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Q60979 (Q60979_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Interactions·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Skil MGI 106203
Synonyms:sno EMBL AAB65848.1
OrganismMus musculus (Mouse) EMBL AAB65848.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length674 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Ontologies

Gene Ontology (GO)
   Biological_processblastocyst formation

Inferred from mutant phenotype PubMed 10811619. Source: MGI

cell cycle arrest

Inferred from mutant phenotype PubMed 10811619. Source: MGI

lens fiber cell differentiation

Inferred from direct assay PubMed 17215516. Source: MGI

lymphocyte homeostasis

Inferred from mutant phenotype PubMed 10811619. Source: MGI

negative regulation of cell differentiation

Inferred from direct assay PubMed 17215516. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 10811619. Source: MGI

negative regulation of transforming growth factor beta receptor signaling pathway

Inferred from mutant phenotype PubMed 15677329. Source: MGI

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Inferred from mutant phenotype PubMed 10811619. Source: MGI

positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Inferred from mutant phenotype PubMed 10811619. Source: MGI

transforming growth factor beta receptor signaling pathway

Inferred from genetic interaction PubMed 18212064. Source: MGI

   Cellular_componentcytoplasm

Inferred from Biological aspect of Ancestor. Source: RefGenome

nucleus

Inferred from direct assay PubMed 18212064. Source: MGI

protein complex

Inferred from sequence orthology PubMed 23610558. Source: MGI

   Molecular_functionSMAD binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

chromatin binding

Inferred from direct assay PubMed 15657445. Source: MGI

protein binding

Inferred from physical interaction PubMed 19745809. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PmlQ609535EBI-7213804,EBI-3895605

Sequences

Sequence LengthMass (Da)Tools
Q60979 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: EE44E8338E95D0D6

FASTA67476,356
        10         20         30         40         50         60 
MENLQSKFSL VQGSNKKLNG MEDDGSPPVK KMMTDIHANG KTLTKVKKEH LDDYGDASVE 

        70         80         90        100        110        120 
PDRARKRNRV SLPETLNLNP SLKHTLAQFH LSSQSSLGGP AAFSARYSQE SMSPTVFLPL 

       130        140        150        160        170        180 
PSPQVLPGTL LIPSDSSTEL TQTLLEGETI SCFQVGGEKR LCLPQVLNSV LREFSLQQIN 

       190        200        210        220        230        240 
TVCDELYIYC SRCTSDQLHI LKVSGILPFN APSCGLITLT DAQRLCNTLL RPRTFPQNGS 

       250        260        270        280        290        300 
ILPAKSSLAQ LKETGSAFEV EHECLGKCQG LFAPQFYVQP DAPCIQCLEC CGMFAPQTFV 

       310        320        330        340        350        360 
MHSHRSPDKR TCHWGFESAK WHCYLHVNQK YLGTPEEKKL KIILEEMKEK FSMRNGKRIQ 

       370        380        390        400        410        420 
SKTDTPSGME LPSWYPVIKQ EGDHVPQTHS FLHPSYYLYM CDKVVAPNVS LTSAASQSKE 

       430        440        450        460        470        480 
ATKAETSKST SKQSEKPHES SQHQKTVSYP DVSLEEQEKM DLKTSRELYS CLDSSISNNS 

       490        500        510        520        530        540 
TSRKKSESAV CSLVRGTSKR DSEDSSPLLV RDGEDDKGKI MEDVMRTYVR QQEKLNSILQ 

       550        560        570        580        590        600 
RKQQLQMEVE MLSSSKAMKE LTEEQQNLQK ELESLQSEHA QRMEEFYIEQ RDLEKKLEQV 

       610        620        630        640        650        660 
MQQKCTCDST LEKDREAEYA GQLAELRQRL DHAEADQREL QDELRQEREA RQKLEMMIKE 

       670 
LKLQIGKSSK PSKD 

« Hide

References

[1]Pearson-White S.H.
Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Swiss Webster EMBL AAB65848.1.
Tissue: Trunk EMBL AAB65848.1.
[2]"Proto-oncogene Sno expression, alternative isoforms and immediate early serum response."
Pearson-White S.H., Crittenden R.
Nucleic Acids Res. 25:2930-2937(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Swiss Webster EMBL AAB65848.1.
Tissue: Trunk EMBL AAB65848.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U36203 mRNA. Translation: AAB65848.1.

3D structure databases

ProteinModelPortalQ60979.
SMRQ60979. Positions 130-230.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ60979. 2 interactions.
MINTMINT-7980291.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:106203. Skil.

Phylogenomic databases

HOVERGENHBG006599.
InParanoidQ60979.

Gene expression databases

GenevestigatorQ60979.

Family and domain databases

Gene3D3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProIPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028373. Ski-rel_Sno.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view]
PANTHERPTHR10005. PTHR10005. 1 hit.
PTHR10005:SF3. PTHR10005:SF3. 1 hit.
PfamPF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view]
SMARTSM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view]
SUPFAMSSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSKIL. mouse.
SOURCESearch...

Entry information

Entry nameQ60979_MOUSE
AccessionPrimary (citable) accession number: Q60979
Secondary accession number(s): Q64741
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)