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Q60900 (ELAV3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ELAV-like protein 3
Alternative name(s):
Hu-antigen C
Short name=HuC
Gene names
Name:Elavl3
Synonyms:Huc
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. Ref.1 Ref.3

Tissue specificity

Brain specific. Ref.1

Domain

RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences. Ref.1 Ref.3

Sequence similarities

Belongs to the RRM elav family.

Contains 3 RRM (RNA recognition motif) domains.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Coding sequence diversityAlternative splicing
   DomainRepeat
   LigandRNA-binding
   Molecular functionDevelopmental protein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

nervous system development

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionAU-rich element binding

Inferred from direct assay Ref.3. Source: UniProtKB

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform HuC-L (identifier: Q60900-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform HuC-S (identifier: Q60900-2)

The sequence of this isoform differs from the canonical sequence as follows:
     251-257: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367ELAV-like protein 3
PRO_0000081582

Regions

Domain39 – 11779RRM 1
Domain125 – 20581RRM 2
Domain284 – 36279RRM 3

Natural variations

Alternative sequence251 – 2577Missing in isoform HuC-S.
VSP_005790

Secondary structure

1 ............................... 367
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform HuC-L [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: ECD1A266512ADF58

FASTA36739,533
        10         20         30         40         50         60 
MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM TQDEFKSLFG 

        70         80         90        100        110        120 
SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL NGLKLQTKTI KVSYARPSSA 

       130        140        150        160        170        180 
SIRDANLYVS GLPKTMSQKE MEQLFSQYGR IITSRILLDQ ATGVSRGVGF IRFDKRIEAE 

       190        200        210        220        230        240 
EAIKGLNGQK PLGAAEPITV KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD 

       250        260        270        280        290        300 
NLLNMAYGVK SPLSLIARFS PIAIDGMSGL AGVGLSGGAA GAGWCIFVYN LSPEADESVL 

       310        320        330        340        350        360 
WQLFGPFGAV TNVKVIRDFT TNKCKGFGFV TMTNYDEAAM AIASLNGYRL GERVLQVSFK 


TSKQHKA

« Hide

Isoform HuC-S [UniParc].

Checksum: 83C56C84B04FB345
Show »

FASTA36038,851

References

« Hide 'large scale' references
[1]"Two different RNA binding activities for the AU-rich element and the poly(A) sequence of the mouse neuronal protein mHuC."
Abe R., Sakashita E., Yamamoto K., Sakamoto H.
Nucleic Acids Res. 24:4895-4901(1996) [PubMed: 9016658] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS HUC-L AND HUC-S), FUNCTION, DOMAIN, TISSUE SPECIFICITY.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM HUC-L).
Strain: C57BL/6.
Tissue: Brain.
[3]"NMR studies on functional structures of the AU-rich element-binding domains of Hu antigen C."
Inoue M., Muto Y., Sakamoto H., Yokoyama S.
Nucleic Acids Res. 28:1743-1750(2000) [PubMed: 10734193] [Abstract]
Cited for: STRUCTURE BY NMR OF 36-208, RNA-BINDING, FUNCTION, DOMAIN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U29148 mRNA. Translation: AAC52999.1.
U29149 mRNA. Translation: AAC53000.1.
BC052097 mRNA. Translation: AAH52097.1.
IPIIPI00122451.
IPI00222990.
RefSeqNP_034617.1. NM_010487.2.
UniGeneMm.390167.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1D8ZNMR-A36-123[»]
1D9ANMR-A124-208[»]
1FNXNMR-H36-208[»]
ProteinModelPortalQ60900.
SMRQ60900. Positions 36-366.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ60900.

PTM databases

PhosphoSiteQ60900.

Proteomic databases

PRIDEQ60900.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000003501; ENSMUSP00000003501; ENSMUSG00000003410.
GeneID15571.
KEGGmmu:15571.
UCSCuc009onl.2. mouse.
uc009onn.1. mouse.

Organism-specific databases

CTD1995.
MGIMGI:109157. Elavl3.

Phylogenomic databases

eggNOGmaNOG18935.
GeneTreeENSGT00560000077064.
HOGENOMHBG756718.
HOVERGENHBG002295.
InParanoidQ60900.
OrthoDBEOG43R3N0.
PhylomeDBQ60900.

Gene expression databases

ArrayExpressQ60900.
BgeeQ60900.
GenevestigatorQ60900.
GermOnlineENSMUSG00000003410. Mus musculus.

Family and domain databases

InterProIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
Gene3DG3DSA:3.30.70.330. a_b_plait_nuc_bd. 3 hits.
KOK13208.
PfamPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSPR00961. HUDSXLRNA.
SMARTSM00360. RRM. 3 hits.
[Graphical view]
TIGRFAMsTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio288556.
SOURCESearch...

Entry information

Entry nameELAV3_MOUSE
AccessionPrimary (citable) accession number: Q60900
Secondary accession number(s): Q60901
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 16, 2011
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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