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Q60987 (FOXG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein G1

Short name=FoxG1
Alternative name(s):
Brain factor 1
Short name=BF-1
Short name=BF1
Forkhead-related protein FKHL1
Gene names
Name:Foxg1
Synonyms:Fkhl1, Foxg1b, Hfhbf1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon By similarity.

Subunit structure

Interacts with KDM5B By similarity.

Subcellular location

Nucleus.

Tissue specificity

CNS, and nasal half of the retina.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaging

Inferred from electronic annotation. Source: Ensembl

axon midline choice point recognition

Inferred from mutant phenotype PubMed 15240555. Source: MGI

cell morphogenesis involved in neuron differentiation

Inferred from mutant phenotype PubMed 16691564. Source: MGI

central nervous system neuron development

Inferred from mutant phenotype PubMed 16680166. Source: MGI

cerebral cortex development

Inferred from direct assay PubMed 22726835. Source: MGI

dorsal/ventral pattern formation

Inferred from mutant phenotype PubMed 14566948PubMed 15893304. Source: MGI

forebrain development

Inferred from mutant phenotype PubMed 12151532PubMed 14566948PubMed 14704420PubMed 7605629. Source: MGI

inner ear morphogenesis

Inferred from mutant phenotype PubMed 16691564. Source: MGI

negative regulation of neuron differentiation

Inferred from mutant phenotype PubMed 12151532PubMed 14704420PubMed 7605629. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

neurogenesis

Inferred from direct assay PubMed 18184563. Source: MGI

neuron fate determination

Inferred from direct assay PubMed 22726835. Source: MGI

positive regulation of cell cycle

Inferred from mutant phenotype PubMed 15893304. Source: MGI

positive regulation of neuroblast proliferation

Inferred from mutant phenotype PubMed 15893304. Source: MGI

pyramidal neuron migration

Inferred from direct assay PubMed 22726835. Source: MGI

regulation of cell cycle

Inferred from direct assay PubMed 22726835. Source: MGI

regulation of gene expression

Inferred from mutant phenotype PubMed 22726835. Source: MGI

regulation of mitotic cell cycle

Inferred from mutant phenotype PubMed 12151532. Source: MGI

regulation of neural precursor cell proliferation

Inferred from genetic interaction PubMed 22516202. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay PubMed 18842901. Source: MGI

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 481481Forkhead box protein G1
PRO_0000091837

Regions

DNA binding172 – 26392Fork-head
Region375 – 39824Interaction with KDM5B By similarity
Compositional bias33 – 5624His-rich
Compositional bias57 – 8327Pro-rich
Compositional bias70 – 756Poly-Gln

Sequences

Sequence LengthMass (Da)Tools
Q60987 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: FF6786C3513AB452

FASTA48151,625
        10         20         30         40         50         60 
MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHPPPP 

        70         80         90        100        110        120 
APQPPPPPPQ QQQQQPPPAP QPPQARGAPA ADDDKGPQPL LLPPSTALDG AKADALGAKG 

       130        140        150        160        170        180 
EPGGGPAELA PVGPDEKEKG AGAGGEEKKG AGEGGKDGEG GKEGDKKNGK YEKPPFSYNA 

       190        200        210        220        230        240 
LIMMAIRQSP EKRLTLNGIY EFIMKNFPYY RENKQGWQNS IRHNLSLNKC FVKVPRHYDD 

       250        260        270        280        290        300 
PGKGNYWMLD PSSDDVFIGG TTGKLRRRST TSRAKLAFKR GARLTSTGLT FMDRAGSLYW 

       310        320        330        340        350        360 
PMSPFLSLHH PRASSTLSYN GTTSAYPSHP MPYSSVLTQN SLGNNHSFST ANGLSVDRLV 

       370        380        390        400        410        420 
NGEIPYATHH LTAAALAASV PCGLSVPCSG TYSLNPCSVN LLAGQTSYFF PHVPHPSMTS 

       430        440        450        460        470        480 
QTSTSMSARA ASSSTSPQAP STLPCESLRP SLPSFTTGLS GGLSDYFTHQ NQGSSSNPLI 


H 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the structure and function of the gene for transcription factor BF-1, an essential regulator of forebrain development."
Li H., Tao W., Lai E.
Brain Res. Mol. Brain Res. 37:96-104(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U36760 mRNA. Translation: AAB42158.1.
BC046958 mRNA. Translation: AAH46958.2.
CCDSCCDS25899.1.
RefSeqNP_001153584.1. NM_001160112.1.
NP_032267.1. NM_008241.2.
UniGeneMm.4704.

3D structure databases

ProteinModelPortalQ60987.
SMRQ60987. Positions 173-261.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200291. 4 interactions.

PTM databases

PhosphoSiteQ60987.

Proteomic databases

PaxDbQ60987.
PRIDEQ60987.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021333; ENSMUSP00000021333; ENSMUSG00000020950.
ENSMUST00000179669; ENSMUSP00000136372; ENSMUSG00000020950.
GeneID15228.
KEGGmmu:15228.
UCSCuc007nmf.2. mouse.

Organism-specific databases

CTD2290.
MGIMGI:1347464. Foxg1.

Phylogenomic databases

eggNOGCOG5025.
GeneTreeENSGT00750000117270.
HOGENOMHOG000112629.
HOVERGENHBG051645.
InParanoidQ60987.
KOK09385.
OMAHPMSYST.
OrthoDBEOG7N37DT.
PhylomeDBQ60987.
TreeFamTF316127.

Gene expression databases

BgeeQ60987.
CleanExMM_FOXG1.
GenevestigatorQ60987.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFOXG1. mouse.
NextBio287819.
PROQ60987.
SOURCESearch...

Entry information

Entry nameFOXG1_MOUSE
AccessionPrimary (citable) accession number: Q60987
Secondary accession number(s): Q80VP3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot