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Protein

Forkhead box protein G1

Gene

Foxg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi172 – 26392Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. axon midline choice point recognition Source: MGI
  2. cell morphogenesis involved in neuron differentiation Source: MGI
  3. central nervous system neuron development Source: MGI
  4. cerebral cortex development Source: MGI
  5. dorsal/ventral pattern formation Source: MGI
  6. forebrain development Source: MGI
  7. inner ear morphogenesis Source: MGI
  8. negative regulation of neuron differentiation Source: MGI
  9. negative regulation of transcription, DNA-templated Source: MGI
  10. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  11. neurogenesis Source: MGI
  12. neuron fate determination Source: MGI
  13. positive regulation of cell cycle Source: MGI
  14. positive regulation of neuroblast proliferation Source: MGI
  15. positive regulation of neuron differentiation Source: MGI
  16. pyramidal neuron migration Source: MGI
  17. regulation of cell cycle Source: MGI
  18. regulation of gene expression Source: MGI
  19. regulation of mitotic cell cycle Source: MGI
  20. regulation of neural precursor cell proliferation Source: MGI
  21. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein G1
Short name:
FoxG1
Alternative name(s):
Brain factor 1
Short name:
BF-1
Short name:
BF1
Forkhead-related protein FKHL1
Gene namesi
Name:Foxg1
Synonyms:Fkhl1, Foxg1b, Hfhbf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1347464. Foxg1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Forkhead box protein G1PRO_0000091837Add
BLAST

Proteomic databases

PaxDbiQ60987.
PRIDEiQ60987.

PTM databases

PhosphoSiteiQ60987.

Expressioni

Tissue specificityi

CNS, and nasal half of the retina.

Gene expression databases

BgeeiQ60987.
CleanExiMM_FOXG1.
ExpressionAtlasiQ60987. baseline and differential.
GenevestigatoriQ60987.

Interactioni

Subunit structurei

Interacts with KDM5B.By similarity

Protein-protein interaction databases

BioGridi200291. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ60987.
SMRiQ60987. Positions 173-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni375 – 39824Interaction with KDM5BBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 5624His-richAdd
BLAST
Compositional biasi57 – 8327Pro-richAdd
BLAST
Compositional biasi70 – 756Poly-Gln

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00780000121840.
HOGENOMiHOG000112629.
HOVERGENiHBG051645.
InParanoidiQ60987.
KOiK09385.
OMAiYPSHPMS.
OrthoDBiEOG7N37DT.
PhylomeDBiQ60987.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60987-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH
60 70 80 90 100
HHHHHHPPPP APQPPPPPPQ QQQQQPPPAP QPPQARGAPA ADDDKGPQPL
110 120 130 140 150
LLPPSTALDG AKADALGAKG EPGGGPAELA PVGPDEKEKG AGAGGEEKKG
160 170 180 190 200
AGEGGKDGEG GKEGDKKNGK YEKPPFSYNA LIMMAIRQSP EKRLTLNGIY
210 220 230 240 250
EFIMKNFPYY RENKQGWQNS IRHNLSLNKC FVKVPRHYDD PGKGNYWMLD
260 270 280 290 300
PSSDDVFIGG TTGKLRRRST TSRAKLAFKR GARLTSTGLT FMDRAGSLYW
310 320 330 340 350
PMSPFLSLHH PRASSTLSYN GTTSAYPSHP MPYSSVLTQN SLGNNHSFST
360 370 380 390 400
ANGLSVDRLV NGEIPYATHH LTAAALAASV PCGLSVPCSG TYSLNPCSVN
410 420 430 440 450
LLAGQTSYFF PHVPHPSMTS QTSTSMSARA ASSSTSPQAP STLPCESLRP
460 470 480
SLPSFTTGLS GGLSDYFTHQ NQGSSSNPLI H
Length:481
Mass (Da):51,625
Last modified:November 1, 1997 - v1
Checksum:iFF6786C3513AB452
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36760 mRNA. Translation: AAB42158.1.
BC046958 mRNA. Translation: AAH46958.2.
CCDSiCCDS25899.1.
RefSeqiNP_001153584.1. NM_001160112.1.
NP_032267.1. NM_008241.2.
UniGeneiMm.4704.

Genome annotation databases

EnsembliENSMUST00000021333; ENSMUSP00000021333; ENSMUSG00000020950.
ENSMUST00000179669; ENSMUSP00000136372; ENSMUSG00000020950.
GeneIDi15228.
KEGGimmu:15228.
UCSCiuc007nmf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36760 mRNA. Translation: AAB42158.1.
BC046958 mRNA. Translation: AAH46958.2.
CCDSiCCDS25899.1.
RefSeqiNP_001153584.1. NM_001160112.1.
NP_032267.1. NM_008241.2.
UniGeneiMm.4704.

3D structure databases

ProteinModelPortaliQ60987.
SMRiQ60987. Positions 173-261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200291. 4 interactions.

PTM databases

PhosphoSiteiQ60987.

Proteomic databases

PaxDbiQ60987.
PRIDEiQ60987.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021333; ENSMUSP00000021333; ENSMUSG00000020950.
ENSMUST00000179669; ENSMUSP00000136372; ENSMUSG00000020950.
GeneIDi15228.
KEGGimmu:15228.
UCSCiuc007nmf.2. mouse.

Organism-specific databases

CTDi2290.
MGIiMGI:1347464. Foxg1.

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00780000121840.
HOGENOMiHOG000112629.
HOVERGENiHBG051645.
InParanoidiQ60987.
KOiK09385.
OMAiYPSHPMS.
OrthoDBiEOG7N37DT.
PhylomeDBiQ60987.
TreeFamiTF316127.

Miscellaneous databases

ChiTaRSiFoxg1. mouse.
NextBioi287819.
PROiQ60987.
SOURCEiSearch...

Gene expression databases

BgeeiQ60987.
CleanExiMM_FOXG1.
ExpressionAtlasiQ60987. baseline and differential.
GenevestigatoriQ60987.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the structure and function of the gene for transcription factor BF-1, an essential regulator of forebrain development."
    Li H., Tao W., Lai E.
    Brain Res. Mol. Brain Res. 37:96-104(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiFOXG1_MOUSE
AccessioniPrimary (citable) accession number: Q60987
Secondary accession number(s): Q80VP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 1, 2015
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.