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Protein
Submitted name:

Filamin A

Gene

FLNA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Keywords - Ligandi

Actin-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Filamin AImported
Gene namesi
Name:FLNAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiQ60FE6.
PRIDEiQ60FE6.

Expressioni

Gene expression databases

BgeeiENSG00000196924.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000358866.

Structurei

3D structure databases

ProteinModelPortaliQ60FE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 122Actin-bindingInterPro annotationAdd BLAST107
Domaini139 – 239Actin-bindingInterPro annotationAdd BLAST101

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0518. Eukaryota.
COG5069. LUCA.
HOGENOMiHOG000044235.
HOVERGENiHBG004163.

Family and domain databases

CDDicd00014. CH. 2 hits.
Gene3Di1.10.418.10. 2 hits.
2.60.40.10. 24 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR028559. FLN_A.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11915:SF173. PTHR11915:SF173. 1 hit.
PfamiPF00307. CH. 2 hits.
PF00630. Filamin. 23 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM00557. IG_FLMN. 24 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF81296. SSF81296. 24 hits.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50194. FILAMIN_REPEAT. 24 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60FE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPATEKDLAE DAPWKKIQQN TFTRWCNEHL KCVSKRIANL QTDLSDGLRL
60 70 80 90 100
IALLEVLSQK KMHRKHNQRP TFRQMQLENV SVALEFLDRE SIKLVSIDSK
110 120 130 140 150
AIVDGNLKLI LGLIWTLILH YSISMPMWDE EEDEEAKKQT PKQRLLGWIQ
160 170 180 190 200
NKLPQLPITN FSRDWQSGRA LGALVDSCAP GLCPDWDSWD ASKPVTNARE
210 220 230 240 250
AMQQADDWLG IPQVITPEEI VDPNVDEHSV MTYLSQFPKA KLKPGAPLRP
260 270 280 290 300
KLNPKKARAY GPGIEPTGNM VKKRAEFTVE TRSAGQGEVL VYVEDPAGHQ
310 320 330 340 350
EEAKVTANND KNRTFSVWYV PEVTGTHKVT VLFAGQHIAK SPFEVYVDKS
360 370 380 390 400
QGDASKVTAQ GPGLEPSGNI ANKTTYFEIF TAGAGTGEVE VVIQDPMGQK
410 420 430 440 450
GTVEPQLEAR GDSTYRCSYQ PTMEGVHTVH VTFAGVPIPR SPYTVTVGQA
460 470 480 490 500
CNPSACRAVG RGLQPKGVRV KETADFKVYT KGAGSGELKV TVKGPKGEER
510 520 530 540 550
VKQKDLGDGV YGFEYYPMVP GTYIVTITWG GQNIGRSPFE VKVGTECGNQ
560 570 580 590 600
KVRAWGPGLE GGVVGKSADF VVEAIGDDVG TLGFSVEGPS QAKIECDDKG
610 620 630 640 650
DGSCDVRYWP QEAGEYAVHV LCNSEDIRLS PFMADIRDAP QDFHPDRVKA
660 670 680 690 700
RGPGLEKTGV AVNKPAEFTV DAKHGGKAPL RVQVQDNEGC PVEALVKDNG
710 720 730 740 750
NGTYSCSYVP RKPVKHTAMV SWGGVSIPNS PFRVNVGAGS HPNKVKVYGP
760 770 780 790 800
GVAKTGLKAH EPTYFTVDCA EAGQGDVSIG IKCAPGVVGP AEADIDFDII
810 820 830 840 850
RNDNDTFTVK YTPRGAGSYT IMVLFADQAT PTSPIRVKVE PSHDASKVKA
860 870 880 890 900
EGPGLSRTGV ELGKPTHFTV NAKAAGKGKL DVQFSGLTKG DAVRDVDIID
910 920 930 940 950
HHDNTYTVKY TPVQQGPVGV NVTYGGDPIP KSPFSVAVSP SLDLSKIKVS
960 970 980 990 1000
GLGEKVDVGK DQEFTVKSKG AGGQGKVASK IVGPSGAAVP CKVEPGLGAD
1010 1020 1030 1040 1050
NSVVRFLPRE EGPYEVEVTY DGVPVPGSPF PLEAVAPTKP SKVKAFGPGL
1060 1070 1080 1090 1100
QGGSAGSPAR FTIDTKGAGT GGLGLTVEGP CEAQLECLDN GDGTCSVSYV
1110 1120 1130 1140 1150
PTEPGDYNIN ILFADTHIPG SPFKAHVVPC FDASKVKCSG PGLERATAGE
1160 1170 1180 1190 1200
VGQFQVDCSS AGSAELTIEI CSEAGLPAEV YIQDHGDGTH TITYIPLCPG
1210 1220 1230 1240 1250
AYTVTIKYGG QPVPNFPSKL QVEPAVDTSG VQCYGPGIEG QGVFREATTE
1260 1270 1280 1290 1300
FSVDARALTQ TGGPHVKARV ANPSGNLTET YVQDRGDGMY KVEYTPYEEG
1310 1320 1330 1340 1350
LHSVDVTYDG SPVPSSPFQV PVTEGCDPSR VRVHGPGIQS GTTNKPNKFT
1360 1370 1380 1390 1400
VETRGAGTGG LGLAVEGPSE AKMSCMDNKD GSCSVEYIPY EAGTYSLNVT
1410 1420 1430 1440 1450
YGGHQVPGSP FKVPVHDVTD ASKVKCSGPG LSPGMVRANL PQSFQVDTSK
1460 1470 1480 1490 1500
AGVAPLQVKV QGPKGLVEPV DVVDNADGTQ TVNYVPSREG PYSISVLYGD
1510 1520 1530 1540 1550
EEVPRSPFKV KVLPTHDASK VKASGPGLNT TGVPASLPVE FTIDAKDAGE
1560 1570 1580 1590 1600
GLLAVQITDP EGKPKKTHIQ DNHDGTYTVA YVPDVTGRYT ILIKYGGDEI
1610 1620 1630 1640 1650
PFSPYRVRAV PTGDASKCTV TGAGIGPTIQ IGEETVITVD TKAAGKGKVT
1660 1670 1680 1690 1700
CTVCTPDGSE VDVDVVENED GTFDIFYTAP QPGKYVICVR FGGEHVPNSP
1710 1720 1730 1740 1750
FQVTALAGDQ PSVQPPLRSQ QLAPQYTYAQ GGQQTWAPER PLVGVNGLDV
1760 1770 1780 1790 1800
TSLRPFDLVI PFTIKKGEIT GEVRMPSGKV AQPTITDNKD GTVTVRYAPS
1810 1820 1830 1840 1850
EAGLHEMDIR YDNMHIPGSP LQFYVDYVNC GHVTAYGPGL THGVVNKPAT
1860 1870 1880 1890 1900
FTVNTKDAGE GGLSLAIEGP SKAEISCTDN QDGTCSVSYL PVLPGDYSIL
1910 1920 1930 1940 1950
VKYNEQHVPG SPFTARVTGD DSMRMSHLKV GSAADIPINI SETDLSLLTA
1960 1970 1980 1990 2000
TVVPPSGREE PCLLKRLRNG HVGISFVPKE TGEHLVHVKK NGQHVASSPI
2010 2020 2030 2040 2050
PVVISQSEIG DASRVRVSGQ GLHEGHTFEP AEFIIDTRDA GYGGLSLSIE
2060 2070 2080 2090 2100
GPSKVDINTE DLEDGTCRVT YCPTEPGNYI INIKFADQHV PGSPFSVKVT
2110 2120 2130 2140 2150
GEGRVKESIT RRRRAPSVAN VGSHCDLSLK IPEISIQDMT AQVTSPSGKT
2160 2170 2180 2190 2200
HEAEIVEGEN HTYCIRFVPA EMGTHTVSVK YKGQHVPGSP FQFTVGPLGE
2210 2220 2230 2240 2250
GGAHKVRAGG PGLERAEAGV PAEFSIWTRE AGAGGLAIAV EGPSKAEISF
2260 2270 2280 2290 2300
EDRKDGSCGV AYVVQEPGDY EVSVKFNEEH IPDSPFVVPV ASPSGDARRL
2310 2320 2330 2340 2350
TVSSLQESGL KVNQPASFAV SLNGAKGAID AKVHSPSGAL EECYVTEIDQ
2360 2370 2380 2390 2400
DKYAVRFIPR ENGVYLIDVK FNGTHIPGSP FKIRVGEPGH GGDPGLVSAY
2410 2420 2430 2440 2450
GAGLEGGVTG NPAEFVVNTS NAGAGALSVT IDGPSKVKMD CQECPEGYRV
2460 2470 2480 2490 2500
TYTPMAPGSY LISIKYGGPY HIGGSPFKAK VTGPRLVSNH SLHETSSVFV
2510 2520 2530 2540 2550
DSLTKATCAP QHGAPGPGPA DASKVVAKGL GLSKAYVGQK SSFTVDCSKA
2560 2570 2580 2590 2600
GNNMLLVGVH GPRTPCEEIL VKHVGSRLYS VSYLLKDKGE YTLVVKWGDE
2610
HIPGSPYRVV VP
Length:2,612
Mass (Da):277,506
Last modified:November 23, 2004 - v1
Checksum:i30FD81C697272455
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB191259 mRNA. Translation: BAD52435.1.
AB371575 mRNA. Translation: BAG48304.1.
AB371578 mRNA. Translation: BAG48307.1.
AB371579 mRNA. Translation: BAG48308.1.
UniGeneiHs.195464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB191259 mRNA. Translation: BAD52435.1.
AB371575 mRNA. Translation: BAG48304.1.
AB371578 mRNA. Translation: BAG48307.1.
AB371579 mRNA. Translation: BAG48308.1.
UniGeneiHs.195464.

3D structure databases

ProteinModelPortaliQ60FE6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000358866.

Proteomic databases

PeptideAtlasiQ60FE6.
PRIDEiQ60FE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0518. Eukaryota.
COG5069. LUCA.
HOGENOMiHOG000044235.
HOVERGENiHBG004163.

Miscellaneous databases

ChiTaRSiFLNA. human.

Gene expression databases

BgeeiENSG00000196924.

Family and domain databases

CDDicd00014. CH. 2 hits.
Gene3Di1.10.418.10. 2 hits.
2.60.40.10. 24 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR028559. FLN_A.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11915:SF173. PTHR11915:SF173. 1 hit.
PfamiPF00307. CH. 2 hits.
PF00630. Filamin. 23 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM00557. IG_FLMN. 24 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF81296. SSF81296. 24 hits.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50194. FILAMIN_REPEAT. 24 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ60FE6_HUMAN
AccessioniPrimary (citable) accession number: Q60FE6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: November 30, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.