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Q60961

- LAP4A_MOUSE

UniProt

Q60961 - LAP4A_MOUSE

Protein

Lysosomal-associated transmembrane protein 4A

Gene

Laptm4a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.74.1.1. the 4 tms multidrug endosomal transporter (met) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosomal-associated transmembrane protein 4A
    Alternative name(s):
    Golgi 4-transmembrane-spanning transporter
    Mouse transporter protein
    Short name:
    MTP
    Gene namesi
    Name:Laptm4a
    Synonyms:Mtrp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:108017. Laptm4a.

    Subcellular locationi

    Endomembrane system Curated; Multi-pass membrane protein Curated
    Note: May reside in an intracellular membrane-bound compartment.Curated

    GO - Cellular componenti

    1. endomembrane system Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233Lysosomal-associated transmembrane protein 4APRO_0000021783Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ60961.
    PRIDEiQ60961.

    PTM databases

    PhosphoSiteiQ60961.

    Expressioni

    Gene expression databases

    CleanExiMM_LAPTM4A.
    GenevestigatoriQ60961.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi226 – 2294Poly-Pro

    Domaini

    The C-terminal domain is necessary for retention within intracellular membranes.

    Sequence similaritiesi

    Belongs to the LAPTM4/LAPTM5 transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG260939.
    HOGENOMiHOG000007698.
    HOVERGENiHBG000908.
    InParanoidiQ60961.
    PhylomeDBiQ60961.

    Family and domain databases

    InterProiIPR004687. LAPTM4/5.
    IPR018396. LAPTM_4A/5.
    [Graphical view]
    PANTHERiPTHR12479. PTHR12479. 1 hit.
    PfamiPF03821. Mtp. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00799. mtp. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform Long (identifier: Q60961-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVSMTFKRSR SDRFYSTRCC GCFHVRTGTI ILGTWYMVVN LLMAILLTVE    50
    VTHPNSMPAV NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG 100
    AISYQVGWLI PFFCYRLFDF VLSCLVAISS LTYLPRIKEY LDQLPDFPYK 150
    DDLLALDSSC LLFIVLVFFV VFIIFKAYLI NCVWNCYKYI NNRNVPEIAV 200
    YPAFETPPQY VLPTYEMAVK IPEKEPPPPY LPA 233
    Length:233
    Mass (Da):26,858
    Last modified:November 1, 1996 - v1
    Checksum:iCA409AC77ACE4D6E
    GO
    Isoform Short (identifier: Q60961-2) [UniParc]FASTAAdd to Basket

    Also known as: Truncated, MTP1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-89: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:144
    Mass (Da):16,781
    Checksum:iD0F40FFCDB841AE5
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8989Missing in isoform Short. CuratedVSP_018821Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34259 mRNA. Translation: AAB04938.1.
    UniGeneiMm.30071.
    Mm.401534.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34259 mRNA. Translation: AAB04938.1 .
    UniGenei Mm.30071.
    Mm.401534.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 2.A.74.1.1. the 4 tms multidrug endosomal transporter (met) family.

    PTM databases

    PhosphoSitei Q60961.

    Proteomic databases

    PaxDbi Q60961.
    PRIDEi Q60961.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:108017. Laptm4a.

    Phylogenomic databases

    eggNOGi NOG260939.
    HOGENOMi HOG000007698.
    HOVERGENi HBG000908.
    InParanoidi Q60961.
    PhylomeDBi Q60961.

    Miscellaneous databases

    ChiTaRSi LAPTM4A. mouse.
    PROi Q60961.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_LAPTM4A.
    Genevestigatori Q60961.

    Family and domain databases

    InterProi IPR004687. LAPTM4/5.
    IPR018396. LAPTM_4A/5.
    [Graphical view ]
    PANTHERi PTHR12479. PTHR12479. 1 hit.
    Pfami PF03821. Mtp. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00799. mtp. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel membrane transporter associated with intracellular membranes by phenotypic complementation in the yeast Saccharomyces cerevisiae."
      Hogue D.L., Ellison M.J., Young J.D., Cass C.E.
      J. Biol. Chem. 271:9801-9808(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: DBA/2.
      Tissue: Brain and Leukemia.

    Entry informationi

    Entry nameiLAP4A_MOUSE
    AccessioniPrimary (citable) accession number: Q60961
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3