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Protein

Protein p13 MTCP-1

Gene

Mtcp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enhances the phosphorylation and activation of AKT1 and AKT2.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein p13 MTCP-1
Short name:
p13MTCP1
Alternative name(s):
Mature T-cell proliferation-1 type B1
Short name:
MTCP-1 type B1
Gene namesi
Name:Mtcp1
Synonyms:C6.1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:102699. Mtcp1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 107107Protein p13 MTCP-1PRO_0000184487Add
BLAST

Proteomic databases

PaxDbiQ60945.
PRIDEiQ60945.

Expressioni

Tissue specificityi

Not found at a significant level in any tissue.

Gene expression databases

BgeeiQ60945.
CleanExiMM_MTCP1.
GenevisibleiQ60945. MM.

Interactioni

Subunit structurei

Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033542.

Structurei

3D structure databases

ProteinModelPortaliQ60945.
SMRiQ60945. Positions 1-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCL1 family.Curated

Phylogenomic databases

eggNOGiENOG410IXNT. Eukaryota.
ENOG41116AR. LUCA.
GeneTreeiENSGT00390000006885.
HOGENOMiHOG000037945.
HOVERGENiHBG052523.
InParanoidiQ60945.
KOiK16837.
OMAiVHQEGVY.
OrthoDBiEOG773XKB.
PhylomeDBiQ60945.
TreeFamiTF337903.

Family and domain databases

Gene3Di2.40.15.10. 1 hit.
InterProiIPR004832. TCL1_MTCP1.
[Graphical view]
PfamiPF01840. TCL1_MTCP1. 1 hit.
[Graphical view]
ProDomiPD015575. TCL1_MTCP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50904. SSF50904. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q60945-1) [UniParc]FASTAAdd to basket

Also known as: Long, Type B1, p13 MTCP-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAREDVGAPP DHLWVHQEGV YRDEYQRTWV AVVEEETSFL KARVQQVQVP
60 70 80 90 100
LGDATKPSHL LTSQLPLMWQ LYPEERYMDN NSRLWQIQHH LMVRGVQELL

LKLLPDD
Note: Shares a non-coding 5' exon with isoform 1 which is spliced to a different set of 3' exons encoding an unrelated protein.
Length:107
Mass (Da):12,645
Last modified:November 1, 1996 - v1
Checksum:i7996813A182C2308
GO
Isoform 1 (identifier: Q61908-1) [UniParc]FASTAAdd to basket

Also known as: Short, Type A, p8 MTCP-1

The sequence of this isoform can be found in the external entry Q61908.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Shares a non-coding 5' exon with isoform 2 which is spliced to a different set of 3' exons encoding an unrelated protein.
Length:68
Mass (Da):7,743
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32332 mRNA. Translation: AAC52444.1.
AL671860 Genomic DNA. Translation: CAM46069.1.
CCDSiCCDS30241.1. [Q60945-1]
RefSeqiNP_001034462.1. NM_001039373.5. [Q60945-1]
UniGeneiMm.16366.

Genome annotation databases

EnsembliENSMUST00000033542; ENSMUSP00000033542; ENSMUSG00000031200. [Q60945-1]
ENSMUST00000114081; ENSMUSP00000109715; ENSMUSG00000031200. [Q60945-1]
GeneIDi17763.
KEGGimmu:17763.
UCSCiuc009tpw.2. mouse. [Q60945-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32332 mRNA. Translation: AAC52444.1.
AL671860 Genomic DNA. Translation: CAM46069.1.
CCDSiCCDS30241.1. [Q60945-1]
RefSeqiNP_001034462.1. NM_001039373.5. [Q60945-1]
UniGeneiMm.16366.

3D structure databases

ProteinModelPortaliQ60945.
SMRiQ60945. Positions 1-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033542.

Proteomic databases

PaxDbiQ60945.
PRIDEiQ60945.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033542; ENSMUSP00000033542; ENSMUSG00000031200. [Q60945-1]
ENSMUST00000114081; ENSMUSP00000109715; ENSMUSG00000031200. [Q60945-1]
GeneIDi17763.
KEGGimmu:17763.
UCSCiuc009tpw.2. mouse. [Q60945-1]

Organism-specific databases

CTDi4515.
MGIiMGI:102699. Mtcp1.

Phylogenomic databases

eggNOGiENOG410IXNT. Eukaryota.
ENOG41116AR. LUCA.
GeneTreeiENSGT00390000006885.
HOGENOMiHOG000037945.
HOVERGENiHBG052523.
InParanoidiQ60945.
KOiK16837.
OMAiVHQEGVY.
OrthoDBiEOG773XKB.
PhylomeDBiQ60945.
TreeFamiTF337903.

Miscellaneous databases

ChiTaRSiMtcp1. mouse.
NextBioi292459.
PROiQ60945.
SOURCEiSearch...

Gene expression databases

BgeeiQ60945.
CleanExiMM_MTCP1.
GenevisibleiQ60945. MM.

Family and domain databases

Gene3Di2.40.15.10. 1 hit.
InterProiIPR004832. TCL1_MTCP1.
[Graphical view]
PfamiPF01840. TCL1_MTCP1. 1 hit.
[Graphical view]
ProDomiPD015575. TCL1_MTCP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50904. SSF50904. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations."
    Madani A., Choukroun V., Soulier J., Cacheux V., Claisse J.-F., Valensi F., Daliphard S., Cazin B., Levy V., Leblond V., Daniel M.-T., Sigaux F., Stern M.-H.
    Blood 87:1923-1927(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: T-cell.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiMTCP1_MOUSE
AccessioniPrimary (citable) accession number: Q60945
Secondary accession number(s): A3KGA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 17, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.