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Q60HE5

- MTHR_MACFA

UniProt

Q60HE5 - MTHR_MACFA

Protein

Methylenetetrahydrofolate reductase

Gene

MTHFR

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.By similarity

    Catalytic activityi

    5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H.

    Cofactori

    FAD.By similarity

    Enzyme regulationi

    Allosterically regulated by S-adenosylmethionine.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei63 – 631Proton donor/acceptorBy similarity
    Binding sitei127 – 1271FADBy similarity
    Binding sitei159 – 1591SubstrateBy similarity
    Binding sitei197 – 1971FADBy similarity
    Binding sitei210 – 2101FADBy similarity
    Binding sitei217 – 2171FADBy similarity
    Binding sitei228 – 2281SubstrateBy similarity
    Binding sitei321 – 3211SubstrateBy similarity
    Binding sitei325 – 3251SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi63 – 686NADBy similarity
    Nucleotide bindingi94 – 952NAD and FADBy similarity
    Nucleotide bindingi157 – 1593FADBy similarity
    Nucleotide bindingi174 – 1752FADBy similarity
    Nucleotide bindingi201 – 2044FADBy similarity

    GO - Molecular functioni

    1. methylenetetrahydrofolate reductase (NAD(P)H) activity Source: UniProtKB-EC

    GO - Biological processi

    1. methionine metabolic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylenetetrahydrofolate reductase (EC:1.5.1.20)
    Gene namesi
    Name:MTHFR
    ORF Names:QtrA-17780
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 656656Methylenetetrahydrofolate reductasePRO_0000190246Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ60HE5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG006414.
    KOiK00297.

    Family and domain databases

    Gene3Di3.20.20.220. 1 hit.
    InterProiIPR029041. FAD-linked_oxidoreductase-like.
    IPR004621. Fadh2_euk.
    IPR003171. Mehydrof_redctse.
    [Graphical view]
    PfamiPF02219. MTHFR. 1 hit.
    [Graphical view]
    SUPFAMiSSF51730. SSF51730. 1 hit.
    TIGRFAMsiTIGR00677. fadh2_euk. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q60HE5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNEARGNDS LNPCLEGSAS SSSESSKDSS RCSTPGLDPE RHERLRDKMR    50
    RRMESGDKWF SLEFFPPRTA EGAVNLISRF DRMAAGGPLF IDVTWHPAGD 100
    PGSDKETSSM MIASTAVNYC GLETILHMTC CCQRLEEITG HLHKAKQLGL 150
    KNIMALRGDP IGDQWEEEEG GFNYAVDLVK HIRSEFGDYF DLCVAGYPKG 200
    HPEAGSFEAD LKHLKEKVSA GADFIITQLF FEADTFFRFV KACTDMGITC 250
    PIVPGIFPIQ GYHSLRQLVK QSKLEVPQEI KDVIEPIKDN DAAIRNYGIE 300
    LAVSLCHELL ASGLVPGLHF YTLNREMATT EVLKRLGMWT EDPRRPLPWA 350
    LSAHPKRREE DVRPIFWASR PKSYIYRTQE WDEFPNGRWG NSSSPAFGEL 400
    KDYYLFYLKS KSPRELLLKM WGEELTSEES VFEVFVLYLS GEPNRNGHKV 450
    TCLPWNDEPL AAETSLLKEE LLRVNRQGIL TINSQPNING KPSSDPVVGW 500
    GPSGGYVFQK AYLEFFTSRE TAEALLQVLK KYELRVNYHL VNVKGENITN 550
    APELQPNAVT WGIFPGREII QPTVVDPISF MFWKDEAFAL WIEQWGKLYE 600
    EESPSRTIIQ YIHDNYFLVN LVDNDFPLDN CLWQVVEDAL ELLNRPTQNE 650
    REMEAP 656
    Length:656
    Mass (Da):74,656
    Last modified:November 23, 2004 - v1
    Checksum:iAFF7FA239B9520FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB125182 mRNA. Translation: BAD51970.1.
    RefSeqiNP_001271578.1. NM_001284649.1.
    UniGeneiMfa.6344.

    Genome annotation databases

    GeneIDi102117536.
    KEGGimcf:102117536.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB125182 mRNA. Translation: BAD51970.1 .
    RefSeqi NP_001271578.1. NM_001284649.1.
    UniGenei Mfa.6344.

    3D structure databases

    ProteinModelPortali Q60HE5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 102117536.
    KEGGi mcf:102117536.

    Organism-specific databases

    CTDi 4524.

    Phylogenomic databases

    HOVERGENi HBG006414.
    KOi K00297.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.20.20.220. 1 hit.
    InterProi IPR029041. FAD-linked_oxidoreductase-like.
    IPR004621. Fadh2_euk.
    IPR003171. Mehydrof_redctse.
    [Graphical view ]
    Pfami PF02219. MTHFR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51730. SSF51730. 1 hit.
    TIGRFAMsi TIGR00677. fadh2_euk. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of cDNA for macaque neurological disease genes."
      Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Temporal cortex.

    Entry informationi

    Entry nameiMTHR_MACFA
    AccessioniPrimary (citable) accession number: Q60HE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3