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Q60HF8 (FUCO_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tissue alpha-L-fucosidase

EC=3.2.1.51
Alternative name(s):
Alpha-L-fucosidase I
Alpha-L-fucoside fucohydrolase 1
Short name=Alpha-L-fucosidase 1
Gene names
Name:FUCA1
ORF Names:QccE-17330
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins By similarity.

Catalytic activity

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

Subunit structure

Homotetramer By similarity.

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 29 family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
Phosphoprotein
Gene Ontology (GO)
   Biological_processfucose metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionalpha-L-fucosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 468439Tissue alpha-L-fucosidase
PRO_0000010309

Sites

Site2981May be important for catalysis By similarity

Amino acid modifications

Modified residue1721Phosphothreonine By similarity
Glycosylation2431N-linked (GlcNAc...) Potential
Glycosylation2701N-linked (GlcNAc...) Potential
Glycosylation3841N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q60HF8 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 847FFF17AEC7109E

FASTA46854,127
        10         20         30         40         50         60 
MRAPGERWRP AGAALWLLLL LLLLGATESV RRAQPLRRYT PDWPSLDSRP LPSWFDEAKF 

        70         80         90        100        110        120 
GVFIHWGVFS VPAWGSEWFW WNWQGEGRPQ YQRFMRDNYP PGSSYADFGP QFTARFFHPE 

       130        140        150        160        170        180 
EWADLFQAAG AKYVVLTTKH HEGFTNWPSP VSWNWNSKDV GPHRDLVGEL GTALRKRNIR 

       190        200        210        220        230        240 
YGLYHSLLEW FHPLYLLDKK NGFKTQYFVG AKTMPELYDL VNSYKPDLIW SDGEWECPDT 

       250        260        270        280        290        300 
YWNSTNFLSW LYNDSPVKDE VVVNDRWGQN CSCHHGGYYN CEDKFKPQSL PDHKWEMCTS 

       310        320        330        340        350        360 
IDKFSWGYRR DMAMSDVTEE SEIISELVQT VSLGGNYLLN IGPTKDGLIV PIFQERLLAL 

       370        380        390        400        410        420 
GKWLSINGEA IYASKPWRVQ WEKNTTSVWY TSKGSAVYAI FLHWPENGVL NLESPITTST 

       430        440        450        460 
TKIMMLRIQG DLKWSTDPDK GLLISLPQLP PSAVPAEFAW TIKLTGVK 

« Hide

References

[1]"Isolation and characterization of cDNA for macaque neurological disease genes."
Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.
[2]"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
International consortium for macaque cDNA sequencing and analysis
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB125169 mRNA. Translation: BAD51957.1.
AB169681 mRNA. Translation: BAE01762.1.
UniGeneMfa.3782.

3D structure databases

ProteinModelPortalQ60HF8.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH29. Glycoside Hydrolase Family 29.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG002155.

Enzyme and pathway databases

BRENDA3.2.1.51. 3121.

Family and domain databases

Gene3D2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProIPR016286. FUC_metazoa-typ.
IPR028755. FUCA1.
IPR013780. Glyco_hydro_13_b.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR10030. PTHR10030. 1 hit.
PTHR10030:SF2. PTHR10030:SF2. 1 hit.
PfamPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSPR00741. GLHYDRLASE29.
SMARTSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFUCO_MACFA
AccessionPrimary (citable) accession number: Q60HF8
Secondary accession number(s): Q4R563
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: November 23, 2004
Last modified: March 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries