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Protein

Voltage-dependent anion-selective channel protein 2

Gene

Vdac2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei85Involved in hexokinase bindingBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi254 – 256NADBy similarity3
Nucleotide bindingi272 – 276NADBy similarity5

GO - Molecular functioni

GO - Biological processi

  • anion transport Source: MGI
  • binding of sperm to zona pellucida Source: MGI
  • negative regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
  • negative regulation of protein polymerization Source: UniProtKB

Keywordsi

Molecular functionPorin
Biological processIon transport, Transport
LigandNAD, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent anion-selective channel protein 2
Short name:
VDAC-2
Short name:
mVDAC2
Alternative name(s):
Outer mitochondrial membrane protein porin 2
Voltage-dependent anion-selective channel protein 6
Short name:
VDAC-6
Short name:
mVDAC6
Gene namesi
Name:Vdac2
Synonyms:Vdac6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:106915 Vdac2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei38 – 47Beta strandedBy similarity10
Transmembranei51 – 59Beta strandedBy similarity9
Transmembranei66 – 76Beta strandedBy similarityAdd BLAST11
Transmembranei81 – 88Beta strandedBy similarity8
Transmembranei92 – 101Beta strandedBy similarity10
Transmembranei107 – 116Beta strandedBy similarity10
Transmembranei123 – 132Beta strandedBy similarity10
Transmembranei135 – 142Beta strandedBy similarity8
Transmembranei149 – 157Beta strandedBy similarity9
Transmembranei162 – 170Beta strandedBy similarity9
Transmembranei175 – 187Beta strandedBy similarityAdd BLAST13
Transmembranei190 – 197Beta strandedBy similarity8
Transmembranei201 – 210Beta strandedBy similarity10
Transmembranei214 – 223Beta strandedBy similarity10
Transmembranei230 – 239Beta strandedBy similarity10
Transmembranei243 – 250Beta strandedBy similarity8
Transmembranei254 – 263Beta strandedBy similarity10
Transmembranei266 – 275Beta strandedBy similarity10
Transmembranei285 – 294Beta strandedBy similarity10

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000505061 – 295Voltage-dependent anion-selective channel protein 2Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32N6-acetyllysine; alternateCombined sources1
Modified residuei32N6-succinyllysine; alternateCombined sources1
Cross-linki32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei79PhosphotyrosineBy similarity1
Modified residuei119PhosphothreonineBy similarity1
Modified residuei121N6-acetyllysine; alternateCombined sources1
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki173Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei252PhosphoserineBy similarity1
Modified residuei278N6-acetyllysine; alternateBy similarity1
Cross-linki278Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity

Post-translational modificationi

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ60930
MaxQBiQ60930
PaxDbiQ60930
PeptideAtlasiQ60930
PRIDEiQ60930

2D gel databases

REPRODUCTION-2DPAGEQ60930

PTM databases

iPTMnetiQ60930
PhosphoSitePlusiQ60930
SwissPalmiQ60930

Expressioni

Tissue specificityi

Highest levels of expression detected in testis, less but still abundant expression in heart, kidney, brain, and skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000021771
CleanExiMM_VDAC2
ExpressionAtlasiQ60930 baseline and differential
GenevisibleiQ60930 MM

Interactioni

Subunit structurei

Interacts with hexokinases.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Bak1O087343EBI-444578,EBI-822441

Protein-protein interaction databases

BioGridi204508, 6 interactors
IntActiQ60930, 19 interactors
MINTiQ60930
STRINGi10090.ENSMUSP00000022293

Structurei

3D structure databases

ProteinModelPortaliQ60930
SMRiQ60930
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3126 Eukaryota
ENOG410ZBK1 LUCA
GeneTreeiENSGT00390000011336
HOGENOMiHOG000188277
HOVERGENiHBG054036
InParanoidiQ60930
KOiK15040
OMAiAKINNAG
OrthoDBiEOG091G0F0O
PhylomeDBiQ60930
TreeFamiTF315091

Family and domain databases

Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR001925 Porin_Euk
IPR027246 Porin_Euk/Tom40
IPR030277 VDAC2
PANTHERiPTHR11743:SF12 PTHR11743:SF12, 1 hit
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit
PRINTSiPR00185 EUKARYTPORIN
PROSITEiView protein in PROSITE
PS00558 EUKARYOTIC_PORIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q60930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAECCVPVCP RPMCIPPPYA DLGKAARDIF NKGFGFGLVK LDVKTKSCSG
60 70 80 90 100
VEFSTSGSSN TDTGKVSGTL ETKYKWCEYG LTFTEKWNTD NTLGTEIAIE
110 120 130 140 150
DQICQGLKLT FDTTFSPNTG KKSGKIKSAY KRECINLGCD VDFDFAGPAI
160 170 180 190 200
HGSAVFGYEG WLAGYQMTFD SAKSKLTRSN FAVGYRTGDF QLHTNVNNGT
210 220 230 240 250
EFGGSIYQKV CEDFDTSVNL AWTSGTNCTR FGIAAKYQLD PTASISAKVN
260 270 280 290
NSSLIGVGYT QTLRPGVKLT LSALVDGKSF NAGGHKLGLA LELEA
Length:295
Mass (Da):31,733
Last modified:August 1, 1998 - v2
Checksum:i7BBCDC625AD013C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti260T → A in AAH03731 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30838 mRNA Translation: AAC13321.1
AK168199 mRNA Translation: BAE40159.1
AK159561 mRNA Translation: BAE35185.1
AK152274 mRNA Translation: BAE31090.1
AK150940 mRNA Translation: BAE29975.1
AK150627 mRNA Translation: BAE29717.1
AK150504 mRNA Translation: BAE29617.1
AK012359 mRNA Translation: BAE43231.1
AY294423 Genomic DNA Translation: AAQ01516.1
BC003731 mRNA Translation: AAH03731.2
CCDSiCCDS26867.1
RefSeqiNP_035825.1, NM_011695.2
UniGeneiMm.262327

Genome annotation databases

EnsembliENSMUST00000022293; ENSMUSP00000022293; ENSMUSG00000021771
GeneIDi22334
KEGGimmu:22334
UCSCiuc007sls.1 mouse

Similar proteinsi

Entry informationi

Entry nameiVDAC2_MOUSE
AccessioniPrimary (citable) accession number: Q60930
Secondary accession number(s): Q78MH6, Q99L98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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