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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63SubstrateUniRule annotation1
Binding sitei138SubstrateUniRule annotation1
Binding sitei198SubstrateUniRule annotation1
Binding sitei228SubstrateUniRule annotation1
Binding sitei232SubstrateUniRule annotation1
Binding sitei233NADUniRule annotation1
Binding sitei285NADUniRule annotation1
Binding sitei320NADUniRule annotation1
Binding sitei386NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 201NADUniRule annotation3
Nucleotide bindingi262 – 267NADUniRule annotation6
Nucleotide bindingi341 – 343NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:MCA0138
OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Taxonomic identifieri243233 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
Proteomesi
  • UP000006821 Componenti: Chromosome

Subcellular locationi

Q60CG8:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001169671 – 472AdenosylhomocysteinaseAdd BLAST472

Interactioni

Protein-protein interaction databases

STRINGi243233.MCA0138.

Structurei

3D structure databases

ProteinModelPortaliQ60CG8.
SMRiQ60CG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227986.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60CG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAVANAASF DDHKVADLSL AGWGRKEIAI AETEMPGLMA IREEYRAAQP
60 70 80 90 100
LKGARIAGSL HMTIQTAVLI ETLVALGAEV RWASCNIFST QDHAAAAIAA
110 120 130 140 150
DGIPVFAYKG ESLDDYWEYT HRILEWPGDV GPNMILDDGG DATLLVTLGA
160 170 180 190 200
RAEKDASLLA NPTCEEEEVL FAAIRKRLAA KPGWYSRIQA GIKGVTEETT
210 220 230 240 250
TGVHRLYEMQ AKGRLPFPAI NVNDSVTKSK FDNLYGCRES LVDGIKRATD
260 270 280 290 300
VMIAGKIAVV LGYGDVGKGC AQSLRGLGAT VWITEIDPIC ALQAAMEGYR
310 320 330 340 350
VVTMDEACDK ADIFVTATGN VGVITHDHMV KMKDQAIVCN IGHFDSEIEV
360 370 380 390 400
AAMRQYTWEN IKPQVDHIVL PNGRRIILLA EGRLVNLGCA TGHPSFVMSN
410 420 430 440 450
SFTNQTLAQI ELFCHGAKYE NKVYVLPKHL DEKVARLHLK KIGARLTELS
460 470
DEQAAYIGVP KEGPYKPDHY RY
Length:472
Mass (Da):51,600
Last modified:November 23, 2004 - v1
Checksum:iE73783EF2DB52F9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017282 Genomic DNA. Translation: AAU90631.1.
RefSeqiWP_010959508.1. NC_002977.6.

Genome annotation databases

EnsemblBacteriaiAAU90631; AAU90631; MCA0138.
KEGGimca:MCA0138.

Similar proteinsi

Entry informationi

Entry nameiSAHH_METCA
AccessioniPrimary (citable) accession number: Q60CG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 23, 2004
Last modified: October 25, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families