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Q60900

- ELAV3_MOUSE

UniProt

Q60900 - ELAV3_MOUSE

Protein

ELAV-like protein 3

Gene

Elavl3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance.2 Publications

    GO - Molecular functioni

    1. AU-rich element binding Source: UniProtKB
    2. nucleotide binding Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. nervous system development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ELAV-like protein 3
    Alternative name(s):
    Hu-antigen C
    Short name:
    HuC
    Gene namesi
    Name:Elavl3
    Synonyms:Huc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:109157. Elavl3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367ELAV-like protein 3PRO_0000081582Add
    BLAST

    Proteomic databases

    MaxQBiQ60900.
    PaxDbiQ60900.
    PRIDEiQ60900.

    PTM databases

    PhosphoSiteiQ60900.

    Expressioni

    Tissue specificityi

    Brain specific.1 Publication

    Gene expression databases

    BgeeiQ60900.
    GenevestigatoriQ60900.

    Interactioni

    Protein-protein interaction databases

    BioGridi200485. 1 interaction.
    IntActiQ60900. 1 interaction.
    MINTiMINT-4094236.
    STRINGi10090.ENSMUSP00000003501.

    Structurei

    Secondary structure

    1
    367
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi41 – 444
    Helixi52 – 609
    Beta strandi61 – 633
    Beta strandi66 – 705
    Beta strandi74 – 763
    Beta strandi81 – 866
    Helixi90 – 10011
    Beta strandi101 – 1044
    Beta strandi109 – 1135
    Beta strandi128 – 1314
    Helixi138 – 1469
    Beta strandi151 – 1577
    Beta strandi160 – 1634
    Beta strandi168 – 1758
    Helixi176 – 18611
    Turni192 – 1954
    Beta strandi199 – 2013

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1D8ZNMR-A36-123[»]
    1D9ANMR-A124-208[»]
    1FNXNMR-H36-208[»]
    ProteinModelPortaliQ60900.
    SMRiQ60900. Positions 36-208, 266-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ60900.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 11779RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini125 – 20581RRM 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini284 – 36279RRM 3PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences.2 Publications

    Sequence similaritiesi

    Belongs to the RRM elav family.Curated
    Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0724.
    GeneTreeiENSGT00560000077064.
    HOGENOMiHOG000231162.
    HOVERGENiHBG002295.
    InParanoidiQ60900.
    KOiK13208.
    OMAiRYTGPLH.
    OrthoDBiEOG77T14R.
    PhylomeDBiQ60900.
    TreeFamiTF313377.

    Family and domain databases

    Gene3Di3.30.70.330. 3 hits.
    InterProiIPR006548. ELAD_HUD_SF.
    IPR002343. Hud_Sxl_RNA.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00076. RRM_1. 3 hits.
    [Graphical view]
    PRINTSiPR00961. HUDSXLRNA.
    SMARTiSM00360. RRM. 3 hits.
    [Graphical view]
    TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
    PROSITEiPS50102. RRM. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform HuC-L (identifier: Q60900-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM    50
    TQDEFKSLFG SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL 100
    NGLKLQTKTI KVSYARPSSA SIRDANLYVS GLPKTMSQKE MEQLFSQYGR 150
    IITSRILLDQ ATGVSRGVGF IRFDKRIEAE EAIKGLNGQK PLGAAEPITV 200
    KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD NLLNMAYGVK 250
    SPLSLIARFS PIAIDGMSGL AGVGLSGGAA GAGWCIFVYN LSPEADESVL 300
    WQLFGPFGAV TNVKVIRDFT TNKCKGFGFV TMTNYDEAAM AIASLNGYRL 350
    GERVLQVSFK TSKQHKA 367
    Length:367
    Mass (Da):39,533
    Last modified:November 1, 1996 - v1
    Checksum:iECD1A266512ADF58
    GO
    Isoform HuC-S (identifier: Q60900-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         251-257: Missing.

    Show »
    Length:360
    Mass (Da):38,851
    Checksum:i83C56C84B04FB345
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei251 – 2577Missing in isoform HuC-S. 1 PublicationVSP_005790

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29148 mRNA. Translation: AAC52999.1.
    U29149 mRNA. Translation: AAC53000.1.
    BC052097 mRNA. Translation: AAH52097.1.
    CCDSiCCDS52741.1. [Q60900-1]
    RefSeqiNP_034617.1. NM_010487.2. [Q60900-1]
    XP_006510085.1. XM_006510022.1. [Q60900-2]
    UniGeneiMm.390167.

    Genome annotation databases

    EnsembliENSMUST00000003501; ENSMUSP00000003501; ENSMUSG00000003410. [Q60900-1]
    GeneIDi15571.
    KEGGimmu:15571.
    UCSCiuc009onl.2. mouse. [Q60900-1]
    uc009onn.1. mouse. [Q60900-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29148 mRNA. Translation: AAC52999.1 .
    U29149 mRNA. Translation: AAC53000.1 .
    BC052097 mRNA. Translation: AAH52097.1 .
    CCDSi CCDS52741.1. [Q60900-1 ]
    RefSeqi NP_034617.1. NM_010487.2. [Q60900-1 ]
    XP_006510085.1. XM_006510022.1. [Q60900-2 ]
    UniGenei Mm.390167.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1D8Z NMR - A 36-123 [» ]
    1D9A NMR - A 124-208 [» ]
    1FNX NMR - H 36-208 [» ]
    ProteinModelPortali Q60900.
    SMRi Q60900. Positions 36-208, 266-363.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200485. 1 interaction.
    IntActi Q60900. 1 interaction.
    MINTi MINT-4094236.
    STRINGi 10090.ENSMUSP00000003501.

    PTM databases

    PhosphoSitei Q60900.

    Proteomic databases

    MaxQBi Q60900.
    PaxDbi Q60900.
    PRIDEi Q60900.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000003501 ; ENSMUSP00000003501 ; ENSMUSG00000003410 . [Q60900-1 ]
    GeneIDi 15571.
    KEGGi mmu:15571.
    UCSCi uc009onl.2. mouse. [Q60900-1 ]
    uc009onn.1. mouse. [Q60900-2 ]

    Organism-specific databases

    CTDi 1995.
    MGIi MGI:109157. Elavl3.

    Phylogenomic databases

    eggNOGi COG0724.
    GeneTreei ENSGT00560000077064.
    HOGENOMi HOG000231162.
    HOVERGENi HBG002295.
    InParanoidi Q60900.
    KOi K13208.
    OMAi RYTGPLH.
    OrthoDBi EOG77T14R.
    PhylomeDBi Q60900.
    TreeFami TF313377.

    Miscellaneous databases

    ChiTaRSi ELAVL3. mouse.
    EvolutionaryTracei Q60900.
    NextBioi 288556.
    PROi Q60900.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q60900.
    Genevestigatori Q60900.

    Family and domain databases

    Gene3Di 3.30.70.330. 3 hits.
    InterProi IPR006548. ELAD_HUD_SF.
    IPR002343. Hud_Sxl_RNA.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00076. RRM_1. 3 hits.
    [Graphical view ]
    PRINTSi PR00961. HUDSXLRNA.
    SMARTi SM00360. RRM. 3 hits.
    [Graphical view ]
    TIGRFAMsi TIGR01661. ELAV_HUD_SF. 1 hit.
    PROSITEi PS50102. RRM. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two different RNA binding activities for the AU-rich element and the poly(A) sequence of the mouse neuronal protein mHuC."
      Abe R., Sakashita E., Yamamoto K., Sakamoto H.
      Nucleic Acids Res. 24:4895-4901(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS HUC-L AND HUC-S), FUNCTION, DOMAIN, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM HUC-L).
      Strain: C57BL/6.
      Tissue: Brain.
    3. "NMR studies on functional structures of the AU-rich element-binding domains of Hu antigen C."
      Inoue M., Muto Y., Sakamoto H., Yokoyama S.
      Nucleic Acids Res. 28:1743-1750(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 36-208, RNA-BINDING, FUNCTION, DOMAIN.

    Entry informationi

    Entry nameiELAV3_MOUSE
    AccessioniPrimary (citable) accession number: Q60900
    Secondary accession number(s): Q60901
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3