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Q60HE9

- MA2B1_MACFA

UniProt

Q60HE9 - MA2B1_MACFA

Protein

Lysosomal alpha-mannosidase

Gene

MAN2B1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi73 – 731ZincBy similarity
    Metal bindingi75 – 751ZincBy similarity
    Active sitei197 – 1971NucleophileBy similarity
    Metal bindingi197 – 1971ZincBy similarity
    Metal bindingi447 – 4471ZincBy similarity

    GO - Molecular functioni

    1. alpha-mannosidase activity Source: UniProtKB-EC
    2. carbohydrate binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. mannose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    CAZyiGH38. Glycoside Hydrolase Family 38.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosomal alpha-mannosidase (EC:3.2.1.24)
    Short name:
    Laman
    Alternative name(s):
    Lysosomal acid alpha-mannosidase
    Mannosidase alpha class 2B member 1
    Mannosidase alpha-B
    Gene namesi
    Name:MAN2B1
    ORF Names:QmoA-10471
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 5050By similarityAdd
    BLAST
    Chaini51 – 1012962Lysosomal alpha-mannosidasePRO_0000012075Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 359By similarity
    Disulfide bondi269 ↔ 274By similarity
    Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi413 ↔ 473By similarity
    Disulfide bondi494 ↔ 502By similarity
    Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi646 – 6461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi652 – 6521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi693 – 6931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi767 – 7671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi833 – 8331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi931 – 9311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi990 – 9901N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ60HE9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60HE9.
    SMRiQ60HE9. Positions 52-342, 350-421, 432-585, 606-875, 886-1007.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 38 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG052391.

    Family and domain databases

    Gene3Di1.20.1270.50. 1 hit.
    2.60.40.1180. 1 hit.
    3.20.110.10. 1 hit.
    InterProiIPR011013. Gal_mutarotase_SF_dom.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR013780. Glyco_hydro_13_b.
    IPR027291. Glyco_hydro_38/57_N.
    IPR011682. Glyco_hydro_38_C.
    IPR015341. Glyco_hydro_38_cen.
    IPR000602. Glyco_hydro_38_N.
    IPR028995. Glyco_hydro_57/38_cen.
    [Graphical view]
    PfamiPF09261. Alpha-mann_mid. 1 hit.
    PF01074. Glyco_hydro_38. 1 hit.
    PF07748. Glyco_hydro_38C. 1 hit.
    [Graphical view]
    SMARTiSM00872. Alpha-mann_mid. 1 hit.
    [Graphical view]
    SUPFAMiSSF74650. SSF74650. 1 hit.
    SSF88688. SSF88688. 1 hit.
    SSF88713. SSF88713. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q60HE9-1 [UniParc]FASTAAdd to Basket

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    MGAYAPAAGV SARGCLDAAG PWTISRALRP PLPPLCFFLL LLLAAPCARA     50
    GGYETCPTVQ PNILNVHLVP HTHDDVGWLK TVDQYFYGIK NDIQHAGVQY 100
    ILDSVISALL ADPTRRFIYV EIAFFSRWWH QQTNAMREVV RDLVRQGRLE 150
    FANGGWVMND EAATHYGAIV DQMTLGLRFL EDTFGSDGRP RVAWHIDPFG 200
    HSREQASLFA QMGFDGFFFG RLDYQDKRVR MQKLEMEQVW RASASLKPPT 250
    ADLFTGVLPN GYNPPMNLCW DVLCVDQPVV EDPRSPEYNA KELVDYFLNV 300
    ATAQGRHYRT NHIVMTMGSD FQYENANMWF KNLDKLIRLV NAQQAKGSSV 350
    HVLYSTPACY LWELNKANLT WSVKHDDFFP YADGPHQFWT GYFSSRPALK 400
    RYERLSYNFL QVCNQLEALV GLAANVGPYG SGDSAPLNKA MAVLQHHDAV 450
    SGTSRQHVAD DYARQLAAGW VSCEVLLSNA LARLRGFKDH LTFCRQLNIS 500
    ICPLSQTAAR FQVIVYNPLG RKVNWMVRLP VSEGVFVVKD PNGRTVPSDV 550
    VIYPSSDSQA HPPELLFSAS LPALGFSTYS VAQVPRWKPQ ARAPQPIPRR 600
    SWSPALTIEN EHIRATFDPD TGLLMEIMNM NQRLLLPVRQ TFFWYNASIG 650
    DNESDQASGA YIFRPNQQKP LPVSRWAQIR LVKTPLVQEV HQNFSAWCSQ 700
    VVRLYPGRRH LELEWSVGPI PVGDTWGKEV ISRFDTPLET KGRFYTDSNG 750
    REILERRRDY RPTWKLNQTE PVAGNYYPVN TRIYITDGKM QLTVLTDRSQ 800
    GGSSLRDGSL ELMVHRRLLK DDERGVSEPL MENGSGAWVR GRHLVLLDTA 850
    QAAAAGHRLL AEQEVLAPQV VLAPGGGAAY NLGAPPRTQF SGLRRELPPS 900
    VHLLTLASWG PEMLLLRLEH QFAVGEDSGR NLSAPVTLNL RDLFSTFTIT 950
    RLQETTLVAN QLREAASRLK WTTNTGPTPH QTPYQLDPAN ITLEPMEIRT 1000
    FLASVQWKEV DG 1012
    Length:1,012
    Mass (Da):113,922
    Last modified:November 23, 2004 - v1
    Checksum:i87FA3277FFBF1326
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB125178 mRNA. Translation: BAD51966.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB125178 mRNA. Translation: BAD51966.1 .

    3D structure databases

    ProteinModelPortali Q60HE9.
    SMRi Q60HE9. Positions 52-342, 350-421, 432-585, 606-875, 886-1007.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH38. Glycoside Hydrolase Family 38.

    Proteomic databases

    PRIDEi Q60HE9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG052391.

    Family and domain databases

    Gene3Di 1.20.1270.50. 1 hit.
    2.60.40.1180. 1 hit.
    3.20.110.10. 1 hit.
    InterProi IPR011013. Gal_mutarotase_SF_dom.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR013780. Glyco_hydro_13_b.
    IPR027291. Glyco_hydro_38/57_N.
    IPR011682. Glyco_hydro_38_C.
    IPR015341. Glyco_hydro_38_cen.
    IPR000602. Glyco_hydro_38_N.
    IPR028995. Glyco_hydro_57/38_cen.
    [Graphical view ]
    Pfami PF09261. Alpha-mann_mid. 1 hit.
    PF01074. Glyco_hydro_38. 1 hit.
    PF07748. Glyco_hydro_38C. 1 hit.
    [Graphical view ]
    SMARTi SM00872. Alpha-mann_mid. 1 hit.
    [Graphical view ]
    SUPFAMi SSF74650. SSF74650. 1 hit.
    SSF88688. SSF88688. 1 hit.
    SSF88713. SSF88713. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of cDNA for macaque neurological disease genes."
      Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Medulla oblongata.

    Entry informationi

    Entry nameiMA2B1_MACFA
    AccessioniPrimary (citable) accession number: Q60HE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3