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Q60902

- EP15R_MOUSE

UniProt

Q60902 - EP15R_MOUSE

Protein

Epidermal growth factor receptor substrate 15-like 1

Gene

Eps15l1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2 By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi172 – 18312PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: IntAct

    GO - Biological processi

    1. endocytosis Source: UniProtKB-KW

    Keywords - Biological processi

    Endocytosis

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_203917. EGFR downregulation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epidermal growth factor receptor substrate 15-like 1
    Alternative name(s):
    Epidermal growth factor receptor pathway substrate 15-related sequence
    Short name:
    Eps15-rs
    Eps15-related protein
    Short name:
    Eps15R
    Gene namesi
    Name:Eps15l1
    Synonyms:Eps15-rs, Eps15R
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:104582. Eps15l1.

    Subcellular locationi

    Cell membrane 1 Publication; Peripheral membrane protein 1 Publication. Nucleus 1 Publication. Membranecoated pit 1 Publication
    Note: Localized to plasma membrane coated pits.

    GO - Cellular componenti

    1. clathrin coat of coated pit Source: MGI
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Coated pit, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 907906Epidermal growth factor receptor substrate 15-like 1PRO_0000146119Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei74 – 741Phosphotyrosine2 Publications
    Modified residuei108 – 1081Phosphoserine2 Publications
    Modified residuei229 – 2291PhosphoserineBy similarity
    Modified residuei244 – 2441Phosphoserine2 Publications
    Modified residuei255 – 2551Phosphoserine2 Publications
    Modified residuei558 – 5581PhosphoserineBy similarity
    Modified residuei562 – 5621Phosphotyrosine2 Publications
    Modified residuei795 – 7951PhosphothreonineBy similarity

    Post-translational modificationi

    Phosphorylated on tyrosine residues by EGFR.5 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ60902.
    PaxDbiQ60902.
    PRIDEiQ60902.

    PTM databases

    PhosphoSiteiQ60902.

    Expressioni

    Gene expression databases

    BgeeiQ60902.
    GenevestigatoriQ60902.

    Interactioni

    Subunit structurei

    Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2). Interacts with FCHO1 By similarity. Interacts with FCHO2. Interacts (via EH domains) with DAB2.By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Dab2P980782EBI-443931,EBI-1391846
    Eps15P425672EBI-443931,EBI-443923

    Protein-protein interaction databases

    BioGridi199490. 9 interactions.
    IntActiQ60902. 6 interactions.
    MINTiMINT-234466.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60902.
    SMRiQ60902. Positions 11-105, 121-214, 267-360, 485-510.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 10490EH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini127 – 21589EH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini159 – 19436EF-handPROSITE-ProRule annotationAdd
    BLAST
    Domaini273 – 36391EH 3PROSITE-ProRule annotationAdd
    BLAST
    Repeati863 – 88220UIM 1Add
    BLAST
    Repeati889 – 90719UIM 2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni15 – 368354Interaction with DAB2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi748 – 848101Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 EF-hand domain.PROSITE-ProRule annotation
    Contains 3 EH domains.PROSITE-ProRule annotation
    Contains 2 UIM (ubiquitin-interacting motif) repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG301764.
    GeneTreeiENSGT00750000117388.
    HOGENOMiHOG000004804.
    HOVERGENiHBG005591.
    InParanoidiQ3UIS9.
    OMAiMDDPFKN.
    OrthoDBiEOG7JHM68.
    TreeFamiTF324293.

    Family and domain databases

    Gene3Di1.10.238.10. 3 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000261. EPS15_homology.
    IPR003903. Ubiquitin-int_motif.
    [Graphical view]
    SMARTiSM00054. EFh. 3 hits.
    SM00027. EH. 3 hits.
    SM00726. UIM. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 4 hits.
    PS50031. EH. 3 hits.
    PS50330. UIM. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q60902-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAPLVPLSQ QIPGGNPLYE SYYKQVDPAY TGRVGASEAA LFLKKSGLSD    50
    IILGKIWDLA DPEGKGFLDK QGFYVALRLV ACAQSGHEVT LSSLSLTMPP 100
    PKFHDTSSPL MATQSSAETH WAVRVEEKAK FDGIFESLLP VNGLLSGDKV 150
    KPVLMNSKLP LDVLGRVWDL SDIDKDGHLD RDEFAVAMHL VYRALEKEPV 200
    PSILPPPLIP PSKRKKTVFA GAVPVLPASP PPKDSLRSTP SHGSVSSLNS 250
    TGSLSPKHSV KQPPVAWVVP VADKMRFDEI FLKTDLDLDG YVSGQEVKEI 300
    FMHSGLTQNL LAHIWALADT RQTGKLSKEQ FALAMYFIQQ KVSKGIDPPQ 350
    VLSPDMVPPS ERGTPIPDSS STLASGEFTG VKELDDISQE IAQLQREKYS 400
    LEQDIREKEE AIRQKTSEVQ ELQNDLDRET SSLQELEAQK QDAQDRLDEM 450
    DQQKAKLRDM LSDVRQKCQD ETQTISSLKT QIQSQESDLK SQEDDLNRAK 500
    SELNRLQQEE TQLEQSIQAG RAQLETILRS LKCTQDDINQ ARSKLSQLQE 550
    SHLEAHRSLE QYDQVPDGVS GTSLPDLATL NEGILLAERG GFGAMDDPFK 600
    NKALLFSNNS QELHPDPFQA EDPFKSDPFK GADPFKGDPF QSDPFSEQQT 650
    AATDPFGGDP FKESDPFHSS SSDDFFKKQT KNDPFTSDPF TKNPSLPSKL 700
    DPFESSDPFS SSSISSKGSD PFGTLDPFGS SSFSSAEGFA DFSQMSKPPP 750
    SGPFSSSLGG TGFSDDPFKS KQDTPALPPK KPAPPRPKPP SGQSTPVSQL 800
    GSSDFPESPD PFQPLGADSG DPFQNKKGFG DPFSGKDPFA PSSSAKPPKT 850
    SSSGFADFTS FGNEEQQLAW AKRESEKAEQ ERLARLRRQE QEDLELAIAL 900
    SKADMPA 907
    Length:907
    Mass (Da):99,309
    Last modified:July 27, 2011 - v3
    Checksum:iB5AF1A89B445E8A7
    GO
    Isoform 2 (identifier: Q60902-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         794-819: STPVSQLGSSDFPESPDPFQPLGADS → YASSSRGTRRWGQGGGHRAPPLSSPE
         820-907: Missing.

    Show »
    Length:819
    Mass (Da):89,728
    Checksum:iD46667729E593945
    GO
    Isoform 3 (identifier: Q60902-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         596-599: DDPF → VKVE
         600-819: Missing.

    Show »
    Length:687
    Mass (Da):75,877
    Checksum:iF30E20D19F47A4DA
    GO
    Isoform 4 (identifier: Q60902-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         565-595: Missing.
         748-860: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:763
    Mass (Da):84,752
    Checksum:i1739157C3A8045B5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141G → S in AAA87202. (PubMed:7568168)Curated
    Sequence conflicti14 – 141G → S in AAH15259. (PubMed:15489334)Curated
    Sequence conflicti29 – 291A → P in AAA87202. (PubMed:7568168)Curated
    Sequence conflicti170 – 1701L → V in BAE31350. (PubMed:16141072)Curated
    Sequence conflicti413 – 4131R → K in AAA87202. (PubMed:7568168)Curated
    Sequence conflicti413 – 4131R → K in AAH15259. (PubMed:15489334)Curated
    Sequence conflicti726 – 7261D → H in BAC29523. (PubMed:16141072)Curated
    Sequence conflicti821 – 8211D → E in AAA87202. (PubMed:7568168)Curated
    Sequence conflicti850 – 8501T → A in AAA87202. (PubMed:7568168)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei565 – 59531Missing in isoform 4. 1 PublicationVSP_022638Add
    BLAST
    Alternative sequencei596 – 5994DDPF → VKVE in isoform 3. 2 PublicationsVSP_010681
    Alternative sequencei600 – 819220Missing in isoform 3. 2 PublicationsVSP_010682Add
    BLAST
    Alternative sequencei748 – 860113Missing in isoform 4. 1 PublicationVSP_022639Add
    BLAST
    Alternative sequencei794 – 81926STPVS…LGADS → YASSSRGTRRWGQGGGHRAP PLSSPE in isoform 2. 1 PublicationVSP_010683Add
    BLAST
    Alternative sequencei820 – 90788Missing in isoform 2. 1 PublicationVSP_010684Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29156 mRNA. Translation: AAA87202.1.
    AK036662 mRNA. Translation: BAC29523.1.
    AK036728 mRNA. Translation: BAC29554.1.
    AK146781 mRNA. Translation: BAE27427.1.
    AK152602 mRNA. Translation: BAE31350.1.
    CH466525 Genomic DNA. Translation: EDL10796.1.
    BC015259 mRNA. Translation: AAH15259.1.
    CCDSiCCDS52597.1. [Q60902-1]
    RefSeqiNP_001116304.1. NM_001122832.1.
    NP_001276788.1. NM_001289859.1. [Q60902-4]
    NP_031970.2. NM_007944.3. [Q60902-1]
    UniGeneiMm.288894.

    Genome annotation databases

    EnsembliENSMUST00000163643; ENSMUSP00000129739; ENSMUSG00000006276. [Q60902-1]
    GeneIDi13859.
    KEGGimmu:13859.
    UCSCiuc009mfr.2. mouse. [Q60902-1]
    uc009mfs.2. mouse. [Q60902-4]
    uc009mft.2. mouse. [Q60902-2]
    uc009mfu.2. mouse. [Q60902-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29156 mRNA. Translation: AAA87202.1 .
    AK036662 mRNA. Translation: BAC29523.1 .
    AK036728 mRNA. Translation: BAC29554.1 .
    AK146781 mRNA. Translation: BAE27427.1 .
    AK152602 mRNA. Translation: BAE31350.1 .
    CH466525 Genomic DNA. Translation: EDL10796.1 .
    BC015259 mRNA. Translation: AAH15259.1 .
    CCDSi CCDS52597.1. [Q60902-1 ]
    RefSeqi NP_001116304.1. NM_001122832.1.
    NP_001276788.1. NM_001289859.1. [Q60902-4 ]
    NP_031970.2. NM_007944.3. [Q60902-1 ]
    UniGenei Mm.288894.

    3D structure databases

    ProteinModelPortali Q60902.
    SMRi Q60902. Positions 11-105, 121-214, 267-360, 485-510.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199490. 9 interactions.
    IntActi Q60902. 6 interactions.
    MINTi MINT-234466.

    PTM databases

    PhosphoSitei Q60902.

    Proteomic databases

    MaxQBi Q60902.
    PaxDbi Q60902.
    PRIDEi Q60902.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000163643 ; ENSMUSP00000129739 ; ENSMUSG00000006276 . [Q60902-1 ]
    GeneIDi 13859.
    KEGGi mmu:13859.
    UCSCi uc009mfr.2. mouse. [Q60902-1 ]
    uc009mfs.2. mouse. [Q60902-4 ]
    uc009mft.2. mouse. [Q60902-2 ]
    uc009mfu.2. mouse. [Q60902-3 ]

    Organism-specific databases

    CTDi 58513.
    MGIi MGI:104582. Eps15l1.

    Phylogenomic databases

    eggNOGi NOG301764.
    GeneTreei ENSGT00750000117388.
    HOGENOMi HOG000004804.
    HOVERGENi HBG005591.
    InParanoidi Q3UIS9.
    OMAi MDDPFKN.
    OrthoDBi EOG7JHM68.
    TreeFami TF324293.

    Enzyme and pathway databases

    Reactomei REACT_203917. EGFR downregulation.

    Miscellaneous databases

    ChiTaRSi EPS15L1. mouse.
    NextBioi 284738.
    PROi Q60902.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q60902.
    Genevestigatori Q60902.

    Family and domain databases

    Gene3Di 1.10.238.10. 3 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000261. EPS15_homology.
    IPR003903. Ubiquitin-int_motif.
    [Graphical view ]
    SMARTi SM00054. EFh. 3 hits.
    SM00027. EH. 3 hits.
    SM00726. UIM. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 4 hits.
    PS50031. EH. 3 hits.
    PS50330. UIM. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution."
      Wong W.T., Schumacher C., Salcini A.E., Romano A., Castagnino P., Pelicci P.G., Di Fiore P.
      Proc. Natl. Acad. Sci. U.S.A. 92:9530-9534(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: BALB/c.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
      Strain: C57BL/6J.
      Tissue: Bone, Bone marrow and Kidney.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Kidney.
    5. "Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization."
      Coda L., Salcini A.E., Confalonieri S., Pelicci G., Sorkina T., Sorkin A., Pelicci P.G., Di Fiore P.P.
      J. Biol. Chem. 273:3003-3012(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION, INTERACTION WITH EPS15; AP-2 COMPLEX; AGFG1 AND AGFG2.
    6. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-562, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-74, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    8. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244 AND SER-255, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    10. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "FCHo proteins are nucleators of clathrin-mediated endocytosis."
      Henne W.M., Boucrot E., Meinecke M., Evergren E., Vallis Y., Mittal R., McMahon H.T.
      Science 328:1281-1284(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FCHO2.
    12. "The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis."
      Teckchandani A., Mulkearns E.E., Randolph T.W., Toida N., Cooper J.A.
      Mol. Biol. Cell 23:2905-2916(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DAB2.

    Entry informationi

    Entry nameiEP15R_MOUSE
    AccessioniPrimary (citable) accession number: Q60902
    Secondary accession number(s): Q3U7L9
    , Q3UIS9, Q8CB60, Q8CB70, Q91WH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 136 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3