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Q60930 (VDAC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Voltage-dependent anion-selective channel protein 2
Short name=VDAC-2
Short name=mVDAC2
Alternative name(s):
Outer mitochondrial membrane protein porin 2
Voltage-dependent anion-selective channel protein 6
Short name=VDAC-6
Short name=mVDAC6
Gene names
Name:Vdac2
Synonyms:Vdac6
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective By similarity.

Subunit structure

Interacts with hexokinases By similarity.

Subcellular location

Mitochondrion outer membrane.

Tissue specificity

Highest levels of expression detected in testis, less but still abundant expression in heart, kidney, brain, and skeletal muscle.

Domain

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands By similarity.

Sequence similarities

Belongs to the eukaryotic mitochondrial porin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Voltage-dependent anion-selective channel protein 2
PRO_0000050506

Regions

Transmembrane38 – 4710Beta stranded; By similarity
Transmembrane51 – 599Beta stranded; By similarity
Transmembrane66 – 7611Beta stranded; By similarity
Transmembrane81 – 888Beta stranded; By similarity
Transmembrane92 – 10110Beta stranded; By similarity
Transmembrane107 – 11610Beta stranded; By similarity
Transmembrane123 – 13210Beta stranded; By similarity
Transmembrane135 – 1428Beta stranded; By similarity
Transmembrane149 – 1579Beta stranded; By similarity
Transmembrane162 – 1709Beta stranded; By similarity
Transmembrane175 – 18713Beta stranded; By similarity
Transmembrane190 – 1978Beta stranded; By similarity
Transmembrane201 – 21010Beta stranded; By similarity
Transmembrane214 – 22310Beta stranded; By similarity
Transmembrane230 – 23910Beta stranded; By similarity
Transmembrane243 – 2508Beta stranded; By similarity
Transmembrane254 – 26310Beta stranded; By similarity
Transmembrane266 – 27510Beta stranded; By similarity
Transmembrane285 – 29410Beta stranded; By similarity
Nucleotide binding254 – 2563NAD By similarity
Nucleotide binding272 – 2765NAD By similarity

Sites

Site851Involved in hexokinase binding By similarity

Amino acid modifications

Modified residue321N6-acetyllysine Ref.6
Modified residue401N6-acetyllysine By similarity
Modified residue731N6-acetyllysine By similarity
Modified residue751N6-acetyllysine Ref.6
Modified residue1161Phosphoserine By similarity
Modified residue2071Phosphotyrosine Ref.7
Modified residue2371Phosphotyrosine By similarity

Experimental info

Sequence conflict2601T → A in AAH03731. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q60930 [UniParc].

Last modified August 1, 1998. Version 2.
Checksum: 7BBCDC625AD013C7

FASTA29531,733
        10         20         30         40         50         60 
MAECCVPVCP RPMCIPPPYA DLGKAARDIF NKGFGFGLVK LDVKTKSCSG VEFSTSGSSN 

        70         80         90        100        110        120 
TDTGKVSGTL ETKYKWCEYG LTFTEKWNTD NTLGTEIAIE DQICQGLKLT FDTTFSPNTG 

       130        140        150        160        170        180 
KKSGKIKSAY KRECINLGCD VDFDFAGPAI HGSAVFGYEG WLAGYQMTFD SAKSKLTRSN 

       190        200        210        220        230        240 
FAVGYRTGDF QLHTNVNNGT EFGGSIYQKV CEDFDTSVNL AWTSGTNCTR FGIAAKYQLD 

       250        260        270        280        290 
PTASISAKVN NSSLIGVGYT QTLRPGVKLT LSALVDGKSF NAGGHKLGLA LELEA

« Hide

References

« Hide 'large scale' references
[1]"Isolation, characterization, and mapping of two mouse mitochondrial voltage-dependent anion channel isoforms."
Sampson M.J., Lovell R.S., Craigen W.J.
Genomics 33:283-288(1996) [PubMed: 8660977] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: BALB/c and C57BL/6J.
Tissue: Bone marrow.
[3]"Genomic sequence analysis in the mouse T-complex region."
Brathwaite M.E., Waeltz P., Qian Y., Dudekula D., Schlessinger D., Nagaraja R.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[5]Lubec G., Klug S., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 33-40; 47-65; 76-121; 179-230 AND 237-278, MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain and Hippocampus.
[6]"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey."
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.
Mol. Cell 23:607-618(2006) [PubMed: 16916647] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-32 AND LYS-75, MASS SPECTROMETRY.
Tissue: Liver.
[7]"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
J. Proteome Res. 7:311-318(2008) [PubMed: 18034455] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-207, MASS SPECTROMETRY.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U30838 mRNA. Translation: AAC13321.1.
AK168199 mRNA. Translation: BAE40159.1.
AK159561 mRNA. Translation: BAE35185.1.
AK152274 mRNA. Translation: BAE31090.1.
AK150940 mRNA. Translation: BAE29975.1.
AK150627 mRNA. Translation: BAE29717.1.
AK150504 mRNA. Translation: BAE29617.1.
AK012359 mRNA. Translation: BAE43231.1.
AY294423 Genomic DNA. Translation: AAQ01516.1.
BC003731 mRNA. Translation: AAH03731.2.
IPIIPI00122547.
RefSeqNP_035825.1. NM_011695.2.
UniGeneMm.262327.

3D structure databases

ProteinModelPortalQ60930.
SMRQ60930. Positions 13-295.
ModBaseSearch...

Protein-protein interaction databases

IntActQ60930. 6 interactions.
STRINGQ60930.

PTM databases

PhosphoSiteQ60930.

2D gel databases

REPRODUCTION-2DPAGEQ60930.

Proteomic databases

PRIDEQ60930.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022293; ENSMUSP00000022293; ENSMUSG00000021771.
GeneID22334.
KEGGmmu:22334.
UCSCuc007sls.1. mouse.

Organism-specific databases

CTD7417.
MGIMGI:106915. Vdac2.

Phylogenomic databases

eggNOGroNOG11568.
GeneTreeENSGT00390000011336.
HOGENOMHBG396026.
HOVERGENHBG054036.
InParanoidQ60930.
OMAQLSWASG.
OrthoDBEOG4T4CVZ.
PhylomeDBQ60930.

Gene expression databases

ArrayExpressQ60930.
BgeeQ60930.
CleanExMM_VDAC2.
GenevestigatorQ60930.
GermOnlineENSMUSG00000021771. Mus musculus.

Family and domain databases

InterProIPR001925. Porin_Euk.
[Graphical view]
KOK15040.
PfamPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSPR00185. EUKARYTPORIN.
PROSITEPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio302579.
SOURCESearch...

Entry information

Entry nameVDAC2_MOUSE
AccessionPrimary (citable) accession number: Q60930
Secondary accession number(s): Q78MH6, Q99L98
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 16, 2011
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents