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Q60925 (DBP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D site-binding protein
Alternative name(s):
Albumin D box-binding protein
Albumin D-element-binding protein
Gene names
Name:Dbp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation By similarity.

Subunit structure

Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF By similarity.

Subcellular location

Nucleus.

Tissue specificity

Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.

Induction

Accumulates according to a robust circadian rhythm in liver and kidney. In liver nuclei, the amplitude of daily oscillation has been estimated to be >50-fold, and 2-fold in the brain. Ref.3

Miscellaneous

Mice deficient for all three PAR bZIP proteins (DBP, HLF and TEF) display a dramatically shortened life span and are highly susceptible to generalized spontaneous and audiogenic epilepsies (due for example to the noise of a vacuum cleaner) that are frequently lethal. The down-regulation of pyridoxal kinase (Pdxk) expression in these mice may participate in this seizure phenotype.

Sequence similarities

Belongs to the bZIP family. PAR subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325D site-binding protein
PRO_0000076508

Regions

Domain255 – 31864bZIP
Region257 – 27923Basic motif By similarity
Region283 – 29715Leucine-zipper By similarity
Compositional bias129 – 1357Poly-Pro
Compositional bias156 – 1616Poly-Ser
Compositional bias188 – 23952Pro-rich (proline/acidic region (PAR))

Amino acid modifications

Modified residue861Phosphoserine By similarity

Experimental info

Sequence conflict601S → T in AAA73924. Ref.1
Sequence conflict1091L → F in AAA73924. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q60925 [UniParc].

Last modified May 10, 2004. Version 2.
Checksum: B2B2A3E091845A16

FASTA32534,380
        10         20         30         40         50         60 
MARPLSDRTP GPLLLGGPAG APPGGGALLG LRSLLQGNSK PKEPASCLLK EKERKATLPS 

        70         80         90        100        110        120 
APVPGPGLET AGPADAPSGA VSGGGSPRGR SGPVAGPSLF APLLWERTLP FGDVEYVDLD 

       130        140        150        160        170        180 
AFLLEHGLPP SPPPPGGLSP APSPARTPAP SPGPGSCSSS SPRSSPGHAP ARATLGAAGG 

       190        200        210        220        230        240 
HRAGLTSRDT PSPVDPDTVE VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI 

       250        260        270        280        290        300 
MKKARKVQVP EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE 

       310        320 
VVAVRQELSH YRAVLSRYQA QHGTL 

« Hide

References

« Hide 'large scale' references
[1]Lee Y.H., Oguchi H., Gonzalez F.J.
Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[3]"The two PAR leucine zipper proteins, TEF and DBP, display similar circadian and tissue-specific expression, but have different target promoter preferences."
Fonjallaz P., Ossipow V., Wanner G., Schibler U.
EMBO J. 15:351-362(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: CIRCADIAN INDUCTION.
[4]"The loss of circadian PAR bZip transcription factors results in epilepsy."
Gachon F., Fonjallaz P., Damiola F., Gos P., Kodama T., Zakany J., Duboule D., Petit B., Tafti M., Schibler U.
Genes Dev. 18:1397-1412(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN EPILEPSY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U29762 Genomic DNA. Translation: AAA73924.1.
BC018323 mRNA. Translation: AAH18323.1.
CCDSCCDS21260.1.
RefSeqNP_058670.2. NM_016974.3.
UniGeneMm.24222.
Mm.378235.

3D structure databases

ProteinModelPortalQ60925.
SMRQ60925. Positions 229-314.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199060. 7 interactions.

PTM databases

PhosphoSiteQ60925.

Proteomic databases

PRIDEQ60925.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000080885; ENSMUSP00000079693; ENSMUSG00000059824.
GeneID13170.
KEGGmmu:13170.
UCSCuc009gws.2. mouse.

Organism-specific databases

CTD1628.
MGIMGI:94866. Dbp.

Phylogenomic databases

eggNOGNOG238019.
GeneTreeENSGT00440000039070.
HOGENOMHOG000234383.
HOVERGENHBG004983.
InParanoidQ60925.
KOK09056.
OMAKEPTSCL.
OrthoDBEOG712TZJ.
PhylomeDBQ60925.
TreeFamTF315869.

Enzyme and pathway databases

ReactomeREACT_200794. Mus musculus biological processes.

Gene expression databases

ArrayExpressQ60925.
BgeeQ60925.
CleanExMM_DBP.
GenevestigatorQ60925.

Family and domain databases

InterProIPR004827. bZIP.
[Graphical view]
PfamPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283264.
PROQ60925.
SOURCESearch...

Entry information

Entry nameDBP_MOUSE
AccessionPrimary (citable) accession number: Q60925
Secondary accession number(s): Q8VCX3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2004
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot