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Q60HE5

- MTHR_MACFA

UniProt

Q60HE5 - MTHR_MACFA

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Protein
Methylenetetrahydrofolate reductase
Gene
MTHFR, QtrA-17780
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine By similarity.

Catalytic activityi

5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H.

Cofactori

FAD By similarity.

Enzyme regulationi

Allosterically regulated by S-adenosylmethionine By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei63 – 631Proton donor/acceptor By similarity
Binding sitei127 – 1271FAD By similarity
Binding sitei159 – 1591Substrate By similarity
Binding sitei197 – 1971FAD By similarity
Binding sitei210 – 2101FAD By similarity
Binding sitei217 – 2171FAD By similarity
Binding sitei228 – 2281Substrate By similarity
Binding sitei321 – 3211Substrate By similarity
Binding sitei325 – 3251Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi63 – 686NAD By similarity
Nucleotide bindingi94 – 952NAD and FAD By similarity
Nucleotide bindingi157 – 1593FAD By similarity
Nucleotide bindingi174 – 1752FAD By similarity
Nucleotide bindingi201 – 2044FAD By similarity

GO - Molecular functioni

  1. methylenetetrahydrofolate reductase (NAD(P)H) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. methionine metabolic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate reductase (EC:1.5.1.20)
Gene namesi
Name:MTHFR
ORF Names:QtrA-17780
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 656656Methylenetetrahydrofolate reductase
PRO_0000190246Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ60HE5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG006414.
KOiK00297.

Family and domain databases

Gene3Di3.20.20.220. 1 hit.
InterProiIPR029041. FAD-linked_oxidoreductase-like.
IPR004621. Fadh2_euk.
IPR003171. Mehydrof_redctse.
[Graphical view]
PfamiPF02219. MTHFR. 1 hit.
[Graphical view]
SUPFAMiSSF51730. SSF51730. 1 hit.
TIGRFAMsiTIGR00677. fadh2_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60HE5-1 [UniParc]FASTAAdd to Basket

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MVNEARGNDS LNPCLEGSAS SSSESSKDSS RCSTPGLDPE RHERLRDKMR    50
RRMESGDKWF SLEFFPPRTA EGAVNLISRF DRMAAGGPLF IDVTWHPAGD 100
PGSDKETSSM MIASTAVNYC GLETILHMTC CCQRLEEITG HLHKAKQLGL 150
KNIMALRGDP IGDQWEEEEG GFNYAVDLVK HIRSEFGDYF DLCVAGYPKG 200
HPEAGSFEAD LKHLKEKVSA GADFIITQLF FEADTFFRFV KACTDMGITC 250
PIVPGIFPIQ GYHSLRQLVK QSKLEVPQEI KDVIEPIKDN DAAIRNYGIE 300
LAVSLCHELL ASGLVPGLHF YTLNREMATT EVLKRLGMWT EDPRRPLPWA 350
LSAHPKRREE DVRPIFWASR PKSYIYRTQE WDEFPNGRWG NSSSPAFGEL 400
KDYYLFYLKS KSPRELLLKM WGEELTSEES VFEVFVLYLS GEPNRNGHKV 450
TCLPWNDEPL AAETSLLKEE LLRVNRQGIL TINSQPNING KPSSDPVVGW 500
GPSGGYVFQK AYLEFFTSRE TAEALLQVLK KYELRVNYHL VNVKGENITN 550
APELQPNAVT WGIFPGREII QPTVVDPISF MFWKDEAFAL WIEQWGKLYE 600
EESPSRTIIQ YIHDNYFLVN LVDNDFPLDN CLWQVVEDAL ELLNRPTQNE 650
REMEAP 656
Length:656
Mass (Da):74,656
Last modified:November 23, 2004 - v1
Checksum:iAFF7FA239B9520FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB125182 mRNA. Translation: BAD51970.1.
RefSeqiNP_001271578.1. NM_001284649.1.
UniGeneiMfa.6344.

Genome annotation databases

GeneIDi102117536.
KEGGimcf:102117536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB125182 mRNA. Translation: BAD51970.1 .
RefSeqi NP_001271578.1. NM_001284649.1.
UniGenei Mfa.6344.

3D structure databases

ProteinModelPortali Q60HE5.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 102117536.
KEGGi mcf:102117536.

Organism-specific databases

CTDi 4524.

Phylogenomic databases

HOVERGENi HBG006414.
KOi K00297.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.20.20.220. 1 hit.
InterProi IPR029041. FAD-linked_oxidoreductase-like.
IPR004621. Fadh2_euk.
IPR003171. Mehydrof_redctse.
[Graphical view ]
Pfami PF02219. MTHFR. 1 hit.
[Graphical view ]
SUPFAMi SSF51730. SSF51730. 1 hit.
TIGRFAMsi TIGR00677. fadh2_euk. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of cDNA for macaque neurological disease genes."
    Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Temporal cortex.

Entry informationi

Entry nameiMTHR_MACFA
AccessioniPrimary (citable) accession number: Q60HE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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