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Q60900

- ELAV3_MOUSE

UniProt

Q60900 - ELAV3_MOUSE

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Protein
ELAV-like protein 3
Gene
Elavl3, Huc
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance.2 Publications

GO - Molecular functioni

  1. AU-rich element binding Source: UniProtKB
  2. nucleotide binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. nervous system development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 3
Alternative name(s):
Hu-antigen C
Short name:
HuC
Gene namesi
Name:Elavl3
Synonyms:Huc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:109157. Elavl3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367ELAV-like protein 3
PRO_0000081582Add
BLAST

Proteomic databases

MaxQBiQ60900.
PaxDbiQ60900.
PRIDEiQ60900.

PTM databases

PhosphoSiteiQ60900.

Expressioni

Tissue specificityi

Brain specific.1 Publication

Gene expression databases

BgeeiQ60900.
GenevestigatoriQ60900.

Interactioni

Protein-protein interaction databases

BioGridi200485. 1 interaction.
IntActiQ60900. 1 interaction.
MINTiMINT-4094236.
STRINGi10090.ENSMUSP00000003501.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi41 – 444
Helixi52 – 609
Beta strandi61 – 633
Beta strandi66 – 705
Beta strandi74 – 763
Beta strandi81 – 866
Helixi90 – 10011
Beta strandi101 – 1044
Beta strandi109 – 1135
Beta strandi128 – 1314
Helixi138 – 1469
Beta strandi151 – 1577
Beta strandi160 – 1634
Beta strandi168 – 1758
Helixi176 – 18611
Turni192 – 1954
Beta strandi199 – 2013

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D8ZNMR-A36-123[»]
1D9ANMR-A124-208[»]
1FNXNMR-H36-208[»]
ProteinModelPortaliQ60900.
SMRiQ60900. Positions 36-208, 266-363.

Miscellaneous databases

EvolutionaryTraceiQ60900.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 11779RRM 1
Add
BLAST
Domaini125 – 20581RRM 2
Add
BLAST
Domaini284 – 36279RRM 3
Add
BLAST

Domaini

RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences.2 Publications

Sequence similaritiesi

Belongs to the RRM elav family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0724.
GeneTreeiENSGT00560000077064.
HOGENOMiHOG000231162.
HOVERGENiHBG002295.
InParanoidiQ60900.
KOiK13208.
OMAiRYTGPLH.
OrthoDBiEOG77T14R.
PhylomeDBiQ60900.
TreeFamiTF313377.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform HuC-L (identifier: Q60900-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM    50
TQDEFKSLFG SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL 100
NGLKLQTKTI KVSYARPSSA SIRDANLYVS GLPKTMSQKE MEQLFSQYGR 150
IITSRILLDQ ATGVSRGVGF IRFDKRIEAE EAIKGLNGQK PLGAAEPITV 200
KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD NLLNMAYGVK 250
SPLSLIARFS PIAIDGMSGL AGVGLSGGAA GAGWCIFVYN LSPEADESVL 300
WQLFGPFGAV TNVKVIRDFT TNKCKGFGFV TMTNYDEAAM AIASLNGYRL 350
GERVLQVSFK TSKQHKA 367
Length:367
Mass (Da):39,533
Last modified:November 1, 1996 - v1
Checksum:iECD1A266512ADF58
GO
Isoform HuC-S (identifier: Q60900-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     251-257: Missing.

Show »
Length:360
Mass (Da):38,851
Checksum:i83C56C84B04FB345
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei251 – 2577Missing in isoform HuC-S.
VSP_005790

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U29148 mRNA. Translation: AAC52999.1.
U29149 mRNA. Translation: AAC53000.1.
BC052097 mRNA. Translation: AAH52097.1.
CCDSiCCDS52741.1. [Q60900-1]
RefSeqiNP_034617.1. NM_010487.2. [Q60900-1]
XP_006510085.1. XM_006510022.1. [Q60900-2]
UniGeneiMm.390167.

Genome annotation databases

EnsembliENSMUST00000003501; ENSMUSP00000003501; ENSMUSG00000003410. [Q60900-1]
GeneIDi15571.
KEGGimmu:15571.
UCSCiuc009onl.2. mouse. [Q60900-1]
uc009onn.1. mouse. [Q60900-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U29148 mRNA. Translation: AAC52999.1 .
U29149 mRNA. Translation: AAC53000.1 .
BC052097 mRNA. Translation: AAH52097.1 .
CCDSi CCDS52741.1. [Q60900-1 ]
RefSeqi NP_034617.1. NM_010487.2. [Q60900-1 ]
XP_006510085.1. XM_006510022.1. [Q60900-2 ]
UniGenei Mm.390167.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1D8Z NMR - A 36-123 [» ]
1D9A NMR - A 124-208 [» ]
1FNX NMR - H 36-208 [» ]
ProteinModelPortali Q60900.
SMRi Q60900. Positions 36-208, 266-363.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200485. 1 interaction.
IntActi Q60900. 1 interaction.
MINTi MINT-4094236.
STRINGi 10090.ENSMUSP00000003501.

PTM databases

PhosphoSitei Q60900.

Proteomic databases

MaxQBi Q60900.
PaxDbi Q60900.
PRIDEi Q60900.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000003501 ; ENSMUSP00000003501 ; ENSMUSG00000003410 . [Q60900-1 ]
GeneIDi 15571.
KEGGi mmu:15571.
UCSCi uc009onl.2. mouse. [Q60900-1 ]
uc009onn.1. mouse. [Q60900-2 ]

Organism-specific databases

CTDi 1995.
MGIi MGI:109157. Elavl3.

Phylogenomic databases

eggNOGi COG0724.
GeneTreei ENSGT00560000077064.
HOGENOMi HOG000231162.
HOVERGENi HBG002295.
InParanoidi Q60900.
KOi K13208.
OMAi RYTGPLH.
OrthoDBi EOG77T14R.
PhylomeDBi Q60900.
TreeFami TF313377.

Miscellaneous databases

ChiTaRSi ELAVL3. mouse.
EvolutionaryTracei Q60900.
NextBioi 288556.
PROi Q60900.
SOURCEi Search...

Gene expression databases

Bgeei Q60900.
Genevestigatori Q60900.

Family and domain databases

Gene3Di 3.30.70.330. 3 hits.
InterProi IPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00076. RRM_1. 3 hits.
[Graphical view ]
PRINTSi PR00961. HUDSXLRNA.
SMARTi SM00360. RRM. 3 hits.
[Graphical view ]
TIGRFAMsi TIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEi PS50102. RRM. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two different RNA binding activities for the AU-rich element and the poly(A) sequence of the mouse neuronal protein mHuC."
    Abe R., Sakashita E., Yamamoto K., Sakamoto H.
    Nucleic Acids Res. 24:4895-4901(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS HUC-L AND HUC-S), FUNCTION, DOMAIN, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM HUC-L).
    Strain: C57BL/6.
    Tissue: Brain.
  3. "NMR studies on functional structures of the AU-rich element-binding domains of Hu antigen C."
    Inoue M., Muto Y., Sakamoto H., Yokoyama S.
    Nucleic Acids Res. 28:1743-1750(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 36-208, RNA-BINDING, FUNCTION, DOMAIN.

Entry informationi

Entry nameiELAV3_MOUSE
AccessioniPrimary (citable) accession number: Q60900
Secondary accession number(s): Q60901
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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