Reviewed, UniProtKB/Swiss-Prot Q60HD0 (SUOX_MACFA)

Names and origin

Protein names

Recommended name:
    Sulfite oxidase, mitochondrial
    EC=1.8.3.1

Gene names

Name:	SUOX
ORF Names:	QccE-18442

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	545 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Sulfite + O2 + H2O = sulfate + H2O2.
Cofactor	Binds 1 protoheme group By similarity. Molybdenum (molybdopterin) By similarity.
Pathway	Energy metabolism; sulfur metabolism.
Subunit structure	Homodimer By similarity.
Subcellular location	Mitochondrion intermembrane space.
Sequence similarities	Contains 1 cytochrome b5 heme-binding domain.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Heme Iron Metal-binding Molybdenum
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro molybdenum ion binding Inferred from electronic annotation. Source: UniProtKB-KW sulfite oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 79	79	Mitochondrion By similarity
	Chain	80 – 545	466	Sulfite oxidase, mitochondrial		PRO_0000006482
Regions
	Domain	82 – 161	80	Cytochrome b5 heme-binding
	Region	165 – 181	17	Hinge By similarity
	Region	182 – 545	364	Molybdenum-pterin domain By similarity
	Region	215 – 219	5	Molybdenum-pterin-binding By similarity
	Region	320 – 322	3	Molybdenum-pterin-binding By similarity
	Region	366 – 379	14	Molybdenum-pterin-binding By similarity
Sites
	Metal binding	118	1	Iron (heme axial ligand) By similarity
	Metal binding	143	1	Iron (heme axial ligand) By similarity
	Metal binding	264	1	Molybdenum-pterin By similarity
	Metal binding	317	1	Molybdenum-pterin By similarity
Amino acid modifications
	Modified residue	285	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q60HD0-1 [UniParc]. Last modified July 10, 2007. Version 3. Checksum: 72723BDBF7C14E77	FASTA	545	60,193
	10 20 30 40 50 60 MLLLHRAVVL RLQQACRLKS IPSRIYIQAC STNDSFRPQY PSLTFSGDNS STRGWKVMGT 70 80 90 100 110 120 LLGLGAVLAY QDHRCRAAQE STRIYTKEEV SSHTSPETGI WVALGSEVFD VTEFADLHPG 130 140 150 160 170 180 GPSKLMLAAG GPLEPFWALY AVHNQSHVRE LLAQYKVGEL NPEDKVAPTV ETSDPYADDP 190 200 210 220 230 240 VRHPALKVNS QRPFNAEPPP ELLTENYITP NPIFFTRNHL PVPNLDPDTY RLHIVGAPGG 250 260 270 280 290 300 QSLSLSLDDL HNFPKYEITV TLQCAGNRRS EMTQVKEVKG LEWRTGAIST ARWAGARLCD 310 320 330 340 350 360 VLAKAGHQLC ETEAHVCFEG LDSDPTGTAY GASIPLARAM DPEAGVLLAY EMNGQPLPRD 370 380 390 400 410 420 HGFPVRVVVP GVVGARHVKW LGRVSVQPEE SYSHWQRRDY KGFSPSVDWD TVDFDSAPSI 430 440 450 460 470 480 QELPVQSAIT EPRDGETVES GEVTIKGYAW SGGGRAVIRV DVSLDGGLTW QVAKLDGEEQ 490 500 510 520 530 540 RPRKAWAWRL WQLQAPVPAG QKELNIVCKA VDDGYNVQPD TVAPIWNLRG VLSNAWHRVH VFVAP

References

[1]	"Isolation and characterization of cDNA for macaque neurological disease genes." Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB125197 mRNA. Translation: BAD51985.1.
3D structure databases
SMR	Q60HD0. Positions 85-543.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q60HD0.
Enzyme and pathway databases
BRENDA	1.8.3.1. 3438.
Family and domain databases
InterPro	IPR001199. Cyt_B5. IPR014756. Ig_E-set. IPR005066. MoCF_OxRdtse_dimer. IPR008335. Mopterin_OxRdtase_euk. IPR000572. OxRdtase_Mopterin-bd. [Graphical view]
Gene3D	G3DSA:3.10.120.10. Cyt_B5. 1 hit. G3DSA:2.60.40.650. MoCF_oxrdtse_dimer. 1 hit. G3DSA:3.90.420.10. Oxred_molyb_bd. 1 hit.
Pfam	PF00173. Cyt-b5. 1 hit. PF03404. Mo-co_dimer. 1 hit. PF00174. Oxidored_molyb. 1 hit. [Graphical view]
PRINTS	PR00363. CYTOCHROMEB5. PR00407. EUMOPTERIN.
PROSITE	PS00191. CYTOCHROME_B5_1. False negative. PS50255. CYTOCHROME_B5_2. 1 hit. PS00559. MOLYBDOPTERIN_EUK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUOX_MACFA

Accession

Primary (citable) accession number: Q60HD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	July 10, 2007
Last modified:	January 19, 2010
This is version 41 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)