Fatty aldehyde dehydrogenase - Macaca fascicularis (Crab-eating macaque)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Fatty aldehyde dehydrogenase
EC=1.2.1.3

Alternative name(s):
Aldehyde dehydrogenase family 3 member A2

Gene names

Name:	ALDH3A2
ORF Names:	QccE-15682

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid By similarity.
Catalytic activity	An aldehyde + NAD⁺ + H₂O = a carboxylate + NADH.
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side By similarity.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	cellular aldehyde metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC aldehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 485

485

Fatty aldehyde dehydrogenase

PRO_0000056474

Regions

Topological domain

1 – 463

463

Cytoplasmic

Transmembrane

464 – 480

17

Helical; Potential

Nucleotide binding

185 – 190

6

NAD Potential

Motif

481 – 484

4

Prevents secretion from ER By similarity

Sites

Active site

207

1

By similarity

Active site

241

1

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q60HH8 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: D01B965D56CBF3D6
Show »

FASTA

485

54,628

        10         20         30         40         50         60 
MEREVQRVRQ AFLSGRSRPL RFRLQQLEAL RRMVQEREKD ILAAIAADLC KSELNAYSQE 

        70         80         90        100        110        120 
VITVLGEIDF MLENLPEWVT AKPVKKNLLT MMDEAYIQPQ PLGVVLIIGA WNYPFVLIIQ 

       130        140        150        160        170        180 
PLIGAIAAGN AVIIKPSELS ENTAKIVAKL LPQYLDQDLY VVINGGVEET TELLKQRFDH 

       190        200        210        220        230        240 
IFYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDKDC DLDIVCRRIT WGKYMNCGQT 

       250        260        270        280        290        300 
CIAPDYILCE ASLQSQIVWK IKETVKEFYG ENIKESPDYE RIINLRHFKR ILSLLEGQKI 

       310        320        330        340        350        360 
ALGGETDEAT RYIAPTVLTD VDPKTKVMQE EIFGPVLPIV PVKNVDEATD FINEREKPLA 

       370        380        390        400        410        420 
LYVFSHNHKL IKRMIDETSS GGVTGNDVIM HFTLNSFPFG GVGSSGMGAY HGKHSFDTFS 

       430        440        450        460        470        480 
HQRPCLLKSL KREGANKLRY PPNSQSKVDW GKFFLLRRFN KEKLGLLVLT FLGIVAAVLV 


NAGYY

« Hide

References

[1]	"Isolation and characterization of cDNA for macaque neurological disease genes." Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB125149 mRNA. Translation: BAD51937.1.
3D structure databases
ProteinModelPortal	Q60HH8.
SMR	Q60HH8. Positions 5-443.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG050483.
Family and domain databases
Gene3D	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR012394. Aldehyde_DH_NAD(P). [Graphical view]
PANTHER	PTHR11699:SF15. PTHR11699:SF15. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PIRSF	PIRSF036492. ALDH. 1 hit.
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL3A2_MACFA

Accession

Primary (citable) accession number: Q60HH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	November 23, 2004
Last modified:	March 6, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families