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Protein
Submitted name:

Protein tyrosine phosphatase phi, long insert variant

Gene

Ptpro

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase phi, long insert variantImported
Gene namesi
Name:PtproImported
Synonyms:PTPphiImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1097152. Ptpro.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3322HelicalSequence analysisAdd
BLAST
Transmembranei69 – 9022HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ60998.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076364.

Structurei

3D structure databases

ProteinModelPortaliQ60998.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini127 – 384258Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini301 – 37575TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
HOVERGENiHBG053969.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTEVNPNVV VISVLAILST LLIGLLLVTL VILRKKHLQM ARECGAGTFV
60 70 80 90 100
NFASLEREGK LPYSWRRSVF ALLTLLPSCL WTDYLLAFYI NPWSKNGLKK
110 120 130 140 150
RKLTNPVQLD DFDSYIKDMA KDSDYKFSLQ FEELKLIGLD IPHFAADLPL
160 170 180 190 200
NRCKNRYTNI LPYDFSRVRL VSMNEEEGAD YINANYIPGY NSPQEYIATQ
210 220 230 240 250
GPLPETRNDF WKMVLQQKSH IIVMLTQCNE KRRVKCDHYW PFTEEPIAYG
260 270 280 290 300
DITVEMVSEE EEEDWASRHF RINYADEAQD VMHFNYTGWP DHGVPPANAA
310 320 330 340 350
ESILQFVFTV RQQAAKSKGP MIIHCSAGVG RTGTFIALDR LLQHIRDHEF
360 370 380 390 400
VDILGLVSEM RSYRMSMVQT EEQYIFIHQC VQLMWLRKKQ QFCISDVIYE

NVSKS
Length:405
Mass (Da):46,948
Last modified:November 1, 1996 - v1
Checksum:i0DA781001EB1E2B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37465 mRNA. Translation: AAC52311.1.
PIRiI49372.
UniGeneiMm.186361.
Mm.491536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37465 mRNA. Translation: AAC52311.1.
PIRiI49372.
UniGeneiMm.186361.
Mm.491536.

3D structure databases

ProteinModelPortaliQ60998.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076364.

Proteomic databases

PaxDbiQ60998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1097152. Ptpro.

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
HOVERGENiHBG053969.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A heteromorphic protein-tyrosine phosphatase, PTP phi, is regulated by CSF-1 in macrophages."
    Pixley F.J., Lee P.S., Dominguez M.G., Einstein D.B., Stanley E.R.
    J. Biol. Chem. 270:27339-27347(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ60998_MOUSE
AccessioniPrimary (citable) accession number: Q60998
Secondary accession number(s): Q60999, Q61000
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.