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Q60CV4

- TRUA_BRUSU

UniProt

Q60CV4 - TRUA_BRUSU

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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521NucleophileUniRule annotation
Binding sitei113 – 1131SubstrateUniRule annotation

GO - Molecular functioni

  1. pseudouridine synthase activity Source: UniProtKB-HAMAP
  2. RNA binding Source: InterPro

GO - Biological processi

  1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:BRA1033, BS1330_II1025
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251tRNA pseudouridine synthase APRO_0000057347Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BRA1033.

Structurei

3D structure databases

ProteinModelPortaliQ60CV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0101.
HOGENOMiHOG000248672.
KOiK06173.
OrthoDBiEOG6Z9B4R.

Family and domain databases

Gene3Di3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00071. hisT_truA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60CV4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRYKLTVEY DGTPYVGWQR QENGHAVQGA IEQAFKKFCG EDLTLSAAGR
60 70 80 90 100
TDAGVHATAQ VAHVDLAKDW GAGKVRDAVN AHLVMADERI SILNVEKTTD
110 120 130 140 150
TFDARFSARA RHYLYRIHNR RAPLAVDYQR AWWVQKQLDA DAMHEAAQRL
160 170 180 190 200
LGEHDFTTFR ATQCQAKSPV KTLDRLDVTR NGDMVEMRVS ARSFLHNQVR
210 220 230 240 250
SFAGSLMEVG VGRWTADDLQ AALEARDRKA CGQVAPPYGL YLVGVDYAFP

F
Length:251
Mass (Da):28,172
Last modified:November 23, 2004 - v1
Checksum:iE2A62312443C2BCD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014292 Genomic DNA. Translation: AAV28867.1.
CP002998 Genomic DNA. Translation: AEM20477.1.
RefSeqiYP_002519393.1. NC_004311.2.
YP_005614703.1. NC_017250.1.

Genome annotation databases

EnsemblBacteriaiAAV28867; AAV28867; BRA1033.
AEM20477; AEM20477; BS1330_II1025.
GeneIDi1165478.
12139258.
KEGGibms:BRA1033.
bsi:BS1330_II1025.
PATRICi17794901. VBIBruSui107850_3258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014292 Genomic DNA. Translation: AAV28867.1 .
CP002998 Genomic DNA. Translation: AEM20477.1 .
RefSeqi YP_002519393.1. NC_004311.2.
YP_005614703.1. NC_017250.1.

3D structure databases

ProteinModelPortali Q60CV4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BRA1033.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV28867 ; AAV28867 ; BRA1033 .
AEM20477 ; AEM20477 ; BS1330_II1025 .
GeneIDi 1165478.
12139258.
KEGGi bms:BRA1033.
bsi:BS1330_II1025.
PATRICi 17794901. VBIBruSui107850_3258.

Phylogenomic databases

eggNOGi COG0101.
HOGENOMi HOG000248672.
KOi K06173.
OrthoDBi EOG6Z9B4R.

Family and domain databases

Gene3Di 3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPi MF_00171. TruA.
InterProi IPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view ]
PANTHERi PTHR11142. PTHR11142. 1 hit.
Pfami PF01416. PseudoU_synth_1. 2 hits.
[Graphical view ]
PIRSFi PIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMi SSF55120. SSF55120. 1 hit.
TIGRFAMsi TIGR00071. hisT_truA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiTRUA_BRUSU
AccessioniPrimary (citable) accession number: Q60CV4
Secondary accession number(s): G0KE39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 23, 2004
Last modified: October 1, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3