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Q60925

- DBP_MOUSE

UniProt

Q60925 - DBP_MOUSE

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Protein

D site-binding protein

Gene

Dbp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation By similarity.By similarity

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  2. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. circadian rhythm Source: MGI
  2. liver development Source: Ensembl
  3. regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_115781. Bmal1:Clock,Npas2 activates circadian gene expression.
REACT_198620. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
D site-binding protein
Alternative name(s):
Albumin D box-binding protein
Albumin D-element-binding protein
Gene namesi
Name:Dbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:94866. Dbp.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325D site-binding proteinPRO_0000076508Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei86 – 861PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ60925.

PTM databases

PhosphoSiteiQ60925.

Expressioni

Tissue specificityi

Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.

Inductioni

Accumulates according to a robust circadian rhythm in liver and kidney. In liver nuclei, the amplitude of daily oscillation has been estimated to be >50-fold, and 2-fold in the brain.

Gene expression databases

BgeeiQ60925.
CleanExiMM_DBP.
ExpressionAtlasiQ60925. baseline and differential.
GenevestigatoriQ60925.

Interactioni

Subunit structurei

Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF By similarity.By similarity

Protein-protein interaction databases

BioGridi199060. 7 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ60925.
SMRiQ60925. Positions 229-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini255 – 31864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni257 – 27923Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni283 – 29715Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi129 – 1357Poly-Pro
Compositional biasi156 – 1616Poly-Ser
Compositional biasi188 – 23952Pro-rich (proline/acidic region (PAR))Add
BLAST

Sequence similaritiesi

Belongs to the bZIP family. PAR subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG238019.
GeneTreeiENSGT00440000039070.
HOGENOMiHOG000234383.
HOVERGENiHBG004983.
InParanoidiQ60925.
KOiK09056.
OMAiKEPTSCL.
OrthoDBiEOG712TZJ.
PhylomeDBiQ60925.
TreeFamiTF315869.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60925-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARPLSDRTP GPLLLGGPAG APPGGGALLG LRSLLQGNSK PKEPASCLLK
60 70 80 90 100
EKERKATLPS APVPGPGLET AGPADAPSGA VSGGGSPRGR SGPVAGPSLF
110 120 130 140 150
APLLWERTLP FGDVEYVDLD AFLLEHGLPP SPPPPGGLSP APSPARTPAP
160 170 180 190 200
SPGPGSCSSS SPRSSPGHAP ARATLGAAGG HRAGLTSRDT PSPVDPDTVE
210 220 230 240 250
VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI MKKARKVQVP
260 270 280 290 300
EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE
310 320
VVAVRQELSH YRAVLSRYQA QHGTL
Length:325
Mass (Da):34,380
Last modified:May 10, 2004 - v2
Checksum:iB2B2A3E091845A16
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601S → T in AAA73924. 1 PublicationCurated
Sequence conflicti109 – 1091L → F in AAA73924. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U29762 Genomic DNA. Translation: AAA73924.1.
BC018323 mRNA. Translation: AAH18323.1.
CCDSiCCDS21260.1.
RefSeqiNP_058670.2. NM_016974.3.
UniGeneiMm.24222.
Mm.378235.

Genome annotation databases

EnsembliENSMUST00000080885; ENSMUSP00000079693; ENSMUSG00000059824.
GeneIDi13170.
KEGGimmu:13170.
UCSCiuc009gws.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U29762 Genomic DNA. Translation: AAA73924.1 .
BC018323 mRNA. Translation: AAH18323.1 .
CCDSi CCDS21260.1.
RefSeqi NP_058670.2. NM_016974.3.
UniGenei Mm.24222.
Mm.378235.

3D structure databases

ProteinModelPortali Q60925.
SMRi Q60925. Positions 229-314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199060. 7 interactions.

PTM databases

PhosphoSitei Q60925.

Proteomic databases

PRIDEi Q60925.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000080885 ; ENSMUSP00000079693 ; ENSMUSG00000059824 .
GeneIDi 13170.
KEGGi mmu:13170.
UCSCi uc009gws.2. mouse.

Organism-specific databases

CTDi 1628.
MGIi MGI:94866. Dbp.

Phylogenomic databases

eggNOGi NOG238019.
GeneTreei ENSGT00440000039070.
HOGENOMi HOG000234383.
HOVERGENi HBG004983.
InParanoidi Q60925.
KOi K09056.
OMAi KEPTSCL.
OrthoDBi EOG712TZJ.
PhylomeDBi Q60925.
TreeFami TF315869.

Enzyme and pathway databases

Reactomei REACT_115781. Bmal1:Clock,Npas2 activates circadian gene expression.
REACT_198620. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

Miscellaneous databases

NextBioi 283264.
PROi Q60925.
SOURCEi Search...

Gene expression databases

Bgeei Q60925.
CleanExi MM_DBP.
ExpressionAtlasi Q60925. baseline and differential.
Genevestigatori Q60925.

Family and domain databases

InterProi IPR004827. bZIP.
[Graphical view ]
Pfami PF07716. bZIP_2. 1 hit.
[Graphical view ]
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Lee Y.H., Oguchi H., Gonzalez F.J.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  3. "The two PAR leucine zipper proteins, TEF and DBP, display similar circadian and tissue-specific expression, but have different target promoter preferences."
    Fonjallaz P., Ossipow V., Wanner G., Schibler U.
    EMBO J. 15:351-362(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CIRCADIAN INDUCTION.
  4. "The loss of circadian PAR bZip transcription factors results in epilepsy."
    Gachon F., Fonjallaz P., Damiola F., Gos P., Kodama T., Zakany J., Duboule D., Petit B., Tafti M., Schibler U.
    Genes Dev. 18:1397-1412(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN EPILEPSY.

Entry informationi

Entry nameiDBP_MOUSE
AccessioniPrimary (citable) accession number: Q60925
Secondary accession number(s): Q8VCX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2004
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Mice deficient for all three PAR bZIP proteins (DBP, HLF and TEF) display a dramatically shortened life span and are highly susceptible to generalized spontaneous and audiogenic epilepsies (due for example to the noise of a vacuum cleaner) that are frequently lethal. The down-regulation of pyridoxal kinase (Pdxk) expression in these mice may participate in this seizure phenotype.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3