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Q60936

- ADCK3_MOUSE

UniProt

Q60936 - ADCK3_MOUSE

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Protein

Chaperone activity of bc1 complex-like, mitochondrial

Gene

Adck3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Putative protein kinase involved in the biosynthesis of coenzyme Q. May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. ubiquinone biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone activity of bc1 complex-like, mitochondrial (EC:2.7.11.-)
Short name:
Chaperone-ABC1-like
Alternative name(s):
aarF domain-containing protein kinase 3
Gene namesi
Name:Adck3
Synonyms:Cabc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1914676. Adck3.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 645Chaperone activity of bc1 complex-like, mitochondrialPRO_0000000263
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

MaxQBiQ60936.
PaxDbiQ60936.
PRIDEiQ60936.

PTM databases

PhosphoSiteiQ60936.

Expressioni

Gene expression databases

BgeeiQ60936.
ExpressionAtlasiQ60936. baseline and differential.
GenevestigatoriQ60936.

Interactioni

Protein-protein interaction databases

IntActiQ60936. 1 interaction.
MINTiMINT-1859515.

Structurei

3D structure databases

ProteinModelPortaliQ60936.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini326 – 515190Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0661.
GeneTreeiENSGT00550000074739.
HOGENOMiHOG000201140.
HOVERGENiHBG061318.
InParanoidiQ60936.
KOiK08869.
OMAiHQDQSPV.
OrthoDBiEOG7X9G6H.
PhylomeDBiQ60936.
TreeFamiTF300630.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q60936-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAMLGDAIM VAKGLAKLTQ AAVETHLQNL GLGGELLLAA RALQSTAVEQ
60 70 80 90 100
FSMVFGKVQG QDKHEDSYAT ENFEDLEAEV QFSTPQAAGT SLDFSAASSL
110 120 130 140 150
DQSLSPSHSQ GPAPAYASSG PFREAGLPGQ ATSPMGRVNG RLFVDHRDLF
160 170 180 190 200
LANGIQRRSF HQDQSSVGGL TAEDIEKARQ AKARPESKPH KQMLSERARE
210 220 230 240 250
RKVPVTRIGR LANFGGLAVG LGIGALAEVA KKSLRSENST GKKAVLDSSP
260 270 280 290 300
FLSEANAERI VSTLCKVRGA ALKLGQMLSI QDDAFINPHL AKIFERVRQS
310 320 330 340 350
ADFMPLKQMT KTLNSDLGPH WRDKLEYFEE RPFAAASIGQ VHLARMKGGR
360 370 380 390 400
EVAMKIQYPG VAQSINSDVN NLMAVLNMSN MLPEGLFPEH LIDVLRRELT
410 420 430 440 450
LECDYQREAA YAKKFRELLK DHPFFYVPEI VDELCSPHVL TTELISGFPL
460 470 480 490 500
DQAEGLSQEV RNEICYNILV LCLRELFEFH VMQTDPNWSN FFYDPQQHKV
510 520 530 540 550
ALLDFGATRE YDRSFTDLYI QVIRAAADQD REAVLKKSIE MKFLTGYEVK
560 570 580 590 600
AMEDAHLDAI LILGEAFASE EPFDFGTQST TEKIHNLIPV MLKHRLIPPP
610 620 630 640
EETYSLHRKM GGSFLICSKL KARFPCKAMF EEAYSNYCRM KSGLQ
Length:645
Mass (Da):71,743
Last modified:January 27, 2003 - v2
Checksum:iC94854B41211F880
GO
Isoform 2 (identifier: Q60936-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-276: Missing.

Note: No experimental confirmation available.

Show »
Length:369
Mass (Da):42,564
Checksum:iE4CB1DDCC02B4309
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti213 – 2131N → D in BAB29459. (PubMed:16141072)Curated
Sequence conflicti388 – 3881P → S in BAB29459. (PubMed:16141072)Curated
Sequence conflicti546 – 5472GY → RP in AAA86413. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 276276Missing in isoform 2. 1 PublicationVSP_022354Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278735 mRNA. Translation: CAC00538.1.
AK004791 mRNA. Translation: BAB23567.2.
AK014605 mRNA. Translation: BAB29459.2.
U31629 mRNA. Translation: AAA86413.1.
CCDSiCCDS15566.1. [Q60936-1]
RefSeqiNP_001156762.1. NM_001163290.1. [Q60936-1]
NP_075830.2. NM_023341.3. [Q60936-1]
XP_006497023.1. XM_006496960.1. [Q60936-1]
XP_006497024.1. XM_006496961.1. [Q60936-1]
XP_006497025.1. XM_006496962.1. [Q60936-1]
UniGeneiMm.38330.

Genome annotation databases

EnsembliENSMUST00000027766; ENSMUSP00000027766; ENSMUSG00000026489. [Q60936-1]
ENSMUST00000170472; ENSMUSP00000128290; ENSMUSG00000026489. [Q60936-1]
GeneIDi67426.
KEGGimmu:67426.
UCSCiuc007dvx.2. mouse. [Q60936-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278735 mRNA. Translation: CAC00538.1 .
AK004791 mRNA. Translation: BAB23567.2 .
AK014605 mRNA. Translation: BAB29459.2 .
U31629 mRNA. Translation: AAA86413.1 .
CCDSi CCDS15566.1. [Q60936-1 ]
RefSeqi NP_001156762.1. NM_001163290.1. [Q60936-1 ]
NP_075830.2. NM_023341.3. [Q60936-1 ]
XP_006497023.1. XM_006496960.1. [Q60936-1 ]
XP_006497024.1. XM_006496961.1. [Q60936-1 ]
XP_006497025.1. XM_006496962.1. [Q60936-1 ]
UniGenei Mm.38330.

3D structure databases

ProteinModelPortali Q60936.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q60936. 1 interaction.
MINTi MINT-1859515.

PTM databases

PhosphoSitei Q60936.

Proteomic databases

MaxQBi Q60936.
PaxDbi Q60936.
PRIDEi Q60936.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027766 ; ENSMUSP00000027766 ; ENSMUSG00000026489 . [Q60936-1 ]
ENSMUST00000170472 ; ENSMUSP00000128290 ; ENSMUSG00000026489 . [Q60936-1 ]
GeneIDi 67426.
KEGGi mmu:67426.
UCSCi uc007dvx.2. mouse. [Q60936-1 ]

Organism-specific databases

CTDi 56997.
MGIi MGI:1914676. Adck3.

Phylogenomic databases

eggNOGi COG0661.
GeneTreei ENSGT00550000074739.
HOGENOMi HOG000201140.
HOVERGENi HBG061318.
InParanoidi Q60936.
KOi K08869.
OMAi HQDQSPV.
OrthoDBi EOG7X9G6H.
PhylomeDBi Q60936.
TreeFami TF300630.

Miscellaneous databases

ChiTaRSi Adck3. mouse.
NextBioi 324532.
PROi Q60936.
SOURCEi Search...

Gene expression databases

Bgeei Q60936.
ExpressionAtlasi Q60936. baseline and differential.
Genevestigatori Q60936.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view ]
Pfami PF03109. ABC1. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Full length sequencing of some human and murine muscular transcript (Telethon Italy project B41)."
    Ievolella C., Millino C., Lanfranchi G.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Skeletal muscle.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Lung and Skin.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Salivary gland.
  4. Wilks J., Billadello J.J.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 250-547 (ISOFORM 1).
    Tissue: Heart.
  5. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiADCK3_MOUSE
AccessioniPrimary (citable) accession number: Q60936
Secondary accession number(s): Q8K0M1
, Q9D657, Q9DBR5, Q9JHR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 27, 2003
Last modified: November 26, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3