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Protein

Voltage-dependent anion-selective channel protein 3

Gene

Vdac3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi242 – 244NADBy similarity3
Nucleotide bindingi260 – 264NADBy similarity5

GO - Molecular functioni

GO - Biological processi

  • behavioral fear response Source: MGI
  • chemical synaptic transmission Source: MGI
  • learning Source: MGI
  • neuron-neuron synaptic transmission Source: MGI
  • regulation of cilium assembly Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

NAD, Nucleotide-binding

Protein family/group databases

TCDBi1.B.8.1.2. the mitochondrial and plastid porin (mpp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent anion-selective channel protein 3
Short name:
VDAC-3
Short name:
mVDAC3
Alternative name(s):
Outer mitochondrial membrane protein porin 3
Gene namesi
Name:Vdac3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:106922. Vdac3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 35Beta strandedBy similarity10
Transmembranei39 – 47Beta strandedBy similarity9
Transmembranei54 – 64Beta strandedBy similarityAdd BLAST11
Transmembranei69 – 76Beta strandedBy similarity8
Transmembranei80 – 89Beta strandedBy similarity10
Transmembranei95 – 104Beta strandedBy similarity10
Transmembranei111 – 120Beta strandedBy similarity10
Transmembranei123 – 130Beta strandedBy similarity8
Transmembranei137 – 145Beta strandedBy similarity9
Transmembranei150 – 158Beta strandedBy similarity9
Transmembranei163 – 175Beta strandedBy similarityAdd BLAST13
Transmembranei178 – 185Beta strandedBy similarity8
Transmembranei189 – 198Beta strandedBy similarity10
Transmembranei202 – 211Beta strandedBy similarity10
Transmembranei218 – 227Beta strandedBy similarity10
Transmembranei231 – 238Beta strandedBy similarity8
Transmembranei242 – 251Beta strandedBy similarity10
Transmembranei254 – 263Beta strandedBy similarity10
Transmembranei273 – 282Beta strandedBy similarity10

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • mitochondrial inner membrane Source: MGI
  • mitochondrial outer membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
  • nucleus Source: MGI
  • pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000505132 – 283Voltage-dependent anion-selective channel protein 3Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteineBy similarity1
Modified residuei4PhosphothreonineBy similarity1
Modified residuei20N6-acetyllysine; alternateBy similarity1
Modified residuei20N6-succinyllysine; alternateBy similarity1
Cross-linki53Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei67PhosphotyrosineBy similarity1
Modified residuei90N6-acetyllysineBy similarity1
Modified residuei107PhosphothreonineBy similarity1
Modified residuei109N6-acetyllysine; alternateBy similarity1
Cross-linki109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Cross-linki110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki161Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei241PhosphoserineBy similarity1
Modified residuei266N6-acetyllysine; alternateBy similarity1
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity

Post-translational modificationi

Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ60931.
MaxQBiQ60931.
PaxDbiQ60931.
PRIDEiQ60931.

PTM databases

iPTMnetiQ60931.
PhosphoSitePlusiQ60931.
SwissPalmiQ60931.

Expressioni

Tissue specificityi

Highest levels of expression detected in testis, less but still abundant expression in heart, kidney, brain, and skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000008892.
CleanExiMM_VDAC3.
ExpressionAtlasiQ60931. baseline and differential.
GenevisibleiQ60931. MM.

Interactioni

Protein-protein interaction databases

BioGridi204509. 3 interactors.
IntActiQ60931. 6 interactors.
MINTiMINT-1858022.
STRINGi10090.ENSMUSP00000009036.

Structurei

3D structure databases

ProteinModelPortaliQ60931.
SMRiQ60931.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
GeneTreeiENSGT00390000011336.
HOGENOMiHOG000188277.
HOVERGENiHBG054036.
InParanoidiQ60931.
KOiK15041.
PhylomeDBiQ60931.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
IPR030271. VDAC3.
[Graphical view]
PANTHERiPTHR11743:SF28. PTHR11743:SF28. 1 hit.
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCNTPTYCDL GKAAKDVFNK GYGFGMVKID LKTKSCSGVE FSTSGHAYTD
60 70 80 90 100
TGKASGNLET KYKVCNYGLT FTQKWNTDNT LGTEISWENK LAEGLKLTLD
110 120 130 140 150
TIFVPNTGKK SGKLKASYRR DCFSLGSNVD IDFSGPTIYG WAVLAFEGWL
160 170 180 190 200
AGYQMSFDTA KSKLSQNNFA LGYKAADFQL HTHVNDGTEF GGSIYQKVNE
210 220 230 240 250
RIETSINLAW TAGSNNTRFG IAAKYKLDCR TSLSAKVNNA SLIGLGYTQT
260 270 280
LRPGVKLTLS ALIDGKNFNA GGHKVGLGFE LEA
Length:283
Mass (Da):30,753
Last modified:November 1, 1996 - v1
Checksum:iA95AFD67C611228C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39V → VM in BAC39019 (PubMed:16141072).Curated1
Sequence conflicti174K → E in BAC39019 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30839 mRNA. Translation: AAB47776.1.
AK083785 mRNA. Translation: BAC39019.1.
BC004743 mRNA. Translation: AAH04743.1.
CCDSiCCDS22179.1.
RefSeqiNP_035826.1. NM_011696.2.
UniGeneiMm.227704.

Genome annotation databases

EnsembliENSMUST00000009036; ENSMUSP00000009036; ENSMUSG00000008892.
GeneIDi22335.
KEGGimmu:22335.
UCSCiuc012gbf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30839 mRNA. Translation: AAB47776.1.
AK083785 mRNA. Translation: BAC39019.1.
BC004743 mRNA. Translation: AAH04743.1.
CCDSiCCDS22179.1.
RefSeqiNP_035826.1. NM_011696.2.
UniGeneiMm.227704.

3D structure databases

ProteinModelPortaliQ60931.
SMRiQ60931.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204509. 3 interactors.
IntActiQ60931. 6 interactors.
MINTiMINT-1858022.
STRINGi10090.ENSMUSP00000009036.

Protein family/group databases

TCDBi1.B.8.1.2. the mitochondrial and plastid porin (mpp) family.

PTM databases

iPTMnetiQ60931.
PhosphoSitePlusiQ60931.
SwissPalmiQ60931.

Proteomic databases

EPDiQ60931.
MaxQBiQ60931.
PaxDbiQ60931.
PRIDEiQ60931.

Protocols and materials databases

DNASUi22335.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009036; ENSMUSP00000009036; ENSMUSG00000008892.
GeneIDi22335.
KEGGimmu:22335.
UCSCiuc012gbf.1. mouse.

Organism-specific databases

CTDi7419.
MGIiMGI:106922. Vdac3.

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
GeneTreeiENSGT00390000011336.
HOGENOMiHOG000188277.
HOVERGENiHBG054036.
InParanoidiQ60931.
KOiK15041.
PhylomeDBiQ60931.

Miscellaneous databases

PROiQ60931.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008892.
CleanExiMM_VDAC3.
ExpressionAtlasiQ60931. baseline and differential.
GenevisibleiQ60931. MM.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
IPR030271. VDAC3.
[Graphical view]
PANTHERiPTHR11743:SF28. PTHR11743:SF28. 1 hit.
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVDAC3_MOUSE
AccessioniPrimary (citable) accession number: Q60931
Secondary accession number(s): Q8BNG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.