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Q60943 (I17RA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-17 receptor A

Short name=IL-17 receptor A
Short name=IL-17RA
Alternative name(s):
CD_antigen=CD217
Gene names
Name:Il17ra
Synonyms:Il17r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length864 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling By similarity. Ref.3

Subunit structure

Forms heterodimers with IL17RE; the heterodimer binds IL17C.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Widely expressed. Ref.4

Sequence similarities

Contains 1 SEFIR domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 864833Interleukin-17 receptor A
PRO_0000011031

Regions

Topological domain32 – 322291Extracellular Potential
Transmembrane323 – 34321Helical; Potential
Topological domain344 – 864521Cytoplasmic Potential
Domain379 – 537159SEFIR
Compositional bias809 – 8146Poly-Glu

Amino acid modifications

Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation2061N-linked (GlcNAc...) Potential
Glycosylation2251N-linked (GlcNAc...) Potential
Glycosylation2421N-linked (GlcNAc...) Potential
Glycosylation2651N-linked (GlcNAc...) Potential
Glycosylation3081N-linked (GlcNAc...) Potential
Disulfide bond43 ↔ 50 By similarity
Disulfide bond57 ↔ 126 By similarity
Disulfide bond185 ↔ 196 By similarity
Disulfide bond245 ↔ 276 By similarity
Disulfide bond290 ↔ 294 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60943 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 343FD51AA687DA31

FASTA86497,808
        10         20         30         40         50         60 
MAIRRCWPRV VPGPALGWLL LLLNVLAPGR ASPRLLDFPA PVCAQEGLSC RVKNSTCLDD 

        70         80         90        100        110        120 
SWIHPKNLTP SSPKNIYINL SVSSTQHGEL VPVLHVEWTL QTDASILYLE GAELSVLQLN 

       130        140        150        160        170        180 
TNERLCVKFQ FLSMLQHHRK RWRFSFSHFV VDPGQEYEVT VHHLPKPIPD GDPNHKSKII 

       190        200        210        220        230        240 
FVPDCEDSKM KMTTSCVSSG SLWDPNITVE TLDTQHLRVD FTLWNESTPY QVLLESFSDS 

       250        260        270        280        290        300 
ENHSCFDVVK QIFAPRQEEF HQRANVTFTL SKFHWCCHHH VQVQPFFSSC LNDCLRHAVT 

       310        320        330        340        350        360 
VPCPVISNTT VPKPVADYIP LWVYGLITLI AILLVGSVIV LIICMTWRLS GADQEKHGDD 

       370        380        390        400        410        420 
SKINGILPVA DLTPPPLRPR KVWIVYSADH PLYVEVVLKF AQFLITACGT EVALDLLEEQ 

       430        440        450        460        470        480 
VISEVGVMTW VSRQKQEMVE SNSKIIILCS RGTQAKWKAI LGWAEPAVQL RCDHWKPAGD 

       490        500        510        520        530        540 
LFTAAMNMIL PDFKRPACFG TYVVCYFSGI CSERDVPDLF NITSRYPLMD RFEEVYFRIQ 

       550        560        570        580        590        600 
DLEMFEPGRM HHVRELTGDN YLQSPSGRQL KEAVLRFQEW QTQCPDWFER ENLCLADGQD 

       610        620        630        640        650        660 
LPSLDEEVFE DPLLPPGGGI VKQQPLVREL PSDGCLVVDV CVSEEESRMA KLDPQLWPQR 

       670        680        690        700        710        720 
ELVAHTLQSM VLPAEQVPAA HVVEPLHLPD GSGAAAQLPM TEDSEACPLL GVQRNSILCL 

       730        740        750        760        770        780 
PVDSDDLPLC STPMMSPDHL QGDAREQLES LMLSVLQQSL SGQPLESWPR PEVVLEGCTP 

       790        800        810        820        830        840 
SEEEQRQSVQ SDQGYISRSS PQPPEWLTEE EELELGEPVE SLSPEELRSL RKLQRQLFFW 

       850        860 
ELEKNPGWNS LEPRRPTPEE QNPS 

« Hide

References

[1]"Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor."
Yao Z., Fanslow W.C., Seldin M.F., Rousseau A.-M., Painter S.L., Comeau M.R., Cohen J.I., Spriggs M.K.
Immunity 3:811-821(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Thymic lymphoma.
[2]"Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E."
Chang S.H., Reynolds J.M., Pappu B.P., Chen G., Martinez G.J., Dong C.
Immunity 35:611-621(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION AS IL17C CORECEPTOR, INTERACTION WITH IL17RE.
[3]"IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens."
Song X., Zhu S., Shi P., Liu Y., Shi Y., Levin S.D., Qian Y.
Nat. Immunol. 12:1151-1158(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION AS IL17C CORECEPTOR, INTERACTION WITH IL17RE.
[4]"IL-17C regulates the innate immune function of epithelial cells in an autocrine manner."
Ramirez-Carrozzi V., Sambandam A., Luis E., Lin Z., Jeet S., Lesch J., Hackney J., Kim J., Zhou M., Lai J., Modrusan Z., Sai T., Lee W., Xu M., Caplazi P., Diehl L., de Voss J., Balazs M. expand/collapse author list , Gonzalez L. Jr., Singh H., Ouyang W., Pappu R.
Nat. Immunol. 12:1159-1166(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION AS IL17C CORECEPTOR, INTERACTION WITH IL17RE, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U31993 mRNA. Translation: AAC52357.1.
RefSeqNP_032385.1. NM_008359.2.
UniGeneMm.4481.

3D structure databases

ProteinModelPortalQ60943.
SMRQ60943. Positions 34-303, 377-544.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200620. 3 interactions.
IntActQ60943. 4 interactions.
STRING10090.ENSMUSP00000002976.

PTM databases

PhosphoSiteQ60943.

Proteomic databases

PRIDEQ60943.

Protocols and materials databases

DNASU16172.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000002976; ENSMUSP00000002976; ENSMUSG00000002897.
GeneID16172.
KEGGmmu:16172.
UCSCuc009dnj.2. mouse.

Organism-specific databases

CTD23765.
MGIMGI:107399. Il17ra.

Phylogenomic databases

eggNOGNOG40152.
GeneTreeENSGT00530000063782.
HOGENOMHOG000015327.
HOVERGENHBG081775.
InParanoidQ60943.
KOK05164.
OMAMTWVGRQ.
OrthoDBEOG7P8P7V.
PhylomeDBQ60943.
TreeFamTF329644.

Gene expression databases

BgeeQ60943.
CleanExMM_IL17RA.
GenevestigatorQ60943.

Family and domain databases

InterProIPR013568. SEFIR.
[Graphical view]
PfamPF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEPS51534. SEFIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIL17RA. mouse.
NextBio289021.
PROQ60943.
SOURCESearch...

Entry information

Entry nameI17RA_MOUSE
AccessionPrimary (citable) accession number: Q60943
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot