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Q60987

- FOXG1_MOUSE

UniProt

Q60987 - FOXG1_MOUSE

Protein

Forkhead box protein G1

Gene

Foxg1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi172 – 26392Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. aging Source: Ensembl
    2. axon midline choice point recognition Source: MGI
    3. cell morphogenesis involved in neuron differentiation Source: MGI
    4. central nervous system neuron development Source: MGI
    5. cerebral cortex development Source: MGI
    6. dorsal/ventral pattern formation Source: MGI
    7. forebrain development Source: MGI
    8. inner ear morphogenesis Source: MGI
    9. negative regulation of neuron differentiation Source: MGI
    10. negative regulation of transcription, DNA-templated Source: Ensembl
    11. neurogenesis Source: MGI
    12. neuron fate determination Source: MGI
    13. positive regulation of cell cycle Source: MGI
    14. positive regulation of neuroblast proliferation Source: MGI
    15. pyramidal neuron migration Source: MGI
    16. regulation of cell cycle Source: MGI
    17. regulation of gene expression Source: MGI
    18. regulation of mitotic cell cycle Source: MGI
    19. regulation of neural precursor cell proliferation Source: MGI
    20. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein G1
    Short name:
    FoxG1
    Alternative name(s):
    Brain factor 1
    Short name:
    BF-1
    Short name:
    BF1
    Forkhead-related protein FKHL1
    Gene namesi
    Name:Foxg1
    Synonyms:Fkhl1, Foxg1b, Hfhbf1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1347464. Foxg1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 481481Forkhead box protein G1PRO_0000091837Add
    BLAST

    Proteomic databases

    PaxDbiQ60987.
    PRIDEiQ60987.

    PTM databases

    PhosphoSiteiQ60987.

    Expressioni

    Tissue specificityi

    CNS, and nasal half of the retina.

    Gene expression databases

    BgeeiQ60987.
    CleanExiMM_FOXG1.
    GenevestigatoriQ60987.

    Interactioni

    Subunit structurei

    Interacts with KDM5B.By similarity

    Protein-protein interaction databases

    BioGridi200291. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60987.
    SMRiQ60987. Positions 173-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni375 – 39824Interaction with KDM5BBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi33 – 5624His-richAdd
    BLAST
    Compositional biasi57 – 8327Pro-richAdd
    BLAST
    Compositional biasi70 – 756Poly-Gln

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    GeneTreeiENSGT00750000117270.
    HOGENOMiHOG000112629.
    HOVERGENiHBG051645.
    InParanoidiQ60987.
    KOiK09385.
    OMAiHPMSYST.
    OrthoDBiEOG7N37DT.
    PhylomeDBiQ60987.
    TreeFamiTF316127.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60987-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH    50
    HHHHHHPPPP APQPPPPPPQ QQQQQPPPAP QPPQARGAPA ADDDKGPQPL 100
    LLPPSTALDG AKADALGAKG EPGGGPAELA PVGPDEKEKG AGAGGEEKKG 150
    AGEGGKDGEG GKEGDKKNGK YEKPPFSYNA LIMMAIRQSP EKRLTLNGIY 200
    EFIMKNFPYY RENKQGWQNS IRHNLSLNKC FVKVPRHYDD PGKGNYWMLD 250
    PSSDDVFIGG TTGKLRRRST TSRAKLAFKR GARLTSTGLT FMDRAGSLYW 300
    PMSPFLSLHH PRASSTLSYN GTTSAYPSHP MPYSSVLTQN SLGNNHSFST 350
    ANGLSVDRLV NGEIPYATHH LTAAALAASV PCGLSVPCSG TYSLNPCSVN 400
    LLAGQTSYFF PHVPHPSMTS QTSTSMSARA ASSSTSPQAP STLPCESLRP 450
    SLPSFTTGLS GGLSDYFTHQ NQGSSSNPLI H 481
    Length:481
    Mass (Da):51,625
    Last modified:November 1, 1997 - v1
    Checksum:iFF6786C3513AB452
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36760 mRNA. Translation: AAB42158.1.
    BC046958 mRNA. Translation: AAH46958.2.
    CCDSiCCDS25899.1.
    RefSeqiNP_001153584.1. NM_001160112.1.
    NP_032267.1. NM_008241.2.
    UniGeneiMm.4704.

    Genome annotation databases

    EnsembliENSMUST00000021333; ENSMUSP00000021333; ENSMUSG00000020950.
    ENSMUST00000179669; ENSMUSP00000136372; ENSMUSG00000020950.
    GeneIDi15228.
    KEGGimmu:15228.
    UCSCiuc007nmf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36760 mRNA. Translation: AAB42158.1 .
    BC046958 mRNA. Translation: AAH46958.2 .
    CCDSi CCDS25899.1.
    RefSeqi NP_001153584.1. NM_001160112.1.
    NP_032267.1. NM_008241.2.
    UniGenei Mm.4704.

    3D structure databases

    ProteinModelPortali Q60987.
    SMRi Q60987. Positions 173-261.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200291. 4 interactions.

    PTM databases

    PhosphoSitei Q60987.

    Proteomic databases

    PaxDbi Q60987.
    PRIDEi Q60987.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021333 ; ENSMUSP00000021333 ; ENSMUSG00000020950 .
    ENSMUST00000179669 ; ENSMUSP00000136372 ; ENSMUSG00000020950 .
    GeneIDi 15228.
    KEGGi mmu:15228.
    UCSCi uc007nmf.2. mouse.

    Organism-specific databases

    CTDi 2290.
    MGIi MGI:1347464. Foxg1.

    Phylogenomic databases

    eggNOGi COG5025.
    GeneTreei ENSGT00750000117270.
    HOGENOMi HOG000112629.
    HOVERGENi HBG051645.
    InParanoidi Q60987.
    KOi K09385.
    OMAi HPMSYST.
    OrthoDBi EOG7N37DT.
    PhylomeDBi Q60987.
    TreeFami TF316127.

    Miscellaneous databases

    ChiTaRSi FOXG1. mouse.
    NextBioi 287819.
    PROi Q60987.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q60987.
    CleanExi MM_FOXG1.
    Genevestigatori Q60987.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the structure and function of the gene for transcription factor BF-1, an essential regulator of forebrain development."
      Li H., Tao W., Lai E.
      Brain Res. Mol. Brain Res. 37:96-104(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiFOXG1_MOUSE
    AccessioniPrimary (citable) accession number: Q60987
    Secondary accession number(s): Q80VP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3