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Q60931 (VDAC3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Voltage-dependent anion-selective channel protein 3
Short name=VDAC-3
Short name=mVDAC3
Alternative name(s):
Outer mitochondrial membrane protein porin 3
Gene names
Name:Vdac3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules By similarity.

Subcellular location

Mitochondrion outer membrane.

Tissue specificity

Highest levels of expression detected in testis, less but still abundant expression in heart, kidney, brain, and skeletal muscle.

Domain

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands By similarity.

Sequence similarities

Belongs to the eukaryotic mitochondrial porin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283Voltage-dependent anion-selective channel protein 3
PRO_0000050513

Regions

Transmembrane26 – 3510Beta stranded; By similarity
Transmembrane39 – 479Beta stranded; By similarity
Transmembrane54 – 6411Beta stranded; By similarity
Transmembrane69 – 768Beta stranded; By similarity
Transmembrane80 – 8910Beta stranded; By similarity
Transmembrane95 – 10410Beta stranded; By similarity
Transmembrane111 – 12010Beta stranded; By similarity
Transmembrane123 – 1308Beta stranded; By similarity
Transmembrane137 – 1459Beta stranded; By similarity
Transmembrane150 – 1589Beta stranded; By similarity
Transmembrane163 – 17513Beta stranded; By similarity
Transmembrane178 – 1858Beta stranded; By similarity
Transmembrane189 – 19810Beta stranded; By similarity
Transmembrane202 – 21110Beta stranded; By similarity
Transmembrane218 – 22710Beta stranded; By similarity
Transmembrane231 – 2388Beta stranded; By similarity
Transmembrane242 – 25110Beta stranded; By similarity
Transmembrane254 – 26310Beta stranded; By similarity
Transmembrane273 – 28210Beta stranded; By similarity
Nucleotide binding242 – 2443NAD By similarity
Nucleotide binding260 – 2645NAD By similarity

Amino acid modifications

Modified residue201N6-acetyllysine Ref.5
Modified residue281N6-acetyllysine By similarity
Modified residue331Phosphothreonine By similarity
Modified residue481Phosphotyrosine Ref.6
Modified residue611N6-acetyllysine Ref.5
Modified residue631N6-acetyllysine By similarity
Modified residue901N6-acetyllysine By similarity
Modified residue2261N6-acetyllysine Ref.5
Modified residue2411Phosphoserine By similarity

Experimental info

Sequence conflict391V → VM in BAC39019. Ref.2
Sequence conflict1741K → E in BAC39019. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q60931 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A95AFD67C611228C

FASTA28330,753
        10         20         30         40         50         60 
MCNTPTYCDL GKAAKDVFNK GYGFGMVKID LKTKSCSGVE FSTSGHAYTD TGKASGNLET 

        70         80         90        100        110        120 
KYKVCNYGLT FTQKWNTDNT LGTEISWENK LAEGLKLTLD TIFVPNTGKK SGKLKASYRR 

       130        140        150        160        170        180 
DCFSLGSNVD IDFSGPTIYG WAVLAFEGWL AGYQMSFDTA KSKLSQNNFA LGYKAADFQL 

       190        200        210        220        230        240 
HTHVNDGTEF GGSIYQKVNE RIETSINLAW TAGSNNTRFG IAAKYKLDCR TSLSAKVNNA 

       250        260        270        280 
SLIGLGYTQT LRPGVKLTLS ALIDGKNFNA GGHKVGLGFE LEA

« Hide

References

« Hide 'large scale' references
[1]"A novel mouse mitochondrial voltage-dependent anion channel gene localizes to chromosome 8."
Sampson M.J., Lovell R.S., Davison D.B., Craigen W.J.
Genomics 36:192-196(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Spinal ganglion.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
[4]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 257-266, MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
[5]"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey."
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.
Mol. Cell 23:607-618(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-20; LYS-61 AND LYS-226, MASS SPECTROMETRY.
Tissue: Liver.
[6]"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-48, MASS SPECTROMETRY.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U30839 mRNA. Translation: AAB47776.1.
AK083785 mRNA. Translation: BAC39019.1.
BC004743 mRNA. Translation: AAH04743.1.
IPIIPI00122548.
RefSeqNP_035826.1. NM_011696.2.
UniGeneMm.227704.

3D structure databases

ProteinModelPortalQ60931.
SMRQ60931. Positions 5-283.
ModBaseSearch...

Protein-protein interaction databases

IntActQ60931. 2 interactions.

Protein family/group databases

TCDB1.B.8.1.2. mitochondrial and plastid porin (MPP) family.

PTM databases

PhosphoSiteQ60931.

Proteomic databases

PaxDbQ60931.
PRIDEQ60931.

Protocols and materials databases

DNASU22335.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000009036; ENSMUSP00000009036; ENSMUSG00000008892.
GeneID22335.
KEGGmmu:22335.

Organism-specific databases

CTD7419.
MGIMGI:106922. Vdac3.

Phylogenomic databases

eggNOGNOG243169.
GeneTreeENSGT00390000011336.
HOGENOMHOG000188277.
HOVERGENHBG054036.
KOK15041.
OrthoDBEOG4JDH78.

Gene expression databases

ArrayExpressQ60931.
BgeeQ60931.
CleanExMM_VDAC3.
GenevestigatorQ60931.
GermOnlineENSMUSG00000008892. Mus musculus.

Family and domain databases

Gene3D2.40.160.10. 1 hit.
InterProIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSPR00185. EUKARYTPORIN.
PROSITEPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio302583.
SOURCESearch...

Entry information

Entry nameVDAC3_MOUSE
AccessionPrimary (citable) accession number: Q60931
Secondary accession number(s): Q8BNG2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents