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Protein

Sulfate adenylyltransferase

Gene

atps

Organism
Pyropia yezoensis (Red alga) (Porphyra yezoensis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + sulfate = diphosphate + adenylyl sulfate.2 Publications

Cofactori

Mg2+1 Publication

Enzyme regulationi

Inhibited by adenosine 5'-phosphosulfate (APS), but not by 3'phosphoadenosine 5'-phosphosulfate (PAPS). Inhibited by AMP, ADP, CTP, GTP, ITP, UTP and anions other than those in group IV.1 Publication

pH dependencei

Optimum pH is 8.2.

Temperature dependencei

Optimum temperature is 37 degrees Celsius.

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes sulfite from sulfate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Sulfate adenylyltransferase (atps)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Cysteine biosynthesis, Methionine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00140; UER00204.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate adenylyltransferase (EC:2.7.7.4)
Alternative name(s):
ATP-sulfurylase
Sulfate adenylate transferase
Short name:
SAT
Gene namesi
Name:atpsImported
OrganismiPyropia yezoensis (Red alga) (Porphyra yezoensis)
Taxonomic identifieri2788 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaBangiophyceaeBangialesBangiaceaePyropia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 420419Sulfate adenylyltransferasePRO_0000105956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfate adenylyltransferase family.Sequence analysis

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR025980. ATP-Sase_PUA-like_dom.
IPR015947. PUA-like_domain.
IPR014729. Rossmann-like_a/b/a_fold.
IPR024951. Sulfurylase_cat_dom.
IPR002650. Sulphate_adenylyltransferase.
[Graphical view]
PfamiPF01747. ATP-sulfurylase. 1 hit.
PF14306. PUA_2. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60FC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANVSPVHGG LSEPVNRVVD SLPSTELLPK IVVNATDYTT LHRIADGTLS
60 70 80 90 100
PLTGPMTKAD YDSVLLKKGI ERDGKLWAWT IPLSLPVTAE EAKALKAGEP
110 120 130 140 150
AALVSESGDV FGTLTVDAAF SWDKPAFLKA VYGTERTDHP GARLWLDDPR
160 170 180 190 200
TDLVGGSISV LAHDEARPFK DRILYPQSMR ALLKEQGYGA SVAFQTRNPL
210 220 230 240 250
HRAHEYALVY GAEKLLKEVG DSSKVGVFLN PLVGQLKGDD VPAATRMETY
260 270 280 290 300
IKLIDGGFIG EGDMDEELWK SKGQNLREQT RLAGLDMRMF YGGPSEAVMH
310 320 330 340 350
AIYRQNLGIT HFIIGRKHAD APFDDKSAIW GDFDAQEIFE KLEGDLQIKT
360 370 380 390 400
VNVGFAAYFE ELGHVGLCSE NKGKTTVSIS GSKMREMLNS GSMPDSRVMR
410 420
PATAQVLMDY YAAKNKSATA
Length:420
Mass (Da):45,878
Last modified:January 23, 2007 - v3
Checksum:iC5CA346DB026E789
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB191688 mRNA. Translation: BAD52446.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB191688 mRNA. Translation: BAD52446.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00140; UER00204.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR025980. ATP-Sase_PUA-like_dom.
IPR015947. PUA-like_domain.
IPR014729. Rossmann-like_a/b/a_fold.
IPR024951. Sulfurylase_cat_dom.
IPR002650. Sulphate_adenylyltransferase.
[Graphical view]
PfamiPF01747. ATP-sulfurylase. 1 hit.
PF14306. PUA_2. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning of cDNA coding for ATP-sulfurylase of Porphyra yezoensis."
    Kanno N., Kogami H.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: ThallusImported.
  2. Kanno N., Kogami H.
    Submitted (OCT-2004) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-420, ACETYLATION AT ALA-2.
  3. "ATP-sulphurylase in marine algae."
    Kanno N., Sato M., Sato Y.
    Nippon Suisan Gakkai Shi 53:1047-1050(1987)
    Cited for: CATALYTIC ACTIVITY.
  4. "Properties of ATP-sulphurylase from marine alga Porphyra yezoensis."
    Kanno N., Sato M., Sato Y.
    Nippon Suisan Gakkai Shi 54:1635-1639(1988)
    Cited for: CATALYTIC ACTIVITY, COFACTOR, ENZYME REGULATION.

Entry informationi

Entry nameiSAT_PYRYE
AccessioniPrimary (citable) accession number: Q60FC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 48 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.