Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q60HE9

- MA2B1_MACFA

UniProt

Q60HE9 - MA2B1_MACFA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Lysosomal alpha-mannosidase

Gene

MAN2B1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover.By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi73 – 731ZincBy similarity
Metal bindingi75 – 751ZincBy similarity
Active sitei197 – 1971NucleophileBy similarity
Metal bindingi197 – 1971ZincBy similarity
Metal bindingi447 – 4471ZincBy similarity

GO - Molecular functioni

  1. alpha-mannosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. mannose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

CAZyiGH38. Glycoside Hydrolase Family 38.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal alpha-mannosidase (EC:3.2.1.24)
Short name:
Laman
Alternative name(s):
Lysosomal acid alpha-mannosidase
Mannosidase alpha class 2B member 1
Mannosidase alpha-B
Gene namesi
Name:MAN2B1
ORF Names:QmoA-10471
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5050By similarityAdd
BLAST
Chaini51 – 1012962Lysosomal alpha-mannosidasePRO_0000012075Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 359By similarity
Disulfide bondi269 ↔ 274By similarity
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi413 ↔ 473By similarity
Disulfide bondi494 ↔ 502By similarity
Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi646 – 6461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi652 – 6521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi693 – 6931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi767 – 7671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi833 – 8331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi931 – 9311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi990 – 9901N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ60HE9.

Structurei

3D structure databases

ProteinModelPortaliQ60HE9.
SMRiQ60HE9. Positions 52-342, 350-421, 432-585, 606-875, 886-1007.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 38 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG052391.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
2.60.40.1180. 1 hit.
3.20.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR013780. Glyco_hydro_13_b.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view]
PfamiPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]
SMARTiSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60HE9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAYAPAAGV SARGCLDAAG PWTISRALRP PLPPLCFFLL LLLAAPCARA
60 70 80 90 100
GGYETCPTVQ PNILNVHLVP HTHDDVGWLK TVDQYFYGIK NDIQHAGVQY
110 120 130 140 150
ILDSVISALL ADPTRRFIYV EIAFFSRWWH QQTNAMREVV RDLVRQGRLE
160 170 180 190 200
FANGGWVMND EAATHYGAIV DQMTLGLRFL EDTFGSDGRP RVAWHIDPFG
210 220 230 240 250
HSREQASLFA QMGFDGFFFG RLDYQDKRVR MQKLEMEQVW RASASLKPPT
260 270 280 290 300
ADLFTGVLPN GYNPPMNLCW DVLCVDQPVV EDPRSPEYNA KELVDYFLNV
310 320 330 340 350
ATAQGRHYRT NHIVMTMGSD FQYENANMWF KNLDKLIRLV NAQQAKGSSV
360 370 380 390 400
HVLYSTPACY LWELNKANLT WSVKHDDFFP YADGPHQFWT GYFSSRPALK
410 420 430 440 450
RYERLSYNFL QVCNQLEALV GLAANVGPYG SGDSAPLNKA MAVLQHHDAV
460 470 480 490 500
SGTSRQHVAD DYARQLAAGW VSCEVLLSNA LARLRGFKDH LTFCRQLNIS
510 520 530 540 550
ICPLSQTAAR FQVIVYNPLG RKVNWMVRLP VSEGVFVVKD PNGRTVPSDV
560 570 580 590 600
VIYPSSDSQA HPPELLFSAS LPALGFSTYS VAQVPRWKPQ ARAPQPIPRR
610 620 630 640 650
SWSPALTIEN EHIRATFDPD TGLLMEIMNM NQRLLLPVRQ TFFWYNASIG
660 670 680 690 700
DNESDQASGA YIFRPNQQKP LPVSRWAQIR LVKTPLVQEV HQNFSAWCSQ
710 720 730 740 750
VVRLYPGRRH LELEWSVGPI PVGDTWGKEV ISRFDTPLET KGRFYTDSNG
760 770 780 790 800
REILERRRDY RPTWKLNQTE PVAGNYYPVN TRIYITDGKM QLTVLTDRSQ
810 820 830 840 850
GGSSLRDGSL ELMVHRRLLK DDERGVSEPL MENGSGAWVR GRHLVLLDTA
860 870 880 890 900
QAAAAGHRLL AEQEVLAPQV VLAPGGGAAY NLGAPPRTQF SGLRRELPPS
910 920 930 940 950
VHLLTLASWG PEMLLLRLEH QFAVGEDSGR NLSAPVTLNL RDLFSTFTIT
960 970 980 990 1000
RLQETTLVAN QLREAASRLK WTTNTGPTPH QTPYQLDPAN ITLEPMEIRT
1010
FLASVQWKEV DG
Length:1,012
Mass (Da):113,922
Last modified:November 23, 2004 - v1
Checksum:i87FA3277FFBF1326
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB125178 mRNA. Translation: BAD51966.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB125178 mRNA. Translation: BAD51966.1 .

3D structure databases

ProteinModelPortali Q60HE9.
SMRi Q60HE9. Positions 52-342, 350-421, 432-585, 606-875, 886-1007.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH38. Glycoside Hydrolase Family 38.

Proteomic databases

PRIDEi Q60HE9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG052391.

Family and domain databases

Gene3Di 1.20.1270.50. 1 hit.
2.60.40.1180. 1 hit.
3.20.110.10. 1 hit.
InterProi IPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR013780. Glyco_hydro_13_b.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view ]
Pfami PF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view ]
SMARTi SM00872. Alpha-mann_mid. 1 hit.
[Graphical view ]
SUPFAMi SSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of cDNA for macaque neurological disease genes."
    Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Medulla oblongata.

Entry informationi

Entry nameiMA2B1_MACFA
AccessioniPrimary (citable) accession number: Q60HE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: November 23, 2004
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3