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Q60HE9

- MA2B1_MACFA

UniProt

Q60HE9 - MA2B1_MACFA

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Protein

Lysosomal alpha-mannosidase

Gene
MAN2B1, QmoA-10471
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover By similarity.

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi73 – 731Zinc By similarity
Metal bindingi75 – 751Zinc By similarity
Active sitei197 – 1971Nucleophile By similarity
Metal bindingi197 – 1971Zinc By similarity
Metal bindingi447 – 4471Zinc By similarity

GO - Molecular functioni

  1. alpha-mannosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. mannose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

CAZyiGH38. Glycoside Hydrolase Family 38.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal alpha-mannosidase (EC:3.2.1.24)
Short name:
Laman
Alternative name(s):
Lysosomal acid alpha-mannosidase
Mannosidase alpha class 2B member 1
Mannosidase alpha-B
Gene namesi
Name:MAN2B1
ORF Names:QmoA-10471
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5050 By similarityAdd
BLAST
Chaini51 – 1012962Lysosomal alpha-mannosidasePRO_0000012075Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 359 By similarity
Disulfide bondi269 ↔ 274 By similarity
Glycosylationi368 – 3681N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi413 ↔ 473 By similarity
Disulfide bondi494 ↔ 502 By similarity
Glycosylationi498 – 4981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi646 – 6461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi652 – 6521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi693 – 6931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi767 – 7671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi833 – 8331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi931 – 9311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi990 – 9901N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ60HE9.

Structurei

3D structure databases

ProteinModelPortaliQ60HE9.
SMRiQ60HE9. Positions 52-342, 350-421, 432-585, 606-875, 886-1007.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG052391.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
2.60.40.1180. 1 hit.
3.20.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR013780. Glyco_hydro_13_b.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view]
PfamiPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]
SMARTiSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60HE9-1 [UniParc]FASTAAdd to Basket

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MGAYAPAAGV SARGCLDAAG PWTISRALRP PLPPLCFFLL LLLAAPCARA     50
GGYETCPTVQ PNILNVHLVP HTHDDVGWLK TVDQYFYGIK NDIQHAGVQY 100
ILDSVISALL ADPTRRFIYV EIAFFSRWWH QQTNAMREVV RDLVRQGRLE 150
FANGGWVMND EAATHYGAIV DQMTLGLRFL EDTFGSDGRP RVAWHIDPFG 200
HSREQASLFA QMGFDGFFFG RLDYQDKRVR MQKLEMEQVW RASASLKPPT 250
ADLFTGVLPN GYNPPMNLCW DVLCVDQPVV EDPRSPEYNA KELVDYFLNV 300
ATAQGRHYRT NHIVMTMGSD FQYENANMWF KNLDKLIRLV NAQQAKGSSV 350
HVLYSTPACY LWELNKANLT WSVKHDDFFP YADGPHQFWT GYFSSRPALK 400
RYERLSYNFL QVCNQLEALV GLAANVGPYG SGDSAPLNKA MAVLQHHDAV 450
SGTSRQHVAD DYARQLAAGW VSCEVLLSNA LARLRGFKDH LTFCRQLNIS 500
ICPLSQTAAR FQVIVYNPLG RKVNWMVRLP VSEGVFVVKD PNGRTVPSDV 550
VIYPSSDSQA HPPELLFSAS LPALGFSTYS VAQVPRWKPQ ARAPQPIPRR 600
SWSPALTIEN EHIRATFDPD TGLLMEIMNM NQRLLLPVRQ TFFWYNASIG 650
DNESDQASGA YIFRPNQQKP LPVSRWAQIR LVKTPLVQEV HQNFSAWCSQ 700
VVRLYPGRRH LELEWSVGPI PVGDTWGKEV ISRFDTPLET KGRFYTDSNG 750
REILERRRDY RPTWKLNQTE PVAGNYYPVN TRIYITDGKM QLTVLTDRSQ 800
GGSSLRDGSL ELMVHRRLLK DDERGVSEPL MENGSGAWVR GRHLVLLDTA 850
QAAAAGHRLL AEQEVLAPQV VLAPGGGAAY NLGAPPRTQF SGLRRELPPS 900
VHLLTLASWG PEMLLLRLEH QFAVGEDSGR NLSAPVTLNL RDLFSTFTIT 950
RLQETTLVAN QLREAASRLK WTTNTGPTPH QTPYQLDPAN ITLEPMEIRT 1000
FLASVQWKEV DG 1012
Length:1,012
Mass (Da):113,922
Last modified:November 23, 2004 - v1
Checksum:i87FA3277FFBF1326
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB125178 mRNA. Translation: BAD51966.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB125178 mRNA. Translation: BAD51966.1 .

3D structure databases

ProteinModelPortali Q60HE9.
SMRi Q60HE9. Positions 52-342, 350-421, 432-585, 606-875, 886-1007.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH38. Glycoside Hydrolase Family 38.

Proteomic databases

PRIDEi Q60HE9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG052391.

Family and domain databases

Gene3Di 1.20.1270.50. 1 hit.
2.60.40.1180. 1 hit.
3.20.110.10. 1 hit.
InterProi IPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR013780. Glyco_hydro_13_b.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view ]
Pfami PF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view ]
SMARTi SM00872. Alpha-mann_mid. 1 hit.
[Graphical view ]
SUPFAMi SSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of cDNA for macaque neurological disease genes."
    Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Medulla oblongata.

Entry informationi

Entry nameiMA2B1_MACFA
AccessioniPrimary (citable) accession number: Q60HE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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