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Q60HG6 (CATC_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dipeptidyl peptidase 1

EC=3.4.14.1
Alternative name(s):
Cathepsin C
Cathepsin J
Dipeptidyl peptidase I
Short name=DPP-I
Short name=DPPI
Dipeptidyl transferase

Cleaved into the following 3 chains:

  1. Dipeptidyl peptidase 1 exclusion domain chain
    Alternative name(s):
    Dipeptidyl peptidase I exclusion domain chain
  2. Dipeptidyl peptidase 1 heavy chain
    Alternative name(s):
    Dipeptidyl peptidase I heavy chain
  3. Dipeptidyl peptidase 1 light chain
    Alternative name(s):
    Dipeptidyl peptidase I light chain
Gene names
Name:CTSC
ORF Names:QnpA-12394
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.

Cofactor

Binds 1 chloride ion per heavy chain By similarity.

Subunit structure

Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains By similarity.

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the peptidase C1 family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   LigandChloride
   Molecular functionHydrolase
Protease
Thiol protease
   PTMDisulfide bond
Glycoprotein
Zymogen
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 By similarity
Chain25 – 134110Dipeptidyl peptidase 1 exclusion domain chain
PRO_0000026342
Propeptide135 – 23096 By similarity
PRO_0000026343
Chain231 – 394164Dipeptidyl peptidase 1 heavy chain By similarity
PRO_0000026344
Chain395 – 46369Dipeptidyl peptidase 1 light chain By similarity
PRO_0000026345

Sites

Active site2581 By similarity
Active site4051 By similarity
Active site4271 By similarity
Binding site3021Chloride By similarity
Binding site3041Chloride; via amide nitrogen By similarity
Binding site3471Chloride By similarity

Amino acid modifications

Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation1191N-linked (GlcNAc...) Potential
Glycosylation2761N-linked (GlcNAc...) Potential
Disulfide bond30 ↔ 118 By similarity
Disulfide bond54 ↔ 136 By similarity
Disulfide bond255 ↔ 298 By similarity
Disulfide bond291 ↔ 331 By similarity
Disulfide bond321 ↔ 337 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60HG6 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 3C66F6C23F8160B4

FASTA46351,866
        10         20         30         40         50         60 
MGVGPASLLA ALLLLLSGDR AVRCDTPANC TYLDLLGTWV FQVGSSGSLR DVNCSVMGPP 

        70         80         90        100        110        120 
EKKVVVHLQK LDTAYDDLGN SGHFTIIYNQ GFEIVLNDYK WFAFFKYKEE GIKVTIYCNE 

       130        140        150        160        170        180 
TMTGWVHDVL GRNWACFTGK KVGTASENVY VNTAHLKNSQ EKYSNRLYKY DHNFVKAINA 

       190        200        210        220        230        240 
IQKSWTATTY MEYETLTLGD MIKRSGGHSR KIPRPKPTPL TAEIQQKILH LPTSWDWRNV 

       250        260        270        280        290        300 
HGINFVSPVR NQASCGSCYS FASVGMLEAR IRILTNNSQT PILSSQEVVS CSQYAQGCEG 

       310        320        330        340        350        360 
GFPYLTAGKY AQDFGLVEEA CFPYTGTDSP CKMKEDCFRY YSSEYHYVGG FYGGCNEALM 

       370        380        390        400        410        420 
KLELVYHGPL AVAFEVYDDF LHYQNGIYHH TGLRDPFNPF ELTNHAVLLV GYGTDSASGM 

       430        440        450        460 
DYWIVKNSWG TSWGEDGYFR IRRGTDECAI ESIAVAATPI PKL 

« Hide

References

[1]"Isolation and characterization of cDNA for macaque neurological disease genes."
Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Parietal cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB125161 mRNA. Translation: BAD51949.1.
RefSeqNP_001270292.1. NM_001283363.1.
UniGeneMfa.8274.

3D structure databases

ProteinModelPortalQ60HG6.
SMRQ60HG6. Positions 25-463.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC01.070.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID102137896.
KEGGmcf:102137896.

Organism-specific databases

CTD1075.

Phylogenomic databases

HOVERGENHBG005248.
KOK01275.

Family and domain databases

Gene3D2.40.128.80. 1 hit.
InterProIPR014882. CathepsinC_exc.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERPTHR12411. PTHR12411. 1 hit.
PfamPF08773. CathepsinC_exc. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSPR00705. PAPAIN.
SMARTSM00645. Pept_C1. 1 hit.
[Graphical view]
SUPFAMSSF75001. SSF75001. 1 hit.
PROSITEPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCATC_MACFA
AccessionPrimary (citable) accession number: Q60HG6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries