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Q60BW4 (GCSPA_METCA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:MCA0349
OrganismMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) [Complete proteome] [HAMAP]
Taxonomic identifier243233 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000045668

Sequences

Sequence LengthMass (Da)Tools
Q60BW4 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 6150023E26AA68E9

FASTA45349,164
        10         20         30         40         50         60 
MPFIPHTEAE VRDMLAAIGA GSIDELFAEI PPDLRCGELK DLPEALSEME VCKLMEERAA 

        70         80         90        100        110        120 
ENRSALCFAG AGAYEHYIPA AVWEIALRGE FYSAYTPYQA EASQGSLQVF YEYQSMMAGL 

       130        140        150        160        170        180 
MAMDVSNASL YDGASALGEA ILMALRTNPE SRSRKILLPR SLNPVYKRVV RTLTRNQRVE 

       190        200        210        220        230        240 
LVDLDYDRSL GRIAENALET FEGGEFAAVV IPQPNHFGVL EEVDVLADWA HRHGARSIAV 

       250        260        270        280        290        300 
VNPTAMALLK PPGEWGEHGA DLACGEGQPL GIPLSAGGPY FGFLCSRQDF VHQLPGRLVG 

       310        320        330        340        350        360 
RTVDVDGREG FTLTLQPREQ HIRRGKATSN ICTNQGLMVT AATLYMALMG PKGLRNVAAA 

       370        380        390        400        410        420 
CHANASALLE RLTRIDGVEP VFPAPFFHEA AIRLPRAADR VLAGLAERGI LGGHVLSADY 

       430        440        450 
PELGDALLIC ATETRGPEDM DRYAAALAEV LEC 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017282 Genomic DNA. Translation: AAU90546.1.
RefSeqYP_112881.1. NC_002977.6.

3D structure databases

ProteinModelPortalQ60BW4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243233.MCA0349.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU90546; AAU90546; MCA0349.
GeneID3105095.
KEGGmca:MCA0349.
PATRIC22604441. VBIMetCap22254_0362.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
OrthoDBEOG6XWV3B.
ProtClustDBPRK00451.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_METCA
AccessionPrimary (citable) accession number: Q60BW4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 23, 2004
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families