Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

5-hydroxytryptamine receptor 2C

Gene

HTR2C

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Behavior

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 2C
Short name:
5-HT-2C
Short name:
5-HT2C
Short name:
5-HTR2C
Alternative name(s):
Serotonin receptor 2C
Gene namesi
Name:HTR2C
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 52ExtracellularBy similarityAdd BLAST20
Transmembranei53 – 78Helical; Name=1By similarityAdd BLAST26
Topological domaini79 – 89CytoplasmicBy similarityAdd BLAST11
Transmembranei90 – 110Helical; Name=2By similarityAdd BLAST21
Topological domaini111 – 127ExtracellularBy similarityAdd BLAST17
Transmembranei128 – 150Helical; Name=3By similarityAdd BLAST23
Topological domaini151 – 170CytoplasmicBy similarityAdd BLAST20
Transmembranei171 – 193Helical; Name=4By similarityAdd BLAST23
Topological domaini194 – 213ExtracellularBy similarityAdd BLAST20
Transmembranei214 – 235Helical; Name=5By similarityAdd BLAST22
Topological domaini236 – 311CytoplasmicBy similarityAdd BLAST76
Transmembranei312 – 333Helical; Name=6By similarityAdd BLAST22
Topological domaini334 – 348ExtracellularBy similarityAdd BLAST15
Transmembranei349 – 371Helical; Name=7By similarityAdd BLAST23
Topological domaini372 – 458CytoplasmicBy similarityAdd BLAST87

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1770041.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32By similarityAdd BLAST32
ChainiPRO_000006895733 – 4585-hydroxytryptamine receptor 2CAdd BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...)By similarity1
Disulfide bondi127 ↔ 207PROSITE-ProRule annotation
Glycosylationi203N-linked (GlcNAc...)Sequence analysis1
Glycosylationi204N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi337 ↔ 341PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ60F97.

Interactioni

Subunit structurei

Interacts with MPDZ. Interacts with ARRB2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000043222.

Chemistry databases

BindingDBiQ60F97.

Structurei

3D structure databases

ProteinModelPortaliQ60F97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni134 – 139Agonist bindingBy similarity6
Regioni324 – 328Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi151 – 153DRY motif; important for ligand-induced conformation changesBy similarity3
Motifi364 – 368NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5
Motifi456 – 458PDZ-binding3

Domaini

The PDZ domain-binding motif is involved in the interaction with MPDZ.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000240378.
HOVERGENiHBG107487.
InParanoidiQ60F97.
KOiK04157.

Family and domain databases

InterProiIPR000377. 5HT2C_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF32. PTHR24247:SF32. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00517. 5HT2CRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60F97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNLRKAVHS FLVHLIGLLV WQCDISVSPV AALVTDIFNT SDGGRFKFPD
60 70 80 90 100
GVQNWPALSI VIIIILTIGG NILVIMAVSL EKKLHNATNY FLMSLAIADM
110 120 130 140 150
LVGLLVMPLS LLAILYDYVW PLPRYLCPVW ISLDVLFSTA SIMHLCAISL
160 170 180 190 200
DRYVAIRNPV EHSRFNSRTK AIMKIAIVWA ISIGVSVPIP VIGLRDEEKV
210 220 230 240 250
FVNNTTCVLN DPNFVLIGSF VAFFIPLTIM VITYCLTIHV LRRQALMLLH
260 270 280 290 300
GHVEEPPRIN LDFLKCCRRN GTEEENSANP NQDSNPRRRK KKERRPRGTM
310 320 330 340 350
QAINNERKAS KVLGIVFFVF LVMWCPFFIT NILSVLCGKA CNQKLMEKLL
360 370 380 390 400
NVFVWIGYVC SGINPLVYTL FNKIYRRAFS NYLRCNYKPE KKPPVRQMPR
410 420 430 440 450
VAATALSGRE LNVNIYRHTN EPVLKKANDK EPGIEMQVEN LELPVNPSSV

VSERISSV
Length:458
Mass (Da):51,836
Last modified:November 23, 2004 - v1
Checksum:i5A03245262B6C7BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB193091 mRNA. Translation: BAD60921.1.
RefSeqiNP_001006649.1. NM_001006648.1.
UniGeneiCfa.16240.

Genome annotation databases

GeneIDi450240.
KEGGicfa:450240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB193091 mRNA. Translation: BAD60921.1.
RefSeqiNP_001006649.1. NM_001006648.1.
UniGeneiCfa.16240.

3D structure databases

ProteinModelPortaliQ60F97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000043222.

Chemistry databases

BindingDBiQ60F97.
ChEMBLiCHEMBL1770041.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ60F97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi450240.
KEGGicfa:450240.

Organism-specific databases

CTDi3358.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000240378.
HOVERGENiHBG107487.
InParanoidiQ60F97.
KOiK04157.

Miscellaneous databases

PROiQ60F97.

Family and domain databases

InterProiIPR000377. 5HT2C_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF32. PTHR24247:SF32. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00517. 5HT2CRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei5HT2C_CANLF
AccessioniPrimary (citable) accession number: Q60F97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.