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Protein

Dipeptidyl peptidase 1

Gene

CTSC

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function (By similarity).By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.

Cofactori

chlorideBy similarityNote: Binds 1 Cl(-) ion per heavy chain.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei258 – 2581By similarity
Binding sitei302 – 3021ChlorideBy similarity
Binding sitei304 – 3041Chloride; via amide nitrogenBy similarity
Binding sitei347 – 3471ChlorideBy similarity
Active sitei405 – 4051By similarity
Active sitei427 – 4271By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 1 (EC:3.4.14.1)
Alternative name(s):
Cathepsin C
Cathepsin J
Dipeptidyl peptidase I
Short name:
DPP-I
Short name:
DPPI
Dipeptidyl transferase
Cleaved into the following 3 chains:
Alternative name(s):
Dipeptidyl peptidase I exclusion domain chain
Alternative name(s):
Dipeptidyl peptidase I heavy chain
Alternative name(s):
Dipeptidyl peptidase I light chain
Gene namesi
Name:CTSC
ORF Names:QnpA-12394
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

  1. Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 134110Dipeptidyl peptidase 1 exclusion domain chainPRO_0000026342Add
BLAST
Propeptidei135 – 23096By similarityPRO_0000026343Add
BLAST
Chaini231 – 394164Dipeptidyl peptidase 1 heavy chainBy similarityPRO_0000026344Add
BLAST
Chaini395 – 46369Dipeptidyl peptidase 1 light chainBy similarityPRO_0000026345Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi30 ↔ 118By similarity
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi54 ↔ 136By similarity
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi255 ↔ 298By similarity
Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi291 ↔ 331By similarity
Disulfide bondi321 ↔ 337By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Subunit structurei

Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ60HG6.
SMRiQ60HG6. Positions 25-463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG005248.
KOiK01275.

Family and domain databases

Gene3Di2.40.128.80. 1 hit.
InterProiIPR014882. CathepsinC_exc.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08773. CathepsinC_exc. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
SUPFAMiSSF75001. SSF75001. 1 hit.
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60HG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVGPASLLA ALLLLLSGDR AVRCDTPANC TYLDLLGTWV FQVGSSGSLR
60 70 80 90 100
DVNCSVMGPP EKKVVVHLQK LDTAYDDLGN SGHFTIIYNQ GFEIVLNDYK
110 120 130 140 150
WFAFFKYKEE GIKVTIYCNE TMTGWVHDVL GRNWACFTGK KVGTASENVY
160 170 180 190 200
VNTAHLKNSQ EKYSNRLYKY DHNFVKAINA IQKSWTATTY MEYETLTLGD
210 220 230 240 250
MIKRSGGHSR KIPRPKPTPL TAEIQQKILH LPTSWDWRNV HGINFVSPVR
260 270 280 290 300
NQASCGSCYS FASVGMLEAR IRILTNNSQT PILSSQEVVS CSQYAQGCEG
310 320 330 340 350
GFPYLTAGKY AQDFGLVEEA CFPYTGTDSP CKMKEDCFRY YSSEYHYVGG
360 370 380 390 400
FYGGCNEALM KLELVYHGPL AVAFEVYDDF LHYQNGIYHH TGLRDPFNPF
410 420 430 440 450
ELTNHAVLLV GYGTDSASGM DYWIVKNSWG TSWGEDGYFR IRRGTDECAI
460
ESIAVAATPI PKL
Length:463
Mass (Da):51,866
Last modified:November 23, 2004 - v1
Checksum:i3C66F6C23F8160B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB125161 mRNA. Translation: BAD51949.1.
RefSeqiNP_001270292.1. NM_001283363.1.
UniGeneiMfa.8274.

Genome annotation databases

GeneIDi102137896.
KEGGimcf:102137896.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB125161 mRNA. Translation: BAD51949.1.
RefSeqiNP_001270292.1. NM_001283363.1.
UniGeneiMfa.8274.

3D structure databases

ProteinModelPortaliQ60HG6.
SMRiQ60HG6. Positions 25-463.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102137896.
KEGGimcf:102137896.

Organism-specific databases

CTDi1075.

Phylogenomic databases

HOVERGENiHBG005248.
KOiK01275.

Family and domain databases

Gene3Di2.40.128.80. 1 hit.
InterProiIPR014882. CathepsinC_exc.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08773. CathepsinC_exc. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
SUPFAMiSSF75001. SSF75001. 1 hit.
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and characterization of cDNA for macaque neurological disease genes."
    Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Parietal cortex.

Entry informationi

Entry nameiCATC_MACFA
AccessioniPrimary (citable) accession number: Q60HG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: November 23, 2004
Last modified: January 7, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.