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Q609X7

- ASSY_METCA

UniProt

Q609X7 - ASSY_METCA

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Protein
Argininosuccinate synthase
Gene
argG, MCA1099
Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei90 – 901Citrulline By similarity
Binding sitei95 – 951Citrulline By similarity
Binding sitei120 – 1201ATP; via amide nitrogen By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei126 – 1261Aspartate By similarity
Binding sitei126 – 1261Citrulline By similarity
Binding sitei127 – 1271Aspartate By similarity
Binding sitei130 – 1301Citrulline By similarity
Binding sitei181 – 1811Citrulline By similarity
Binding sitei190 – 1901Citrulline By similarity
Binding sitei266 – 2661Citrulline By similarity
Binding sitei278 – 2781Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 209ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:MCA1099
OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Taxonomic identifieri243233 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
ProteomesiUP000006821: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Argininosuccinate synthaseUniRule annotation
PRO_0000148611Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243233.MCA1099.

Structurei

3D structure databases

ProteinModelPortaliQ609X7.
SMRiQ609X7. Positions 8-399.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q609X7-1 [UniParc]FASTAAdd to Basket

« Hide

MSSSNVKKVA LAYSGGLDTS VILKWLQETY GCEVVTFTAD LGQGEEVEPA    50
RAKAQAMGVK EIYIDDLREE FSRDFVFPMF RANAIYEGEY LLGTSIARPL 100
IAKRLIEIAN ETGADAIAHG ATGKGNDQVR FELGAYALRP DIRVIAPWRE 150
WELTSRETLL AYAESRGIPI EMKRGKTSPY SMDANLLHIS YEGGILEDPW 200
AEPEETMWRW SVSPENAPDR PTYVELTYEH GDIVAIDGER MTAAAVLARL 250
NQLGGANGIG RLDIVENRYV GMKSRGCYET PGGTIMLKAH RAIESITLDR 300
EVAHLKDELM PRYASLIYNG YWWSPERRML QQMIDASQAT VNGVVRVKLY 350
KGNVSVVGRK SESNSLFDMN IATFEDDRGA YDQKDAEGFI KLNALRLRIA 400
GRKGASFA 408
Length:408
Mass (Da):45,511
Last modified:November 23, 2004 - v1
Checksum:i567D8160689206A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017282 Genomic DNA. Translation: AAU92618.1.
RefSeqiYP_113570.1. NC_002977.6.

Genome annotation databases

EnsemblBacteriaiAAU92618; AAU92618; MCA1099.
GeneIDi3102446.
KEGGimca:MCA1099.
PATRICi22606018. VBIMetCap22254_1125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017282 Genomic DNA. Translation: AAU92618.1 .
RefSeqi YP_113570.1. NC_002977.6.

3D structure databases

ProteinModelPortali Q609X7.
SMRi Q609X7. Positions 8-399.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243233.MCA1099.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU92618 ; AAU92618 ; MCA1099 .
GeneIDi 3102446.
KEGGi mca:MCA1099.
PATRICi 22606018. VBIMetCap22254_1125.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33009 / NCIMB 11132 / Bath.

Entry informationi

Entry nameiASSY_METCA
AccessioniPrimary (citable) accession number: Q609X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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