Q60902 (EP15R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Epidermal growth factor receptor substrate 15-like 1

Alternative name(s):
Epidermal growth factor receptor pathway substrate 15-related sequence
Short name=Eps15-rs
Eps15-related protein
Short name=Eps15R

Gene names

Name:	Eps15l1
Synonyms:	Eps15-rs, Eps15R

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	907 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2 By similarity.
Subunit structure	Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2). Interacts with FCHO1 By similarity. Interacts with FCHO2. Interacts (via EH domains) with DAB2. Ref.5 Ref.11 Ref.12
Subcellular location	Cell membrane; Peripheral membrane protein. Nucleus. Membrane › coated pit. Note: Localized to plasma membrane coated pits. Ref.5
Post-translational modification	Phosphorylated on tyrosine residues by EGFR. Ref.5
Sequence similarities	Contains 1 EF-hand domain. Contains 3 EH domains. Contains 2 UIM (ubiquitin-interacting motif) repeats.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Cell membrane Coated pit Membrane Nucleus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat
Ligand	Calcium Metal-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	endocytosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	coated pit Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Dab2	P98078	2	EBI-443931,EBI-1391846
Eps15	P42567	2	EBI-443931,EBI-443923

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q60902-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q60902-2)

The sequence of this isoform differs from the canonical sequence as follows:
     794-819: STPVSQLGSSDFPESPDPFQPLGADS → YASSSRGTRRWGQGGGHRAPPLSSPE
     820-907: Missing.

Isoform 3 (identifier: Q60902-3)

The sequence of this isoform differs from the canonical sequence as follows:
     596-599: DDPF → VKVE
     600-819: Missing.

Isoform 4 (identifier: Q60902-4)

The sequence of this isoform differs from the canonical sequence as follows:
     565-595: Missing.
     748-860: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 907	907	Epidermal growth factor receptor substrate 15-like 1		PRO_0000146119
Regions
	Domain	15 – 104	90	EH 1
	Domain	127 – 215	89	EH 2
	Domain	159 – 194	36	EF-hand
	Domain	273 – 363	91	EH 3
	Repeat	863 – 882	20	UIM 1
	Repeat	889 – 907	19	UIM 2
	Calcium binding	172 – 183	12	Potential
	Region	15 – 368	354	Interaction with DAB2
	Compositional bias	748 – 848	101	Pro-rich
Amino acid modifications
	Modified residue	9	1	Phosphoserine Ref.10
	Modified residue	30	1	Phosphotyrosine Ref.10
	Modified residue	31	1	Phosphothreonine Ref.10
	Modified residue	74	1	Phosphotyrosine Ref.6
	Modified residue	229	1	Phosphoserine Ref.7
	Modified residue	238	1	Phosphoserine Ref.10
	Modified residue	244	1	Phosphoserine Ref.8
	Modified residue	250	1	Phosphoserine Ref.8
	Modified residue	255	1	Phosphoserine Ref.8 Ref.9 Ref.10
	Modified residue	353	1	Phosphoserine Ref.7
	Modified residue	364	1	Phosphothreonine Ref.7
	Modified residue	558	1	Phosphoserine By similarity
	Modified residue	795	1	Phosphothreonine By similarity
Natural variations
	Alternative sequence	565 – 595	31	Missing in isoform 4.		VSP_022638
	Alternative sequence	596 – 599	4	DDPF → VKVE in isoform 3.		VSP_010681
	Alternative sequence	600 – 819	220	Missing in isoform 3.		VSP_010682
	Alternative sequence	748 – 860	113	Missing in isoform 4.		VSP_022639
	Alternative sequence	794 – 819	26	STPVS…LGADS → YASSSRGTRRWGQGGGHRAP PLSSPE in isoform 2.		VSP_010683
	Alternative sequence	820 – 907	88	Missing in isoform 2.		VSP_010684
Experimental info
	Sequence conflict	14	1	G → S in AAA87202. Ref.1
	Sequence conflict	14	1	G → S in AAH15259. Ref.4
	Sequence conflict	29	1	A → P in AAA87202. Ref.1
	Sequence conflict	170	1	L → V in BAE31350. Ref.2
	Sequence conflict	413	1	R → K in AAA87202. Ref.1
	Sequence conflict	413	1	R → K in AAH15259. Ref.4
	Sequence conflict	726	1	D → H in BAC29523. Ref.2
	Sequence conflict	821	1	D → E in AAA87202. Ref.1
	Sequence conflict	850	1	T → A in AAA87202. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 27, 2011. Version 3. Checksum: B5AF1A89B445E8A7	FASTA	907	99,309
	10 20 30 40 50 60 MAAPLVPLSQ QIPGGNPLYE SYYKQVDPAY TGRVGASEAA LFLKKSGLSD IILGKIWDLA 70 80 90 100 110 120 DPEGKGFLDK QGFYVALRLV ACAQSGHEVT LSSLSLTMPP PKFHDTSSPL MATQSSAETH 130 140 150 160 170 180 WAVRVEEKAK FDGIFESLLP VNGLLSGDKV KPVLMNSKLP LDVLGRVWDL SDIDKDGHLD 190 200 210 220 230 240 RDEFAVAMHL VYRALEKEPV PSILPPPLIP PSKRKKTVFA GAVPVLPASP PPKDSLRSTP 250 260 270 280 290 300 SHGSVSSLNS TGSLSPKHSV KQPPVAWVVP VADKMRFDEI FLKTDLDLDG YVSGQEVKEI 310 320 330 340 350 360 FMHSGLTQNL LAHIWALADT RQTGKLSKEQ FALAMYFIQQ KVSKGIDPPQ VLSPDMVPPS 370 380 390 400 410 420 ERGTPIPDSS STLASGEFTG VKELDDISQE IAQLQREKYS LEQDIREKEE AIRQKTSEVQ 430 440 450 460 470 480 ELQNDLDRET SSLQELEAQK QDAQDRLDEM DQQKAKLRDM LSDVRQKCQD ETQTISSLKT 490 500 510 520 530 540 QIQSQESDLK SQEDDLNRAK SELNRLQQEE TQLEQSIQAG RAQLETILRS LKCTQDDINQ 550 560 570 580 590 600 ARSKLSQLQE SHLEAHRSLE QYDQVPDGVS GTSLPDLATL NEGILLAERG GFGAMDDPFK 610 620 630 640 650 660 NKALLFSNNS QELHPDPFQA EDPFKSDPFK GADPFKGDPF QSDPFSEQQT AATDPFGGDP 670 680 690 700 710 720 FKESDPFHSS SSDDFFKKQT KNDPFTSDPF TKNPSLPSKL DPFESSDPFS SSSISSKGSD 730 740 750 760 770 780 PFGTLDPFGS SSFSSAEGFA DFSQMSKPPP SGPFSSSLGG TGFSDDPFKS KQDTPALPPK 790 800 810 820 830 840 KPAPPRPKPP SGQSTPVSQL GSSDFPESPD PFQPLGADSG DPFQNKKGFG DPFSGKDPFA 850 860 870 880 890 900 PSSSAKPPKT SSSGFADFTS FGNEEQQLAW AKRESEKAEQ ERLARLRRQE QEDLELAIAL SKADMPA
	Isoform 2 [UniParc]. Checksum: D46667729E593945	FASTA	819	89,728
	10 20 30 40 50 60 MAAPLVPLSQ QIPGGNPLYE SYYKQVDPAY TGRVGASEAA LFLKKSGLSD IILGKIWDLA 70 80 90 100 110 120 DPEGKGFLDK QGFYVALRLV ACAQSGHEVT LSSLSLTMPP PKFHDTSSPL MATQSSAETH 130 140 150 160 170 180 WAVRVEEKAK FDGIFESLLP VNGLLSGDKV KPVLMNSKLP LDVLGRVWDL SDIDKDGHLD 190 200 210 220 230 240 RDEFAVAMHL VYRALEKEPV PSILPPPLIP PSKRKKTVFA GAVPVLPASP PPKDSLRSTP 250 260 270 280 290 300 SHGSVSSLNS TGSLSPKHSV KQPPVAWVVP VADKMRFDEI FLKTDLDLDG YVSGQEVKEI 310 320 330 340 350 360 FMHSGLTQNL LAHIWALADT RQTGKLSKEQ FALAMYFIQQ KVSKGIDPPQ VLSPDMVPPS 370 380 390 400 410 420 ERGTPIPDSS STLASGEFTG VKELDDISQE IAQLQREKYS LEQDIREKEE AIRQKTSEVQ 430 440 450 460 470 480 ELQNDLDRET SSLQELEAQK QDAQDRLDEM DQQKAKLRDM LSDVRQKCQD ETQTISSLKT 490 500 510 520 530 540 QIQSQESDLK SQEDDLNRAK SELNRLQQEE TQLEQSIQAG RAQLETILRS LKCTQDDINQ 550 560 570 580 590 600 ARSKLSQLQE SHLEAHRSLE QYDQVPDGVS GTSLPDLATL NEGILLAERG GFGAMDDPFK 610 620 630 640 650 660 NKALLFSNNS QELHPDPFQA EDPFKSDPFK GADPFKGDPF QSDPFSEQQT AATDPFGGDP 670 680 690 700 710 720 FKESDPFHSS SSDDFFKKQT KNDPFTSDPF TKNPSLPSKL DPFESSDPFS SSSISSKGSD 730 740 750 760 770 780 PFGTLDPFGS SSFSSAEGFA DFSQMSKPPP SGPFSSSLGG TGFSDDPFKS KQDTPALPPK 790 800 810 KPAPPRPKPP SGQYASSSRG TRRWGQGGGH RAPPLSSPE
	Isoform 3 [UniParc]. Checksum: F30E20D19F47A4DA	FASTA	687	75,877
	10 20 30 40 50 60 MAAPLVPLSQ QIPGGNPLYE SYYKQVDPAY TGRVGASEAA LFLKKSGLSD IILGKIWDLA 70 80 90 100 110 120 DPEGKGFLDK QGFYVALRLV ACAQSGHEVT LSSLSLTMPP PKFHDTSSPL MATQSSAETH 130 140 150 160 170 180 WAVRVEEKAK FDGIFESLLP VNGLLSGDKV KPVLMNSKLP LDVLGRVWDL SDIDKDGHLD 190 200 210 220 230 240 RDEFAVAMHL VYRALEKEPV PSILPPPLIP PSKRKKTVFA GAVPVLPASP PPKDSLRSTP 250 260 270 280 290 300 SHGSVSSLNS TGSLSPKHSV KQPPVAWVVP VADKMRFDEI FLKTDLDLDG YVSGQEVKEI 310 320 330 340 350 360 FMHSGLTQNL LAHIWALADT RQTGKLSKEQ FALAMYFIQQ KVSKGIDPPQ VLSPDMVPPS 370 380 390 400 410 420 ERGTPIPDSS STLASGEFTG VKELDDISQE IAQLQREKYS LEQDIREKEE AIRQKTSEVQ 430 440 450 460 470 480 ELQNDLDRET SSLQELEAQK QDAQDRLDEM DQQKAKLRDM LSDVRQKCQD ETQTISSLKT 490 500 510 520 530 540 QIQSQESDLK SQEDDLNRAK SELNRLQQEE TQLEQSIQAG RAQLETILRS LKCTQDDINQ 550 560 570 580 590 600 ARSKLSQLQE SHLEAHRSLE QYDQVPDGVS GTSLPDLATL NEGILLAERG GFGAMVKVEG 610 620 630 640 650 660 DPFQNKKGFG DPFSGKDPFA PSSSAKPPKT SSSGFADFTS FGNEEQQLAW AKRESEKAEQ 670 680 ERLARLRRQE QEDLELAIAL SKADMPA
	Isoform 4 [UniParc]. Checksum: 1739157C3A8045B5	FASTA	763	84,752
	10 20 30 40 50 60 MAAPLVPLSQ QIPGGNPLYE SYYKQVDPAY TGRVGASEAA LFLKKSGLSD IILGKIWDLA 70 80 90 100 110 120 DPEGKGFLDK QGFYVALRLV ACAQSGHEVT LSSLSLTMPP PKFHDTSSPL MATQSSAETH 130 140 150 160 170 180 WAVRVEEKAK FDGIFESLLP VNGLLSGDKV KPVLMNSKLP LDVLGRVWDL SDIDKDGHLD 190 200 210 220 230 240 RDEFAVAMHL VYRALEKEPV PSILPPPLIP PSKRKKTVFA GAVPVLPASP PPKDSLRSTP 250 260 270 280 290 300 SHGSVSSLNS TGSLSPKHSV KQPPVAWVVP VADKMRFDEI FLKTDLDLDG YVSGQEVKEI 310 320 330 340 350 360 FMHSGLTQNL LAHIWALADT RQTGKLSKEQ FALAMYFIQQ KVSKGIDPPQ VLSPDMVPPS 370 380 390 400 410 420 ERGTPIPDSS STLASGEFTG VKELDDISQE IAQLQREKYS LEQDIREKEE AIRQKTSEVQ 430 440 450 460 470 480 ELQNDLDRET SSLQELEAQK QDAQDRLDEM DQQKAKLRDM LSDVRQKCQD ETQTISSLKT 490 500 510 520 530 540 QIQSQESDLK SQEDDLNRAK SELNRLQQEE TQLEQSIQAG RAQLETILRS LKCTQDDINQ 550 560 570 580 590 600 ARSKLSQLQE SHLEAHRSLE QYDQDDPFKN KALLFSNNSQ ELHPDPFQAE DPFKSDPFKG 610 620 630 640 650 660 ADPFKGDPFQ SDPFSEQQTA ATDPFGGDPF KESDPFHSSS SDDFFKKQTK NDPFTSDPFT 670 680 690 700 710 720 KNPSLPSKLD PFESSDPFSS SSISSKGSDP FGTLDPFGSS SFSSAEGFAD FSQMSKFGNE 730 740 750 760 EQQLAWAKRE SEKAEQERLA RLRRQEQEDL ELAIALSKAD MPA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution." Wong W.T., Schumacher C., Salcini A.E., Romano A., Castagnino P., Pelicci P.G., Di Fiore P. Proc. Natl. Acad. Sci. U.S.A. 92:9530-9534(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: BALB/c.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4). Strain: C57BL/6J. Tissue: Bone, Bone marrow and Kidney.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Kidney.
[5]	"Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization." Coda L., Salcini A.E., Confalonieri S., Pelicci G., Sorkina T., Sorkin A., Pelicci P.G., Di Fiore P.P. J. Biol. Chem. 273:3003-3012(1998) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION, INTERACTION WITH EPS15; AP-2 COMPLEX; AGFG1 AND AGFG2.
[6]	"Comprehensive identification of phosphorylation sites in postsynaptic density preparations." Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L. Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-74, MASS SPECTROMETRY. Tissue: Brain.
[7]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229; SER-353 AND THR-364, MASS SPECTROMETRY. Tissue: Brain cortex.
[8]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244; SER-250 AND SER-255, MASS SPECTROMETRY. Tissue: Liver.
[9]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255, MASS SPECTROMETRY. Tissue: Melanoma.
[10]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9; TYR-30; THR-31; SER-238 AND SER-255, MASS SPECTROMETRY. Tissue: Macrophage.
[11]	"FCHo proteins are nucleators of clathrin-mediated endocytosis." Henne W.M., Boucrot E., Meinecke M., Evergren E., Vallis Y., Mittal R., McMahon H.T. Science 328:1281-1284(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FCHO2.
[12]	"The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis." Teckchandani A., Mulkearns E.E., Randolph T.W., Toida N., Cooper J.A. Mol. Biol. Cell 23:2905-2916(2012) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DAB2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U29156 mRNA. Translation: AAA87202.1. AK036662 mRNA. Translation: BAC29523.1. AK036728 mRNA. Translation: BAC29554.1. AK146781 mRNA. Translation: BAE27427.1. AK152602 mRNA. Translation: BAE31350.1. CH466525 Genomic DNA. Translation: EDL10796.1. BC015259 mRNA. Translation: AAH15259.1.
IPI	IPI00420185. IPI00420186. IPI00420187. IPI00653328.
RefSeq	NP_001116304.1. NM_001122832.1. NP_031970.2. NM_007944.3.
UniGene	Mm.288894.
3D structure databases
ProteinModelPortal	Q60902.
SMR	Q60902. Positions 11-105, 121-214, 267-360.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q60902. 4 interactions.
MINT	MINT-234466.
PTM databases
PhosphoSite	Q60902.
Proteomic databases
PaxDb	Q60902.
PRIDE	Q60902.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000163643; ENSMUSP00000129739; ENSMUSG00000006276.
GeneID	13859.
KEGG	mmu:13859.
UCSC	uc009mfs.2. mouse.
Organism-specific databases
CTD	58513.
MGI	MGI:104582. Eps15l1.
Phylogenomic databases
eggNOG	NOG301764.
GeneTree	ENSGT00700000104202.
HOGENOM	HOG000004804.
HOVERGEN	HBG005591.
InParanoid	Q3UIS9.
OMA	MDDPFKN.
OrthoDB	EOG4JM7P3.
Gene expression databases
Bgee	Q60902.
Genevestigator	Q60902.
GermOnline	ENSMUSG00000006276. Mus musculus.
Family and domain databases
Gene3D	1.10.238.10. 3 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR000261. EPS15_homology. IPR003903. Ubiquitin-int_motif. [Graphical view]
SMART	SM00054. EFh. 3 hits. SM00027. EH. 3 hits. SM00726. UIM. 2 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 4 hits. PS50031. EH. 3 hits. PS50330. UIM. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	EPS15L1. mouse.
NextBio	284738.
SOURCE	Search...

Entry information

Entry name

EP15R_MOUSE

Accession

Primary (citable) accession number: Q60902
Secondary accession number(s): Q3U7L9 , Q3UIS9, Q8CB60, Q8CB70, Q91WH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 122 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program