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Q60979

- Q60979_MOUSE

UniProt

Q60979 - Q60979_MOUSE

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Protein
Submitted name:

SnoN protein

Gene

Skil

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. SMAD binding Source: RefGenome

GO - Biological processi

  1. blastocyst formation Source: MGI
  2. cell cycle arrest Source: MGI
  3. lens fiber cell differentiation Source: MGI
  4. lymphocyte homeostasis Source: MGI
  5. negative regulation of cell differentiation Source: MGI
  6. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  7. negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  8. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  9. positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  10. transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
SnoN proteinImported
Gene namesi
Name:SkilImported
Synonyms:snoImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:106203. Skil.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. nucleus Source: MGI
  3. protein complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ60979.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PmlQ609535EBI-7213804,EBI-3895605

Protein-protein interaction databases

IntActiQ60979. 2 interactions.
MINTiMINT-7980291.

Structurei

3D structure databases

ProteinModelPortaliQ60979.
SMRiQ60979. Positions 130-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG006599.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProiIPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028373. Ski-rel_Sno.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view]
PANTHERiPTHR10005. PTHR10005. 1 hit.
PTHR10005:SF3. PTHR10005:SF3. 1 hit.
PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view]
SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60979 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENLQSKFSL VQGSNKKLNG MEDDGSPPVK KMMTDIHANG KTLTKVKKEH
60 70 80 90 100
LDDYGDASVE PDRARKRNRV SLPETLNLNP SLKHTLAQFH LSSQSSLGGP
110 120 130 140 150
AAFSARYSQE SMSPTVFLPL PSPQVLPGTL LIPSDSSTEL TQTLLEGETI
160 170 180 190 200
SCFQVGGEKR LCLPQVLNSV LREFSLQQIN TVCDELYIYC SRCTSDQLHI
210 220 230 240 250
LKVSGILPFN APSCGLITLT DAQRLCNTLL RPRTFPQNGS ILPAKSSLAQ
260 270 280 290 300
LKETGSAFEV EHECLGKCQG LFAPQFYVQP DAPCIQCLEC CGMFAPQTFV
310 320 330 340 350
MHSHRSPDKR TCHWGFESAK WHCYLHVNQK YLGTPEEKKL KIILEEMKEK
360 370 380 390 400
FSMRNGKRIQ SKTDTPSGME LPSWYPVIKQ EGDHVPQTHS FLHPSYYLYM
410 420 430 440 450
CDKVVAPNVS LTSAASQSKE ATKAETSKST SKQSEKPHES SQHQKTVSYP
460 470 480 490 500
DVSLEEQEKM DLKTSRELYS CLDSSISNNS TSRKKSESAV CSLVRGTSKR
510 520 530 540 550
DSEDSSPLLV RDGEDDKGKI MEDVMRTYVR QQEKLNSILQ RKQQLQMEVE
560 570 580 590 600
MLSSSKAMKE LTEEQQNLQK ELESLQSEHA QRMEEFYIEQ RDLEKKLEQV
610 620 630 640 650
MQQKCTCDST LEKDREAEYA GQLAELRQRL DHAEADQREL QDELRQEREA
660 670
RQKLEMMIKE LKLQIGKSSK PSKD
Length:674
Mass (Da):76,356
Last modified:November 1, 1996 - v1
Checksum:iEE44E8338E95D0D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36203 mRNA. Translation: AAB65848.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36203 mRNA. Translation: AAB65848.1 .

3D structure databases

ProteinModelPortali Q60979.
SMRi Q60979. Positions 130-230.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q60979. 2 interactions.
MINTi MINT-7980291.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:106203. Skil.

Phylogenomic databases

HOVERGENi HBG006599.

Miscellaneous databases

ChiTaRSi SKIL. mouse.
SOURCEi Search...

Gene expression databases

Genevestigatori Q60979.

Family and domain databases

Gene3Di 3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProi IPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028373. Ski-rel_Sno.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view ]
PANTHERi PTHR10005. PTHR10005. 1 hit.
PTHR10005:SF3. PTHR10005:SF3. 1 hit.
Pfami PF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view ]
SMARTi SM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Pearson-White S.H.
    Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Swiss WebsterImported.
    Tissue: TrunkImported.
  2. "Proto-oncogene Sno expression, alternative isoforms and immediate early serum response."
    Pearson-White S.H., Crittenden R.
    Nucleic Acids Res. 25:2930-2937(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Swiss WebsterImported.
    Tissue: TrunkImported.

Entry informationi

Entry nameiQ60979_MOUSE
AccessioniPrimary (citable) accession number: Q60979
Secondary accession number(s): Q64741
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)