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Q60BW4

- GCSPA_METCA

UniProt

Q60BW4 - GCSPA_METCA

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, MCA0349
Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:MCA0349
OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Taxonomic identifieri243233 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
ProteomesiUP000006821: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_1000045668Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi243233.MCA0349.

Structurei

3D structure databases

ProteinModelPortaliQ60BW4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60BW4-1 [UniParc]FASTAAdd to Basket

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MPFIPHTEAE VRDMLAAIGA GSIDELFAEI PPDLRCGELK DLPEALSEME    50
VCKLMEERAA ENRSALCFAG AGAYEHYIPA AVWEIALRGE FYSAYTPYQA 100
EASQGSLQVF YEYQSMMAGL MAMDVSNASL YDGASALGEA ILMALRTNPE 150
SRSRKILLPR SLNPVYKRVV RTLTRNQRVE LVDLDYDRSL GRIAENALET 200
FEGGEFAAVV IPQPNHFGVL EEVDVLADWA HRHGARSIAV VNPTAMALLK 250
PPGEWGEHGA DLACGEGQPL GIPLSAGGPY FGFLCSRQDF VHQLPGRLVG 300
RTVDVDGREG FTLTLQPREQ HIRRGKATSN ICTNQGLMVT AATLYMALMG 350
PKGLRNVAAA CHANASALLE RLTRIDGVEP VFPAPFFHEA AIRLPRAADR 400
VLAGLAERGI LGGHVLSADY PELGDALLIC ATETRGPEDM DRYAAALAEV 450
LEC 453
Length:453
Mass (Da):49,164
Last modified:November 23, 2004 - v1
Checksum:i6150023E26AA68E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017282 Genomic DNA. Translation: AAU90546.1.
RefSeqiYP_112881.1. NC_002977.6.

Genome annotation databases

EnsemblBacteriaiAAU90546; AAU90546; MCA0349.
GeneIDi3105095.
KEGGimca:MCA0349.
PATRICi22604441. VBIMetCap22254_0362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017282 Genomic DNA. Translation: AAU90546.1 .
RefSeqi YP_112881.1. NC_002977.6.

3D structure databases

ProteinModelPortali Q60BW4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243233.MCA0349.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU90546 ; AAU90546 ; MCA0349 .
GeneIDi 3105095.
KEGGi mca:MCA0349.
PATRICi 22604441. VBIMetCap22254_0362.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33009 / NCIMB 11132 / Bath.

Entry informationi

Entry nameiGCSPA_METCA
AccessioniPrimary (citable) accession number: Q60BW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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