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Protein

Lysosomal-associated transmembrane protein 4A

Gene

Laptm4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.74.1.1. the 4 tms multidrug endosomal transporter (met) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 4A
Alternative name(s):
Golgi 4-transmembrane-spanning transporter
Mouse transporter protein
Short name:
MTP
Gene namesi
Name:Laptm4a
Synonyms:Mtrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:108017. Laptm4a.

Subcellular locationi

Endomembrane system Curated; Multi-pass membrane protein Curated
Note: May reside in an intracellular membrane-bound compartment.Curated

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921HelicalSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence AnalysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: ParkinsonsUK-UCL
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Lysosomal-associated transmembrane protein 4APRO_0000021783Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ60961.
PaxDbiQ60961.
PRIDEiQ60961.

PTM databases

PhosphoSiteiQ60961.

Expressioni

Gene expression databases

CleanExiMM_LAPTM4A.
GenevestigatoriQ60961.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi226 – 2294Poly-Pro

Domaini

The C-terminal domain is necessary for retention within intracellular membranes.

Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG260939.
HOGENOMiHOG000007698.
HOVERGENiHBG000908.
InParanoidiQ60961.
PhylomeDBiQ60961.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00799. mtp. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform Long (identifier: Q60961-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSMTFKRSR SDRFYSTRCC GCFHVRTGTI ILGTWYMVVN LLMAILLTVE
60 70 80 90 100
VTHPNSMPAV NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG
110 120 130 140 150
AISYQVGWLI PFFCYRLFDF VLSCLVAISS LTYLPRIKEY LDQLPDFPYK
160 170 180 190 200
DDLLALDSSC LLFIVLVFFV VFIIFKAYLI NCVWNCYKYI NNRNVPEIAV
210 220 230
YPAFETPPQY VLPTYEMAVK IPEKEPPPPY LPA
Length:233
Mass (Da):26,858
Last modified:October 31, 1996 - v1
Checksum:iCA409AC77ACE4D6E
GO
Isoform Short (identifier: Q60961-2) [UniParc]FASTAAdd to basket

Also known as: Truncated, MTP1

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Note: No experimental confirmation available.

Show »
Length:144
Mass (Da):16,781
Checksum:iD0F40FFCDB841AE5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8989Missing in isoform Short. CuratedVSP_018821Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34259 mRNA. Translation: AAB04938.1.
UniGeneiMm.30071.
Mm.401534.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34259 mRNA. Translation: AAB04938.1.
UniGeneiMm.30071.
Mm.401534.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.74.1.1. the 4 tms multidrug endosomal transporter (met) family.

PTM databases

PhosphoSiteiQ60961.

Proteomic databases

MaxQBiQ60961.
PaxDbiQ60961.
PRIDEiQ60961.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:108017. Laptm4a.

Phylogenomic databases

eggNOGiNOG260939.
HOGENOMiHOG000007698.
HOVERGENiHBG000908.
InParanoidiQ60961.
PhylomeDBiQ60961.

Miscellaneous databases

ChiTaRSiLaptm4a. mouse.
PROiQ60961.
SOURCEiSearch...

Gene expression databases

CleanExiMM_LAPTM4A.
GenevestigatoriQ60961.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00799. mtp. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Identification of a novel membrane transporter associated with intracellular membranes by phenotypic complementation in the yeast Saccharomyces cerevisiae."
    Hogue D.L., Ellison M.J., Young J.D., Cass C.E.
    J. Biol. Chem. 271:9801-9808(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA/2.
    Tissue: Brain and Leukemia.

Entry informationi

Entry nameiLAP4A_MOUSE
AccessioniPrimary (citable) accession number: Q60961
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 14, 1998
Last sequence update: October 31, 1996
Last modified: March 3, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.