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Protein

Interleukin-17 receptor A

Gene

Il17ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for IL17A (PubMed:17911633, PubMed:20554964, PubMed:8777726). Receptor for IL17F (PubMed:17911633, PubMed:20554964). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (By similarity). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848, PubMed:21993849, PubMed:21982598). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (By similarity).By similarity6 Publications

GO - Molecular functioni

  • interleukin-17 receptor activity Source: GO_Central
  • receptor binding Source: UniProtKB

GO - Biological processi

  • defense response to fungus Source: UniProtKB
  • fibroblast activation Source: MGI
  • granulocyte chemotaxis Source: UniProtKB
  • positive regulation of cytokine production involved in inflammatory response Source: MGI
  • positive regulation of inflammatory response Source: MGI
  • positive regulation of interleukin-13 secretion Source: MGI
  • positive regulation of interleukin-23 production Source: MGI
  • positive regulation of interleukin-5 secretion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-448424. Interleukin-17 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17 receptor A
Short name:
IL-17 receptor A
Short name:
IL-17RA
Alternative name(s):
CD_antigen: CD217
Gene namesi
Name:Il17ra
Synonyms:Il17r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107399. Il17ra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 322291ExtracellularSequence analysisAdd
BLAST
Transmembranei323 – 34321HelicalSequence analysisAdd
BLAST
Topological domaini344 – 864521CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 864833Interleukin-17 receptor APRO_0000011031Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 50By similarity
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence analysis
Disulfide bondi57 ↔ 126By similarity
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence analysis
Disulfide bondi185 ↔ 196By similarity
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis
Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence analysis
Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence analysis
Disulfide bondi245 ↔ 276By similarity
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence analysis
Disulfide bondi290 ↔ 294By similarity
Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence analysis
Modified residuei736 – 7361PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ60943.
PaxDbiQ60943.
PeptideAtlasiQ60943.
PRIDEiQ60943.

PTM databases

iPTMnetiQ60943.
PhosphoSiteiQ60943.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000002897.
CleanExiMM_IL17RA.
GenevisibleiQ60943. MM.

Interactioni

Subunit structurei

Forms heterodimers with IL17RE; the heterodimer binds IL17C (PubMed:21993848). Forms heterodimers with IL17RC; the heterodimer binds IL17A and IL17F homodimers as well as the heterodimer formed by IL17A and IL17F (PubMed:20554964).2 Publications

GO - Molecular functioni

  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi200620. 4 interactions.
IntActiQ60943. 4 interactions.
STRINGi10090.ENSMUSP00000002976.

Structurei

3D structure databases

ProteinModelPortaliQ60943.
SMRiQ60943. Positions 34-303, 378-593.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini379 – 537159SEFIRPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi809 – 8146Poly-Glu

Sequence similaritiesi

Contains 1 SEFIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH6C. Eukaryota.
ENOG4111HRA. LUCA.
GeneTreeiENSGT00840000129816.
HOGENOMiHOG000015327.
HOVERGENiHBG081775.
InParanoidiQ60943.
KOiK05164.
OMAiRMHRVGE.
OrthoDBiEOG091G01XZ.
PhylomeDBiQ60943.
TreeFamiTF329644.

Family and domain databases

InterProiIPR032356. IL17R_fnIII_D1.
IPR013568. SEFIR_dom.
[Graphical view]
PfamiPF16556. IL17R_fnIII_D1. 1 hit.
PF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRRCWPRV VPGPALGWLL LLLNVLAPGR ASPRLLDFPA PVCAQEGLSC
60 70 80 90 100
RVKNSTCLDD SWIHPKNLTP SSPKNIYINL SVSSTQHGEL VPVLHVEWTL
110 120 130 140 150
QTDASILYLE GAELSVLQLN TNERLCVKFQ FLSMLQHHRK RWRFSFSHFV
160 170 180 190 200
VDPGQEYEVT VHHLPKPIPD GDPNHKSKII FVPDCEDSKM KMTTSCVSSG
210 220 230 240 250
SLWDPNITVE TLDTQHLRVD FTLWNESTPY QVLLESFSDS ENHSCFDVVK
260 270 280 290 300
QIFAPRQEEF HQRANVTFTL SKFHWCCHHH VQVQPFFSSC LNDCLRHAVT
310 320 330 340 350
VPCPVISNTT VPKPVADYIP LWVYGLITLI AILLVGSVIV LIICMTWRLS
360 370 380 390 400
GADQEKHGDD SKINGILPVA DLTPPPLRPR KVWIVYSADH PLYVEVVLKF
410 420 430 440 450
AQFLITACGT EVALDLLEEQ VISEVGVMTW VSRQKQEMVE SNSKIIILCS
460 470 480 490 500
RGTQAKWKAI LGWAEPAVQL RCDHWKPAGD LFTAAMNMIL PDFKRPACFG
510 520 530 540 550
TYVVCYFSGI CSERDVPDLF NITSRYPLMD RFEEVYFRIQ DLEMFEPGRM
560 570 580 590 600
HHVRELTGDN YLQSPSGRQL KEAVLRFQEW QTQCPDWFER ENLCLADGQD
610 620 630 640 650
LPSLDEEVFE DPLLPPGGGI VKQQPLVREL PSDGCLVVDV CVSEEESRMA
660 670 680 690 700
KLDPQLWPQR ELVAHTLQSM VLPAEQVPAA HVVEPLHLPD GSGAAAQLPM
710 720 730 740 750
TEDSEACPLL GVQRNSILCL PVDSDDLPLC STPMMSPDHL QGDAREQLES
760 770 780 790 800
LMLSVLQQSL SGQPLESWPR PEVVLEGCTP SEEEQRQSVQ SDQGYISRSS
810 820 830 840 850
PQPPEWLTEE EELELGEPVE SLSPEELRSL RKLQRQLFFW ELEKNPGWNS
860
LEPRRPTPEE QNPS
Length:864
Mass (Da):97,808
Last modified:November 1, 1996 - v1
Checksum:i343FD51AA687DA31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31993 mRNA. Translation: AAC52357.1.
CCDSiCCDS20482.1.
RefSeqiNP_032385.1. NM_008359.2.
UniGeneiMm.4481.

Genome annotation databases

EnsembliENSMUST00000002976; ENSMUSP00000002976; ENSMUSG00000002897.
GeneIDi16172.
KEGGimmu:16172.
UCSCiuc009dnj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31993 mRNA. Translation: AAC52357.1.
CCDSiCCDS20482.1.
RefSeqiNP_032385.1. NM_008359.2.
UniGeneiMm.4481.

3D structure databases

ProteinModelPortaliQ60943.
SMRiQ60943. Positions 34-303, 378-593.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200620. 4 interactions.
IntActiQ60943. 4 interactions.
STRINGi10090.ENSMUSP00000002976.

PTM databases

iPTMnetiQ60943.
PhosphoSiteiQ60943.

Proteomic databases

EPDiQ60943.
PaxDbiQ60943.
PeptideAtlasiQ60943.
PRIDEiQ60943.

Protocols and materials databases

DNASUi16172.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002976; ENSMUSP00000002976; ENSMUSG00000002897.
GeneIDi16172.
KEGGimmu:16172.
UCSCiuc009dnj.2. mouse.

Organism-specific databases

CTDi23765.
MGIiMGI:107399. Il17ra.

Phylogenomic databases

eggNOGiENOG410IH6C. Eukaryota.
ENOG4111HRA. LUCA.
GeneTreeiENSGT00840000129816.
HOGENOMiHOG000015327.
HOVERGENiHBG081775.
InParanoidiQ60943.
KOiK05164.
OMAiRMHRVGE.
OrthoDBiEOG091G01XZ.
PhylomeDBiQ60943.
TreeFamiTF329644.

Enzyme and pathway databases

ReactomeiR-MMU-448424. Interleukin-17 signaling.

Miscellaneous databases

ChiTaRSiIl17ra. mouse.
PROiQ60943.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002897.
CleanExiMM_IL17RA.
GenevisibleiQ60943. MM.

Family and domain databases

InterProiIPR032356. IL17R_fnIII_D1.
IPR013568. SEFIR_dom.
[Graphical view]
PfamiPF16556. IL17R_fnIII_D1. 1 hit.
PF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI17RA_MOUSE
AccessioniPrimary (citable) accession number: Q60943
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.