Q60943 (I17RA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-17 receptor A
Short name=IL-17 receptor A
Short name=IL-17RA

Alternative name(s):
CD_antigen=CD217

Gene names

Name:	Il17ra
Synonyms:	Il17r

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	864 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling By similarity. Ref.3
Subunit structure	Forms heterodimers with IL17RE; the heterodimer binds IL17C.
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Tissue specificity	Widely expressed. Ref.4
Sequence similarities	Contains 1 SEFIR domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fibroblast activation Inferred from electronic annotation. Source: Compara positive regulation of cytokine production involved in inflammatory response Inferred from genetic interaction PubMed 16785495. Source: MGI positive regulation of interleukin-23 production Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay PubMed 17911633. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Potential
	Chain	32 – 864	833	Interleukin-17 receptor A		PRO_0000011031
Regions
	Topological domain	32 – 322	291	Extracellular Potential
	Transmembrane	323 – 343	21	Helical; Potential
	Topological domain	344 – 864	521	Cytoplasmic Potential
	Domain	379 – 537	159	SEFIR
	Compositional bias	809 – 814	6	Poly-Glu
Amino acid modifications
	Glycosylation	54	1	N-linked (GlcNAc...) Potential
	Glycosylation	79	1	N-linked (GlcNAc...) Potential
	Glycosylation	206	1	N-linked (GlcNAc...) Potential
	Glycosylation	225	1	N-linked (GlcNAc...) Potential
	Glycosylation	242	1	N-linked (GlcNAc...) Potential
	Glycosylation	265	1	N-linked (GlcNAc...) Potential
	Glycosylation	308	1	N-linked (GlcNAc...) Potential
	Disulfide bond	43 ↔ 50		By similarity
	Disulfide bond	57 ↔ 126		By similarity
	Disulfide bond	185 ↔ 196		By similarity
	Disulfide bond	245 ↔ 276		By similarity
	Disulfide bond	290 ↔ 294		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q60943 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 343FD51AA687DA31	FASTA	864	97,808
	10 20 30 40 50 60 MAIRRCWPRV VPGPALGWLL LLLNVLAPGR ASPRLLDFPA PVCAQEGLSC RVKNSTCLDD 70 80 90 100 110 120 SWIHPKNLTP SSPKNIYINL SVSSTQHGEL VPVLHVEWTL QTDASILYLE GAELSVLQLN 130 140 150 160 170 180 TNERLCVKFQ FLSMLQHHRK RWRFSFSHFV VDPGQEYEVT VHHLPKPIPD GDPNHKSKII 190 200 210 220 230 240 FVPDCEDSKM KMTTSCVSSG SLWDPNITVE TLDTQHLRVD FTLWNESTPY QVLLESFSDS 250 260 270 280 290 300 ENHSCFDVVK QIFAPRQEEF HQRANVTFTL SKFHWCCHHH VQVQPFFSSC LNDCLRHAVT 310 320 330 340 350 360 VPCPVISNTT VPKPVADYIP LWVYGLITLI AILLVGSVIV LIICMTWRLS GADQEKHGDD 370 380 390 400 410 420 SKINGILPVA DLTPPPLRPR KVWIVYSADH PLYVEVVLKF AQFLITACGT EVALDLLEEQ 430 440 450 460 470 480 VISEVGVMTW VSRQKQEMVE SNSKIIILCS RGTQAKWKAI LGWAEPAVQL RCDHWKPAGD 490 500 510 520 530 540 LFTAAMNMIL PDFKRPACFG TYVVCYFSGI CSERDVPDLF NITSRYPLMD RFEEVYFRIQ 550 560 570 580 590 600 DLEMFEPGRM HHVRELTGDN YLQSPSGRQL KEAVLRFQEW QTQCPDWFER ENLCLADGQD 610 620 630 640 650 660 LPSLDEEVFE DPLLPPGGGI VKQQPLVREL PSDGCLVVDV CVSEEESRMA KLDPQLWPQR 670 680 690 700 710 720 ELVAHTLQSM VLPAEQVPAA HVVEPLHLPD GSGAAAQLPM TEDSEACPLL GVQRNSILCL 730 740 750 760 770 780 PVDSDDLPLC STPMMSPDHL QGDAREQLES LMLSVLQQSL SGQPLESWPR PEVVLEGCTP 790 800 810 820 830 840 SEEEQRQSVQ SDQGYISRSS PQPPEWLTEE EELELGEPVE SLSPEELRSL RKLQRQLFFW 850 860 ELEKNPGWNS LEPRRPTPEE QNPS

References

[1]	"Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor." Yao Z., Fanslow W.C., Seldin M.F., Rousseau A.-M., Painter S.L., Comeau M.R., Cohen J.I., Spriggs M.K. Immunity 3:811-821(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Thymic lymphoma.
[2]	"Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E." Chang S.H., Reynolds J.M., Pappu B.P., Chen G., Martinez G.J., Dong C. Immunity 35:611-621(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION AS IL17C CORECEPTOR, INTERACTION WITH IL17RE.
[3]	"IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens." Song X., Zhu S., Shi P., Liu Y., Shi Y., Levin S.D., Qian Y. Nat. Immunol. 12:1151-1158(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, IDENTIFICATION AS IL17C CORECEPTOR, INTERACTION WITH IL17RE.
[4]	"IL-17C regulates the innate immune function of epithelial cells in an autocrine manner." Ramirez-Carrozzi V., Sambandam A., Luis E., Lin Z., Jeet S., Lesch J., Hackney J., Kim J., Zhou M., Lai J., Modrusan Z., Sai T., Lee W., Xu M., Caplazi P., Diehl L., de Voss J., Balazs M. , Gonzalez L. Jr., Singh H., Ouyang W., Pappu R. Nat. Immunol. 12:1159-1166(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION AS IL17C CORECEPTOR, INTERACTION WITH IL17RE, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U31993 mRNA. Translation: AAC52357.1.
IPI	IPI00122584.
RefSeq	NP_032385.1. NM_008359.2.
UniGene	Mm.4481.
3D structure databases
ProteinModelPortal	Q60943.
SMR	Q60943. Positions 34-303.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q60943. 4 interactions.
STRING	10090.ENSMUSP00000002976.
PTM databases
PhosphoSite	Q60943.
Proteomic databases
PRIDE	Q60943.
Protocols and materials databases
DNASU	16172.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000002976; ENSMUSP00000002976; ENSMUSG00000002897.
GeneID	16172.
KEGG	mmu:16172.
UCSC	uc009dnj.2. mouse.
Organism-specific databases
CTD	23765.
MGI	MGI:107399. Il17ra.
Phylogenomic databases
eggNOG	NOG40152.
GeneTree	ENSGT00530000063782.
HOGENOM	HOG000015327.
HOVERGEN	HBG081775.
InParanoid	Q60943.
KO	K05164.
OMA	MTWVGRQ.
OrthoDB	EOG4ZCT3T.
Gene expression databases
Bgee	Q60943.
CleanEx	MM_IL17RA.
Genevestigator	Q60943.
GermOnline	ENSMUSG00000002897. Mus musculus.
Family and domain databases
InterPro	IPR013568. SEFIR. [Graphical view]
Pfam	PF08357. SEFIR. 1 hit. [Graphical view]
PROSITE	PS51534. SEFIR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	IL17RA. mouse.
NextBio	289021.
SOURCE	Search...

Entry information

Entry name

I17RA_MOUSE

Accession

Primary (citable) accession number: Q60943

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program