Q60987 (FOXG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Forkhead box protein G1
Short name=FoxG1

Alternative name(s):
Brain factor 1
Short name=BF-1
Short name=BF1
Forkhead-related protein FKHL1

Gene names

Name:	Foxg1
Synonyms:	Fkhl1, Foxg1b, Hfhbf1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon By similarity.
Subunit structure	Interacts with KDM5B By similarity.
Subcellular location	Nucleus.
Tissue specificity	CNS, and nasal half of the retina.
Sequence similarities	Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aging Inferred from electronic annotation. Source: Compara axon midline choice point recognition Inferred from mutant phenotype PubMed 15240555. Source: MGI central nervous system neuron development Inferred from mutant phenotype PubMed 16680166. Source: MGI dorsal/ventral pattern formation Inferred from mutant phenotype PubMed 14566948PubMed 15893304. Source: MGI embryo development ending in birth or egg hatching Inferred from Biological aspect of Ancestor. Source: RefGenome forebrain development Inferred from mutant phenotype PubMed 12151532PubMed 14566948PubMed 14704420PubMed 7605629. Source: MGI hindbrain development Inferred from Biological aspect of Ancestor. Source: RefGenome inner ear morphogenesis Inferred from mutant phenotype PubMed 16691564. Source: MGI negative regulation of neuron differentiation Inferred from mutant phenotype PubMed 12151532PubMed 14704420PubMed 7605629. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome nonmotile primary cilium assembly Inferred from Biological aspect of Ancestor. Source: RefGenome nose development Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of cell cycle Inferred from mutant phenotype PubMed 15893304. Source: MGI positive regulation of neuroblast proliferation Inferred from mutant phenotype PubMed 15893304. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of mitotic cell cycle Inferred from mutant phenotype PubMed 12151532. Source: MGI regulation of sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome tissue development Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	transcription factor complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	DNA binding, bending Inferred from Biological aspect of Ancestor. Source: RefGenome RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome double-stranded DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 481	481	Forkhead box protein G1		PRO_0000091837
Regions
	DNA binding	172 – 263	92	Fork-head
	Region	375 – 398	24	Interaction with KDM5B By similarity
	Compositional bias	33 – 56	24	His-rich
	Compositional bias	57 – 83	27	Pro-rich
	Compositional bias	70 – 75	6	Poly-Gln

Sequences

	Sequence		Length	Mass (Da)
	Q60987 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: FF6786C3513AB452	FASTA	481	51,625
	10 20 30 40 50 60 MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHPPPP 70 80 90 100 110 120 APQPPPPPPQ QQQQQPPPAP QPPQARGAPA ADDDKGPQPL LLPPSTALDG AKADALGAKG 130 140 150 160 170 180 EPGGGPAELA PVGPDEKEKG AGAGGEEKKG AGEGGKDGEG GKEGDKKNGK YEKPPFSYNA 190 200 210 220 230 240 LIMMAIRQSP EKRLTLNGIY EFIMKNFPYY RENKQGWQNS IRHNLSLNKC FVKVPRHYDD 250 260 270 280 290 300 PGKGNYWMLD PSSDDVFIGG TTGKLRRRST TSRAKLAFKR GARLTSTGLT FMDRAGSLYW 310 320 330 340 350 360 PMSPFLSLHH PRASSTLSYN GTTSAYPSHP MPYSSVLTQN SLGNNHSFST ANGLSVDRLV 370 380 390 400 410 420 NGEIPYATHH LTAAALAASV PCGLSVPCSG TYSLNPCSVN LLAGQTSYFF PHVPHPSMTS 430 440 450 460 470 480 QTSTSMSARA ASSSTSPQAP STLPCESLRP SLPSFTTGLS GGLSDYFTHQ NQGSSSNPLI H

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the structure and function of the gene for transcription factor BF-1, an essential regulator of forebrain development." Li H., Tao W., Lai E. Brain Res. Mol. Brain Res. 37:96-104(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Olfactory epithelium.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U36760 mRNA. Translation: AAB42158.1. BC046958 mRNA. Translation: AAH46958.2.
IPI	IPI00122768.
RefSeq	NP_001153584.1. NM_001160112.1. NP_032267.1. NM_008241.2.
UniGene	Mm.4704.
3D structure databases
ProteinModelPortal	Q60987.
SMR	Q60987. Positions 173-261.
ModBase	Search...
PTM databases
PhosphoSite	Q60987.
Proteomic databases
PaxDb	Q60987.
PRIDE	Q60987.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000021333; ENSMUSP00000021333; ENSMUSG00000020950. ENSMUST00000179669; ENSMUSP00000136372; ENSMUSG00000020950.
GeneID	15228.
KEGG	mmu:15228.
Organism-specific databases
CTD	2290.
MGI	MGI:1347464. Foxg1.
Phylogenomic databases
eggNOG	COG5025.
GeneTree	ENSGT00700000104051.
HOGENOM	HOG000112629.
HOVERGEN	HBG051645.
InParanoid	Q60987.
KO	K09385.
OMA	YSTMLTQ.
OrthoDB	EOG4M0F2T.
Gene expression databases
ArrayExpress	Q60987.
Bgee	Q60987.
CleanEx	MM_FOXG1.
Genevestigator	Q60987.
GermOnline	ENSMUSG00000020950. Mus musculus.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00250. Fork_head. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
SMART	SM00339. FH. 1 hit. [Graphical view]
PROSITE	PS00657. FORK_HEAD_1. 1 hit. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FOXG1. mouse.
NextBio	287819.
SOURCE	Search...

Entry information

Entry name

FOXG1_MOUSE

Accession

Primary (citable) accession number: Q60987
Secondary accession number(s): Q80VP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program