ID   LAP4A_MOUSE             Reviewed;         233 AA.
AC   Q60961;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   08-NOV-2023, entry version 134.
DE   RecName: Full=Lysosomal-associated transmembrane protein 4A;
DE   AltName: Full=Golgi 4-transmembrane-spanning transporter;
DE   AltName: Full=Mouse transporter protein;
DE            Short=MTP;
GN   Name=Laptm4a; Synonyms=Mtrp;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=DBA/2J; TISSUE=Brain, and Leukemia;
RX   PubMed=8621662; DOI=10.1074/jbc.271.16.9801;
RA   Hogue D.L., Ellison M.J., Young J.D., Cass C.E.;
RT   "Identification of a novel membrane transporter associated with
RT   intracellular membranes by phenotypic complementation in the yeast
RT   Saccharomyces cerevisiae.";
RL   J. Biol. Chem. 271:9801-9808(1996).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Lung, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May function in the transport of nucleosides and/or
CC       nucleoside derivatives between the cytosol and the lumen of an
CC       intracellular membrane-bound compartment.
CC   -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}. Note=May reside in an intracellular
CC       membrane-bound compartment. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: [Isoform Short]: Cell membrane {ECO:0000305};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=Long;
CC         IsoId=Q60961-1; Sequence=Displayed;
CC       Name=Short; Synonyms=Truncated, MTP1;
CC         IsoId=Q60961-2; Sequence=VSP_018821;
CC   -!- DOMAIN: The C-terminal domain is necessary for retention within
CC       intracellular membranes.
CC   -!- SIMILARITY: Belongs to the LAPTM4/LAPTM5 transporter family.
CC       {ECO:0000305}.
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DR   EMBL; U34259; AAB04938.1; -; mRNA.
DR   CCDS; CCDS36402.1; -. [Q60961-1]
DR   AlphaFoldDB; Q60961; -.
DR   SMR; Q60961; -.
DR   STRING; 10090.ENSMUSP00000020909; -.
DR   TCDB; 2.A.74.1.1; the 4 tms multidrug endosomal transporter (met) family.
DR   iPTMnet; Q60961; -.
DR   PhosphoSitePlus; Q60961; -.
DR   SwissPalm; Q60961; -.
DR   MaxQB; Q60961; -.
DR   PaxDb; 10090-ENSMUSP00000020909; -.
DR   PeptideAtlas; Q60961; -.
DR   ProteomicsDB; 264971; -. [Q60961-1]
DR   ProteomicsDB; 264972; -. [Q60961-2]
DR   Pumba; Q60961; -.
DR   AGR; MGI:108017; -.
DR   MGI; MGI:108017; Laptm4a.
DR   eggNOG; ENOG502QSAX; Eukaryota.
DR   InParanoid; Q60961; -.
DR   PhylomeDB; Q60961; -.
DR   ChiTaRS; Laptm4a; mouse.
DR   PRO; PR:Q60961; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q60961; Protein.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR   GO; GO:0031902; C:late endosome membrane; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; IMP:ParkinsonsUK-UCL.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004687; LAPTM4/5.
DR   InterPro; IPR018396; LAPTM_4A/5.
DR   NCBIfam; TIGR00799; mtp; 1.
DR   PANTHER; PTHR12479; LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN; 1.
DR   PANTHER; PTHR12479:SF5; LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN 4A; 1.
DR   Pfam; PF03821; Mtp; 2.
PE   1: Evidence at protein level;
KW   Acetylation; Alternative initiation; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..233
FT                   /note="Lysosomal-associated transmembrane protein 4A"
FT                   /id="PRO_0000021783"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15012"
FT   VAR_SEQ         1..89
FT                   /note="Missing (in isoform Short)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_018821"
SQ   SEQUENCE   233 AA;  26858 MW;  CA409AC77ACE4D6E CRC64;
     MVSMTFKRSR SDRFYSTRCC GCFHVRTGTI ILGTWYMVVN LLMAILLTVE VTHPNSMPAV
     NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG AISYQVGWLI PFFCYRLFDF
     VLSCLVAISS LTYLPRIKEY LDQLPDFPYK DDLLALDSSC LLFIVLVFFV VFIIFKAYLI
     NCVWNCYKYI NNRNVPEIAV YPAFETPPQY VLPTYEMAVK IPEKEPPPPY LPA
//