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Q60936 (ADCK3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chaperone activity of bc1 complex-like, mitochondrial
Short name=Chaperone-ABC1-like
EC=2.7.11.-
Alternative name(s):
aarF domain-containing protein kinase 3
Gene names
Name:Adck3
Synonyms:Cabc1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length645 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. ADCK protein kinase family.

Contains 1 protein kinase domain.

Caution

It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityAlternative splicing
   DomainTransit peptide
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
Kinase
Serine/threonine-protein kinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmitochondrion

Inferred from direct assay PubMed 18614015. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q60936-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q60936-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-276: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 645Chaperone activity of bc1 complex-like, mitochondrialPRO_0000000263

Regions

Domain326 – 515190Protein kinase

Natural variations

Alternative sequence1 – 276276Missing in isoform 2.
VSP_022354

Experimental info

Sequence conflict2131N → D in BAB29459. Ref.2
Sequence conflict3881P → S in BAB29459. Ref.2
Sequence conflict546 – 5472GY → RP in AAA86413. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 27, 2003. Version 2.
Checksum: C94854B41211F880

FASTA64571,743
        10         20         30         40         50         60 
MAAMLGDAIM VAKGLAKLTQ AAVETHLQNL GLGGELLLAA RALQSTAVEQ FSMVFGKVQG 

        70         80         90        100        110        120 
QDKHEDSYAT ENFEDLEAEV QFSTPQAAGT SLDFSAASSL DQSLSPSHSQ GPAPAYASSG 

       130        140        150        160        170        180 
PFREAGLPGQ ATSPMGRVNG RLFVDHRDLF LANGIQRRSF HQDQSSVGGL TAEDIEKARQ 

       190        200        210        220        230        240 
AKARPESKPH KQMLSERARE RKVPVTRIGR LANFGGLAVG LGIGALAEVA KKSLRSENST 

       250        260        270        280        290        300 
GKKAVLDSSP FLSEANAERI VSTLCKVRGA ALKLGQMLSI QDDAFINPHL AKIFERVRQS 

       310        320        330        340        350        360 
ADFMPLKQMT KTLNSDLGPH WRDKLEYFEE RPFAAASIGQ VHLARMKGGR EVAMKIQYPG 

       370        380        390        400        410        420 
VAQSINSDVN NLMAVLNMSN MLPEGLFPEH LIDVLRRELT LECDYQREAA YAKKFRELLK 

       430        440        450        460        470        480 
DHPFFYVPEI VDELCSPHVL TTELISGFPL DQAEGLSQEV RNEICYNILV LCLRELFEFH 

       490        500        510        520        530        540 
VMQTDPNWSN FFYDPQQHKV ALLDFGATRE YDRSFTDLYI QVIRAAADQD REAVLKKSIE 

       550        560        570        580        590        600 
MKFLTGYEVK AMEDAHLDAI LILGEAFASE EPFDFGTQST TEKIHNLIPV MLKHRLIPPP 

       610        620        630        640 
EETYSLHRKM GGSFLICSKL KARFPCKAMF EEAYSNYCRM KSGLQ

« Hide

Isoform 2 [UniParc].

Checksum: E4CB1DDCC02B4309
Show »

FASTA36942,564

References

« Hide 'large scale' references
[1]"Full length sequencing of some human and murine muscular transcript (Telethon Italy project B41)."
Ievolella C., Millino C., Lanfranchi G.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Skeletal muscle.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Lung and Skin.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Salivary gland.
[4]Wilks J., Billadello J.J.
Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 250-547 (ISOFORM 1).
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ278735 mRNA. Translation: CAC00538.1.
AK004791 mRNA. Translation: BAB23567.2.
AK014605 mRNA. Translation: BAB29459.2.
U31629 mRNA. Translation: AAA86413.1.
IPIIPI00122554.
IPI00816885.
RefSeqNP_001156762.1. NM_001163290.1.
NP_075830.2. NM_023341.3.
UniGeneMm.38330.

3D structure databases

ProteinModelPortalQ60936.
ModBaseSearch...

PTM databases

PhosphoSiteQ60936.

Proteomic databases

PaxDbQ60936.
PRIDEQ60936.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027766; ENSMUSP00000027766; ENSMUSG00000026489.
ENSMUST00000170472; ENSMUSP00000128290; ENSMUSG00000026489.
GeneID67426.
KEGGmmu:67426.
UCSCuc007dvx.2. mouse.

Organism-specific databases

CTD56997.
MGIMGI:1914676. Adck3.

Phylogenomic databases

eggNOGCOG0661.
GeneTreeENSGT00550000074739.
HOGENOMHOG000201140.
HOVERGENHBG061318.
InParanoidQ60936.
KOK08869.
OMAGATREYD.
OrthoDBEOG4K0QNB.

Gene expression databases

ArrayExpressQ60936.
BgeeQ60936.
GenevestigatorQ60936.
GermOnlineENSMUSG00000026489. Mus musculus.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. False negative.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSADCK3. mouse.
NextBio324532.
SOURCESearch...

Entry information

Entry nameADCK3_MOUSE
AccessionPrimary (citable) accession number: Q60936
Secondary accession number(s): Q8K0M1 expand/collapse secondary AC list , Q9D657, Q9DBR5, Q9JHR3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 27, 2003
Last modified: May 1, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents