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Q60HD6

- PMM2_MACFA

UniProt

Q60HD6 - PMM2_MACFA

Protein

Phosphomannomutase 2

Gene

PMM2

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

    Catalytic activityi

    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei12 – 121NucleophileBy similarity
    Active sitei14 – 141Proton donor/acceptorSequence Analysis
    Binding sitei21 – 211SubstrateBy similarity
    Binding sitei123 – 1231SubstrateBy similarity
    Binding sitei134 – 1341SubstrateBy similarity
    Binding sitei141 – 1411SubstrateBy similarity
    Binding sitei179 – 1791SubstrateBy similarity
    Binding sitei181 – 1811SubstrateBy similarity

    GO - Molecular functioni

    1. phosphomannomutase activity Source: UniProtKB-EC

    GO - Biological processi

    1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
    2. mannose biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    UniPathwayiUPA00126; UER00424.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphomannomutase 2 (EC:5.4.2.8)
    Short name:
    PMM 2
    Gene namesi
    Name:PMM2
    ORF Names:QtrA-14736
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 246245Phosphomannomutase 2PRO_0000199695Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei149 – 1491N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ60HD6.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ60HD6.
    SMRiQ60HD6. Positions 4-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic PMM family.Curated

    Phylogenomic databases

    HOVERGENiHBG009971.
    KOiK17497.

    Family and domain databases

    Gene3Di3.40.50.1000. 2 hits.
    InterProiIPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR005002. PMM.
    [Graphical view]
    PANTHERiPTHR10466. PTHR10466. 1 hit.
    PfamiPF03332. PMM. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q60HD6-1 [UniParc]FASTAAdd to Basket

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    MAAPGPALCL FDVDGTLTAP RQKITKEMDD FLQKLRQKIK IGVVGGSDFE    50
    KVQEQLGNDV VEKYDYVFPE NGLVAYKDGK LLCKQNIQSH LGEALIQDLI 100
    NYCLSYIAKV KLPKKRGTFI EFRNGMLNVS PIGRSCSQEE RIEFYELDKK 150
    ENIRQKFVAD LRKEFAGKGL TFSIGGQISF DVFPDGWDKR YCLRHVENDG 200
    YKTIYFFGDK TMPGGNDHEI FTDPRTVGYS VTAPEDTRRI CEELFS 246
    Length:246
    Mass (Da):28,024
    Last modified:November 23, 2004 - v1
    Checksum:i39F129672C141EB2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB125191 mRNA. Translation: BAD51979.1.
    RefSeqiNP_001272027.1. NM_001285098.1.
    UniGeneiMfa.6346.

    Genome annotation databases

    GeneIDi102146519.
    KEGGimcf:102146519.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB125191 mRNA. Translation: BAD51979.1 .
    RefSeqi NP_001272027.1. NM_001285098.1.
    UniGenei Mfa.6346.

    3D structure databases

    ProteinModelPortali Q60HD6.
    SMRi Q60HD6. Positions 4-246.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q60HD6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 102146519.
    KEGGi mcf:102146519.

    Organism-specific databases

    CTDi 5373.

    Phylogenomic databases

    HOVERGENi HBG009971.
    KOi K17497.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00424 .

    Family and domain databases

    Gene3Di 3.40.50.1000. 2 hits.
    InterProi IPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR005002. PMM.
    [Graphical view ]
    PANTHERi PTHR10466. PTHR10466. 1 hit.
    Pfami PF03332. PMM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of cDNA for macaque neurological disease genes."
      Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Temporal cortex.

    Entry informationi

    Entry nameiPMM2_MACFA
    AccessioniPrimary (citable) accession number: Q60HD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3