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Q60943

- I17RA_MOUSE

UniProt

Q60943 - I17RA_MOUSE

Protein

Interleukin-17 receptor A

Gene

Il17ra

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling By similarity.By similarity

    GO - Biological processi

    1. cellular response to cytokine stimulus Source: Ensembl
    2. fibroblast activation Source: Ensembl
    3. positive regulation of cytokine production involved in inflammatory response Source: MGI
    4. positive regulation of interleukin-23 production Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-17 receptor A
    Short name:
    IL-17 receptor A
    Short name:
    IL-17RA
    Alternative name(s):
    CD_antigen: CD217
    Gene namesi
    Name:Il17ra
    Synonyms:Il17r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:107399. Il17ra.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 864833Interleukin-17 receptor APRO_0000011031Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 50By similarity
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi57 ↔ 126By similarity
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi185 ↔ 196By similarity
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi245 ↔ 276By similarity
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi290 ↔ 294By similarity
    Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ60943.

    PTM databases

    PhosphoSiteiQ60943.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    BgeeiQ60943.
    CleanExiMM_IL17RA.
    GenevestigatoriQ60943.

    Interactioni

    Subunit structurei

    Forms heterodimers with IL17RE; the heterodimer binds IL17C.

    Protein-protein interaction databases

    BioGridi200620. 3 interactions.
    IntActiQ60943. 4 interactions.
    STRINGi10090.ENSMUSP00000002976.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60943.
    SMRiQ60943. Positions 34-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini32 – 322291ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini344 – 864521CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei323 – 34321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini379 – 537159SEFIRPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi809 – 8146Poly-Glu

    Sequence similaritiesi

    Contains 1 SEFIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40152.
    GeneTreeiENSGT00530000063782.
    HOGENOMiHOG000015327.
    HOVERGENiHBG081775.
    InParanoidiQ60943.
    KOiK05164.
    OMAiMTWVGRQ.
    OrthoDBiEOG7P8P7V.
    PhylomeDBiQ60943.
    TreeFamiTF329644.

    Family and domain databases

    InterProiIPR013568. SEFIR.
    [Graphical view]
    PfamiPF08357. SEFIR. 1 hit.
    [Graphical view]
    PROSITEiPS51534. SEFIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q60943-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIRRCWPRV VPGPALGWLL LLLNVLAPGR ASPRLLDFPA PVCAQEGLSC    50
    RVKNSTCLDD SWIHPKNLTP SSPKNIYINL SVSSTQHGEL VPVLHVEWTL 100
    QTDASILYLE GAELSVLQLN TNERLCVKFQ FLSMLQHHRK RWRFSFSHFV 150
    VDPGQEYEVT VHHLPKPIPD GDPNHKSKII FVPDCEDSKM KMTTSCVSSG 200
    SLWDPNITVE TLDTQHLRVD FTLWNESTPY QVLLESFSDS ENHSCFDVVK 250
    QIFAPRQEEF HQRANVTFTL SKFHWCCHHH VQVQPFFSSC LNDCLRHAVT 300
    VPCPVISNTT VPKPVADYIP LWVYGLITLI AILLVGSVIV LIICMTWRLS 350
    GADQEKHGDD SKINGILPVA DLTPPPLRPR KVWIVYSADH PLYVEVVLKF 400
    AQFLITACGT EVALDLLEEQ VISEVGVMTW VSRQKQEMVE SNSKIIILCS 450
    RGTQAKWKAI LGWAEPAVQL RCDHWKPAGD LFTAAMNMIL PDFKRPACFG 500
    TYVVCYFSGI CSERDVPDLF NITSRYPLMD RFEEVYFRIQ DLEMFEPGRM 550
    HHVRELTGDN YLQSPSGRQL KEAVLRFQEW QTQCPDWFER ENLCLADGQD 600
    LPSLDEEVFE DPLLPPGGGI VKQQPLVREL PSDGCLVVDV CVSEEESRMA 650
    KLDPQLWPQR ELVAHTLQSM VLPAEQVPAA HVVEPLHLPD GSGAAAQLPM 700
    TEDSEACPLL GVQRNSILCL PVDSDDLPLC STPMMSPDHL QGDAREQLES 750
    LMLSVLQQSL SGQPLESWPR PEVVLEGCTP SEEEQRQSVQ SDQGYISRSS 800
    PQPPEWLTEE EELELGEPVE SLSPEELRSL RKLQRQLFFW ELEKNPGWNS 850
    LEPRRPTPEE QNPS 864
    Length:864
    Mass (Da):97,808
    Last modified:November 1, 1996 - v1
    Checksum:i343FD51AA687DA31
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31993 mRNA. Translation: AAC52357.1.
    CCDSiCCDS20482.1.
    RefSeqiNP_032385.1. NM_008359.2.
    UniGeneiMm.4481.

    Genome annotation databases

    EnsembliENSMUST00000002976; ENSMUSP00000002976; ENSMUSG00000002897.
    GeneIDi16172.
    KEGGimmu:16172.
    UCSCiuc009dnj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31993 mRNA. Translation: AAC52357.1 .
    CCDSi CCDS20482.1.
    RefSeqi NP_032385.1. NM_008359.2.
    UniGenei Mm.4481.

    3D structure databases

    ProteinModelPortali Q60943.
    SMRi Q60943. Positions 34-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200620. 3 interactions.
    IntActi Q60943. 4 interactions.
    STRINGi 10090.ENSMUSP00000002976.

    PTM databases

    PhosphoSitei Q60943.

    Proteomic databases

    PRIDEi Q60943.

    Protocols and materials databases

    DNASUi 16172.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000002976 ; ENSMUSP00000002976 ; ENSMUSG00000002897 .
    GeneIDi 16172.
    KEGGi mmu:16172.
    UCSCi uc009dnj.2. mouse.

    Organism-specific databases

    CTDi 23765.
    MGIi MGI:107399. Il17ra.

    Phylogenomic databases

    eggNOGi NOG40152.
    GeneTreei ENSGT00530000063782.
    HOGENOMi HOG000015327.
    HOVERGENi HBG081775.
    InParanoidi Q60943.
    KOi K05164.
    OMAi MTWVGRQ.
    OrthoDBi EOG7P8P7V.
    PhylomeDBi Q60943.
    TreeFami TF329644.

    Miscellaneous databases

    ChiTaRSi IL17RA. mouse.
    NextBioi 289021.
    PROi Q60943.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q60943.
    CleanExi MM_IL17RA.
    Genevestigatori Q60943.

    Family and domain databases

    InterProi IPR013568. SEFIR.
    [Graphical view ]
    Pfami PF08357. SEFIR. 1 hit.
    [Graphical view ]
    PROSITEi PS51534. SEFIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor."
      Yao Z., Fanslow W.C., Seldin M.F., Rousseau A.-M., Painter S.L., Comeau M.R., Cohen J.I., Spriggs M.K.
      Immunity 3:811-821(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Thymic lymphoma.
    2. "Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E."
      Chang S.H., Reynolds J.M., Pappu B.P., Chen G., Martinez G.J., Dong C.
      Immunity 35:611-621(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION AS IL17C CORECEPTOR, INTERACTION WITH IL17RE.
    3. "IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens."
      Song X., Zhu S., Shi P., Liu Y., Shi Y., Levin S.D., Qian Y.
      Nat. Immunol. 12:1151-1158(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION AS IL17C CORECEPTOR, INTERACTION WITH IL17RE.
    4. Cited for: IDENTIFICATION AS IL17C CORECEPTOR, INTERACTION WITH IL17RE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiI17RA_MOUSE
    AccessioniPrimary (citable) accession number: Q60943
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3