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Protein

Lysosomal-associated transmembrane protein 4A

Gene

Laptm4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.74.1.1. the 4 tms multidrug endosomal transporter (met) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 4A
Alternative name(s):
Golgi 4-transmembrane-spanning transporter
Mouse transporter protein
Short name:
MTP
Gene namesi
Name:Laptm4a
Synonyms:Mtrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:108017. Laptm4a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • Golgi apparatus Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: ParkinsonsUK-UCL
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000217831 – 233Lysosomal-associated transmembrane protein 4AAdd BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ60961.
PeptideAtlasiQ60961.
PRIDEiQ60961.

PTM databases

iPTMnetiQ60961.
PhosphoSitePlusiQ60961.
SwissPalmiQ60961.

Expressioni

Gene expression databases

CleanExiMM_LAPTM4A.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020909.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi226 – 229Poly-Pro4

Domaini

The C-terminal domain is necessary for retention within intracellular membranes.

Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEGH. Eukaryota.
ENOG4111K1Z. LUCA.
HOGENOMiHOG000007698.
HOVERGENiHBG000908.
InParanoidiQ60961.
PhylomeDBiQ60961.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PfamiPF03821. Mtp. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00799. mtp. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform Long (identifier: Q60961-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSMTFKRSR SDRFYSTRCC GCFHVRTGTI ILGTWYMVVN LLMAILLTVE
60 70 80 90 100
VTHPNSMPAV NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG
110 120 130 140 150
AISYQVGWLI PFFCYRLFDF VLSCLVAISS LTYLPRIKEY LDQLPDFPYK
160 170 180 190 200
DDLLALDSSC LLFIVLVFFV VFIIFKAYLI NCVWNCYKYI NNRNVPEIAV
210 220 230
YPAFETPPQY VLPTYEMAVK IPEKEPPPPY LPA
Length:233
Mass (Da):26,858
Last modified:November 1, 1996 - v1
Checksum:iCA409AC77ACE4D6E
GO
Isoform Short (identifier: Q60961-2) [UniParc]FASTAAdd to basket
Also known as: Truncated, MTP1

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Note: No experimental confirmation available.
Show »
Length:144
Mass (Da):16,781
Checksum:iD0F40FFCDB841AE5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0188211 – 89Missing in isoform Short. CuratedAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34259 mRNA. Translation: AAB04938.1.
UniGeneiMm.30071.
Mm.401534.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34259 mRNA. Translation: AAB04938.1.
UniGeneiMm.30071.
Mm.401534.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020909.

Protein family/group databases

TCDBi2.A.74.1.1. the 4 tms multidrug endosomal transporter (met) family.

PTM databases

iPTMnetiQ60961.
PhosphoSitePlusiQ60961.
SwissPalmiQ60961.

Proteomic databases

PaxDbiQ60961.
PeptideAtlasiQ60961.
PRIDEiQ60961.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:108017. Laptm4a.

Phylogenomic databases

eggNOGiENOG410IEGH. Eukaryota.
ENOG4111K1Z. LUCA.
HOGENOMiHOG000007698.
HOVERGENiHBG000908.
InParanoidiQ60961.
PhylomeDBiQ60961.

Miscellaneous databases

ChiTaRSiLaptm4a. mouse.
PROiQ60961.
SOURCEiSearch...

Gene expression databases

CleanExiMM_LAPTM4A.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PfamiPF03821. Mtp. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00799. mtp. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLAP4A_MOUSE
AccessioniPrimary (citable) accession number: Q60961
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.