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Q60HG6

- CATC_MACFA

UniProt

Q60HG6 - CATC_MACFA

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Protein
Dipeptidyl peptidase 1
Gene
CTSC, QnpA-12394
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.

Cofactori

Binds 1 chloride ion per heavy chain By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei258 – 2581 By similarity
Binding sitei302 – 3021Chloride By similarity
Binding sitei304 – 3041Chloride; via amide nitrogen By similarity
Binding sitei347 – 3471Chloride By similarity
Active sitei405 – 4051 By similarity
Active sitei427 – 4271 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Ligandi

    Chloride

    Protein family/group databases

    MEROPSiC01.070.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dipeptidyl peptidase 1 (EC:3.4.14.1)
    Alternative name(s):
    Cathepsin C
    Cathepsin J
    Dipeptidyl peptidase I
    Short name:
    DPP-I
    Short name:
    DPPI
    Dipeptidyl transferase
    Cleaved into the following 3 chains:
    Alternative name(s):
    Dipeptidyl peptidase I exclusion domain chain
    Alternative name(s):
    Dipeptidyl peptidase I heavy chain
    Alternative name(s):
    Dipeptidyl peptidase I light chain
    Gene namesi
    Name:CTSC
    ORF Names:QnpA-12394
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424 By similarity
    Add
    BLAST
    Chaini25 – 134110Dipeptidyl peptidase 1 exclusion domain chain
    PRO_0000026342Add
    BLAST
    Propeptidei135 – 23096 By similarity
    PRO_0000026343Add
    BLAST
    Chaini231 – 394164Dipeptidyl peptidase 1 heavy chain By similarity
    PRO_0000026344Add
    BLAST
    Chaini395 – 46369Dipeptidyl peptidase 1 light chain By similarity
    PRO_0000026345Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi30 ↔ 118 By similarity
    Glycosylationi53 – 531N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi54 ↔ 136 By similarity
    Glycosylationi119 – 1191N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi255 ↔ 298 By similarity
    Glycosylationi276 – 2761N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi291 ↔ 331 By similarity
    Disulfide bondi321 ↔ 337 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Interactioni

    Subunit structurei

    Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains By similarity.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60HG6.
    SMRiQ60HG6. Positions 25-463.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C1 family.

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG005248.
    KOiK01275.

    Family and domain databases

    Gene3Di2.40.128.80. 1 hit.
    InterProiIPR014882. CathepsinC_exc.
    IPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PfamiPF08773. CathepsinC_exc. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00645. Pept_C1. 1 hit.
    [Graphical view]
    SUPFAMiSSF75001. SSF75001. 1 hit.
    PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q60HG6-1 [UniParc]FASTAAdd to Basket

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    MGVGPASLLA ALLLLLSGDR AVRCDTPANC TYLDLLGTWV FQVGSSGSLR    50
    DVNCSVMGPP EKKVVVHLQK LDTAYDDLGN SGHFTIIYNQ GFEIVLNDYK 100
    WFAFFKYKEE GIKVTIYCNE TMTGWVHDVL GRNWACFTGK KVGTASENVY 150
    VNTAHLKNSQ EKYSNRLYKY DHNFVKAINA IQKSWTATTY MEYETLTLGD 200
    MIKRSGGHSR KIPRPKPTPL TAEIQQKILH LPTSWDWRNV HGINFVSPVR 250
    NQASCGSCYS FASVGMLEAR IRILTNNSQT PILSSQEVVS CSQYAQGCEG 300
    GFPYLTAGKY AQDFGLVEEA CFPYTGTDSP CKMKEDCFRY YSSEYHYVGG 350
    FYGGCNEALM KLELVYHGPL AVAFEVYDDF LHYQNGIYHH TGLRDPFNPF 400
    ELTNHAVLLV GYGTDSASGM DYWIVKNSWG TSWGEDGYFR IRRGTDECAI 450
    ESIAVAATPI PKL 463
    Length:463
    Mass (Da):51,866
    Last modified:November 23, 2004 - v1
    Checksum:i3C66F6C23F8160B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB125161 mRNA. Translation: BAD51949.1.
    RefSeqiNP_001270292.1. NM_001283363.1.
    UniGeneiMfa.8274.

    Genome annotation databases

    GeneIDi102137896.
    KEGGimcf:102137896.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB125161 mRNA. Translation: BAD51949.1 .
    RefSeqi NP_001270292.1. NM_001283363.1.
    UniGenei Mfa.8274.

    3D structure databases

    ProteinModelPortali Q60HG6.
    SMRi Q60HG6. Positions 25-463.
    ModBasei Search...

    Protein family/group databases

    MEROPSi C01.070.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 102137896.
    KEGGi mcf:102137896.

    Organism-specific databases

    CTDi 1075.

    Phylogenomic databases

    HOVERGENi HBG005248.
    KOi K01275.

    Family and domain databases

    Gene3Di 2.40.128.80. 1 hit.
    InterProi IPR014882. CathepsinC_exc.
    IPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    Pfami PF08773. CathepsinC_exc. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF75001. SSF75001. 1 hit.
    PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of cDNA for macaque neurological disease genes."
      Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Parietal cortex.

    Entry informationi

    Entry nameiCATC_MACFA
    AccessioniPrimary (citable) accession number: Q60HG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: November 23, 2004
    Last modified: May 14, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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