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Q60936

- ADCK3_MOUSE

UniProt

Q60936 - ADCK3_MOUSE

Protein

Chaperone activity of bc1 complex-like, mitochondrial

Gene

Adck3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (27 Jan 2003)
      Previous versions | rss
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    Functioni

    Putative protein kinase involved in the biosynthesis of coenzyme Q. May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. ubiquinone biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Ubiquinone biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chaperone activity of bc1 complex-like, mitochondrial (EC:2.7.11.-)
    Short name:
    Chaperone-ABC1-like
    Alternative name(s):
    aarF domain-containing protein kinase 3
    Gene namesi
    Name:Adck3
    Synonyms:Cabc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1914676. Adck3.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 645Chaperone activity of bc1 complex-like, mitochondrialPRO_0000000263
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiQ60936.
    PaxDbiQ60936.
    PRIDEiQ60936.

    PTM databases

    PhosphoSiteiQ60936.

    Expressioni

    Gene expression databases

    ArrayExpressiQ60936.
    BgeeiQ60936.
    GenevestigatoriQ60936.

    Interactioni

    Protein-protein interaction databases

    IntActiQ60936. 1 interaction.
    MINTiMINT-1859515.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60936.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini326 – 515190Protein kinaseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0661.
    GeneTreeiENSGT00550000074739.
    HOGENOMiHOG000201140.
    HOVERGENiHBG061318.
    InParanoidiQ60936.
    KOiK08869.
    OMAiHQDQSPV.
    OrthoDBiEOG7X9G6H.
    PhylomeDBiQ60936.
    TreeFamiTF300630.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR004147. UbiB_dom.
    [Graphical view]
    PfamiPF03109. ABC1. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q60936-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAMLGDAIM VAKGLAKLTQ AAVETHLQNL GLGGELLLAA RALQSTAVEQ    50
    FSMVFGKVQG QDKHEDSYAT ENFEDLEAEV QFSTPQAAGT SLDFSAASSL 100
    DQSLSPSHSQ GPAPAYASSG PFREAGLPGQ ATSPMGRVNG RLFVDHRDLF 150
    LANGIQRRSF HQDQSSVGGL TAEDIEKARQ AKARPESKPH KQMLSERARE 200
    RKVPVTRIGR LANFGGLAVG LGIGALAEVA KKSLRSENST GKKAVLDSSP 250
    FLSEANAERI VSTLCKVRGA ALKLGQMLSI QDDAFINPHL AKIFERVRQS 300
    ADFMPLKQMT KTLNSDLGPH WRDKLEYFEE RPFAAASIGQ VHLARMKGGR 350
    EVAMKIQYPG VAQSINSDVN NLMAVLNMSN MLPEGLFPEH LIDVLRRELT 400
    LECDYQREAA YAKKFRELLK DHPFFYVPEI VDELCSPHVL TTELISGFPL 450
    DQAEGLSQEV RNEICYNILV LCLRELFEFH VMQTDPNWSN FFYDPQQHKV 500
    ALLDFGATRE YDRSFTDLYI QVIRAAADQD REAVLKKSIE MKFLTGYEVK 550
    AMEDAHLDAI LILGEAFASE EPFDFGTQST TEKIHNLIPV MLKHRLIPPP 600
    EETYSLHRKM GGSFLICSKL KARFPCKAMF EEAYSNYCRM KSGLQ 645
    Length:645
    Mass (Da):71,743
    Last modified:January 27, 2003 - v2
    Checksum:iC94854B41211F880
    GO
    Isoform 2 (identifier: Q60936-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-276: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:369
    Mass (Da):42,564
    Checksum:iE4CB1DDCC02B4309
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti213 – 2131N → D in BAB29459. (PubMed:16141072)Curated
    Sequence conflicti388 – 3881P → S in BAB29459. (PubMed:16141072)Curated
    Sequence conflicti546 – 5472GY → RP in AAA86413. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 276276Missing in isoform 2. 1 PublicationVSP_022354Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278735 mRNA. Translation: CAC00538.1.
    AK004791 mRNA. Translation: BAB23567.2.
    AK014605 mRNA. Translation: BAB29459.2.
    U31629 mRNA. Translation: AAA86413.1.
    CCDSiCCDS15566.1. [Q60936-1]
    RefSeqiNP_001156762.1. NM_001163290.1. [Q60936-1]
    NP_075830.2. NM_023341.3. [Q60936-1]
    XP_006497023.1. XM_006496960.1. [Q60936-1]
    XP_006497024.1. XM_006496961.1. [Q60936-1]
    XP_006497025.1. XM_006496962.1. [Q60936-1]
    UniGeneiMm.38330.

    Genome annotation databases

    EnsembliENSMUST00000027766; ENSMUSP00000027766; ENSMUSG00000026489. [Q60936-1]
    ENSMUST00000170472; ENSMUSP00000128290; ENSMUSG00000026489. [Q60936-1]
    GeneIDi67426.
    KEGGimmu:67426.
    UCSCiuc007dvx.2. mouse. [Q60936-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278735 mRNA. Translation: CAC00538.1 .
    AK004791 mRNA. Translation: BAB23567.2 .
    AK014605 mRNA. Translation: BAB29459.2 .
    U31629 mRNA. Translation: AAA86413.1 .
    CCDSi CCDS15566.1. [Q60936-1 ]
    RefSeqi NP_001156762.1. NM_001163290.1. [Q60936-1 ]
    NP_075830.2. NM_023341.3. [Q60936-1 ]
    XP_006497023.1. XM_006496960.1. [Q60936-1 ]
    XP_006497024.1. XM_006496961.1. [Q60936-1 ]
    XP_006497025.1. XM_006496962.1. [Q60936-1 ]
    UniGenei Mm.38330.

    3D structure databases

    ProteinModelPortali Q60936.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q60936. 1 interaction.
    MINTi MINT-1859515.

    PTM databases

    PhosphoSitei Q60936.

    Proteomic databases

    MaxQBi Q60936.
    PaxDbi Q60936.
    PRIDEi Q60936.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027766 ; ENSMUSP00000027766 ; ENSMUSG00000026489 . [Q60936-1 ]
    ENSMUST00000170472 ; ENSMUSP00000128290 ; ENSMUSG00000026489 . [Q60936-1 ]
    GeneIDi 67426.
    KEGGi mmu:67426.
    UCSCi uc007dvx.2. mouse. [Q60936-1 ]

    Organism-specific databases

    CTDi 56997.
    MGIi MGI:1914676. Adck3.

    Phylogenomic databases

    eggNOGi COG0661.
    GeneTreei ENSGT00550000074739.
    HOGENOMi HOG000201140.
    HOVERGENi HBG061318.
    InParanoidi Q60936.
    KOi K08869.
    OMAi HQDQSPV.
    OrthoDBi EOG7X9G6H.
    PhylomeDBi Q60936.
    TreeFami TF300630.

    Miscellaneous databases

    ChiTaRSi ADCK3. mouse.
    NextBioi 324532.
    PROi Q60936.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q60936.
    Bgeei Q60936.
    Genevestigatori Q60936.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR004147. UbiB_dom.
    [Graphical view ]
    Pfami PF03109. ABC1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Full length sequencing of some human and murine muscular transcript (Telethon Italy project B41)."
      Ievolella C., Millino C., Lanfranchi G.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Skeletal muscle.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Lung and Skin.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Salivary gland.
    4. Wilks J., Billadello J.J.
      Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 250-547 (ISOFORM 1).
      Tissue: Heart.
    5. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiADCK3_MOUSE
    AccessioniPrimary (citable) accession number: Q60936
    Secondary accession number(s): Q8K0M1
    , Q9D657, Q9DBR5, Q9JHR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 27, 2003
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3