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Protein

GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

Gene

Art1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has ADP-ribosyltransferase activity toward GLP1R.By similarity

Catalytic activityi

NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei117 – 1171NADBy similarity
Binding sitei174 – 1741NADBy similarity
Binding sitei228 – 2281NADBy similarity
Active sitei242 – 2421By similarity

GO - Molecular functioni

GO - Biological processi

  • protein ADP-ribosylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (EC:2.4.2.31)
Alternative name(s):
ADP-ribosyltransferase C2 and C3 toxin-like 1
Short name:
ARTC1
Mono(ADP-ribosyl)transferase 1
YAC-1
CD_antigen: CD296
Gene namesi
Name:Art1
Synonyms:Art2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107511. Art1.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: MGI
  • cell surface Source: MGI
  • sarcoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 290268GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1PRO_0000019313Add
BLAST
Propeptidei291 – 32535Removed in mature formSequence analysisPRO_0000019314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 272By similarity
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence analysis
Disulfide bondi169 ↔ 219By similarity
Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence analysis
Lipidationi290 – 2901GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ60935.
PaxDbiQ60935.
PRIDEiQ60935.

PTM databases

iPTMnetiQ60935.
PhosphoSiteiQ60935.

Expressioni

Tissue specificityi

Abundantly expressed in cardiac and skeletal muscle. Low levels also found in lung.

Gene expression databases

BgeeiENSMUSG00000030996.
CleanExiMM_ART1.
ExpressionAtlasiQ60935. baseline and differential.
GenevisibleiQ60935. MM.

Interactioni

Protein-protein interaction databases

IntActiQ60935. 1 interaction.
STRINGi10090.ENSMUSP00000033300.

Structurei

3D structure databases

ProteinModelPortaliQ60935.
SMRiQ60935. Positions 39-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGR0. Eukaryota.
ENOG4111WZG. LUCA.
GeneTreeiENSGT00530000062975.
HOGENOMiHOG000273888.
HOVERGENiHBG004464.
InParanoidiQ60935.
KOiK06716.
OMAiCLGAPIK.
OrthoDBiEOG091G0BSN.
PhylomeDBiQ60935.
TreeFamiTF335356.

Family and domain databases

InterProiIPR000768. ART.
[Graphical view]
PfamiPF01129. ART. 1 hit.
[Graphical view]
PRINTSiPR00970. RIBTRNSFRASE.
PROSITEiPS01291. ART. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIPAMMSLL LVSVGLRDGV QVQSYSISQL DIFSQETPLD MAPASFDDQY
60 70 80 90 100
AGCLADMTAA LPDLNHSEFQ ANKVYADGWA QANNQWQERR AWGSVWGSLP
110 120 130 140 150
PSPPGFRDEH GVALLAYTAN SPLHKEFNAA VREAGRSRAH YLHHFSFKTL
160 170 180 190 200
HFLLTEALQL LRSHRSRGCQ QVYRGVHGLR FRPAGPGATV RLGGFASASL
210 220 230 240 250
KNVAAQQFGE DTFFGIWTCL GAPIRGYSFF PEEEEVLIPP FETFQVINTS
260 270 280 290 300
RPTQGPARIY LRALGKRSTY NCEYIKEKKC RSGPCWLGSS APGSISASCS
310 320
LLLLLLFLVL SALPENPGLQ QLTRC
Length:325
Mass (Da):35,898
Last modified:November 1, 1997 - v1
Checksum:i763EB891F2A49474
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431P → Q in CAA65094 (PubMed:8812442).Curated
Sequence conflicti132 – 1321R → L in CAA65094 (PubMed:8812442).Curated
Sequence conflicti277 – 29014Missing in CAA65094 (PubMed:8812442).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31510 mRNA. Translation: AAB18628.1.
X95825 Genomic DNA. Translation: CAA65094.1.
X95842 mRNA. Translation: CAA65099.1.
BC063760 mRNA. Translation: AAH63760.1.
CCDSiCCDS21526.1.
RefSeqiNP_033840.2. NM_009710.4.
XP_011239959.1. XM_011241657.1.
UniGeneiMm.261071.

Genome annotation databases

EnsembliENSMUST00000033300; ENSMUSP00000033300; ENSMUSG00000030996.
GeneIDi11870.
KEGGimmu:11870.
UCSCiuc009iqu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31510 mRNA. Translation: AAB18628.1.
X95825 Genomic DNA. Translation: CAA65094.1.
X95842 mRNA. Translation: CAA65099.1.
BC063760 mRNA. Translation: AAH63760.1.
CCDSiCCDS21526.1.
RefSeqiNP_033840.2. NM_009710.4.
XP_011239959.1. XM_011241657.1.
UniGeneiMm.261071.

3D structure databases

ProteinModelPortaliQ60935.
SMRiQ60935. Positions 39-274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ60935. 1 interaction.
STRINGi10090.ENSMUSP00000033300.

PTM databases

iPTMnetiQ60935.
PhosphoSiteiQ60935.

Proteomic databases

MaxQBiQ60935.
PaxDbiQ60935.
PRIDEiQ60935.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033300; ENSMUSP00000033300; ENSMUSG00000030996.
GeneIDi11870.
KEGGimmu:11870.
UCSCiuc009iqu.1. mouse.

Organism-specific databases

CTDi417.
MGIiMGI:107511. Art1.

Phylogenomic databases

eggNOGiENOG410IGR0. Eukaryota.
ENOG4111WZG. LUCA.
GeneTreeiENSGT00530000062975.
HOGENOMiHOG000273888.
HOVERGENiHBG004464.
InParanoidiQ60935.
KOiK06716.
OMAiCLGAPIK.
OrthoDBiEOG091G0BSN.
PhylomeDBiQ60935.
TreeFamiTF335356.

Miscellaneous databases

PROiQ60935.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030996.
CleanExiMM_ART1.
ExpressionAtlasiQ60935. baseline and differential.
GenevisibleiQ60935. MM.

Family and domain databases

InterProiIPR000768. ART.
[Graphical view]
PfamiPF01129. ART. 1 hit.
[Graphical view]
PRINTSiPR00970. RIBTRNSFRASE.
PROSITEiPS01291. ART. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAR1_MOUSE
AccessioniPrimary (citable) accession number: Q60935
Secondary accession number(s): P70688
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.