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Q60925

- DBP_MOUSE

UniProt

Q60925 - DBP_MOUSE

Protein

D site-binding protein

Gene

Dbp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (10 May 2004)
      Previous versions | rss
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    Functioni

    This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation By similarity.By similarity

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
    2. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl

    GO - Biological processi

    1. circadian rhythm Source: MGI
    2. liver development Source: Ensembl
    3. regulation of transcription, DNA-templated Source: MGI

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Biological rhythms, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_115781. Bmal1:Clock,Npas2 activates circadian gene expression.
    REACT_198620. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D site-binding protein
    Alternative name(s):
    Albumin D box-binding protein
    Albumin D-element-binding protein
    Gene namesi
    Name:Dbp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:94866. Dbp.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325D site-binding proteinPRO_0000076508Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei86 – 861PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ60925.

    PTM databases

    PhosphoSiteiQ60925.

    Expressioni

    Tissue specificityi

    Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.

    Inductioni

    Accumulates according to a robust circadian rhythm in liver and kidney. In liver nuclei, the amplitude of daily oscillation has been estimated to be >50-fold, and 2-fold in the brain.

    Gene expression databases

    ArrayExpressiQ60925.
    BgeeiQ60925.
    CleanExiMM_DBP.
    GenevestigatoriQ60925.

    Interactioni

    Subunit structurei

    Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF By similarity.By similarity

    Protein-protein interaction databases

    BioGridi199060. 7 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60925.
    SMRiQ60925. Positions 229-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini255 – 31864bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni257 – 27923Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni283 – 29715Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi129 – 1357Poly-Pro
    Compositional biasi156 – 1616Poly-Ser
    Compositional biasi188 – 23952Pro-rich (proline/acidic region (PAR))Add
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. PAR subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG238019.
    GeneTreeiENSGT00440000039070.
    HOGENOMiHOG000234383.
    HOVERGENiHBG004983.
    InParanoidiQ60925.
    KOiK09056.
    OMAiKEPTSCL.
    OrthoDBiEOG712TZJ.
    PhylomeDBiQ60925.
    TreeFamiTF315869.

    Family and domain databases

    InterProiIPR004827. bZIP.
    [Graphical view]
    PfamiPF07716. bZIP_2. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60925-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARPLSDRTP GPLLLGGPAG APPGGGALLG LRSLLQGNSK PKEPASCLLK    50
    EKERKATLPS APVPGPGLET AGPADAPSGA VSGGGSPRGR SGPVAGPSLF 100
    APLLWERTLP FGDVEYVDLD AFLLEHGLPP SPPPPGGLSP APSPARTPAP 150
    SPGPGSCSSS SPRSSPGHAP ARATLGAAGG HRAGLTSRDT PSPVDPDTVE 200
    VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI MKKARKVQVP 250
    EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE 300
    VVAVRQELSH YRAVLSRYQA QHGTL 325
    Length:325
    Mass (Da):34,380
    Last modified:May 10, 2004 - v2
    Checksum:iB2B2A3E091845A16
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti60 – 601S → T in AAA73924. 1 PublicationCurated
    Sequence conflicti109 – 1091L → F in AAA73924. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29762 Genomic DNA. Translation: AAA73924.1.
    BC018323 mRNA. Translation: AAH18323.1.
    CCDSiCCDS21260.1.
    RefSeqiNP_058670.2. NM_016974.3.
    UniGeneiMm.24222.
    Mm.378235.

    Genome annotation databases

    EnsembliENSMUST00000080885; ENSMUSP00000079693; ENSMUSG00000059824.
    GeneIDi13170.
    KEGGimmu:13170.
    UCSCiuc009gws.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29762 Genomic DNA. Translation: AAA73924.1 .
    BC018323 mRNA. Translation: AAH18323.1 .
    CCDSi CCDS21260.1.
    RefSeqi NP_058670.2. NM_016974.3.
    UniGenei Mm.24222.
    Mm.378235.

    3D structure databases

    ProteinModelPortali Q60925.
    SMRi Q60925. Positions 229-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199060. 7 interactions.

    PTM databases

    PhosphoSitei Q60925.

    Proteomic databases

    PRIDEi Q60925.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000080885 ; ENSMUSP00000079693 ; ENSMUSG00000059824 .
    GeneIDi 13170.
    KEGGi mmu:13170.
    UCSCi uc009gws.2. mouse.

    Organism-specific databases

    CTDi 1628.
    MGIi MGI:94866. Dbp.

    Phylogenomic databases

    eggNOGi NOG238019.
    GeneTreei ENSGT00440000039070.
    HOGENOMi HOG000234383.
    HOVERGENi HBG004983.
    InParanoidi Q60925.
    KOi K09056.
    OMAi KEPTSCL.
    OrthoDBi EOG712TZJ.
    PhylomeDBi Q60925.
    TreeFami TF315869.

    Enzyme and pathway databases

    Reactomei REACT_115781. Bmal1:Clock,Npas2 activates circadian gene expression.
    REACT_198620. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

    Miscellaneous databases

    NextBioi 283264.
    PROi Q60925.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q60925.
    Bgeei Q60925.
    CleanExi MM_DBP.
    Genevestigatori Q60925.

    Family and domain databases

    InterProi IPR004827. bZIP.
    [Graphical view ]
    Pfami PF07716. bZIP_2. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Lee Y.H., Oguchi H., Gonzalez F.J.
      Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    3. "The two PAR leucine zipper proteins, TEF and DBP, display similar circadian and tissue-specific expression, but have different target promoter preferences."
      Fonjallaz P., Ossipow V., Wanner G., Schibler U.
      EMBO J. 15:351-362(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: CIRCADIAN INDUCTION.
    4. "The loss of circadian PAR bZip transcription factors results in epilepsy."
      Gachon F., Fonjallaz P., Damiola F., Gos P., Kodama T., Zakany J., Duboule D., Petit B., Tafti M., Schibler U.
      Genes Dev. 18:1397-1412(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN EPILEPSY.

    Entry informationi

    Entry nameiDBP_MOUSE
    AccessioniPrimary (citable) accession number: Q60925
    Secondary accession number(s): Q8VCX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Mice deficient for all three PAR bZIP proteins (DBP, HLF and TEF) display a dramatically shortened life span and are highly susceptible to generalized spontaneous and audiogenic epilepsies (due for example to the noise of a vacuum cleaner) that are frequently lethal. The down-regulation of pyridoxal kinase (Pdxk) expression in these mice may participate in this seizure phenotype.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3