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Q60HH8 (AL3A2_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fatty aldehyde dehydrogenase

EC=1.2.1.3
Alternative name(s):
Aldehyde dehydrogenase family 3 member A2
Gene names
Name:ALDH3A2
ORF Names:QccE-15682
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid By similarity.

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side By similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 485485Fatty aldehyde dehydrogenase
PRO_0000056474

Regions

Topological domain1 – 463463Cytoplasmic
Transmembrane464 – 48017Helical; Potential
Nucleotide binding185 – 1906NAD Potential
Motif481 – 4844Prevents secretion from ER By similarity

Sites

Active site2071 By similarity
Active site2411 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60HH8 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: D01B965D56CBF3D6

FASTA48554,628
        10         20         30         40         50         60 
MEREVQRVRQ AFLSGRSRPL RFRLQQLEAL RRMVQEREKD ILAAIAADLC KSELNAYSQE 

        70         80         90        100        110        120 
VITVLGEIDF MLENLPEWVT AKPVKKNLLT MMDEAYIQPQ PLGVVLIIGA WNYPFVLIIQ 

       130        140        150        160        170        180 
PLIGAIAAGN AVIIKPSELS ENTAKIVAKL LPQYLDQDLY VVINGGVEET TELLKQRFDH 

       190        200        210        220        230        240 
IFYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDKDC DLDIVCRRIT WGKYMNCGQT 

       250        260        270        280        290        300 
CIAPDYILCE ASLQSQIVWK IKETVKEFYG ENIKESPDYE RIINLRHFKR ILSLLEGQKI 

       310        320        330        340        350        360 
ALGGETDEAT RYIAPTVLTD VDPKTKVMQE EIFGPVLPIV PVKNVDEATD FINEREKPLA 

       370        380        390        400        410        420 
LYVFSHNHKL IKRMIDETSS GGVTGNDVIM HFTLNSFPFG GVGSSGMGAY HGKHSFDTFS 

       430        440        450        460        470        480 
HQRPCLLKSL KREGANKLRY PPNSQSKVDW GKFFLLRRFN KEKLGLLVLT FLGIVAAVLV 


NAGYY 

« Hide

References

[1]"Isolation and characterization of cDNA for macaque neurological disease genes."
Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB125149 mRNA. Translation: BAD51937.1.
RefSeqNP_001270311.1. NM_001283382.1.
UniGeneMfa.8344.

3D structure databases

ProteinModelPortalQ60HH8.
SMRQ60HH8. Positions 5-443.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID102138923.
KEGGmcf:102138923.

Organism-specific databases

CTD224.

Phylogenomic databases

HOVERGENHBG050483.
KOK00128.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF036492. ALDH. 1 hit.
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAL3A2_MACFA
AccessionPrimary (citable) accession number: Q60HH8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families