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Q60961 (LAP4A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosomal-associated transmembrane protein 4A
Alternative name(s):
Golgi 4-transmembrane-spanning transporter
Mouse transporter protein
Short name=MTP
Gene names
Name:Laptm4a
Synonyms:Mtrp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.

Subcellular location

Endomembrane system; Multi-pass membrane protein Potential. Note: May reside in an intracellular membrane-bound compartment Potential.

Isoform Short: Cell membrane; Multi-pass membrane protein Probable.

Domain

The C-terminal domain is necessary for retention within intracellular membranes.

Sequence similarities

Belongs to the LAPTM4/LAPTM5 transporter family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative initiation
   DomainTransmembrane
Transmembrane helix
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendomembrane system

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform Long (identifier: Q60961-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: Q60961-2)

Also known as: Truncated; MTP1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 233233Lysosomal-associated transmembrane protein 4A
PRO_0000021783

Regions

Transmembrane29 – 4921Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane108 – 12821Helical; Potential
Transmembrane160 – 18021Helical; Potential
Compositional bias226 – 2294Poly-Pro

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Natural variations

Alternative sequence1 – 8989Missing in isoform Short.
VSP_018821

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: CA409AC77ACE4D6E

FASTA23326,858
        10         20         30         40         50         60 
MVSMTFKRSR SDRFYSTRCC GCFHVRTGTI ILGTWYMVVN LLMAILLTVE VTHPNSMPAV 

        70         80         90        100        110        120 
NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG AISYQVGWLI PFFCYRLFDF 

       130        140        150        160        170        180 
VLSCLVAISS LTYLPRIKEY LDQLPDFPYK DDLLALDSSC LLFIVLVFFV VFIIFKAYLI 

       190        200        210        220        230 
NCVWNCYKYI NNRNVPEIAV YPAFETPPQY VLPTYEMAVK IPEKEPPPPY LPA 

« Hide

Isoform Short (Truncated) (MTP1) [UniParc].

Checksum: D0F40FFCDB841AE5
Show »

FASTA14416,781

References

[1]"Identification of a novel membrane transporter associated with intracellular membranes by phenotypic complementation in the yeast Saccharomyces cerevisiae."
Hogue D.L., Ellison M.J., Young J.D., Cass C.E.
J. Biol. Chem. 271:9801-9808(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: DBA/2.
Tissue: Brain and Leukemia.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U34259 mRNA. Translation: AAB04938.1.
UniGeneMm.30071.
Mm.401534.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB2.A.74.1.1. the 4 tms multidrug endosomal transporter (met) family.

PTM databases

PhosphoSiteQ60961.

Proteomic databases

PaxDbQ60961.
PRIDEQ60961.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:108017. Laptm4a.

Phylogenomic databases

eggNOGNOG260939.
HOGENOMHOG000007698.
HOVERGENHBG000908.
InParanoidQ60961.
PhylomeDBQ60961.

Gene expression databases

CleanExMM_LAPTM4A.
GenevestigatorQ60961.

Family and domain databases

InterProIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
[Graphical view]
PANTHERPTHR12479. PTHR12479. 1 hit.
PfamPF03821. Mtp. 1 hit.
[Graphical view]
TIGRFAMsTIGR00799. mtp. 1 hit.
ProtoNetSearch...

Other

ChiTaRSLAPTM4A. mouse.
PROQ60961.
SOURCESearch...

Entry information

Entry nameLAP4A_MOUSE
AccessionPrimary (citable) accession number: Q60961
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot