Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q60HD5 (PPOX_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protoporphyrinogen oxidase

Short name=PPO
EC=1.3.3.4
Gene names
Name:PPOX
ORF Names:QccE-13968
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length477 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX By similarity.

Catalytic activity

Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.

Cofactor

Binds 1 FAD per subunit By similarity.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.

Subunit structure

Monomer. Homodimer By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side By similarity. Note: Bound to the mitochondrial inner membrane with its active site facing the cytosolic side By similarity.

Sequence similarities

Belongs to the protoporphyrinogen oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 477477Protoporphyrinogen oxidase
PRO_0000135271

Regions

Nucleotide binding9 – 146FAD By similarity
Nucleotide binding34 – 352FAD By similarity
Nucleotide binding57 – 604FAD By similarity
Nucleotide binding454 – 4563FAD By similarity

Sites

Binding site421FAD; via amide nitrogen By similarity
Binding site2571FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding site4491FAD; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60HD5 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 5665D8871470AEA5

FASTA47750,613
        10         20         30         40         50         60 
MGRTVVVLGG GISGLAASYH LSRAPCPPKV VLVEGSERLG GWIRSVRGPN GAIFELGPRG 

        70         80         90        100        110        120 
IRPAGALGAR TLLLVSELGL DSEVLPVRGD HPAAQNRFLY VGGALHALPT GLRGLLRPSP 

       130        140        150        160        170        180 
PFSKPLFWAG LRELTKPRGK EPDETVHSFA QRRLGPEVAS LAMDSLCRGV FAGNSRELSI 

       190        200        210        220        230        240 
RSCFPSLFQA EQTHRSVLLG LLLGAGRTPQ PDSALIRQAL AERWSQWSLR GGLEMLPQAL 

       250        260        270        280        290        300 
ETHLTSRGVS VLRGQPVCGL SLQAEGRWKV SLRDSSLEAD HVISAIPASV LSELLPAEAA 

       310        320        330        340        350        360 
PLARALSAIT AVSVAVVNLQ YQGAHLPVQG FGHLVPSSED PGVLGIVYDS VAFPEQDGSP 

       370        380        390        400        410        420 
PGLRVTVMLG GSWLQTLEAS GCVLSQELFQ QRAQEAAAAQ LGLKELPSHC LVHLHKNCIP 

       430        440        450        460        470 
QYTLGHWQKL ESARQFLAAH RLPLTLAGAS YEGVAVNDCI ESGRQAAVSV LGTEPNG 

« Hide

References

[1]"Isolation and characterization of cDNA for macaque neurological disease genes."
Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB125192 mRNA. Translation: BAD51980.1.

3D structure databases

ProteinModelPortalQ60HD5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG001709.

Enzyme and pathway databases

UniPathwayUPA00251; UER00324.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.660.20. 1 hit.
InterProIPR002937. Amino_oxidase.
IPR016040. NAD(P)-bd_dom.
IPR004572. Protoporphyrinogen_oxidase.
IPR027418. Protoporphyrinogen_oxidase_C.
[Graphical view]
PfamPF01593. Amino_oxidase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00562. proto_IX_ox. 1 hit.
ProtoNetSearch...

Entry information

Entry namePPOX_MACFA
AccessionPrimary (citable) accession number: Q60HD5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways