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Protein
Submitted name:

SnoN protein

Gene

Skil

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. protein complex binding Source: MGI
  3. protein domain specific binding Source: MGI
  4. SMAD binding Source: MGI
  5. transcription corepressor activity Source: MGI

GO - Biological processi

  1. blastocyst formation Source: MGI
  2. cell cycle arrest Source: MGI
  3. lens fiber cell differentiation Source: MGI
  4. lymphocyte homeostasis Source: MGI
  5. negative regulation of cell differentiation Source: MGI
  6. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  7. negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  8. positive regulation of axonogenesis Source: MGI
  9. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  10. positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  11. protein heterotrimerization Source: MGI
  12. protein homotrimerization Source: MGI
  13. response to growth factor Source: MGI
  14. skeletal muscle tissue development Source: MGI
  15. transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
SnoN proteinImported
Gene namesi
Name:SkilImported
Synonyms:snoImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:106203. Skil.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
  3. PML body Source: MGI
  4. protein complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ60979.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PmlQ609535EBI-7213804,EBI-3895605

Protein-protein interaction databases

IntActiQ60979. 2 interactions.
MINTiMINT-7980291.

Structurei

3D structure databases

ProteinModelPortaliQ60979.
SMRiQ60979. Positions 130-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG006599.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProiIPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028373. Ski-rel_Sno.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view]
PANTHERiPTHR10005. PTHR10005. 1 hit.
PTHR10005:SF3. PTHR10005:SF3. 1 hit.
PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view]
SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60979-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENLQSKFSL VQGSNKKLNG MEDDGSPPVK KMMTDIHANG KTLTKVKKEH
60 70 80 90 100
LDDYGDASVE PDRARKRNRV SLPETLNLNP SLKHTLAQFH LSSQSSLGGP
110 120 130 140 150
AAFSARYSQE SMSPTVFLPL PSPQVLPGTL LIPSDSSTEL TQTLLEGETI
160 170 180 190 200
SCFQVGGEKR LCLPQVLNSV LREFSLQQIN TVCDELYIYC SRCTSDQLHI
210 220 230 240 250
LKVSGILPFN APSCGLITLT DAQRLCNTLL RPRTFPQNGS ILPAKSSLAQ
260 270 280 290 300
LKETGSAFEV EHECLGKCQG LFAPQFYVQP DAPCIQCLEC CGMFAPQTFV
310 320 330 340 350
MHSHRSPDKR TCHWGFESAK WHCYLHVNQK YLGTPEEKKL KIILEEMKEK
360 370 380 390 400
FSMRNGKRIQ SKTDTPSGME LPSWYPVIKQ EGDHVPQTHS FLHPSYYLYM
410 420 430 440 450
CDKVVAPNVS LTSAASQSKE ATKAETSKST SKQSEKPHES SQHQKTVSYP
460 470 480 490 500
DVSLEEQEKM DLKTSRELYS CLDSSISNNS TSRKKSESAV CSLVRGTSKR
510 520 530 540 550
DSEDSSPLLV RDGEDDKGKI MEDVMRTYVR QQEKLNSILQ RKQQLQMEVE
560 570 580 590 600
MLSSSKAMKE LTEEQQNLQK ELESLQSEHA QRMEEFYIEQ RDLEKKLEQV
610 620 630 640 650
MQQKCTCDST LEKDREAEYA GQLAELRQRL DHAEADQREL QDELRQEREA
660 670
RQKLEMMIKE LKLQIGKSSK PSKD
Length:674
Mass (Da):76,356
Last modified:November 1, 1996 - v1
Checksum:iEE44E8338E95D0D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36203 mRNA. Translation: AAB65848.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36203 mRNA. Translation: AAB65848.1.

3D structure databases

ProteinModelPortaliQ60979.
SMRiQ60979. Positions 130-230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ60979. 2 interactions.
MINTiMINT-7980291.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:106203. Skil.

Phylogenomic databases

HOVERGENiHBG006599.

Miscellaneous databases

ChiTaRSiSkil. mouse.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ60979.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProiIPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028373. Ski-rel_Sno.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view]
PANTHERiPTHR10005. PTHR10005. 1 hit.
PTHR10005:SF3. PTHR10005:SF3. 1 hit.
PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view]
SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Pearson-White S.H.
    Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Swiss WebsterImported.
    Tissue: TrunkImported.
  2. "Proto-oncogene Sno expression, alternative isoforms and immediate early serum response."
    Pearson-White S.H., Crittenden R.
    Nucleic Acids Res. 25:2930-2937(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Swiss WebsterImported.
    Tissue: TrunkImported.

Entry informationi

Entry nameiQ60979_MOUSE
AccessioniPrimary (citable) accession number: Q60979
Secondary accession number(s): Q64741
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: February 4, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.