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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei353 – 3531Proton donorUniRule annotation
Active sitei384 – 3841UniRule annotation
Active sitei512 – 5121UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:MCA1247
OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Taxonomic identifieri243233 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
ProteomesiUP000006821: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 546546Glucose-6-phosphate isomerasePRO_0000180672Add
BLAST

Proteomic databases

PRIDEiQ609I7.

Interactioni

Protein-protein interaction databases

STRINGi243233.MCA1247.

Structurei

3D structure databases

ProteinModelPortaliQ609I7.
SMRiQ609I7. Positions 4-546.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q609I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQSTDLPAW RTLSEHFKTI APRHMRDMFA DDPGRFEAFS VRLGDLLFDY
60 70 80 90 100
SKNRITRETV ATLIQLAEEA GLREKIDAMF RGERLNVTEN RAVLHVALRN
110 120 130 140 150
RSNRPIRVDG KDVMPEVNRV LDRMRRFSQS VRTGEWRGAT GKAITDVVNI
160 170 180 190 200
GIGGSDLGPK MVVKALQPYA DPRLRAHFVS NVDESDLVEI LRPLNPETTL
210 220 230 240 250
FVVASKTFTT QETMTNGRSA RAWFLERISD ESAIARHFVA ISTNRNKVAE
260 270 280 290 300
FGIDPRNMFE FWDWVGGRYS LWSAIGLPIA LSVGMDRFEE LLEGAHFVDE
310 320 330 340 350
HFRTAPFERN IPVLMGLLGI WYINFFGAQS HAVLPYDQYL EDLPAHLQQA
360 370 380 390 400
DMESNGKTVD VEGRPVNYST GPVIFGQPGT NGQHAFYQLL HQGSMLVPCD
410 420 430 440 450
FLAAAESHHP LAEHHDILIS NFLAQTEALM RGRTTDEARQ EIASEELPPE
460 470 480 490 500
RLEALAAAKT FPGNKPTNSF LYRRLDPHTL GMLIALYEHK IFTQGVIWYI
510 520 530 540
NSFDQMGVEL GKQLAKTILA ELPGDAPVAS HDASTNGLIR YFKSLR
Length:546
Mass (Da):61,530
Last modified:November 23, 2004 - v1
Checksum:i6944A9E2C776464C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017282 Genomic DNA. Translation: AAU92469.1.
RefSeqiWP_010960530.1. NC_002977.6.
YP_113710.1. NC_002977.6.

Genome annotation databases

EnsemblBacteriaiAAU92469; AAU92469; MCA1247.
GeneIDi3104273.
KEGGimca:MCA1247.
PATRICi22606330. VBIMetCap22254_1279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017282 Genomic DNA. Translation: AAU92469.1.
RefSeqiWP_010960530.1. NC_002977.6.
YP_113710.1. NC_002977.6.

3D structure databases

ProteinModelPortaliQ609I7.
SMRiQ609I7. Positions 4-546.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243233.MCA1247.

Proteomic databases

PRIDEiQ609I7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU92469; AAU92469; MCA1247.
GeneIDi3104273.
KEGGimca:MCA1247.
PATRICi22606330. VBIMetCap22254_1279.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33009 / NCIMB 11132 / Bath.

Entry informationi

Entry nameiG6PI_METCA
AccessioniPrimary (citable) accession number: Q609I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: November 23, 2004
Last modified: January 7, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.