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Q60HG9 (CPT2_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Carnitine O-palmitoyltransferase 2, mitochondrial
EC=2.3.1.21
Alternative name(s):
Carnitine palmitoyltransferase II
Short name=CPT II
Gene names
Name:CPT2
ORF Names:QorA-10180
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length658 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.

Pathway

Lipid metabolism; fatty acid beta-oxidation.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the carnitine/choline acetyltransferase family.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
Transport
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   DomainTransit peptide
   Molecular functionAcyltransferase
Transferase
   PTMAcetylation
Gene Ontology (GO)
   Biological_processfatty acid beta-oxidation

Inferred from electronic annotation. Source: UniProtKB-UniPathway

transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentmitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncarnitine O-palmitoyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2525Mitochondrion By similarity
Chain26 – 658633Carnitine O-palmitoyltransferase 2, mitochondrial
PRO_0000004425

Regions

Topological domain26 – 178153Mitochondrial matrix By similarity
Intramembrane179 – 20830Note=Mitochondrial inner membrane; By similarity
Topological domain209 – 658450Mitochondrial matrix By similarity
Region452 – 46413Coenzyme A binding By similarity

Sites

Active site3721Proton acceptor By similarity
Binding site4861Carnitine By similarity
Binding site4881Carnitine By similarity
Binding site4991Carnitine By similarity

Amino acid modifications

Modified residue5441N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60HG9 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: F6DB87AF3A141E2A

FASTA65873,773
        10         20         30         40         50         60 
MVPRLLLRAW PRGPAVGPGA PSRPLSAGSG PGQYLQRSIV PTMHYQDSLP RLPIPKLEDT 

        70         80         90        100        110        120 
IRRYLSAQKP LLDDGQFRKT EQFCKNFENG IGKELHEQLV AQDKQNKHTS YISGPWFDMY 

       130        140        150        160        170        180 
LSARDSVVLN FNPFMAFNPD PKSEYNDQLT RATNMTVSAI RFLKTLRDGL LEPEVFHLNP 

       190        200        210        220        230        240 
AKSDTDTFKR LIRFVPSSLS WYGAYLVNAY PLDMSQYFRL FNSTRLPKPS RDELFTDDKA 

       250        260        270        280        290        300 
RHLLVLRKGN FYIFDVLDQD GNIVSPSEIQ AHLKYILSDS SPAPEFPLAY LTSENRDIWA 

       310        320        330        340        350        360 
ELRQKLMSSG NEESLRKVDS AVFCLCLDDF PIKDLVHLSH NMLHGDGTNR WFDKSFNLII 

       370        380        390        400        410        420 
AKDGSAAVHF EHSWGDGVAV LRFFNEVFKD STQIPAITPQ SQPATADSTV TVQKLNFKLT 

       430        440        450        460        470        480 
DALKTGITAA KEKFDATMKT LTIDCLQFQR GGKEFLKKQK LSPDAVAQLA FQMAFLRQYG 

       490        500        510        520        530        540 
QTVATYESCS TAAFKHGRTE TIRPASIYTK RCSEAFVREP SRHSAGELQQ MMAECSKYHG 

       550        560        570        580        590        600 
QLTKEAAMGQ GFDRHLFALR HLAAAKGIIL PELYLDPAYG QINHNVLSTS TLSSPAVNLG 

       610        620        630        640        650 
GFAPVVSDGF GVGYAVHGNW IGCNVSSYPG RNAREFLQCV EKALEDMFDA LEGKSIKS

« Hide

References

[1]"Isolation and characterization of cDNA for macaque neurological disease genes."
Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Occipital cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB125158 mRNA. Translation: BAD51946.1.

3D structure databases

ProteinModelPortalQ60HG9.
SMRQ60HG9. Positions 34-654.
ModBaseSearch...

Proteomic databases

PRIDEQ60HG9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG098001.
OrthoDBEOG4WM4TB.

Enzyme and pathway databases

UniPathwayUPA00659.

Family and domain databases

InterProIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERPTHR22589. PTHR22589. 1 hit.
PfamPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEPS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCPT2_MACFA
AccessionPrimary (citable) accession number: Q60HG9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: November 23, 2004
Last modified: March 6, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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