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Q60979

- Q60979_MOUSE

UniProt

Q60979 - Q60979_MOUSE

Protein
Submitted name:

SnoN protein

Gene

Skil

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. protein binding Source: IntAct
    3. SMAD binding Source: RefGenome

    GO - Biological processi

    1. blastocyst formation Source: MGI
    2. cell cycle arrest Source: MGI
    3. lens fiber cell differentiation Source: MGI
    4. lymphocyte homeostasis Source: MGI
    5. negative regulation of cell differentiation Source: MGI
    6. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    7. negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
    8. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
    9. positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
    10. transforming growth factor beta receptor signaling pathway Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    SnoN proteinImported
    Gene namesi
    Name:SkilImported
    Synonyms:snoImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:106203. Skil.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. nucleus Source: MGI
    3. protein complex Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ60979.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PmlQ609535EBI-7213804,EBI-3895605

    Protein-protein interaction databases

    IntActiQ60979. 2 interactions.
    MINTiMINT-7980291.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60979.
    SMRiQ60979. Positions 130-230.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG006599.
    InParanoidiQ60979.

    Family and domain databases

    Gene3Di3.10.260.20. 1 hit.
    3.10.390.10. 1 hit.
    InterProiIPR014890. c-SKI_SMAD4-bd_dom.
    IPR009061. DNA-bd_dom_put.
    IPR010919. SAND_dom-like.
    IPR028373. Ski-rel_Sno.
    IPR003380. Transform_Ski.
    IPR023216. Tscrpt_reg_SKI_SnoN.
    [Graphical view]
    PANTHERiPTHR10005. PTHR10005. 1 hit.
    PTHR10005:SF3. PTHR10005:SF3. 1 hit.
    PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
    PF02437. Ski_Sno. 1 hit.
    [Graphical view]
    SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 1 hit.
    SSF63763. SSF63763. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q60979-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENLQSKFSL VQGSNKKLNG MEDDGSPPVK KMMTDIHANG KTLTKVKKEH    50
    LDDYGDASVE PDRARKRNRV SLPETLNLNP SLKHTLAQFH LSSQSSLGGP 100
    AAFSARYSQE SMSPTVFLPL PSPQVLPGTL LIPSDSSTEL TQTLLEGETI 150
    SCFQVGGEKR LCLPQVLNSV LREFSLQQIN TVCDELYIYC SRCTSDQLHI 200
    LKVSGILPFN APSCGLITLT DAQRLCNTLL RPRTFPQNGS ILPAKSSLAQ 250
    LKETGSAFEV EHECLGKCQG LFAPQFYVQP DAPCIQCLEC CGMFAPQTFV 300
    MHSHRSPDKR TCHWGFESAK WHCYLHVNQK YLGTPEEKKL KIILEEMKEK 350
    FSMRNGKRIQ SKTDTPSGME LPSWYPVIKQ EGDHVPQTHS FLHPSYYLYM 400
    CDKVVAPNVS LTSAASQSKE ATKAETSKST SKQSEKPHES SQHQKTVSYP 450
    DVSLEEQEKM DLKTSRELYS CLDSSISNNS TSRKKSESAV CSLVRGTSKR 500
    DSEDSSPLLV RDGEDDKGKI MEDVMRTYVR QQEKLNSILQ RKQQLQMEVE 550
    MLSSSKAMKE LTEEQQNLQK ELESLQSEHA QRMEEFYIEQ RDLEKKLEQV 600
    MQQKCTCDST LEKDREAEYA GQLAELRQRL DHAEADQREL QDELRQEREA 650
    RQKLEMMIKE LKLQIGKSSK PSKD 674
    Length:674
    Mass (Da):76,356
    Last modified:November 1, 1996 - v1
    Checksum:iEE44E8338E95D0D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36203 mRNA. Translation: AAB65848.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36203 mRNA. Translation: AAB65848.1 .

    3D structure databases

    ProteinModelPortali Q60979.
    SMRi Q60979. Positions 130-230.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q60979. 2 interactions.
    MINTi MINT-7980291.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:106203. Skil.

    Phylogenomic databases

    HOVERGENi HBG006599.
    InParanoidi Q60979.

    Miscellaneous databases

    ChiTaRSi SKIL. mouse.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q60979.

    Family and domain databases

    Gene3Di 3.10.260.20. 1 hit.
    3.10.390.10. 1 hit.
    InterProi IPR014890. c-SKI_SMAD4-bd_dom.
    IPR009061. DNA-bd_dom_put.
    IPR010919. SAND_dom-like.
    IPR028373. Ski-rel_Sno.
    IPR003380. Transform_Ski.
    IPR023216. Tscrpt_reg_SKI_SnoN.
    [Graphical view ]
    PANTHERi PTHR10005. PTHR10005. 1 hit.
    PTHR10005:SF3. PTHR10005:SF3. 1 hit.
    Pfami PF08782. c-SKI_SMAD_bind. 1 hit.
    PF02437. Ski_Sno. 1 hit.
    [Graphical view ]
    SMARTi SM01046. c-SKI_SMAD_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 1 hit.
    SSF63763. SSF63763. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Pearson-White S.H.
      Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Swiss WebsterImported.
      Tissue: TrunkImported.
    2. "Proto-oncogene Sno expression, alternative isoforms and immediate early serum response."
      Pearson-White S.H., Crittenden R.
      Nucleic Acids Res. 25:2930-2937(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Swiss WebsterImported.
      Tissue: TrunkImported.

    Entry informationi

    Entry nameiQ60979_MOUSE
    AccessioniPrimary (citable) accession number: Q60979
    Secondary accession number(s): Q64741
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)