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Protein

Cytochrome b-245 light chain

Gene

p22phox

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport
LigandHemeUniRule annotation, Iron, Metal-binding, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-245 light chainUniRule annotation
Alternative name(s):
Cytochrome b(558) alpha chainUniRule annotation
Cytochrome b558 subunit alphaUniRule annotation
Neutrophil cytochrome b 22 kDa polypeptideUniRule annotation
Superoxide-generating NADPH oxidase light chain subunitUniRule annotation
p22 phagocyte B-cytochromeUniRule annotation
p22-phoxUniRule annotation
Gene namesi
Name:p22phoxImported
ORF Names:GSONMT00002541001Imported
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)Imported
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

  • Cell membrane UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei38 – 54HelicalSequence analysisAdd BLAST17
Transmembranei91 – 124HelicalSequence analysisAdd BLAST34

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the p22phox family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG051278.

Family and domain databases

InterProiView protein in InterPro
IPR007732. Cyt_b558_asu.
PANTHERiPTHR15168. PTHR15168. 1 hit.
PfamiView protein in Pfam
PF05038. Cytochrom_B558a. 1 hit.
PIRSFiPIRSF019635. Cytochr_b558a. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60FB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIEWAMWA NEQALAAGLI LLTGGIVGVA GQFRDWEFAA YAIAAGVFVC
60 70 80 90 100
LLEYPRGKRN KGTSVERTGQ YCFTVCVKSF GPLTRNYYVR AFLHAAICVP
110 120 130 140 150
GGFILATVLG CVCLGIASLI YLAAAIRGEQ WEPILPRKES ARKPVGESIK
160 170 180
LPPQNPPPRP PAEMRRKRAE DLEAAAYVNP IAVTANDD
Length:188
Mass (Da):20,424
Last modified:November 23, 2004 - v1
Checksum:i950B18869591FC65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY597051 mRNA. Translation: AAU04547.1.
AB192466 mRNA. Translation: BAD60780.1.
FR907970 Genomic DNA. Translation: CDQ87523.1.
RefSeqiNP_001153784.1. NM_001160312.1.
UniGeneiOmy.8225.

Genome annotation databases

GeneIDi100301566.

Similar proteinsi

Entry informationi

Entry nameiQ60FB8_ONCMY
AccessioniPrimary (citable) accession number: Q60FB8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: June 7, 2017
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)