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Q60943

- I17RA_MOUSE

UniProt

Q60943 - I17RA_MOUSE

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Protein

Interleukin-17 receptor A

Gene
Il17ra, Il17r
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling By similarity.1 Publication

GO - Biological processi

  1. cellular response to cytokine stimulus Source: Ensembl
  2. fibroblast activation Source: Ensembl
  3. positive regulation of cytokine production involved in inflammatory response Source: MGI
  4. positive regulation of interleukin-23 production Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17 receptor A
Short name:
IL-17 receptor A
Short name:
IL-17RA
Alternative name(s):
CD_antigen: CD217
Gene namesi
Name:Il17ra
Synonyms:Il17r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:107399. Il17ra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 322291Extracellular Reviewed predictionAdd
BLAST
Transmembranei323 – 34321Helical; Reviewed predictionAdd
BLAST
Topological domaini344 – 864521Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131 Reviewed predictionAdd
BLAST
Chaini32 – 864833Interleukin-17 receptor APRO_0000011031Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 50 By similarity
Glycosylationi54 – 541N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi57 ↔ 126 By similarity
Glycosylationi79 – 791N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi185 ↔ 196 By similarity
Glycosylationi206 – 2061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi225 – 2251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi242 – 2421N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi245 ↔ 276 By similarity
Glycosylationi265 – 2651N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi290 ↔ 294 By similarity
Glycosylationi308 – 3081N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ60943.

PTM databases

PhosphoSiteiQ60943.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ60943.
CleanExiMM_IL17RA.
GenevestigatoriQ60943.

Interactioni

Subunit structurei

Forms heterodimers with IL17RE; the heterodimer binds IL17C.

Protein-protein interaction databases

BioGridi200620. 3 interactions.
IntActiQ60943. 4 interactions.
STRINGi10090.ENSMUSP00000002976.

Structurei

3D structure databases

ProteinModelPortaliQ60943.
SMRiQ60943. Positions 34-303.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini379 – 537159SEFIRAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi809 – 8146Poly-Glu

Sequence similaritiesi

Contains 1 SEFIR domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40152.
GeneTreeiENSGT00530000063782.
HOGENOMiHOG000015327.
HOVERGENiHBG081775.
InParanoidiQ60943.
KOiK05164.
OMAiMTWVGRQ.
OrthoDBiEOG7P8P7V.
PhylomeDBiQ60943.
TreeFamiTF329644.

Family and domain databases

InterProiIPR013568. SEFIR.
[Graphical view]
PfamiPF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60943-1 [UniParc]FASTAAdd to Basket

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MAIRRCWPRV VPGPALGWLL LLLNVLAPGR ASPRLLDFPA PVCAQEGLSC    50
RVKNSTCLDD SWIHPKNLTP SSPKNIYINL SVSSTQHGEL VPVLHVEWTL 100
QTDASILYLE GAELSVLQLN TNERLCVKFQ FLSMLQHHRK RWRFSFSHFV 150
VDPGQEYEVT VHHLPKPIPD GDPNHKSKII FVPDCEDSKM KMTTSCVSSG 200
SLWDPNITVE TLDTQHLRVD FTLWNESTPY QVLLESFSDS ENHSCFDVVK 250
QIFAPRQEEF HQRANVTFTL SKFHWCCHHH VQVQPFFSSC LNDCLRHAVT 300
VPCPVISNTT VPKPVADYIP LWVYGLITLI AILLVGSVIV LIICMTWRLS 350
GADQEKHGDD SKINGILPVA DLTPPPLRPR KVWIVYSADH PLYVEVVLKF 400
AQFLITACGT EVALDLLEEQ VISEVGVMTW VSRQKQEMVE SNSKIIILCS 450
RGTQAKWKAI LGWAEPAVQL RCDHWKPAGD LFTAAMNMIL PDFKRPACFG 500
TYVVCYFSGI CSERDVPDLF NITSRYPLMD RFEEVYFRIQ DLEMFEPGRM 550
HHVRELTGDN YLQSPSGRQL KEAVLRFQEW QTQCPDWFER ENLCLADGQD 600
LPSLDEEVFE DPLLPPGGGI VKQQPLVREL PSDGCLVVDV CVSEEESRMA 650
KLDPQLWPQR ELVAHTLQSM VLPAEQVPAA HVVEPLHLPD GSGAAAQLPM 700
TEDSEACPLL GVQRNSILCL PVDSDDLPLC STPMMSPDHL QGDAREQLES 750
LMLSVLQQSL SGQPLESWPR PEVVLEGCTP SEEEQRQSVQ SDQGYISRSS 800
PQPPEWLTEE EELELGEPVE SLSPEELRSL RKLQRQLFFW ELEKNPGWNS 850
LEPRRPTPEE QNPS 864
Length:864
Mass (Da):97,808
Last modified:November 1, 1996 - v1
Checksum:i343FD51AA687DA31
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31993 mRNA. Translation: AAC52357.1.
CCDSiCCDS20482.1.
RefSeqiNP_032385.1. NM_008359.2.
UniGeneiMm.4481.

Genome annotation databases

EnsembliENSMUST00000002976; ENSMUSP00000002976; ENSMUSG00000002897.
GeneIDi16172.
KEGGimmu:16172.
UCSCiuc009dnj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31993 mRNA. Translation: AAC52357.1 .
CCDSi CCDS20482.1.
RefSeqi NP_032385.1. NM_008359.2.
UniGenei Mm.4481.

3D structure databases

ProteinModelPortali Q60943.
SMRi Q60943. Positions 34-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200620. 3 interactions.
IntActi Q60943. 4 interactions.
STRINGi 10090.ENSMUSP00000002976.

PTM databases

PhosphoSitei Q60943.

Proteomic databases

PRIDEi Q60943.

Protocols and materials databases

DNASUi 16172.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000002976 ; ENSMUSP00000002976 ; ENSMUSG00000002897 .
GeneIDi 16172.
KEGGi mmu:16172.
UCSCi uc009dnj.2. mouse.

Organism-specific databases

CTDi 23765.
MGIi MGI:107399. Il17ra.

Phylogenomic databases

eggNOGi NOG40152.
GeneTreei ENSGT00530000063782.
HOGENOMi HOG000015327.
HOVERGENi HBG081775.
InParanoidi Q60943.
KOi K05164.
OMAi MTWVGRQ.
OrthoDBi EOG7P8P7V.
PhylomeDBi Q60943.
TreeFami TF329644.

Miscellaneous databases

ChiTaRSi IL17RA. mouse.
NextBioi 289021.
PROi Q60943.
SOURCEi Search...

Gene expression databases

Bgeei Q60943.
CleanExi MM_IL17RA.
Genevestigatori Q60943.

Family and domain databases

InterProi IPR013568. SEFIR.
[Graphical view ]
Pfami PF08357. SEFIR. 1 hit.
[Graphical view ]
PROSITEi PS51534. SEFIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor."
    Yao Z., Fanslow W.C., Seldin M.F., Rousseau A.-M., Painter S.L., Comeau M.R., Cohen J.I., Spriggs M.K.
    Immunity 3:811-821(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thymic lymphoma.
  2. "Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E."
    Chang S.H., Reynolds J.M., Pappu B.P., Chen G., Martinez G.J., Dong C.
    Immunity 35:611-621(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS IL17C CORECEPTOR, INTERACTION WITH IL17RE.
  3. "IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens."
    Song X., Zhu S., Shi P., Liu Y., Shi Y., Levin S.D., Qian Y.
    Nat. Immunol. 12:1151-1158(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION AS IL17C CORECEPTOR, INTERACTION WITH IL17RE.
  4. Cited for: IDENTIFICATION AS IL17C CORECEPTOR, INTERACTION WITH IL17RE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiI17RA_MOUSE
AccessioniPrimary (citable) accession number: Q60943
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi