ID   Q60979_MOUSE            Unreviewed;       674 AA.
AC   Q60979; Q64741;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 127.
DE   SubName: Full=SnoN protein {ECO:0000313|EMBL:AAB65848.1};
GN   Name=Skil {ECO:0000313|MGI:MGI:106203};
GN   Synonyms=sno {ECO:0000313|EMBL:AAB65848.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAB65848.1};
RN   [1] {ECO:0000313|EMBL:AAB65848.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Swiss Webster {ECO:0000313|EMBL:AAB65848.1};
RC   TISSUE=Trunk {ECO:0000313|EMBL:AAB65848.1};
RA   Pearson-White S.H.;
RL   Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAB65848.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Swiss Webster {ECO:0000313|EMBL:AAB65848.1};
RC   TISSUE=Trunk {ECO:0000313|EMBL:AAB65848.1};
RX   PubMed=9207045; DOI=10.1093/nar/25.14.2930;
RA   Pearson-White S.H., Crittenden R.;
RT   "Proto-oncogene Sno expression, alternative isoforms and immediate early
RT   serum response.";
RL   Nucleic Acids Res. 25:2930-2937(1997).
CC   -!- INTERACTION:
CC       Q60979; Q60953: Pml; NbExp=5; IntAct=EBI-7213804, EBI-3895605;
CC   -!- SIMILARITY: Belongs to the SKI family. {ECO:0000256|ARBA:ARBA00009513}.
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DR   EMBL; U36203; AAB65848.1; -; mRNA.
DR   AlphaFoldDB; Q60979; -.
DR   IntAct; Q60979; 2.
DR   MINT; Q60979; -.
DR   AGR; MGI:106203; -.
DR   MGI; MGI:106203; Skil.
DR   ChiTaRS; Skil; mouse.
DR   GO; GO:0046332; F:SMAD binding; IEA:InterPro.
DR   CDD; cd21084; DHD_Sno; 1.
DR   Gene3D; 3.10.390.10; SAND domain-like; 1.
DR   Gene3D; 3.10.260.20; Ski; 1.
DR   InterPro; IPR014890; c-SKI_SMAD4-bd_dom.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR010919; SAND-like_dom_sf.
DR   InterPro; IPR003380; SKI/SNO/DAC.
DR   InterPro; IPR037000; Ski_DNA-bd_sf.
DR   InterPro; IPR023216; Tscrpt_reg_SKI_SnoN.
DR   PANTHER; PTHR10005; SKI ONCOGENE-RELATED; 1.
DR   PANTHER; PTHR10005:SF3; SKI-LIKE PROTEIN; 1.
DR   Pfam; PF08782; c-SKI_SMAD_bind; 1.
DR   Pfam; PF02437; Ski_Sno; 1.
DR   SMART; SM01046; c-SKI_SMAD_bind; 1.
DR   SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR   SUPFAM; SSF63763; SAND domain-like; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          257..352
FT                   /note="c-SKI SMAD4-binding"
FT                   /evidence="ECO:0000259|SMART:SM01046"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          52..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          414..460
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          474..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          528..664
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..70
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        425..442
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        474..495
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        497..517
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   674 AA;  76356 MW;  EE44E8338E95D0D6 CRC64;
     MENLQSKFSL VQGSNKKLNG MEDDGSPPVK KMMTDIHANG KTLTKVKKEH LDDYGDASVE
     PDRARKRNRV SLPETLNLNP SLKHTLAQFH LSSQSSLGGP AAFSARYSQE SMSPTVFLPL
     PSPQVLPGTL LIPSDSSTEL TQTLLEGETI SCFQVGGEKR LCLPQVLNSV LREFSLQQIN
     TVCDELYIYC SRCTSDQLHI LKVSGILPFN APSCGLITLT DAQRLCNTLL RPRTFPQNGS
     ILPAKSSLAQ LKETGSAFEV EHECLGKCQG LFAPQFYVQP DAPCIQCLEC CGMFAPQTFV
     MHSHRSPDKR TCHWGFESAK WHCYLHVNQK YLGTPEEKKL KIILEEMKEK FSMRNGKRIQ
     SKTDTPSGME LPSWYPVIKQ EGDHVPQTHS FLHPSYYLYM CDKVVAPNVS LTSAASQSKE
     ATKAETSKST SKQSEKPHES SQHQKTVSYP DVSLEEQEKM DLKTSRELYS CLDSSISNNS
     TSRKKSESAV CSLVRGTSKR DSEDSSPLLV RDGEDDKGKI MEDVMRTYVR QQEKLNSILQ
     RKQQLQMEVE MLSSSKAMKE LTEEQQNLQK ELESLQSEHA QRMEEFYIEQ RDLEKKLEQV
     MQQKCTCDST LEKDREAEYA GQLAELRQRL DHAEADQREL QDELRQEREA RQKLEMMIKE
     LKLQIGKSSK PSKD
//