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Protein

Forkhead box protein G1

Gene

Foxg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi172 – 263Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

  • axon midline choice point recognition Source: MGI
  • cell morphogenesis involved in neuron differentiation Source: MGI
  • central nervous system neuron development Source: MGI
  • cerebral cortex development Source: MGI
  • dorsal/ventral pattern formation Source: MGI
  • forebrain development Source: MGI
  • inner ear morphogenesis Source: MGI
  • negative regulation of neuron differentiation Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • neurogenesis Source: MGI
  • neuron fate determination Source: MGI
  • positive regulation of cell cycle Source: MGI
  • positive regulation of neuroblast proliferation Source: MGI
  • positive regulation of neuron differentiation Source: MGI
  • pyramidal neuron migration Source: MGI
  • regulation of cell cycle Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of mitotic cell cycle Source: MGI
  • regulation of neural precursor cell proliferation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein G1
Short name:
FoxG1
Alternative name(s):
Brain factor 1
Short name:
BF-1
Short name:
BF1
Forkhead-related protein FKHL1
Gene namesi
Name:Foxg1
Synonyms:Fkhl1, Foxg1b, Hfhbf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1347464. Foxg1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918371 – 481Forkhead box protein G1Add BLAST481

Proteomic databases

MaxQBiQ60987.
PaxDbiQ60987.
PRIDEiQ60987.

PTM databases

iPTMnetiQ60987.
PhosphoSitePlusiQ60987.

Expressioni

Tissue specificityi

CNS, and nasal half of the retina.

Gene expression databases

BgeeiENSMUSG00000020950.
CleanExiMM_FOXG1.
ExpressionAtlasiQ60987. baseline and differential.
GenevisibleiQ60987. MM.

Interactioni

Subunit structurei

Interacts with KDM5B.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FOXO3O435245EBI-11166131,EBI-1644164From Homo sapiens.

Protein-protein interaction databases

BioGridi200291. 4 interactors.
IntActiQ60987. 3 interactors.
STRINGi10090.ENSMUSP00000021333.

Structurei

3D structure databases

ProteinModelPortaliQ60987.
SMRiQ60987.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni375 – 398Interaction with KDM5BBy similarityAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 56His-richAdd BLAST24
Compositional biasi57 – 83Pro-richAdd BLAST27
Compositional biasi70 – 75Poly-Gln6

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
HOGENOMiHOG000112629.
HOVERGENiHBG051645.
InParanoidiQ60987.
KOiK09385.
OMAiLPYATHH.
OrthoDBiEOG091G0JF7.
PhylomeDBiQ60987.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60987-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH
60 70 80 90 100
HHHHHHPPPP APQPPPPPPQ QQQQQPPPAP QPPQARGAPA ADDDKGPQPL
110 120 130 140 150
LLPPSTALDG AKADALGAKG EPGGGPAELA PVGPDEKEKG AGAGGEEKKG
160 170 180 190 200
AGEGGKDGEG GKEGDKKNGK YEKPPFSYNA LIMMAIRQSP EKRLTLNGIY
210 220 230 240 250
EFIMKNFPYY RENKQGWQNS IRHNLSLNKC FVKVPRHYDD PGKGNYWMLD
260 270 280 290 300
PSSDDVFIGG TTGKLRRRST TSRAKLAFKR GARLTSTGLT FMDRAGSLYW
310 320 330 340 350
PMSPFLSLHH PRASSTLSYN GTTSAYPSHP MPYSSVLTQN SLGNNHSFST
360 370 380 390 400
ANGLSVDRLV NGEIPYATHH LTAAALAASV PCGLSVPCSG TYSLNPCSVN
410 420 430 440 450
LLAGQTSYFF PHVPHPSMTS QTSTSMSARA ASSSTSPQAP STLPCESLRP
460 470 480
SLPSFTTGLS GGLSDYFTHQ NQGSSSNPLI H
Length:481
Mass (Da):51,625
Last modified:November 1, 1997 - v1
Checksum:iFF6786C3513AB452
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36760 mRNA. Translation: AAB42158.1.
BC046958 mRNA. Translation: AAH46958.2.
CCDSiCCDS25899.1.
RefSeqiNP_001153584.1. NM_001160112.1.
NP_032267.1. NM_008241.2.
UniGeneiMm.4704.

Genome annotation databases

EnsembliENSMUST00000021333; ENSMUSP00000021333; ENSMUSG00000020950.
ENSMUST00000179669; ENSMUSP00000136372; ENSMUSG00000020950.
GeneIDi15228.
KEGGimmu:15228.
UCSCiuc007nmf.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFOXG1_MOUSE
AccessioniPrimary (citable) accession number: Q60987
Secondary accession number(s): Q80VP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 5, 2017
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot