSeqiNP_035573.3. NM_011443.4.
UniGeneiMm.65396.

Genome annotation databases

EnsembliENSMUST00000099151; ENSMUSP00000096755; ENSMUSG00000074637.
GeneIDi20674.
KEGGimmu:20674.
UCSCiuc008oxu.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ60I23_MOUSE
AccessioniPrimary (citable) accession number: Q60I23
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 22, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported