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Q60HD0 (SUOX_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 28, 2011. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sulfite oxidase, mitochondrial
EC=1.8.3.1
Gene names
Name:SUOX
ORF Names:QccE-18442
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length545 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Sulfite + O2 + H2O = sulfate + H2O2.

Cofactor

Binds 1 protoheme group By similarity.

Molybdenum (molybdopterin) By similarity.

Pathway

Energy metabolism; sulfur metabolism.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion intermembrane space.

Sequence similarities

Contains 1 cytochrome b5 heme-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 7979Mitochondrion By similarity
Chain80 – 545466Sulfite oxidase, mitochondrial
PRO_0000006482

Regions

Domain82 – 16180Cytochrome b5 heme-binding
Region165 – 18117Hinge By similarity
Region182 – 545364Molybdenum-pterin domain By similarity
Region215 – 2195Molybdenum-pterin-binding By similarity
Region320 – 3223Molybdenum-pterin-binding By similarity
Region366 – 37914Molybdenum-pterin-binding By similarity

Sites

Metal binding1181Iron (heme axial ligand) By similarity
Metal binding1431Iron (heme axial ligand) By similarity
Metal binding2641Molybdenum-pterin By similarity
Metal binding3171Molybdenum-pterin By similarity

Amino acid modifications

Modified residue2851Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60HD0 [UniParc].

Last modified July 10, 2007. Version 3.
Checksum: 72723BDBF7C14E77

FASTA54560,193
        10         20         30         40         50         60 
MLLLHRAVVL RLQQACRLKS IPSRIYIQAC STNDSFRPQY PSLTFSGDNS STRGWKVMGT 

        70         80         90        100        110        120 
LLGLGAVLAY QDHRCRAAQE STRIYTKEEV SSHTSPETGI WVALGSEVFD VTEFADLHPG 

       130        140        150        160        170        180 
GPSKLMLAAG GPLEPFWALY AVHNQSHVRE LLAQYKVGEL NPEDKVAPTV ETSDPYADDP 

       190        200        210        220        230        240 
VRHPALKVNS QRPFNAEPPP ELLTENYITP NPIFFTRNHL PVPNLDPDTY RLHIVGAPGG 

       250        260        270        280        290        300 
QSLSLSLDDL HNFPKYEITV TLQCAGNRRS EMTQVKEVKG LEWRTGAIST ARWAGARLCD 

       310        320        330        340        350        360 
VLAKAGHQLC ETEAHVCFEG LDSDPTGTAY GASIPLARAM DPEAGVLLAY EMNGQPLPRD 

       370        380        390        400        410        420 
HGFPVRVVVP GVVGARHVKW LGRVSVQPEE SYSHWQRRDY KGFSPSVDWD TVDFDSAPSI 

       430        440        450        460        470        480 
QELPVQSAIT EPRDGETVES GEVTIKGYAW SGGGRAVIRV DVSLDGGLTW QVAKLDGEEQ 

       490        500        510        520        530        540 
RPRKAWAWRL WQLQAPVPAG QKELNIVCKA VDDGYNVQPD TVAPIWNLRG VLSNAWHRVH 


VFVAP

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References

[1]"Isolation and characterization of cDNA for macaque neurological disease genes."
Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB125197 mRNA. Translation: BAD51985.1.

3D structure databases

ProteinModelPortalQ60HD0.
SMRQ60HD0. Positions 85-543.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG017865.

Family and domain databases

InterProIPR001199. Cyt_B5.
IPR014756. Ig_E-set.
IPR005066. MoCF_OxRdtse_dimer.
IPR008335. Mopterin_OxRdtase_euk.
IPR000572. OxRdtase_Mopterin-bd_dom.
IPR022407. OxRdtase_Mopterin_BS.
[Graphical view]
Gene3DG3DSA:3.10.120.10. Cyt_B5. 1 hit.
G3DSA:2.60.40.650. MoCF_oxrdtse_dimer. 1 hit.
G3DSA:3.90.420.10. Oxred_molyb_bd. 1 hit.
PfamPF00173. Cyt-b5. 1 hit.
PF03404. Mo-co_dimer. 1 hit.
PF00174. Oxidored_molyb. 1 hit.
[Graphical view]
PRINTSPR00363. CYTOCHROMEB5.
PR00407. EUMOPTERIN.
SUPFAMSSF55856. Cyt_B5. 1 hit.
SSF81296. Ig_E-set. 1 hit.
SSF56524. Oxidored_molyb. 1 hit.
PROSITEPS00191. CYTOCHROME_B5_1. False negative.
PS50255. CYTOCHROME_B5_2. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUOX_MACFA
AccessionPrimary (citable) accession number: Q60HD0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 10, 2007
Last modified: June 28, 2011
This is version 49 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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